| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NORGES BANK | 0 | 2,094,616 | +2,094,616 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 0 | 1,659,966 | +1,659,966 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 1,333,815 | +1,333,815 | 0.00 | 0.33 | +0.33 | buy |
| FMR LLC | 4,217,524 | 5,221,599 | +1,004,075 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 498,408 | 1,284,617 | +786,209 | 0.05 | 0.14 | +0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 118,243 | 735,003 | +616,760 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 526,565 | +526,565 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 224,602 | +224,602 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 224,602 | +224,602 | 0.00 | 0.00 | +0.00 | buy |
| Capital World Investors | 4,004,149 | 4,215,632 | +211,483 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 197,543 | +197,543 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 129,406 | +129,406 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 185,000 | 245,000 | +60,000 | 0.40 | 0.59 | +0.19 | buy |
| Bank of New York Mellon Corp | 0 | 57,326 | +57,326 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 350,000 | 400,000 | +50,000 | 0.26 | 0.33 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,109,633 | 2,156,627 | +46,994 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 70,894 | 116,902 | +46,008 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 44,470 | +44,470 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 337,302 | 377,994 | +40,692 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 39,685 | +39,685 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 31,510 | +31,510 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 30,648 | +30,648 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,244 | 30,587 | +28,343 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 26,430 | +26,430 | 0.00 | 0.10 | +0.10 | buy |
| XTX Topco Ltd | 0 | 24,956 | +24,956 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 0 | 24,135 | +24,135 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 23,302 | +23,302 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 22,650 | +22,650 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 34,196 | 55,430 | +21,234 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 18,374 | +18,374 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 19,203 | 37,226 | +18,023 | 0.02 | 0.04 | +0.02 | buy |
| Magnus Financial Group LLC | 0 | 15,600 | +15,600 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 0 | 14,841 | +14,841 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 13,087 | +13,087 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 12,946 | +12,946 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 12,088 | +12,088 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 11,193 | +11,193 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 74,312 | 84,803 | +10,491 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 9,277 | +9,277 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 8,600 | +8,600 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 42,866 | 50,748 | +7,882 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 7,200 | +7,200 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 5,550 | 11,191 | +5,641 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 4,800 | +4,800 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 3,800 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 87,335 | 91,100 | +3,765 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,374 | +2,374 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,215 | +2,215 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 1,407 | +1,407 | 0.00 | 0.00 | +0.00 | buy |
| STANCE CAPITAL LLC | 0 | 1,384 | +1,384 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,014 | +1,014 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 573 | +573 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 336 | +336 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 212 | +212 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Avion Wealth | 100 | 200 | +100 | 0.00 | 0.00 | +0.00 | buy |
| HOLLENCREST CAPITAL MANAGEMENT | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NVIDIA CORP | 833,325 | 833,325 | 0 | 0.06 | 0.02 | -0.03 | hold |
| ALBION FINANCIAL GROUP /UT | 4,854 | 4,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HARVARD MANAGEMENT CO INC | 1,111,100 | 1,111,100 | 0 | 0.76 | 0.44 | -0.33 | hold |
| HARBOURVEST PARTNERS LLC | 1,722,210 | 1,722,210 | 0 | 21.33 | 17.09 | -4.25 | hold |
| BAKER BROS. ADVISORS LP | 1,423,602 | 1,423,602 | 0 | 0.10 | 0.12 | +0.02 | hold |
| ARCH Venture Management, LLC | 1,944,426 | 1,944,426 | 0 | 3.59 | 2.98 | -0.61 | hold |
| Flagship Pioneering Inc. | 62,673,117 | 62,673,117 | 0 | 67.44 | 68.66 | +1.21 | hold |
| LMR Partners LLP | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SEVEN GRAND MANAGERS, LLC | 125,000 | 125,000 | 0 | 0.10 | 0.08 | -0.02 | hold |
| Siren, L.L.C. | 736,104 | 736,104 | 0 | 0.26 | 0.25 | -0.00 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 40,344 | 38,665 | -1,679 | 0.00 | 0.00 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 40,344 | 38,218 | -2,126 | 0.01 | 0.01 | +0.00 | sell |
| FNY Investment Advisers, LLC | 3,000 | 0 | -3,000 | 0.02 | 0.00 | -0.02 | sell |
| Squarepoint Ops LLC | 37,203 | 31,406 | -5,797 | 0.00 | 0.00 | +0.00 | sell |
| Diametric Capital, LP | 10,497 | 0 | -10,497 | 0.03 | 0.00 | -0.03 | sell |
| Hudson Bay Capital Management LP | 16,678 | 0 | -16,678 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 18,362 | 0 | -18,362 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 23,833 | 0 | -23,833 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 30,000 | 5,000 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 356,704 | 326,273 | -30,431 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 50,221 | 0 | -50,221 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 58,762 | 0 | -58,762 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 79,489 | 0 | -79,489 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 95,000 | 0 | -95,000 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | 0 | -100,000 | 0.15 | 0.00 | -0.15 | sell |
| JANE STREET GROUP, LLC | 123,371 | 0 | -123,371 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 266,813 | 131,560 | -135,253 | 0.18 | 0.11 | -0.07 | sell |
| GOLDMAN SACHS GROUP INC | 170,695 | 0 | -170,695 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 3,592,999 | 3,283,844 | -309,155 | 1.50 | 2.05 | +0.55 | sell |
| ExodusPoint Capital Management, LP | 311,986 | 0 | -311,986 | 0.04 | 0.00 | -0.04 | sell |
| MILLENNIUM MANAGEMENT LLC | 376,893 | 21,926 | -354,967 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 500,000 | 0 | -500,000 | 0.02 | 0.00 | -0.02 | sell |
| JPMORGAN CHASE & CO | 2,947,259 | 1,409,649 | -1,537,610 | 0.00 | 0.00 | -0.00 | sell |