| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 4,963,052 | 5,013,052 | +50,000 | 1.56 | 1.40 | -0.16 | buy |
| BlackRock, Inc. | 3,159,863 | 3,195,530 | +35,667 | 0.00 | 0.00 | -0.00 | buy |
| AIGH Capital Management LLC | 2,000,000 | 3,100,000 | +1,100,000 | 3.12 | 2.84 | -0.27 | buy |
| Cable Car Capital, LP | 2,500,000 | 3,007,329 | +507,329 | 0.82 | 4.65 | +3.84 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,676,000 | 2,676,000 | 0 | 0.35 | 0.33 | -0.03 | hold |
| Propel Bio Management, LLC | 830,780 | 1,329,899 | +499,119 | 3.74 | 3.79 | +0.05 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,050,095 | 1,263,511 | +213,416 | 0.12 | 0.12 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,137,127 | 1,209,797 | +72,670 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 502,184 | 1,130,619 | +628,435 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 898,438 | 957,328 | +58,890 | 0.00 | 0.00 | -0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 956,770 | 956,770 | 0 | 0.40 | 0.47 | +0.07 | hold |
| AWM Investment Company, Inc. | 774,130 | 803,130 | +29,000 | 0.39 | 0.40 | +0.00 | buy |
| 683 Capital Management, LLC | 770,000 | 770,000 | 0 | 0.34 | 0.32 | -0.02 | hold |
| Stonepine Capital Management, LLC | 709,505 | 746,587 | +37,082 | 2.96 | 2.94 | -0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 627,738 | 648,942 | +21,204 | 0.48 | 0.34 | -0.14 | buy |
| J. Goldman & Co LP | 398,916 | 640,530 | +241,614 | 0.08 | 0.13 | +0.05 | buy |
| Diametric Capital, LP | 694,421 | 611,520 | -82,901 | 0.98 | 0.72 | -0.26 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 591,737 | 589,847 | -1,890 | 0.01 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 521,087 | 522,445 | +1,358 | 0.00 | 0.00 | -0.00 | buy |
| Simplify Asset Management Inc. | 500,342 | 507,988 | +7,646 | 0.04 | 0.04 | -0.01 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 500,000 | +500,000 | 0.00 | 0.00 | +0.00 | buy |
| Knoll Capital Management, LLC | 235,953 | 485,515 | +249,562 | 0.57 | 1.21 | +0.64 | buy |
| NORTHERN TRUST CORP | 419,330 | 435,973 | +16,643 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 701,288 | 432,370 | -268,918 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 343,568 | 425,426 | +81,858 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,000,000 | 400,000 | -600,000 | 0.26 | 0.09 | -0.17 | sell |
| BANK OF AMERICA CORP /DE/ | 507,625 | 394,274 | -113,351 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 473,661 | 337,562 | -136,099 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 21,347 | 266,497 | +245,150 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 160,401 | 233,924 | +73,523 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 216,305 | +216,305 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 323,986 | 209,607 | -114,379 | 0.05 | 0.03 | -0.02 | sell |
| PANAGORA ASSET MANAGEMENT INC | 166,711 | 199,145 | +32,434 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 168,455 | 194,813 | +26,358 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 194,264 | 193,632 | -632 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 71,153 | 172,460 | +101,307 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 116,200 | 161,082 | +44,882 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,903 | 127,109 | -5,794 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 122,944 | +122,944 | 0.00 | 0.01 | +0.01 | buy |
| Palo Alto Investors LP | 108,865 | 108,865 | 0 | 0.08 | 0.07 | -0.01 | hold |
| AQR CAPITAL MANAGEMENT LLC | 114,520 | 102,645 | -11,875 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 105,965 | 101,065 | -4,900 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 111,179 | 93,073 | -18,106 | 0.04 | 0.03 | -0.01 | sell |
| Pale Fire Capital SE | 174,705 | 69,845 | -104,860 | 0.12 | 0.03 | -0.09 | sell |
| XTX Topco Ltd | 49,338 | 69,120 | +19,782 | 0.01 | 0.01 | -0.00 | buy |
| Headlands Technologies LLC | 0 | 63,345 | +63,345 | 0.00 | 0.03 | +0.03 | buy |
| Rangeley Capital, LLC | 57,600 | 60,000 | +2,400 | 0.26 | 0.29 | +0.03 | buy |
| Nuveen, LLC | 56,719 | 56,719 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 55,931 | 55,847 | -84 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 39,368 | 44,927 | +5,559 | 0.00 | 0.00 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 35,094 | +35,094 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 34,371 | +34,371 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 154,986 | 33,561 | -121,425 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 98,238 | 31,096 | -67,142 | 0.01 | 0.00 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,127 | 31,005 | +6,878 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 21,707 | 29,263 | +7,556 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 99,311 | 27,248 | -72,063 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 23,938 | 23,772 | -166 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 23,060 | 22,979 | -81 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,242 | 20,760 | +518 | 0.00 | 0.00 | -0.00 | buy |
| Riverwater Partners LLC | 19,375 | 19,066 | -309 | 0.04 | 0.03 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 17,920 | 17,920 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 47,852 | 16,702 | -31,150 | 0.00 | 0.00 | -0.00 | sell |
| Cetera Investment Advisers | 18,258 | 15,845 | -2,413 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 13,095 | 14,054 | +959 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 13,975 | +13,975 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 13,308 | 13,291 | -17 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,651 | 12,901 | -750 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 12,718 | +12,718 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 21,249 | 12,193 | -9,056 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 11,005 | 11,005 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Kovack Advisors, Inc. | 0 | 10,560 | +10,560 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 10,307 | 10,307 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 9,554 | 9,888 | +334 | 0.00 | 0.00 | -0.00 | buy |
| MAI Capital Management | 5,620 | 9,433 | +3,813 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,662 | 7,516 | +3,854 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 57,031 | 4,874 | -52,157 | 0.01 | 0.00 | -0.01 | sell |
| Allworth Financial LP | 4,500 | 4,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,459 | 4,459 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 4,604 | 3,975 | -629 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 134 | 3,412 | +3,278 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 3,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,689 | 2,364 | -325 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,700 | 1,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rockefeller Capital Management L.P. | 1,250 | 1,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 90 | 909 | +819 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 2,124 | 618 | -1,506 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 427 | 346 | -81 | 0.00 | 0.00 | -0.00 | sell |
| BEACON INVESTMENT ADVISORY SERVICES, INC. | 0 | 240 | +240 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 136 | +136 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 78 | 74 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Darwin Wealth Management, LLC | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 40,000 | 0 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 10,731 | 0 | -10,731 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 62,873 | 0 | -62,873 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 127,618 | 0 | -127,618 | 0.00 | 0.00 | -0.00 | sell |