| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Nantahala Capital Management, LLC | 4,564,665 | 4,963,052 | +398,387 | 1.49 | 1.56 | +0.07 | buy |
| BlackRock, Inc. | 3,147,150 | 3,159,863 | +12,713 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 2,602,901 | 2,757,143 | +154,242 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,676,000 | 2,676,000 | 0 | 0.43 | 0.35 | -0.08 | hold |
| Cable Car Capital, LP | 600,000 | 2,500,000 | +1,900,000 | 1.36 | 0.82 | -0.54 | buy |
| AIGH Capital Management LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 3.12 | +3.12 | buy |
| Vivo Capital, LLC | 1,842,751 | 1,842,751 | 0 | 0.78 | 0.63 | -0.16 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,127,131 | 1,137,127 | +9,996 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,050,863 | 1,050,095 | -768 | 0.12 | 0.12 | -0.01 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.26 | +0.26 | buy |
| NAN FUNG TRINITY (HK) Ltd | 560,770 | 956,770 | +396,000 | 0.30 | 0.40 | +0.10 | buy |
| STATE STREET CORP | 716,154 | 898,438 | +182,284 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 974,022 | 830,780 | -143,242 | 5.15 | 3.74 | -1.41 | sell |
| AWM Investment Company, Inc. | 547,000 | 774,130 | +227,130 | 0.27 | 0.39 | +0.12 | buy |
| 683 Capital Management, LLC | 770,000 | 770,000 | 0 | 0.37 | 0.34 | -0.03 | hold |
| Stonepine Capital Management, LLC | 450,970 | 709,505 | +258,535 | 1.94 | 2.96 | +1.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 701,288 | +701,288 | 0.00 | 0.01 | +0.01 | buy |
| Diametric Capital, LP | 173,201 | 694,421 | +521,220 | 0.34 | 0.98 | +0.64 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 994,754 | 627,738 | -367,016 | 0.76 | 0.48 | -0.28 | sell |
| Aberdeen Group plc | 0 | 616,413 | +616,413 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 591,737 | +591,737 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 523,956 | 521,087 | -2,869 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 912,912 | 507,625 | -405,287 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 322,431 | 502,184 | +179,753 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 565,009 | 500,342 | -64,667 | 0.06 | 0.04 | -0.02 | sell |
| MORGAN STANLEY | 607,641 | 473,661 | -133,980 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 422,227 | 419,330 | -2,897 | 0.00 | 0.00 | -0.00 | sell |
| J. Goldman & Co LP | 0 | 398,916 | +398,916 | 0.00 | 0.08 | +0.08 | buy |
| Jain Global LLC | 0 | 366,067 | +366,067 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 709,349 | 343,568 | -365,781 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 48,000 | 323,986 | +275,986 | 0.01 | 0.05 | +0.04 | buy |
| Knoll Capital Management, LLC | 62,689 | 235,953 | +173,264 | 0.18 | 0.57 | +0.39 | buy |
| Bank of New York Mellon Corp | 213,842 | 194,264 | -19,578 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 0 | 174,705 | +174,705 | 0.00 | 0.12 | +0.12 | buy |
| FMR LLC | 5,784 | 168,455 | +162,671 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 160,557 | 166,711 | +6,154 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 128,232 | 160,401 | +32,169 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 207,777 | 154,986 | -52,791 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 133,560 | 132,903 | -657 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 273,446 | 127,618 | -145,828 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 526,437 | 116,200 | -410,237 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 33,612 | 114,520 | +80,908 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 47,915 | 111,179 | +63,264 | 0.02 | 0.04 | +0.02 | buy |
| Palo Alto Investors LP | 108,865 | 108,865 | 0 | 0.11 | 0.08 | -0.03 | hold |
| D. E. Shaw & Co., Inc. | 126,384 | 105,965 | -20,419 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 62,297 | 99,311 | +37,014 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 32,772 | 98,238 | +65,466 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 75,940 | +75,940 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 0 | 71,153 | +71,153 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 59,708 | 62,873 | +3,165 | 0.00 | 0.00 | -0.00 | buy |
| Rangeley Capital, LLC | 0 | 57,600 | +57,600 | 0.00 | 0.26 | +0.26 | buy |
| Caption Management, LLC | 0 | 57,031 | +57,031 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 56,719 | 56,719 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 63,673 | 55,931 | -7,742 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 39,359 | 49,338 | +9,979 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 27,179 | 47,852 | +20,673 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 37,065 | 39,368 | +2,303 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 33,581 | +33,581 | 0.00 | 0.04 | +0.04 | buy |
| Brooklyn Investment Group | 0 | 25,779 | +25,779 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 23,158 | 24,127 | +969 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 26,626 | 23,938 | -2,688 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 23,011 | 23,060 | +49 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 21,707 | +21,707 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 282,259 | 21,347 | -260,912 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 25,176 | 21,249 | -3,927 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 20,483 | 20,242 | -241 | 0.00 | 0.00 | -0.00 | sell |
| Riverwater Partners LLC | 15,857 | 19,375 | +3,518 | 0.03 | 0.04 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 18,258 | +18,258 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 17,920 | 17,920 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SHERBROOKE PARK ADVISERS LLC | 12,179 | 15,556 | +3,377 | 0.03 | 0.21 | +0.18 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,412 | 13,651 | -1,761 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 13,308 | +13,308 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 7,082 | 13,095 | +6,013 | 0.00 | 0.00 | +0.00 | buy |
| PVG ASSET MANAGEMENT CORP | 0 | 12,570 | +12,570 | 0.00 | 0.14 | +0.14 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,005 | 11,005 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 0 | 10,731 | +10,731 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 3,537 | 10,307 | +6,770 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,002 | 9,554 | -448 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 1,620 | 5,620 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,815 | 4,604 | -211 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 4,528 | 4,500 | -28 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 4,459 | 4,459 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 8,567 | 3,662 | -4,905 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,727 | 2,689 | -38 | 0.00 | 0.00 | -0.00 | sell |
| Farther Finance Advisors, LLC | 723 | 2,124 | +1,401 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,700 | 1,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,492 | 1,372 | -120 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 1,250 | 1,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JONES FINANCIAL COMPANIES LLLP | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 258 | 427 | +169 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vermillion & White Wealth Management Group, LLC | 370 | 370 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 48 | 90 | +42 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 195 | 78 | -117 | 0.00 | 0.00 | -0.00 | sell |
| Darwin Wealth Management, LLC | 26 | 26 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NewEdge Advisors, LLC | 226 | 1 | -225 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 13,400 | 0 | -13,400 | 0.00 | 0.00 | -0.00 | sell |
| MassMutual Private Wealth & Trust, FSB | 126 | 0 | -126 | 0.00 | 0.00 | -0.00 | sell |