| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 0 | 378,346 | +378,346 | 0.00 | 0.04 | +0.04 | buy |
| Integral Health Asset Management, LLC | 0 | 167,000 | +167,000 | 0.00 | 0.12 | +0.12 | buy |
| ADAR1 Capital Management, LLC | 34,693 | 68,741 | +34,048 | 0.04 | 0.09 | +0.04 | buy |
| CITADEL ADVISORS LLC | 0 | 23,141 | +23,141 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 24,354 | 33,341 | +8,987 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 192 | +192 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 22,287 | 22,287 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 339,549 | 339,549 | 0 | 0.07 | 0.09 | +0.02 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 83,333 | 83,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 208,333 | 208,333 | 0 | 0.09 | 0.12 | +0.03 | hold |
| Vivo Capital, LLC | 208,333 | 208,333 | 0 | 0.14 | 0.18 | +0.04 | hold |
| Union Bancaire Privee, UBP SA | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Physician Wealth Advisors, Inc. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 83,333 | 83,333 | 0 | 0.45 | 0.56 | +0.12 | hold |
| SBI Securities Co., Ltd. | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 26,809 | 26,626 | -183 | 0.00 | 0.00 | +0.00 | sell |
| Vestal Point Capital, LP | 55,189 | 53,439 | -1,750 | 0.02 | 0.02 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 21,006 | 19,243 | -1,763 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 13,521 | 0 | -13,521 | 0.00 | 0.00 | -0.00 | sell |