| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 2,951,116 | +2,951,116 | 0.00 | 0.01 | +0.01 | buy |
| VR Adviser, LLC | 0 | 1,675,262 | +1,675,262 | 0.00 | 1.00 | +1.00 | buy |
| JANUS HENDERSON GROUP PLC | 166,666 | 1,815,474 | +1,648,808 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 439,142 | 1,447,782 | +1,008,640 | 0.10 | 0.46 | +0.36 | buy |
| Stonepine Capital Management, LLC | 11,884 | 975,200 | +963,316 | 0.11 | 13.72 | +13.60 | buy |
| Logos Global Management LP | 0 | 625,000 | +625,000 | 0.00 | 0.51 | +0.51 | buy |
| Velan Capital Investment Management LP | 83,333 | 583,333 | +500,000 | 0.59 | 5.84 | +5.25 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 478,827 | +478,827 | 0.00 | 0.25 | +0.25 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 83,333 | 540,126 | +456,793 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 0 | 399,184 | +399,184 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 381,419 | +381,419 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 0 | 327,307 | +327,307 | 0.00 | 1.28 | +1.28 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 279,537 | +279,537 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 302,473 | 533,889 | +231,416 | 0.00 | 0.01 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 215,934 | +215,934 | 0.00 | 0.70 | +0.70 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 200,000 | +200,000 | 0.00 | 0.98 | +0.98 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 194,616 | +194,616 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 0 | 188,700 | +188,700 | 0.00 | 0.58 | +0.58 | buy |
| FMR LLC | 141,100 | 322,600 | +181,500 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 143,481 | 323,911 | +180,430 | 0.01 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 63,673 | 213,462 | +149,789 | 0.06 | 0.21 | +0.15 | buy |
| ExodusPoint Capital Management, LP | 0 | 120,529 | +120,529 | 0.00 | 0.02 | +0.02 | buy |
| Point72 Asset Management, L.P. | 423,415 | 533,965 | +110,550 | 0.01 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 0 | 104,400 | +104,400 | 0.00 | 0.08 | +0.08 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 62,786 | +62,786 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 298,153 | 352,572 | +54,419 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 0 | 50,712 | +50,712 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 967,600 | 1,017,600 | +50,000 | 1.53 | 2.33 | +0.80 | buy |
| XTX Topco Ltd | 0 | 47,851 | +47,851 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 0 | 41,819 | +41,819 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 33,470 | 68,588 | +35,118 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 33,628 | +33,628 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 31,336 | +31,336 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 28,990 | +28,990 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 28,977 | +28,977 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 28,285 | +28,285 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 125,579 | 152,600 | +27,021 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 129,528 | 152,516 | +22,988 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 16,698 | +16,698 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 15,296 | 30,647 | +15,351 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 352,206 | 366,791 | +14,585 | 0.11 | 0.14 | +0.03 | buy |
| Verition Fund Management LLC | 0 | 13,589 | +13,589 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 55,699 | 69,160 | +13,461 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 12,049 | +12,049 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 22,409 | 31,854 | +9,445 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 9,418 | +9,418 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,502 | +4,502 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 1 | 2,501 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 199 | 1,100 | +901 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 16,714 | 16,977 | +263 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 596,376 | 596,564 | +188 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 57 | +57 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 339,549 | 339,549 | 0 | 0.14 | 0.17 | +0.03 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 44,900 | 44,900 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 10,650 | 10,650 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 208,333 | 208,333 | 0 | 0.16 | 0.28 | +0.11 | hold |
| Union Bancaire Privee, UBP SA | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Integral Health Asset Management, LLC | 167,000 | 167,000 | 0 | 0.10 | 0.14 | +0.04 | hold |
| Physician Wealth Advisors, Inc. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Artia Global Partners LP | 42,080 | 42,080 | 0 | 0.08 | 0.15 | +0.07 | hold |
| Corient Private Wealth LLC | 12,388 | 12,388 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vestal Point Capital, LP | 53,439 | 53,439 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Siren, L.L.C. | 427,141 | 427,141 | 0 | 0.16 | 0.19 | +0.03 | hold |
| CITIGROUP INC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 20,648 | 15,472 | -5,176 | 0.00 | 0.00 | +0.00 | sell |
| Persistent Asset Partners Ltd | 65,272 | 58,182 | -7,090 | 0.38 | 0.36 | -0.02 | sell |
| RTW INVESTMENTS, LP | 378,346 | 370,246 | -8,100 | 0.05 | 0.06 | +0.01 | sell |
| TWO SIGMA ADVISERS, LP | 13,178 | 0 | -13,178 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 190,111 | 136,015 | -54,096 | 0.48 | 0.37 | -0.11 | sell |
| DIADEMA PARTNERS LP | 243,170 | 179,738 | -63,432 | 1.77 | 1.19 | -0.58 | sell |