| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 322,600 | 3,942,373 | +3,619,773 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 208,333 | 2,500,000 | +2,291,667 | 0.28 | 3.32 | +3.04 | buy |
| BlackRock, Inc. | 16,977 | 1,727,988 | +1,711,011 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 749,588 | +749,588 | 0.00 | 0.05 | +0.05 | buy |
| BRAIDWELL LP | 0 | 584,412 | +584,412 | 0.00 | 0.31 | +0.31 | buy |
| CITADEL ADVISORS LLC | 152,516 | 728,561 | +576,045 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 69,160 | 639,537 | +570,377 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 28,990 | 510,814 | +481,824 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 28,285 | 429,893 | +401,608 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 104,400 | 500,039 | +395,639 | 0.08 | 0.39 | +0.31 | buy |
| MILLENNIUM MANAGEMENT LLC | 533,889 | 876,230 | +342,341 | 0.01 | 0.01 | +0.00 | buy |
| RTW INVESTMENTS, LP | 370,246 | 696,570 | +326,324 | 0.06 | 0.09 | +0.03 | buy |
| Bank of New York Mellon Corp | 0 | 325,296 | +325,296 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 68,588 | 353,390 | +284,802 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 50,712 | 321,604 | +270,892 | 0.01 | 0.03 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,977 | 289,164 | +260,187 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 255,000 | +255,000 | 0.00 | 0.13 | +0.13 | buy |
| PERCEPTIVE ADVISORS LLC | 1,447,782 | 1,700,000 | +252,218 | 0.46 | 0.38 | -0.07 | buy |
| GOLDMAN SACHS GROUP INC | 31,854 | 274,946 | +243,092 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 33,628 | 266,656 | +233,028 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 352,572 | 585,578 | +233,006 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 323,911 | 531,254 | +207,343 | 0.02 | 0.02 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 62,786 | 253,518 | +190,732 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 12,049 | 199,134 | +187,085 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 176,889 | +176,889 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 161,187 | +161,187 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 156,062 | +156,062 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 136,428 | +136,428 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 132,272 | +132,272 | 0.00 | 0.12 | +0.12 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 117,482 | +117,482 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 105,237 | +105,237 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 95,513 | +95,513 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 71,967 | +71,967 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 47,851 | 113,767 | +65,916 | 0.01 | 0.02 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 120,529 | 184,501 | +63,972 | 0.02 | 0.02 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 61,174 | +61,174 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 61,174 | +61,174 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 215,934 | 265,934 | +50,000 | 0.70 | 0.62 | -0.08 | buy |
| Man Group plc | 0 | 49,044 | +49,044 | 0.00 | 0.00 | +0.00 | buy |
| Quinn Opportunity Partners LLC | 0 | 40,000 | +40,000 | 0.00 | 0.03 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 0 | 35,267 | +35,267 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 33,334 | +33,334 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 31,291 | +31,291 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 26,924 | +26,924 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 24,557 | +24,557 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 533,965 | 556,761 | +22,796 | 0.01 | 0.01 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 21,084 | +21,084 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 19,993 | +19,993 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 19,900 | +19,900 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 30,647 | 47,835 | +17,188 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,336 | 47,249 | +15,913 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 44,900 | 59,900 | +15,000 | 0.01 | 0.02 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 14,940 | +14,940 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 13,096 | +13,096 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1 | 11,623 | +11,622 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 11,544 | +11,544 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 152,600 | 164,000 | +11,400 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 10,735 | +10,735 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 0 | 10,110 | +10,110 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 0 | 10,022 | +10,022 | 0.00 | 0.00 | +0.00 | buy |
| K2 PRINCIPAL FUND, L.P. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 8,800 | +8,800 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 7,425 | +7,425 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 213,462 | 220,462 | +7,000 | 0.21 | 0.15 | -0.05 | buy |
| STRS OHIO | 0 | 4,900 | +4,900 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 3,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,442 | +2,442 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 2,285 | +2,285 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,100 | 2,308 | +1,208 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 9,418 | 10,511 | +1,093 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 0 | 507 | +507 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 347 | +347 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 192 | +192 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 57 | 150 | +93 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 57 | +57 | 0.00 | 0.00 | +0.00 | buy |
| Commonwealth Retirement Investments LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 339,549 | 339,549 | 0 | 0.17 | 0.13 | -0.05 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 540,126 | 540,126 | 0 | 0.01 | 0.01 | -0.00 | hold |
| LETKO, BROSSEAU & ASSOCIATES INC | 10,650 | 10,650 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Verition Fund Management LLC | 13,589 | 13,589 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Union Bancaire Privee, UBP SA | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Integral Health Asset Management, LLC | 167,000 | 167,000 | 0 | 0.14 | 0.10 | -0.04 | hold |
| Physician Wealth Advisors, Inc. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Artia Global Partners LP | 42,080 | 42,080 | 0 | 0.15 | 0.12 | -0.04 | hold |
| Corient Private Wealth LLC | 12,388 | 12,388 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vestal Point Capital, LP | 53,439 | 53,439 | 0 | 0.02 | 0.02 | -0.01 | hold |
| Siren, L.L.C. | 427,141 | 427,141 | 0 | 0.19 | 0.13 | -0.06 | hold |
| MAI Capital Management | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 2,501 | 1 | -2,500 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 4,502 | 0 | -4,502 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 16,698 | 8,054 | -8,644 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 15,472 | 0 | -15,472 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 136,015 | 120,200 | -15,815 | 0.37 | 0.25 | -0.12 | sell |
| Velan Capital Investment Management LP | 583,333 | 549,985 | -33,348 | 5.84 | 4.90 | -0.94 | sell |
| HRT FINANCIAL LP | 41,819 | 0 | -41,819 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 366,791 | 311,087 | -55,704 | 0.14 | 0.08 | -0.05 | sell |
| Persistent Asset Partners Ltd | 58,182 | 0 | -58,182 | 0.36 | 0.00 | -0.36 | sell |
| STEMPOINT CAPITAL LP | 188,700 | 96,273 | -92,427 | 0.58 | 0.24 | -0.34 | sell |
| MORGAN STANLEY | 596,564 | 432,220 | -164,344 | 0.00 | 0.00 | -0.00 | sell |