| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 0 | 339,549 | +339,549 | 0.00 | 0.03 | +0.03 | buy |
| VR Adviser, LLC | 0 | 208,333 | +208,333 | 0.00 | 0.04 | +0.04 | buy |
| Vivo Capital, LLC | 0 | 208,333 | +208,333 | 0.00 | 0.06 | +0.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 83,333 | +83,333 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 83,333 | +83,333 | 0.00 | 0.31 | +0.31 | buy |
| Vestal Point Capital, LP | 0 | 83,333 | +83,333 | 0.00 | 0.02 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 0 | 62,423 | +62,423 | 0.00 | 0.04 | +0.04 | buy |
| Stonepine Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.11 | +0.11 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 29,166 | +29,166 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 24,000 | +24,000 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 21,006 | +21,006 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 14,751 | +14,751 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 11,041 | 18,390 | +7,349 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 961 | 1,693 | +732 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 343 | 0 | -343 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 4,407 | 0 | -4,407 | 0.00 | 0.00 | -0.00 | sell |