| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | 0 | 967,600 | +967,600 | 0.00 | 1.49 | +1.49 | buy |
| VR Adviser, LLC | 98,564 | 437,708 | +339,144 | 0.04 | 0.19 | +0.14 | buy |
| RTW INVESTMENTS, LP | 378,346 | 378,346 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Siren, L.L.C. | 0 | 352,441 | +352,441 | 0.00 | 0.10 | +0.10 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 352,206 | +352,206 | 0.00 | 0.07 | +0.07 | buy |
| BVF INC/IL | 339,549 | 339,549 | 0 | 0.07 | 0.10 | +0.03 | hold |
| MILLENNIUM MANAGEMENT LLC | 233,714 | 313,712 | +79,998 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 208,333 | 208,333 | 0 | 0.12 | 0.13 | +0.00 | hold |
| MARSHALL WACE, LLP | 0 | 177,209 | +177,209 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 167,000 | 167,000 | 0 | 0.09 | 0.09 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VANGUARD GROUP INC | 22,287 | 161,800 | +139,513 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 88,211 | +88,211 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 83,333 | 83,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 83,333 | 83,333 | 0 | 0.48 | 0.60 | +0.12 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 56,600 | +56,600 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 53,439 | 53,439 | 0 | 0.02 | 0.02 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 155,557 | 53,428 | -102,129 | 0.15 | 0.04 | -0.11 | sell |
| CITADEL ADVISORS LLC | 0 | 43,253 | +43,253 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 34,236 | 34,425 | +189 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 12,119 | +12,119 | 0.00 | 0.01 | +0.01 | buy |
| DRW Securities, LLC | 0 | 10,514 | +10,514 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,249 | 501 | -748 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Wealthspire Advisors, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Union Bancaire Privee, UBP SA | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Physician Wealth Advisors, Inc. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 15,930 | 0 | -15,930 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |