| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 166,666 | +166,666 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 26,809 | +26,809 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 22,287 | +22,287 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 13,521 | +13,521 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 18,390 | 24,354 | +5,964 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 339,549 | 339,549 | 0 | 0.03 | 0.07 | +0.04 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 83,333 | 83,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VR Adviser, LLC | 208,333 | 208,333 | 0 | 0.04 | 0.09 | +0.05 | hold |
| Vivo Capital, LLC | 208,333 | 208,333 | 0 | 0.06 | 0.14 | +0.08 | hold |
| Velan Capital Investment Management LP | 83,333 | 83,333 | 0 | 0.31 | 0.45 | +0.13 | hold |
| DIMENSIONAL FUND ADVISORS LP | 21,006 | 21,006 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,693 | 0 | -1,693 | 0.00 | 0.00 | -0.00 | sell |
| Lynx1 Capital Management LP | 14,751 | 0 | -14,751 | 0.02 | 0.00 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 24,000 | 0 | -24,000 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 62,423 | 34,693 | -27,730 | 0.04 | 0.04 | +0.01 | sell |
| Vestal Point Capital, LP | 83,333 | 55,189 | -28,144 | 0.02 | 0.02 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 29,166 | 0 | -29,166 | 0.02 | 0.00 | -0.02 | sell |
| Stonepine Capital Management, LLC | 50,000 | 0 | -50,000 | 0.11 | 0.00 | -0.11 | sell |