| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 0 | 596,376 | +596,376 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 439,142 | +439,142 | 0.00 | 0.10 | +0.10 | buy |
| Point72 Asset Management, L.P. | 0 | 423,415 | +423,415 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 243,170 | +243,170 | 0.00 | 1.77 | +1.77 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 190,111 | +190,111 | 0.00 | 0.48 | +0.48 | buy |
| FMR LLC | 0 | 141,100 | +141,100 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 177,209 | 298,153 | +120,944 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 161,800 | 255,664 | +93,864 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 43,253 | 129,528 | +86,275 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 352,441 | 427,141 | +74,700 | 0.10 | 0.16 | +0.05 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 56,600 | 125,579 | +68,979 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 65,272 | +65,272 | 0.00 | 0.38 | +0.38 | buy |
| Woodline Partners LP | 88,211 | 143,481 | +55,270 | 0.00 | 0.01 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 44,900 | +44,900 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 0 | 42,080 | +42,080 | 0.00 | 0.08 | +0.08 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 33,470 | +33,470 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 22,409 | +22,409 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 34,425 | 55,699 | +21,274 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 20,648 | +20,648 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 0 | 16,714 | +16,714 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 15,296 | +15,296 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 13,178 | +13,178 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 12,388 | +12,388 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 0 | 11,884 | +11,884 | 0.00 | 0.11 | +0.11 | buy |
| LETKO, BROSSEAU & ASSOCIATES INC | 0 | 10,650 | +10,650 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 53,428 | 63,673 | +10,245 | 0.04 | 0.06 | +0.02 | buy |
| CITIGROUP INC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 339,549 | 339,549 | 0 | 0.10 | 0.14 | +0.03 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 83,333 | 83,333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 166,666 | 166,666 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 378,346 | 378,346 | 0 | 0.04 | 0.05 | +0.01 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 352,206 | 352,206 | 0 | 0.07 | 0.11 | +0.04 | hold |
| Allworth Financial LP | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 208,333 | 208,333 | 0 | 0.13 | 0.16 | +0.04 | hold |
| Union Bancaire Privee, UBP SA | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Integral Health Asset Management, LLC | 167,000 | 167,000 | 0 | 0.09 | 0.10 | +0.01 | hold |
| Ikarian Capital, LLC | 967,600 | 967,600 | 0 | 1.49 | 1.53 | +0.04 | hold |
| Physician Wealth Advisors, Inc. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Velan Capital Investment Management LP | 83,333 | 83,333 | 0 | 0.60 | 0.59 | -0.00 | hold |
| Vestal Point Capital, LP | 53,439 | 53,439 | 0 | 0.02 | 0.02 | +0.01 | hold |
| Wealthspire Advisors, LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 2 | 1 | -1 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 501 | 199 | -302 | 0.00 | 0.00 | -0.00 | sell |
| DRW Securities, LLC | 10,514 | 0 | -10,514 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 313,712 | 302,473 | -11,239 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 12,119 | 0 | -12,119 | 0.01 | 0.00 | -0.01 | sell |
| VR Adviser, LLC | 437,708 | 0 | -437,708 | 0.19 | 0.00 | -0.19 | sell |