| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 28,177,636 | +28,177,636 | 0.00 | 0.58 | +0.58 | buy |
| Commodore Capital LP | 0 | 21,052,631 | +21,052,631 | 0.00 | 1.68 | +1.68 | buy |
| MARSHALL WACE, LLP | 0 | 18,971,733 | +18,971,733 | 0.00 | 0.04 | +0.04 | buy |
| Octagon Capital Advisors LP | 0 | 14,718,422 | +14,718,422 | 0.00 | 2.13 | +2.13 | buy |
| Point72 Asset Management, L.P. | 0 | 13,453,255 | +13,453,255 | 0.00 | 0.05 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 13,089,476 | +13,089,476 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 25,671 | 12,443,621 | +12,417,950 | 0.00 | 2.40 | +2.40 | buy |
| CITADEL ADVISORS LLC | 0 | 12,267,432 | +12,267,432 | 0.00 | 0.01 | +0.01 | buy |
| Hills Bank & Trust Co | 0 | 10,358,305 | +10,358,305 | 0.00 | 1.05 | +1.05 | buy |
| Laurion Capital Management LP | 0 | 8,918,918 | +8,918,918 | 0.00 | 0.30 | +0.30 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 8,108,108 | +8,108,108 | 0.00 | 2.71 | +2.71 | buy |
| ORBIMED ADVISORS LLC | 0 | 6,505,800 | +6,505,800 | 0.00 | 0.14 | +0.14 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 5,794,725 | +5,794,725 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 5,100,000 | +5,100,000 | 0.00 | 0.99 | +0.99 | buy |
| VANGUARD GROUP INC | 13,213,750 | 17,780,106 | +4,566,356 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 3,103,644 | +3,103,644 | 0.00 | 0.84 | +0.84 | buy |
| ExodusPoint Capital Management, LP | 0 | 2,888,937 | +2,888,937 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 2,830,400 | +2,830,400 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 0 | 2,581,128 | +2,581,128 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 1,996,511 | +1,996,511 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,516,649 | 4,375,677 | +1,859,028 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,035,339 | +1,035,339 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 671,524 | 1,582,424 | +910,900 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 850,000 | +850,000 | 0.00 | 0.01 | +0.01 | buy |
| Informed Momentum Co LLC | 0 | 843,161 | +843,161 | 0.00 | 0.16 | +0.16 | buy |
| Tri Locum Partners LP | 0 | 780,303 | +780,303 | 0.00 | 0.32 | +0.32 | buy |
| MORGAN STANLEY | 0 | 774,355 | +774,355 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 42,200 | 676,725 | +634,525 | 0.01 | 0.22 | +0.21 | buy |
| Atom Investors LP | 0 | 551,279 | +551,279 | 0.00 | 0.08 | +0.08 | buy |
| Altium Capital Management LLC | 0 | 535,657 | +535,657 | 0.00 | 0.28 | +0.28 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 535,293 | +535,293 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 527,470 | +527,470 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 393,312 | 845,304 | +451,992 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 430,105 | +430,105 | 0.00 | 0.03 | +0.03 | buy |
| AMG National Trust Bank | 0 | 373,300 | +373,300 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 246,244 | +246,244 | 0.00 | 0.00 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 142,550 | 342,550 | +200,000 | 0.02 | 0.12 | +0.10 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 192,282 | +192,282 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 116,009 | 234,692 | +118,683 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 115,762 | +115,762 | 0.00 | 0.01 | +0.01 | buy |
| LMR Partners LLP | 0 | 115,488 | +115,488 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 111,723 | +111,723 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 103,773 | +103,773 | 0.00 | 0.03 | +0.03 | buy |
| HRT FINANCIAL LP | 20,272 | 122,167 | +101,895 | 0.00 | 0.00 | +0.00 | buy |
| RIA Advisory Group LLC | 7,560 | 106,853 | +99,293 | 0.54 | 0.05 | -0.48 | buy |
| Vontobel Holding Ltd. | 0 | 80,000 | +80,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 15,000 | 93,201 | +78,201 | 0.00 | 0.00 | +0.00 | buy |
| CTC Alternative Strategies, Ltd. | 0 | 69,900 | +69,900 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 0 | 69,006 | +69,006 | 0.00 | 0.00 | +0.00 | buy |
| Marathon Trading Investment Management LLC | 0 | 47,000 | +47,000 | 0.00 | 0.02 | +0.02 | buy |
| OMERS ADMINISTRATION Corp | 0 | 45,200 | +45,200 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 138,500 | 183,500 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 43,500 | +43,500 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 38,994 | +38,994 | 0.00 | 0.00 | +0.00 | buy |
| SYKON CAPITAL LLC | 0 | 36,215 | +36,215 | 0.00 | 0.02 | +0.02 | buy |
| Simplicity Wealth,LLC | 0 | 33,570 | +33,570 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 33,570 | +33,570 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 28,990 | +28,990 | 0.00 | 0.00 | +0.00 | buy |
| TradeLink Capital LLC | 0 | 27,000 | +27,000 | 0.00 | 0.48 | +0.48 | buy |
| MONETA GROUP INVESTMENT ADVISORS LLC | 0 | 23,708 | +23,708 | 0.00 | 0.00 | +0.00 | buy |
| ZWJ INVESTMENT COUNSEL INC | 0 | 22,000 | +22,000 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 14,400 | +14,400 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 14,377 | +14,377 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 14,152 | +14,152 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 13,988 | +13,988 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 42,284 | 48,284 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| OLD POINT TRUST & FINANCIAL SERVICES N A | 0 | 2,500 | +2,500 | 0.00 | 0.00 | +0.00 | buy |
| Scarborough Advisors, LLC | 0 | 109 | +109 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 4 | +4 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 184,000 | 184,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 38 | 38 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mariner, LLC | 47,778 | 47,778 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighTower Advisors, LLC | 1,332,238 | 1,332,238 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cerity Partners LLC | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JNBA Financial Advisors | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighPoint Advisor Group LLC | 15,700 | 15,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GREAT VALLEY ADVISOR GROUP, INC. | 12,000 | 12,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Wealth Advisors of Iowa, LLC | 20,000 | 20,000 | 0 | 0.01 | 0.01 | +0.01 | hold |
| CW Advisors, LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JDM Financial Group LLC | 35,000 | 35,000 | 0 | 0.01 | 0.03 | +0.02 | hold |
| TD Waterhouse Canada Inc. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| THRIVENT FINANCIAL FOR LUTHERANS | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAPITAL ADVISORS INC/OK | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 204 | 0 | -204 | 0.00 | 0.00 | -0.00 | sell |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 362 | 0 | -362 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 1,000 | 0 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH EFFECTS LLC | 120,000 | 117,500 | -2,500 | 0.02 | 0.05 | +0.03 | sell |
| Mendota Financial Group, LLC | 15,000 | 7,500 | -7,500 | 0.00 | 0.01 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 19,271 | 10,881 | -8,390 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 32,400 | 23,100 | -9,300 | 0.00 | 0.00 | +0.00 | sell |
| AE Wealth Management LLC | 10,850 | 0 | -10,850 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 154,240 | 43,720 | -110,520 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 306,746 | 31,746 | -275,000 | 0.00 | 0.00 | -0.00 | sell |
| OSTERWEIS CAPITAL MANAGEMENT INC | 1,582,100 | 1,244,932 | -337,168 | 0.04 | 0.09 | +0.05 | sell |
| Taylor & Morgan Wealth Management, LLC | 625,000 | 250,000 | -375,000 | 0.20 | 0.22 | +0.02 | sell |
| PERKINS CAPITAL MANAGEMENT INC | 700,000 | 0 | -700,000 | 0.24 | 0.00 | -0.24 | sell |
| BAKER BROS. ADVISORS LP | 7,639,703 | 149,787 | -7,489,916 | 0.03 | 0.00 | -0.03 | sell |