| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 7,915,567 | +7,915,567 | 0.00 | 0.94 | +0.94 | buy |
| Commodore Capital LP | 0 | 6,336,782 | +6,336,782 | 0.00 | 1.53 | +1.53 | buy |
| Avidity Partners Management LP | 3,210,733 | 6,049,999 | +2,839,266 | 2.55 | 5.11 | +2.56 | buy |
| BlackRock, Inc. | 4,559,977 | 5,348,561 | +788,584 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 1,184,500 | 4,675,000 | +3,490,500 | 0.66 | 2.57 | +1.91 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,406,374 | 4,046,640 | +2,640,266 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 270,491 | 3,566,504 | +3,296,013 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 300,000 | 3,164,582 | +2,864,582 | 0.06 | 0.77 | +0.71 | buy |
| STATE STREET CORP | 1,141,247 | 3,132,670 | +1,991,423 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 2,994,460 | +2,994,460 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 4,474,522 | 2,983,342 | -1,491,180 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,414,522 | 1,766,960 | +352,438 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 1,132,815 | 1,625,000 | +492,185 | 0.67 | 1.20 | +0.54 | buy |
| Nicholson Wealth Management Group, LLC | 1,617,993 | 1,618,993 | +1,000 | 2.61 | 3.94 | +1.33 | buy |
| GOLDMAN SACHS GROUP INC | 159,837 | 1,241,816 | +1,081,979 | 0.00 | 0.00 | +0.00 | buy |
| VESTOR CAPITAL, LLC | 502 | 1,098,691 | +1,098,189 | 0.18 | 0.33 | +0.15 | buy |
| Yu Fan | 0 | 1,055,409 | +1,055,409 | 0.00 | 4.54 | +4.54 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,198,644 | 1,003,474 | -195,170 | 0.00 | 0.00 | -0.00 | sell |
| Ally Bridge Group (NY) LLC | 0 | 926,557 | +926,557 | 0.00 | 3.84 | +3.84 | buy |
| Nuveen, LLC | 1,274,007 | 910,221 | -363,786 | 0.00 | 0.00 | +0.00 | sell |
| Hills Bank & Trust Co | 938,200 | 872,200 | -66,000 | 0.15 | 0.18 | +0.03 | sell |
| Octagon Capital Advisors LP | 0 | 791,555 | +791,555 | 0.00 | 0.37 | +0.37 | buy |
| ADAR1 Capital Management, LLC | 95,193 | 749,335 | +654,142 | 0.02 | 0.19 | +0.17 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 535,477 | 661,318 | +125,841 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 439,214 | 528,928 | +89,714 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 926,331 | 520,905 | -405,426 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 91,557 | 450,097 | +358,540 | 0.00 | 0.00 | +0.00 | buy |
| WealthPlan Investment Management, LLC | 404,071 | 404,071 | 0 | 0.07 | 0.09 | +0.02 | hold |
| FMR LLC | 307,055 | 313,658 | +6,603 | 0.00 | 0.00 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 250,000 | 250,000 | 0 | 0.21 | 0.33 | +0.13 | hold |
| BANK OF AMERICA CORP /DE/ | 424,519 | 241,924 | -182,595 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 24,278 | 231,355 | +207,077 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 213,759 | 222,142 | +8,383 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 75,041 | 212,131 | +137,090 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 200,000 | +200,000 | 0.00 | 0.11 | +0.11 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 81,441 | 186,630 | +105,189 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 188,605 | 185,335 | -3,270 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 183,342 | +183,342 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 169,147 | +169,147 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 168,223 | +168,223 | 0.00 | 0.00 | +0.00 | buy |
| Sentinus, LLC | 164,714 | 164,821 | +107 | 0.04 | 0.06 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 119,114 | +119,114 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 117,051 | +117,051 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 10,675 | 115,489 | +104,814 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 95,800 | 110,800 | +15,000 | 0.01 | 0.01 | +0.00 | buy |
| Trueblood Wealth Management, LLC | 119,061 | 99,061 | -20,000 | 0.13 | 0.16 | +0.03 | sell |
| Rafferty Asset Management, LLC | 0 | 92,812 | +92,812 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 83,470 | 83,470 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 76,571 | 77,090 | +519 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 40,415 | 71,464 | +31,049 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 65,494 | +65,494 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 61,864 | +61,864 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 54,245 | 53,163 | -1,082 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 42,486 | +42,486 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,769 | 42,282 | +12,513 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 41,567 | +41,567 | 0.00 | 0.01 | +0.01 | buy |
| SYKON CAPITAL LLC | 37,932 | 37,932 | 0 | 0.03 | 0.05 | +0.02 | hold |
| GSA CAPITAL PARTNERS LLP | 86,212 | 37,317 | -48,895 | 0.02 | 0.01 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 12,567 | 35,722 | +23,155 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,665 | 34,841 | +7,176 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 33,946 | +33,946 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,717 | 33,079 | +16,362 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH EFFECTS LLC | 25,000 | 33,000 | +8,000 | 0.02 | 0.05 | +0.03 | buy |
| Taylor & Morgan Wealth Management, LLC | 97,000 | 29,000 | -68,000 | 0.15 | 0.07 | -0.08 | sell |
| AQR CAPITAL MANAGEMENT LLC | 0 | 26,716 | +26,716 | 0.00 | 0.00 | +0.00 | buy |
| Koa Wealth Management, LLC | 25,975 | 25,975 | 0 | 0.05 | 0.08 | +0.03 | hold |
| WINTON GROUP Ltd | 0 | 24,300 | +24,300 | 0.00 | 0.00 | +0.00 | buy |
| MONETA GROUP INVESTMENT ADVISORS LLC | 23,707 | 23,707 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 66,820 | 23,491 | -43,329 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 23,090 | +23,090 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 27,704 | 22,269 | -5,435 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 12,510 | 21,661 | +9,151 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 20,917 | 20,917 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 20,787 | 20,787 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighTower Advisors, LLC | 36,882 | 20,027 | -16,855 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 25,702 | 19,507 | -6,195 | 0.00 | 0.00 | +0.00 | sell |
| Iowa State Bank | 19,061 | 19,061 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Vontobel Holding Ltd. | 25,000 | 18,000 | -7,000 | 0.00 | 0.00 | +0.00 | sell |
| AXQ CAPITAL, LP | 12,749 | 17,048 | +4,299 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,031 | 16,681 | -2,350 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 81,296 | 15,608 | -65,688 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 92,791 | 15,049 | -77,742 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 14,888 | +14,888 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 14,056 | +14,056 | 0.00 | 0.01 | +0.01 | buy |
| Polymer Capital Management (US) LLC | 0 | 13,083 | +13,083 | 0.00 | 0.01 | +0.01 | buy |
| NISA INVESTMENT ADVISORS, LLC | 140 | 12,692 | +12,552 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 12,528 | +12,528 | 0.00 | 0.00 | +0.00 | buy |
| Scientech Research LLC | 0 | 11,905 | +11,905 | 0.00 | 0.04 | +0.04 | buy |
| Mariner, LLC | 0 | 11,815 | +11,815 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 0 | 11,794 | +11,794 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 10,191 | 11,675 | +1,484 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 11,667 | +11,667 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 10,810 | +10,810 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 10,567 | +10,567 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,300 | 10,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pekin Hardy Strauss, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 8,477 | 8,477 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 5,476 | 5,476 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 5,426 | 5,426 | 0 | 0.00 | 0.00 | +0.00 | hold |