| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 134,430 | 5,504,822 | +5,370,392 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 4,443,667 | 4,799,352 | +355,685 | 0.02 | 0.03 | +0.01 | buy |
| Avidity Partners Management LP | 3,037,668 | 3,444,002 | +406,334 | 1.29 | 2.35 | +1.06 | buy |
| Commodore Capital LP | 4,657,345 | 3,350,000 | -1,307,345 | 3.17 | 2.79 | -0.37 | sell |
| VANGUARD GROUP INC | 2,921,268 | 3,076,941 | +155,673 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,817,763 | 2,817,763 | 0 | 0.47 | 0.56 | +0.09 | hold |
| STATE STREET CORP | 997,427 | 2,190,239 | +1,192,812 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 1,283,942 | 1,490,791 | +206,849 | 0.02 | 0.03 | +0.01 | buy |
| Octagon Capital Advisors LP | 1,580,249 | 1,422,224 | -158,025 | 2.60 | 3.04 | +0.44 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,034,550 | 1,164,204 | +129,654 | 0.00 | 0.00 | +0.00 | buy |
| Hills Bank & Trust Co | 0 | 1,027,830 | +1,027,830 | 0.00 | 1.04 | +1.04 | buy |
| Paradigm Biocapital Advisors LP | 919,692 | 919,692 | 0 | 0.35 | 0.43 | +0.08 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 381,640 | 750,000 | +368,360 | 0.01 | 0.02 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 662,496 | +662,496 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 525,800 | 591,623 | +65,823 | 0.04 | 0.06 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 786,909 | 589,295 | -197,614 | 1.28 | 1.29 | +0.01 | sell |
| ExodusPoint Capital Management, LP | 596,054 | 581,614 | -14,440 | 0.07 | 0.08 | +0.01 | sell |
| Affinity Asset Advisors, LLC | 550,000 | 500,000 | -50,000 | 0.86 | 1.04 | +0.17 | sell |
| NORTHERN TRUST CORP | 137,840 | 474,158 | +336,318 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 448,683 | +448,683 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 134,744 | 433,522 | +298,778 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 401,196 | 414,396 | +13,200 | 0.12 | 0.18 | +0.06 | buy |
| Ally Bridge Group (NY) LLC | 396,242 | 341,739 | -54,503 | 2.35 | 2.44 | +0.09 | sell |
| WealthPlan Investment Management, LLC | 0 | 339,292 | +339,292 | 0.00 | 0.46 | +0.46 | buy |
| Altium Capital Management LLC | 191,450 | 290,000 | +98,550 | 0.79 | 1.15 | +0.36 | buy |
| MORGAN STANLEY | 151,896 | 285,401 | +133,505 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 343,810 | 238,084 | -105,726 | 1.01 | 0.95 | -0.06 | sell |
| DAFNA Capital Management LLC | 231,634 | 230,322 | -1,312 | 0.55 | 0.73 | +0.17 | sell |
| BANK OF AMERICA CORP /DE/ | 67,655 | 174,344 | +106,689 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 260,009 | 167,986 | -92,023 | 0.64 | 0.51 | -0.13 | sell |
| HighTower Advisors, LLC | 141,236 | 141,236 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bank of New York Mellon Corp | 137,268 | 138,776 | +1,508 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 113,550 | 138,350 | +24,800 | 0.41 | 0.64 | +0.22 | buy |
| Sofinnova Investments, Inc. | 132,089 | 120,632 | -11,457 | 0.08 | 0.13 | +0.05 | sell |
| BARCLAYS PLC | 16,582 | 114,075 | +97,493 | 0.00 | 0.00 | +0.00 | buy |
| SANDLER CAPITAL MANAGEMENT | 106,697 | 102,806 | -3,891 | 0.21 | 0.27 | +0.06 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 102,292 | +102,292 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 101,138 | +101,138 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 142,499 | 100,000 | -42,499 | 0.16 | 0.14 | -0.02 | sell |
| Swiss National Bank | 69,260 | 92,160 | +22,900 | 0.00 | 0.00 | +0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 91,293 | 91,293 | 0 | 0.05 | 0.06 | +0.01 | hold |
| RHUMBLINE ADVISERS | 63,170 | 90,917 | +27,747 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 18,302 | 86,386 | +68,084 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 85,013 | 70,923 | -14,090 | 0.02 | 0.02 | -0.00 | sell |
| PORTLAND INVESTMENT COUNSEL INC. | 70,001 | 70,001 | 0 | 0.25 | 0.34 | +0.08 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55,467 | 58,678 | +3,211 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,770 | 50,460 | +38,690 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,320 | 49,690 | +25,370 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 36,375 | 48,538 | +12,163 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 24,390 | 48,136 | +23,746 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,391 | 47,565 | +44,174 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,364 | 45,148 | +9,784 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 17,520 | 41,175 | +23,655 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 10,305 | 39,067 | +28,762 | 0.00 | 0.00 | +0.00 | buy |
| SYKON CAPITAL LLC | 37,932 | 37,932 | 0 | 0.14 | 0.18 | +0.04 | hold |
| AMG National Trust Bank | 37,330 | 37,330 | 0 | 0.01 | 0.01 | +0.00 | hold |
| XTX Topco Ltd | 0 | 37,300 | +37,300 | 0.00 | 0.04 | +0.04 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 33,545 | +33,545 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 12,028 | 31,165 | +19,137 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 30,000 | +30,000 | 0.00 | 0.01 | +0.01 | buy |
| Taylor & Morgan Wealth Management, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.27 | +0.27 | buy |
| Corebridge Financial, Inc. | 25,333 | 28,905 | +3,572 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 28,723 | +28,723 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 948 | 26,459 | +25,511 | 0.00 | 0.00 | +0.00 | buy |
| RIA Advisory Group LLC | 0 | 25,620 | +25,620 | 0.00 | 0.12 | +0.12 | buy |
| JANE STREET GROUP, LLC | 78,660 | 25,256 | -53,404 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 0 | 24,912 | +24,912 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 23,523 | 24,587 | +1,064 | 0.00 | 0.00 | +0.00 | buy |
| MONETA GROUP INVESTMENT ADVISORS LLC | 23,707 | 23,707 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 20,586 | +20,586 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 18,842 | 20,514 | +1,672 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 11,000 | 20,400 | +9,400 | 0.04 | 0.16 | +0.12 | buy |
| PROFUND ADVISORS LLC | 0 | 20,261 | +20,261 | 0.00 | 0.01 | +0.01 | buy |
| CIBC Asset Management Inc | 0 | 19,415 | +19,415 | 0.00 | 0.00 | +0.00 | buy |
| Iowa State Bank | 0 | 19,061 | +19,061 | 0.00 | 0.05 | +0.05 | buy |
| SG Americas Securities, LLC | 0 | 18,461 | +18,461 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,119 | 18,168 | +2,049 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 512,823 | 18,117 | -494,706 | 0.05 | 0.00 | -0.05 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 15,019 | 17,908 | +2,889 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,869 | 17,105 | +1,236 | 0.00 | 0.00 | +0.00 | buy |
| Trueblood Wealth Management, LLC | 0 | 16,236 | +16,236 | 0.00 | 0.11 | +0.11 | buy |
| Nebula Research & Development LLC | 0 | 14,843 | +14,843 | 0.00 | 0.02 | +0.02 | buy |
| Arizona State Retirement System | 0 | 13,588 | +13,588 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 13,272 | +13,272 | 0.00 | 0.15 | +0.15 | buy |
| WEALTH EFFECTS LLC | 17,350 | 13,250 | -4,100 | 0.06 | 0.06 | -0.00 | sell |
| CITADEL ADVISORS LLC | 575,549 | 12,024 | -563,525 | 0.01 | 0.00 | -0.01 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 11,836 | +11,836 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 11,424 | +11,424 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 11,378 | +11,378 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 19,000 | 10,300 | -8,700 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 10,289 | +10,289 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 10,214 | +10,214 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,803 | 7,945 | +142 | 0.04 | 0.05 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 6,809 | +6,809 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 2,710 | 6,576 | +3,866 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 4,613 | 5,476 | +863 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 8,700 | 5,300 | -3,400 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 0 | 4,300 | +4,300 | 0.00 | 0.03 | +0.03 | buy |
| JDM Financial Group LLC | 0 | 3,500 | +3,500 | 0.00 | 0.03 | +0.03 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 2,871 | +2,871 | 0.00 | 0.00 | +0.00 | buy |