| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avidity Partners Management LP | 3,037,668 | 3,444,002 | +406,334 | 1.29 | 2.35 | +1.06 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 381,640 | 750,000 | +368,360 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 4,443,667 | 4,799,352 | +355,685 | 0.02 | 0.03 | 0.00 | buy |
| Altium Capital Management LLC | 191,450 | 290,000 | +98,550 | 0.79 | 1.15 | +0.36 | buy |
| HighVista Strategies LLC | 113,550 | 138,350 | +24,800 | 0.41 | 0.64 | +0.22 | buy |
| ExodusPoint Capital Management, LP | 596,054 | 581,614 | +14,440 | 0.07 | 0.08 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 85,013 | 70,923 | +14,090 | 0.05 | 0.07 | 0.00 | sell |
| Rock Springs Capital Management LP | 401,196 | 414,396 | +13,200 | 0.12 | 0.18 | +0.06 | buy |
| SECTORAL ASSET MANAGEMENT INC | 11,000 | 20,400 | +9,400 | 0.04 | 0.16 | +0.12 | buy |
| VIRTUS ADVISERS, LLC | 7,803 | 7,945 | +142 | 0.04 | 0.05 | +0.01 | buy |
| DAFNA Capital Management LLC | 231,634 | 230,322 | -1,312 | 0.55 | 0.73 | +0.17 | sell |
| SANDLER CAPITAL MANAGEMENT | 106,697 | 102,806 | -3,891 | 0.21 | 0.27 | +0.06 | sell |
| WEALTH EFFECTS LLC | 17,350 | 13,250 | -4,100 | 0.06 | 0.06 | -0.00 | sell |
| Sofinnova Investments, Inc. | 132,089 | 120,632 | -11,457 | 0.07 | 0.13 | +0.06 | sell |
| Atika Capital Management LLC | 142,499 | 100,000 | -42,499 | 0.14 | 0.14 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 550,000 | 500,000 | -50,000 | 0.86 | 1.04 | +0.17 | sell |
| Ally Bridge Group (NY) LLC | 396,242 | 341,739 | -54,503 | 2.35 | 2.44 | +0.09 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 260,009 | 167,986 | -92,023 | 0.64 | 0.51 | -0.13 | sell |
| STEMPOINT CAPITAL LP | 343,810 | 238,084 | -105,726 | 1.01 | 0.95 | -0.06 | sell |
| Octagon Capital Advisors LP | 1,580,249 | 1,422,224 | -158,025 | 2.60 | 3.04 | +0.44 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 786,909 | 589,295 | -197,614 | 1.07 | 1.25 | +0.18 | sell |
| Commodore Capital LP | 4,657,345 | 3,350,000 | -1,307,345 | 3.17 | 2.79 | -0.37 | sell |