| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 5,504,822 | 10,027,301 | +4,522,479 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 4,039,974 | 4,105,247 | +65,273 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 3,076,941 | 3,144,867 | +67,926 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,817,763 | 2,938,754 | +120,991 | 0.56 | 0.18 | -0.38 | buy |
| Avidity Partners Management LP | 3,444,002 | 2,694,600 | -749,402 | 2.35 | 0.86 | -1.49 | sell |
| Octagon Capital Advisors LP | 1,422,224 | 2,304,752 | +882,528 | 3.04 | 1.25 | -1.79 | buy |
| Nicholson Wealth Management Group, LLC | 1,602,283 | 1,609,283 | +7,000 | 17.57 | 3.43 | -14.14 | buy |
| Affinity Asset Advisors, LLC | 500,000 | 1,300,000 | +800,000 | 1.04 | 0.65 | -0.39 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 1,295,343 | +1,295,343 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,190,263 | +1,190,263 | 0.00 | 0.11 | +0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,164,204 | 1,167,428 | +3,224 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 285,401 | 1,143,462 | +858,061 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 2,190,239 | 1,108,193 | -1,082,046 | 0.00 | 0.00 | -0.00 | sell |
| Hills Bank & Trust Co | 1,027,830 | 1,027,830 | 0 | 1.04 | 0.25 | -0.79 | hold |
| GOLDMAN SACHS GROUP INC | 448,683 | 902,918 | +454,235 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 1,490,791 | 807,172 | -683,619 | 0.03 | 0.00 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 0 | 650,351 | +650,351 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 86,386 | 571,748 | +485,362 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 500,000 | +500,000 | 0.00 | 1.38 | +1.38 | buy |
| NORTHERN TRUST CORP | 474,158 | 487,273 | +13,115 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 18,117 | 475,792 | +457,675 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 589,295 | 460,247 | -129,048 | 1.29 | 0.27 | -1.02 | sell |
| Rock Springs Capital Management LP | 414,396 | 444,383 | +29,987 | 0.18 | 0.05 | -0.13 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 433,522 | 406,966 | -26,556 | 0.00 | 0.00 | -0.00 | sell |
| WealthPlan Investment Management, LLC | 339,292 | 401,049 | +61,757 | 0.46 | 0.13 | -0.33 | buy |
| Qube Research & Technologies Ltd | 0 | 270,453 | +270,453 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 261,474 | +261,474 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 215,725 | +215,725 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 12,024 | 214,778 | +202,754 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 196,208 | +196,208 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 141,236 | 178,111 | +36,875 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 591,623 | 168,500 | -423,123 | 0.06 | 0.00 | -0.06 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 151,610 | +151,610 | 0.00 | 0.00 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 70,001 | 150,000 | +79,999 | 0.34 | 0.12 | -0.21 | buy |
| JPMORGAN CHASE & CO | 24,912 | 149,045 | +124,133 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 138,776 | 143,469 | +4,693 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 138,350 | 138,350 | 0 | 0.64 | 0.16 | -0.47 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,136 | 134,391 | +86,255 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 130,914 | +130,914 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 130,600 | +130,600 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 230,322 | 130,169 | -100,153 | 0.73 | 0.11 | -0.62 | sell |
| Verition Fund Management LLC | 28,723 | 125,690 | +96,967 | 0.00 | 0.00 | -0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 70,923 | 123,243 | +52,320 | 0.02 | 0.01 | -0.01 | buy |
| Ikarian Capital, LLC | 0 | 108,300 | +108,300 | 0.00 | 0.10 | +0.10 | buy |
| RHUMBLINE ADVISERS | 90,917 | 94,992 | +4,075 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 114,075 | 94,879 | -19,196 | 0.00 | 0.00 | -0.00 | sell |
| Altium Capital Management LLC | 290,000 | 92,224 | -197,776 | 1.15 | 0.09 | -1.06 | sell |
| Swiss National Bank | 92,160 | 86,260 | -5,900 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 58,678 | 70,150 | +11,472 | 0.00 | 0.00 | -0.00 | buy |
| Aristides Capital LLC | 0 | 58,700 | +58,700 | 0.00 | 0.06 | +0.06 | buy |
| Taylor & Morgan Wealth Management, LLC | 30,000 | 56,000 | +26,000 | 0.27 | 0.13 | -0.14 | buy |
| Point72 Asset Management, L.P. | 0 | 54,893 | +54,893 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 47,565 | 51,094 | +3,529 | 0.00 | 0.00 | -0.00 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 49,690 | 49,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 50,460 | 49,420 | -1,040 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 48,538 | 48,538 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mariner, LLC | 0 | 46,900 | +46,900 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 26,459 | 46,579 | +20,120 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 39,067 | 45,241 | +6,174 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,148 | 41,702 | -3,446 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 41,175 | 40,260 | -915 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH EFFECTS LLC | 13,250 | 38,000 | +24,750 | 0.06 | 0.04 | -0.02 | buy |
| SYKON CAPITAL LLC | 37,932 | 37,932 | 0 | 0.18 | 0.04 | -0.14 | hold |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 102,292 | 36,752 | -65,540 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 32,718 | +32,718 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 31,150 | +31,150 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33,545 | 30,939 | -2,606 | 0.00 | 0.00 | -0.00 | sell |
| AMG National Trust Bank | 37,330 | 29,980 | -7,350 | 0.01 | 0.00 | -0.01 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 28,577 | +28,577 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 28,905 | 26,876 | -2,029 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,378 | 26,591 | +15,213 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 10,289 | 26,584 | +16,295 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,168 | 26,462 | +8,294 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 18,461 | 26,088 | +7,627 | 0.00 | 0.00 | -0.00 | buy |
| Koa Wealth Management, LLC | 0 | 25,975 | +25,975 | 0.00 | 0.07 | +0.07 | buy |
| Invesco Ltd. | 24,587 | 25,174 | +587 | 0.00 | 0.00 | -0.00 | buy |
| MONETA GROUP INVESTMENT ADVISORS LLC | 23,707 | 23,707 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Trueblood Wealth Management, LLC | 16,236 | 22,236 | +6,000 | 0.11 | 0.03 | -0.07 | buy |
| MetLife Investment Management, LLC | 31,165 | 22,228 | -8,937 | 0.00 | 0.00 | -0.00 | sell |
| Nebula Research & Development LLC | 14,843 | 21,850 | +7,007 | 0.02 | 0.01 | -0.02 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 21,564 | +21,564 | 0.00 | 0.02 | +0.02 | buy |
| CIBC Asset Management Inc | 19,415 | 20,516 | +1,101 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,945 | 20,487 | +12,542 | 0.05 | 0.03 | -0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 20,514 | 20,160 | -354 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 0 | 20,000 | +20,000 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,908 | 19,692 | +1,784 | 0.00 | 0.00 | -0.00 | buy |
| Corton Capital Inc. | 0 | 19,180 | +19,180 | 0.00 | 0.04 | +0.04 | buy |
| Iowa State Bank | 19,061 | 19,061 | 0 | 0.05 | 0.01 | -0.04 | hold |
| XTX Topco Ltd | 37,300 | 18,070 | -19,230 | 0.04 | 0.00 | -0.03 | sell |
| JANUS HENDERSON GROUP PLC | 4,799,352 | 17,839 | -4,781,513 | 0.03 | 0.00 | -0.03 | sell |
| AMERIPRISE FINANCIAL INC | 662,496 | 17,326 | -645,170 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 17,105 | 16,293 | -812 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 16,088 | +16,088 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 16,000 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,214 | 15,225 | +5,011 | 0.00 | 0.00 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,836 | 13,220 | +1,384 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 13,588 | 12,720 | -868 | 0.00 | 0.00 | -0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 11,424 | 11,424 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 2 | 11,000 | +10,998 | 0.00 | 0.00 | +0.00 | buy |