| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 665,370 | 1,182,611 | +517,241 | 0.12 | 0.22 | +0.10 | buy |
| TSP Capital Management Group, LLC | 0 | 371,127 | +371,127 | 2.90 | 3.30 | +0.40 | buy |
| Candriam S.C.A. | 278,888 | 481,125 | +202,237 | 0.05 | 0.08 | +0.03 | buy |
| Redmile Group, LLC | 261,508 | 433,921 | +172,413 | 0.55 | 1.08 | +0.53 | buy |
| Rock Springs Capital Management LP | 650,270 | 699,146 | +48,876 | 1.22 | 1.27 | +0.05 | buy |
| SummitTX Capital, L.P. | 236,637 | 254,959 | +18,322 | 0.23 | 0.24 | +0.01 | buy |
| PFM Health Sciences, LP | 324,957 | 342,751 | +17,794 | 0.94 | 1.09 | +0.15 | buy |
| Apella Capital, LLC | 17,024 | 26,658 | +9,634 | 0.01 | 0.02 | +0.01 | buy |
| Mirador Capital Partners LP | 178,053 | 181,054 | +3,001 | 0.80 | 0.82 | +0.03 | buy |
| Birchview Capital, LP | 70,095 | 69,900 | -195 | 1.27 | 1.22 | -0.05 | sell |
| Hennion & Walsh Asset Management, Inc. | 47,525 | 47,113 | -412 | 0.05 | 0.05 | -0.00 | sell |
| HighVista Strategies LLC | 89,397 | 86,964 | -2,433 | 0.78 | 0.74 | -0.05 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 243,575 | 240,868 | -2,707 | 1.23 | 1.17 | -0.06 | sell |
| SEGALL BRYANT & HAMILL, LLC | 346,919 | 336,291 | -10,628 | 0.16 | 0.15 | -0.01 | sell |
| Simplify Asset Management Inc. | 68,994 | 53,134 | -15,860 | 0.03 | 0.03 | -0.01 | sell |
| PDT Partners, LLC | 97,822 | 80,899 | -16,923 | 0.18 | 0.16 | -0.03 | sell |
| TFG Asset Management GP Ltd | 312,316 | 290,441 | -21,875 | 1.92 | 1.70 | -0.22 | sell |
| Rosalind Advisors, Inc. | 330,000 | 200,000 | -130,000 | 4.21 | 2.76 | -1.44 | sell |
| Novo Holdings A/S | 1,200,000 | 1,025,000 | -175,000 | 3.08 | 2.21 | -0.87 | sell |