| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JENNISON ASSOCIATES LLC | 20,078 | 688,080 | +668,002 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 969,646 | 1,372,185 | +402,539 | 0.95 | 1.46 | +0.52 | buy |
| Bellevue Group AG | 2,416,296 | 2,796,615 | +380,319 | 1.47 | 1.79 | +0.32 | buy |
| Woodline Partners LP | 387,652 | 751,060 | +363,408 | 0.17 | 0.29 | +0.12 | buy |
| Commodore Capital LP | 701,967 | 866,468 | +164,501 | 2.43 | 2.43 | -0.00 | buy |
| Laurion Capital Management LP | 138,531 | 248,818 | +110,287 | 0.05 | 0.09 | +0.04 | buy |
| Affinity Asset Advisors, LLC | 400,000 | 510,000 | +110,000 | 3.16 | 3.48 | +0.32 | buy |
| Fisher Asset Management, LLC | 21,812 | 123,836 | +102,024 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 247,215 | 299,316 | +52,101 | 3.02 | 3.52 | +0.50 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 69,400 | 109,000 | +39,600 | 1.55 | 2.97 | +1.42 | buy |
| Values First Advisors, Inc. | 7,399 | 19,692 | +12,293 | 0.18 | 0.48 | +0.31 | buy |
| ALPS ADVISORS INC | 37,645 | 45,440 | +7,795 | 0.01 | 0.01 | +0.00 | buy |
| Atom Investors LP | 40,882 | 45,140 | +4,258 | 0.29 | 0.24 | -0.05 | buy |
| Crestline Management, LP | 67,243 | 69,289 | +2,046 | 0.23 | 0.26 | +0.03 | buy |
| E Fund Management Co., Ltd. | 7,949 | 9,046 | +1,097 | 0.02 | 0.02 | +0.00 | buy |
| NEOS Investment Management LLC | 11,560 | 11,910 | +350 | 0.04 | 0.03 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 2,561 | 2,399 | -162 | 0.06 | 0.05 | -0.01 | sell |
| Overbrook Management Corp | 7,644 | 7,089 | -555 | 0.06 | 0.08 | +0.02 | sell |
| TSP Capital Management Group, LLC | 251,495 | 249,220 | -2,275 | 3.46 | 3.37 | -0.09 | sell |
| Mirador Capital Partners LP | 107,910 | 104,759 | -3,151 | 0.91 | 0.84 | -0.07 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 11,249 | 4,824 | -6,425 | 0.11 | 0.04 | -0.07 | sell |
| Monashee Investment Management LLC | 100,209 | 87,500 | -12,709 | 0.70 | 0.43 | -0.27 | sell |
| TWINBEECH CAPITAL LP | 37,177 | 18,546 | -18,631 | 0.02 | 0.02 | -0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 62,172 | 33,586 | -28,586 | 0.05 | 0.03 | -0.02 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 315,644 | 276,996 | -38,648 | 2.01 | 1.63 | -0.38 | sell |
| Exome Asset Management LLC | 111,300 | 71,100 | -40,200 | 4.36 | 2.56 | -1.81 | sell |
| Sofinnova Investments, Inc. | 844,008 | 801,777 | -42,231 | 1.87 | 1.87 | +0.00 | sell |
| Eversept Partners, LP | 754,107 | 711,115 | -42,992 | 2.63 | 1.99 | -0.64 | sell |
| Polar Capital Holdings Plc | 3,135,871 | 3,059,492 | -76,379 | 0.77 | 0.67 | -0.09 | sell |
| Redmile Group, LLC | 993,803 | 896,454 | -97,349 | 1.41 | 1.38 | -0.03 | sell |
| Kynam Capital Management, LP | 3,005,904 | 2,900,000 | -105,904 | 13.49 | 13.54 | +0.05 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,630,013 | 3,119,087 | -510,926 | 2.35 | 2.05 | -0.30 | sell |