| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,050,409 | 9,726,041 | +2,675,632 | 0.02 | 0.03 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,476,561 | 7,647,457 | +1,170,896 | 0.05 | 0.06 | +0.01 | buy |
| VANGUARD GROUP INC | 3,046,331 | 3,650,582 | +604,251 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,630,013 | 3,119,087 | -510,926 | 2.35 | 2.05 | -0.30 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 422,293 | 3,087,208 | +2,664,915 | 0.00 | 0.02 | +0.01 | buy |
| Polar Capital Holdings Plc | 3,135,871 | 3,059,492 | -76,379 | 0.77 | 0.67 | -0.09 | sell |
| STATE STREET CORP | 2,377,326 | 2,979,751 | +602,425 | 0.00 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 3,005,904 | 2,900,000 | -105,904 | 13.49 | 13.54 | +0.05 | sell |
| Bellevue Group AG | 2,416,296 | 2,796,615 | +380,319 | 1.47 | 1.79 | +0.32 | buy |
| Pictet Asset Management Holding SA | 2,225,448 | 1,494,955 | -730,493 | 0.10 | 0.07 | -0.03 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,117,994 | 1,414,378 | +296,384 | 0.00 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 969,646 | 1,372,185 | +402,539 | 0.95 | 1.46 | +0.51 | buy |
| Point72 Asset Management, L.P. | 2,756,122 | 1,283,797 | -1,472,325 | 0.33 | 0.16 | -0.17 | sell |
| MARSHALL WACE, LLP | 1,280,084 | 898,800 | -381,284 | 0.10 | 0.06 | -0.03 | sell |
| Redmile Group, LLC | 993,803 | 896,454 | -97,349 | 1.41 | 1.38 | -0.03 | sell |
| Commodore Capital LP | 701,967 | 866,468 | +164,501 | 2.43 | 2.43 | -0.00 | buy |
| Sofinnova Investments, Inc. | 844,008 | 801,777 | -42,231 | 1.88 | 1.99 | +0.11 | sell |
| Woodline Partners LP | 387,652 | 751,060 | +363,408 | 0.17 | 0.29 | +0.12 | buy |
| Eversept Partners, LP | 754,107 | 711,115 | -42,992 | 2.93 | 2.23 | -0.70 | sell |
| JENNISON ASSOCIATES LLC | 20,078 | 688,080 | +668,002 | 0.00 | 0.02 | +0.02 | buy |
| EcoR1 Capital, LLC | 0 | 650,000 | +650,000 | 0.00 | 0.69 | +0.69 | buy |
| Logos Global Management LP | 0 | 650,000 | +650,000 | 0.00 | 2.87 | +2.87 | buy |
| D. E. Shaw & Co., Inc. | 23,746 | 573,171 | +549,425 | 0.00 | 0.03 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 437,759 | 564,803 | +127,044 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 444,805 | 553,861 | +109,056 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 400,000 | 510,000 | +110,000 | 3.16 | 3.48 | +0.32 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 409,391 | 499,221 | +89,830 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 497,270 | 497,270 | 0 | 5.23 | 4.67 | -0.56 | hold |
| MORGAN STANLEY | 658,365 | 376,121 | -282,244 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 317,509 | 317,509 | 0 | 0.09 | 0.09 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 312,470 | +312,470 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 247,215 | 299,316 | +52,101 | 3.02 | 3.52 | +0.50 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 315,644 | 276,996 | -38,648 | 2.32 | 1.88 | -0.44 | sell |
| BANK OF AMERICA CORP /DE/ | 217,814 | 271,611 | +53,797 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 158,092 | 256,348 | +98,256 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 0 | 253,000 | +253,000 | 0.00 | 0.27 | +0.27 | buy |
| TSP Capital Management Group, LLC | 251,495 | 249,220 | -2,275 | 3.46 | 3.37 | -0.09 | sell |
| Laurion Capital Management LP | 138,531 | 248,818 | +110,287 | 0.20 | 0.29 | +0.09 | buy |
| BAKER BROS. ADVISORS LP | 247,644 | 247,644 | 0 | 0.11 | 0.13 | +0.02 | hold |
| TD ASSET MANAGEMENT INC | 52,322 | 225,478 | +173,156 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 257,563 | 214,348 | -43,215 | 0.00 | 0.00 | -0.00 | sell |
| NATIXIS | 0 | 213,900 | +213,900 | 0.00 | 0.05 | +0.05 | buy |
| EMERALD ADVISERS, LLC | 0 | 212,035 | +212,035 | 0.00 | 0.36 | +0.36 | buy |
| MILLENNIUM MANAGEMENT LLC | 10,997 | 208,251 | +197,254 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 44,968 | 206,164 | +161,196 | 0.00 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 169,139 | 200,838 | +31,699 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 200,000 | +200,000 | 0.00 | 0.21 | +0.21 | buy |
| Rafferty Asset Management, LLC | 148,009 | 191,415 | +43,406 | 0.02 | 0.03 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 161,051 | 182,072 | +21,021 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 62,341 | 180,980 | +118,639 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 179,611 | 178,429 | -1,182 | 0.01 | 0.01 | -0.00 | sell |
| JANE STREET GROUP, LLC | 128,161 | 176,881 | +48,720 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 151,391 | +151,391 | 0.00 | 0.02 | +0.02 | buy |
| AXA S.A. | 142,170 | 142,209 | +39 | 0.02 | 0.02 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 43,427 | 129,544 | +86,117 | 0.00 | 0.01 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 126,963 | +126,963 | 0.00 | 0.28 | +0.28 | buy |
| Fisher Asset Management, LLC | 21,812 | 123,836 | +102,024 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 530 | 121,573 | +121,043 | 0.00 | 0.03 | +0.03 | buy |
| Swiss National Bank | 97,000 | 114,300 | +17,300 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 69,400 | 109,000 | +39,600 | 1.55 | 2.97 | +1.42 | buy |
| Squarepoint Ops LLC | 17,554 | 108,490 | +90,936 | 0.00 | 0.02 | +0.02 | buy |
| Mirador Capital Partners LP | 107,910 | 104,759 | -3,151 | 0.91 | 0.84 | -0.07 | sell |
| RHUMBLINE ADVISERS | 76,022 | 98,530 | +22,508 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 90,931 | +90,931 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 31,429 | 88,022 | +56,593 | 0.03 | 0.07 | +0.05 | buy |
| Monashee Investment Management LLC | 100,209 | 87,500 | -12,709 | 0.70 | 0.43 | -0.27 | sell |
| CITADEL ADVISORS LLC | 126,328 | 85,446 | -40,882 | 0.01 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,888 | 71,218 | +22,330 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 111,300 | 71,100 | -40,200 | 4.36 | 2.56 | -1.81 | sell |
| Informed Momentum Co LLC | 0 | 70,115 | +70,115 | 0.00 | 0.46 | +0.46 | buy |
| FIRST TRUST ADVISORS LP | 11,563 | 69,895 | +58,332 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 67,243 | 69,289 | +2,046 | 0.25 | 0.28 | +0.03 | buy |
| Cinctive Capital Management LP | 0 | 68,481 | +68,481 | 0.00 | 0.15 | +0.15 | buy |
| Cubist Systematic Strategies, LLC | 0 | 67,434 | +67,434 | 0.00 | 0.03 | +0.03 | buy |
| TUDOR INVESTMENT CORP ET AL | 14,542 | 67,384 | +52,842 | 0.01 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 145,894 | 66,714 | -79,180 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 24,119 | 64,769 | +40,650 | 0.00 | 0.01 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 54,080 | 61,710 | +7,630 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,474 | 58,403 | +6,929 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 57,809 | +57,809 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 52,012 | 56,406 | +4,394 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 136,601 | 56,044 | -80,557 | 0.01 | 0.00 | -0.01 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 49,457 | +49,457 | 0.00 | 0.07 | +0.07 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 48,099 | 48,099 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JPMORGAN CHASE & CO | 75,470 | 46,755 | -28,715 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 36,315 | 45,892 | +9,577 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 37,645 | 45,440 | +7,795 | 0.01 | 0.01 | +0.00 | buy |
| Atom Investors LP | 40,882 | 45,140 | +4,258 | 0.29 | 0.24 | -0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 230,471 | 43,431 | -187,040 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 9,910 | 43,050 | +33,140 | 0.02 | 0.07 | +0.05 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 34,868 | 38,709 | +3,841 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,518 | 36,232 | -4,286 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 35,000 | 35,000 | 0 | 0.08 | 0.07 | -0.01 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 62,172 | 33,586 | -28,586 | 0.05 | 0.03 | -0.02 | sell |
| MetLife Investment Management, LLC | 24,073 | 31,764 | +7,691 | 0.01 | 0.01 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 32,697 | 30,729 | -1,968 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 23,094 | 30,629 | +7,535 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 24,486 | 30,347 | +5,861 | 0.04 | 0.05 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,116 | 26,790 | +4,674 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 9,070 | 26,606 | +17,536 | 0.01 | 0.03 | +0.02 | buy |