| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 8,079,608 | 8,560,476 | +480,868 | 0.04 | 0.05 | +0.01 | buy |
| Kynam Capital Management, LP | 5,943,180 | 5,840,567 | -102,613 | 10.51 | 11.76 | +1.25 | sell |
| BlackRock, Inc. | 5,451,815 | 5,369,885 | -81,930 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 4,907,469 | 3,749,048 | -1,158,421 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 1,758,357 | 3,229,939 | +1,471,582 | 0.07 | 0.18 | +0.10 | buy |
| STATE STREET CORP | 3,397,713 | 2,804,168 | -593,545 | 0.00 | 0.00 | -0.00 | sell |
| Commodore Capital LP | 2,565,000 | 2,696,616 | +131,616 | 4.64 | 4.95 | +0.31 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,039,705 | 2,086,332 | +46,627 | 0.01 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 1,434,725 | 1,788,016 | +353,291 | 2.18 | 3.74 | +1.55 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,627,529 | 1,688,074 | +60,545 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,858,109 | 1,356,082 | -502,027 | 1.61 | 1.43 | -0.18 | sell |
| Deep Track Capital, LP | 1,900,738 | 1,283,979 | -616,759 | 1.18 | 0.84 | -0.34 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,212,705 | 1,253,532 | +40,827 | 0.02 | 0.03 | +0.01 | buy |
| Vestal Point Capital, LP | 1,165,000 | 1,224,165 | +59,165 | 1.16 | 1.09 | -0.07 | buy |
| Novo Holdings A/S | 1,200,000 | 1,200,000 | 0 | 2.53 | 3.08 | +0.55 | hold |
| Bellevue Group AG | 3,617,669 | 1,200,000 | -2,417,669 | 1.86 | 0.91 | -0.96 | sell |
| DIMENSIONAL FUND ADVISORS LP | 651,716 | 1,059,534 | +407,818 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,642,559 | 1,037,000 | -605,559 | 0.70 | 0.54 | -0.15 | sell |
| Fisher Asset Management, LLC | 937,158 | 1,013,648 | +76,490 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,068,131 | 988,416 | -79,715 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 968,616 | 923,696 | -44,920 | 0.03 | 0.03 | +0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 855,226 | 856,310 | +1,084 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 414,888 | 708,647 | +293,759 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 665,370 | 665,370 | 0 | 0.11 | 0.12 | +0.02 | hold |
| Rock Springs Capital Management LP | 692,538 | 650,270 | -42,268 | 0.97 | 1.22 | +0.25 | sell |
| NORTHERN TRUST CORP | 549,998 | 577,267 | +27,269 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 550,729 | 545,486 | -5,243 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 500,127 | 500,127 | 0 | 0.05 | 0.06 | +0.01 | hold |
| Affinity Asset Advisors, LLC | 350,000 | 500,000 | +150,000 | 0.68 | 0.93 | +0.25 | buy |
| 5AM Venture Management, LLC | 497,270 | 497,270 | 0 | 4.25 | 4.38 | +0.13 | hold |
| Ikarian Capital, LLC | 0 | 461,247 | +461,247 | 0.00 | 2.09 | +2.09 | buy |
| Logos Global Management LP | 350,000 | 450,000 | +100,000 | 0.63 | 0.74 | +0.10 | buy |
| ADAR1 Capital Management, LLC | 646,767 | 427,816 | -218,951 | 1.31 | 0.82 | -0.50 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 352,302 | +352,302 | 0.00 | 0.24 | +0.24 | buy |
| SEGALL BRYANT & HAMILL, LLC | 514,531 | 346,919 | -167,612 | 0.19 | 0.11 | -0.08 | sell |
| Rosalind Advisors, Inc. | 0 | 330,000 | +330,000 | 0.00 | 4.29 | +4.29 | buy |
| PFM Health Sciences, LP | 133,161 | 324,957 | +191,796 | 0.37 | 1.08 | +0.72 | buy |
| Foresite Capital Management VI LLC | 0 | 315,913 | +315,913 | 0.00 | 2.18 | +2.18 | buy |
| TFG Asset Management GP Ltd | 243,800 | 312,316 | +68,516 | 1.40 | 1.95 | +0.55 | buy |
| UBS Group AG | 326,462 | 296,970 | -29,492 | 0.00 | 0.00 | -0.00 | sell |
| Palo Alto Investors LP | 0 | 296,408 | +296,408 | 0.00 | 1.44 | +1.44 | buy |
| Candriam S.C.A. | 0 | 278,888 | +278,888 | 0.00 | 0.05 | +0.05 | buy |
| SEGALL BRYANT & HAMILL, LLC | 514,531 | 266,670 | -247,861 | 0.19 | 0.09 | -0.10 | sell |
| Redmile Group, LLC | 283,308 | 261,508 | -21,800 | 0.57 | 0.55 | -0.02 | sell |
| STEMPOINT CAPITAL LP | 0 | 254,267 | +254,267 | 0.00 | 1.55 | +1.55 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 239,764 | 243,575 | +3,811 | 1.36 | 1.33 | -0.03 | buy |
| SummitTX Capital, L.P. | 43,324 | 236,637 | +193,313 | 0.04 | 0.24 | +0.20 | buy |
| MORGAN STANLEY | 285,535 | 217,549 | -67,986 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 14,922 | 217,335 | +202,413 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 98,847 | 215,159 | +116,312 | 0.04 | 0.10 | +0.06 | buy |
| Nuveen, LLC | 200,696 | 201,949 | +1,253 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 55,101 | 200,612 | +145,511 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 194,552 | 190,399 | -4,153 | 0.00 | 0.00 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 118,205 | 184,104 | +65,899 | 0.01 | 0.01 | +0.01 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 88,308 | 180,048 | +91,740 | 1.28 | 4.08 | +2.80 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 191,074 | 178,378 | -12,696 | 0.75 | 0.67 | -0.08 | sell |
| Mirador Capital Partners LP | 170,659 | 178,053 | +7,394 | 0.64 | 0.80 | +0.16 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 230,662 | 175,788 | -54,874 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 173,677 | 164,778 | -8,899 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 0 | 146,525 | +146,525 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 136,485 | 143,037 | +6,552 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 21,856 | 142,327 | +120,471 | 0.00 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 132,533 | 137,015 | +4,482 | 0.01 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 134,945 | +134,945 | 0.00 | 0.10 | +0.10 | buy |
| Propel Bio Management, LLC | 154,300 | 131,364 | -22,936 | 3.58 | 2.61 | -0.97 | sell |
| BNP Paribas Asset Management Holding S.A. | 123,165 | 122,404 | -761 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 117,589 | 120,807 | +3,218 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 117,900 | 117,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PDT Partners, LLC | 97,822 | 97,822 | 0 | 0.17 | 0.18 | +0.01 | hold |
| Invesco Ltd. | 90,144 | 93,684 | +3,540 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 90,321 | +90,321 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 51,805 | 89,397 | +37,592 | 0.36 | 0.78 | +0.42 | buy |
| RHUMBLINE ADVISERS | 87,264 | 85,983 | -1,281 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 85,026 | +85,026 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,397 | 79,630 | +21,233 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75,130 | 77,772 | +2,642 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 66,570 | 70,292 | +3,722 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 70,095 | +70,095 | 0.00 | 1.27 | +1.27 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 32,263 | 70,053 | +37,790 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 85,000 | 68,994 | -16,006 | 0.04 | 0.03 | -0.00 | sell |
| DAFNA Capital Management LLC | 68,518 | 68,518 | 0 | 0.43 | 0.49 | +0.06 | hold |
| FIRST TRUST ADVISORS LP | 38,313 | 68,470 | +30,157 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 23,586 | 65,744 | +42,158 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 65,540 | 65,540 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 114,230 | 65,050 | -49,180 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 62,599 | 55,080 | -7,519 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 54,559 | 54,190 | -369 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 136,324 | 52,860 | -83,464 | 0.00 | 0.00 | -0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 46,965 | 47,525 | +560 | 0.04 | 0.05 | +0.01 | buy |
| HRT FINANCIAL LP | 77,640 | 46,745 | -30,895 | 0.01 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 45,192 | +45,192 | 0.00 | 0.03 | +0.03 | buy |
| Cinctive Capital Management LP | 0 | 41,233 | +41,233 | 0.00 | 0.09 | +0.09 | buy |
| SEI INVESTMENTS CO | 0 | 38,152 | +38,152 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 47,340 | 38,008 | -9,332 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 37,012 | 36,663 | -349 | 0.00 | 0.01 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 35,948 | +35,948 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 35,393 | +35,393 | 0.00 | 0.01 | +0.01 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 37,066 | 35,339 | -1,727 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 91,599 | 35,158 | -56,441 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,066 | 34,109 | -3,957 | 0.00 | 0.00 | +0.00 | sell |