| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Novo Holdings A/S | 0 | 850,000 | +850,000 | 0.00 | 1.70 | +1.70 | buy |
| Point72 Asset Management, L.P. | 1,283,797 | 1,937,991 | +654,194 | 0.16 | 0.23 | +0.08 | buy |
| Commodore Capital LP | 866,468 | 1,425,000 | +558,532 | 2.43 | 3.60 | +1.17 | buy |
| Kynam Capital Management, LP | 2,900,000 | 3,388,967 | +488,967 | 13.54 | 13.13 | -0.41 | buy |
| MARSHALL WACE, LLP | 898,800 | 1,377,868 | +479,068 | 0.06 | 0.07 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 7,647,457 | 8,075,940 | +428,483 | 0.06 | 0.05 | -0.00 | buy |
| JENNISON ASSOCIATES LLC | 688,080 | 1,003,085 | +315,005 | 0.02 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 564,803 | 874,193 | +309,390 | 0.00 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 573,171 | 845,560 | +272,389 | 0.03 | 0.04 | +0.01 | buy |
| CITADEL ADVISORS LLC | 85,446 | 321,212 | +235,766 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 182,072 | 416,000 | +233,928 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,119,087 | 3,327,132 | +208,045 | 2.05 | 2.11 | +0.05 | buy |
| Bellevue Group AG | 2,796,615 | 2,971,615 | +175,000 | 1.79 | 1.79 | -0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 144,467 | +144,467 | 0.00 | 1.57 | +1.57 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 119,629 | +119,629 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,414,378 | 1,533,956 | +119,578 | 0.01 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 118,347 | +118,347 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 3,650,582 | 3,739,039 | +88,457 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,087,208 | 3,172,399 | +85,191 | 0.02 | 0.01 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 299,316 | 374,910 | +75,594 | 3.52 | 3.43 | -0.10 | buy |
| Artia Global Partners LP | 0 | 75,300 | +75,300 | 0.00 | 0.71 | +0.71 | buy |
| PRUDENTIAL FINANCIAL INC | 14,086 | 72,901 | +58,815 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 38,709 | 96,326 | +57,617 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 108,490 | 163,007 | +54,517 | 0.02 | 0.02 | +0.00 | buy |
| Walleye Capital LLC | 1,036 | 50,183 | +49,147 | 0.00 | 0.02 | +0.02 | buy |
| Assenagon Asset Management S.A. | 90,931 | 139,162 | +48,231 | 0.01 | 0.01 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 44,445 | +44,445 | 0.00 | 0.02 | +0.02 | buy |
| Laurion Capital Management LP | 248,818 | 290,850 | +42,032 | 0.29 | 0.35 | +0.06 | buy |
| ExodusPoint Capital Management, LP | 0 | 38,150 | +38,150 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 43,050 | 75,614 | +32,564 | 0.07 | 0.09 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 276,996 | 309,265 | +32,269 | 1.88 | 1.87 | -0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 499,221 | 530,443 | +31,222 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 200,838 | 230,162 | +29,324 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 27,392 | +27,392 | 0.00 | 0.06 | +0.06 | buy |
| Rock Springs Capital Management LP | 1,372,185 | 1,398,994 | +26,809 | 1.46 | 1.56 | +0.10 | buy |
| Cinctive Capital Management LP | 68,481 | 91,127 | +22,646 | 0.15 | 0.18 | +0.03 | buy |
| TWINBEECH CAPITAL LP | 18,546 | 37,005 | +18,459 | 0.02 | 0.03 | +0.01 | buy |
| Polar Capital Holdings Plc | 3,059,492 | 3,076,783 | +17,291 | 0.67 | 0.67 | -0.00 | buy |
| PFM Health Sciences, LP | 35,000 | 52,120 | +17,120 | 0.07 | 0.11 | +0.03 | buy |
| NEOS Investment Management LLC | 11,910 | 28,535 | +16,625 | 0.03 | 0.04 | +0.01 | buy |
| Crestline Management, LP | 69,289 | 85,351 | +16,062 | 0.28 | 0.25 | -0.03 | buy |
| JANE STREET GROUP, LLC | 176,881 | 190,329 | +13,448 | 0.01 | 0.01 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 735 | 13,102 | +12,367 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 10,945 | +10,945 | 0.00 | 0.03 | +0.03 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 30,729 | 40,558 | +9,829 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 9,627 | +9,627 | 0.00 | 0.13 | +0.13 | buy |
| JPMORGAN CHASE & CO | 46,755 | 56,364 | +9,609 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,570 | 13,617 | +9,047 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 69,895 | 77,736 | +7,841 | 0.00 | 0.00 | -0.00 | buy |
| Mirador Capital Partners LP | 104,759 | 112,379 | +7,620 | 0.84 | 0.78 | -0.06 | buy |
| Atom Investors LP | 45,140 | 52,164 | +7,024 | 0.24 | 0.19 | -0.04 | buy |
| AlphaQuest LLC | 504 | 7,383 | +6,879 | 0.00 | 0.04 | +0.03 | buy |
| Woodline Partners LP | 751,060 | 757,771 | +6,711 | 0.29 | 0.27 | -0.02 | buy |
| Magnetar Financial LLC | 10,777 | 17,390 | +6,613 | 0.01 | 0.01 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 6,375 | +6,375 | 0.00 | 0.11 | +0.11 | buy |
| Corton Capital Inc. | 0 | 6,179 | +6,179 | 0.00 | 0.12 | +0.12 | buy |
| ALPS ADVISORS INC | 45,440 | 51,399 | +5,959 | 0.01 | 0.01 | -0.00 | buy |
| Headlands Technologies LLC | 3,513 | 9,182 | +5,669 | 0.04 | 0.04 | +0.00 | buy |
| MetLife Investment Management, LLC | 31,764 | 37,332 | +5,568 | 0.01 | 0.01 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 9,597 | 14,537 | +4,940 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 1,871 | 6,626 | +4,755 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 10,018 | 14,111 | +4,093 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 29 | 4,048 | +4,019 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 61,710 | 65,540 | +3,830 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 8,100 | 11,200 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,790 | 29,737 | +2,947 | 0.00 | 0.00 | -0.00 | buy |
| DnB Asset Management AS | 5,349 | 7,872 | +2,523 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 2,053 | +2,053 | 0.00 | 0.02 | +0.02 | buy |
| Prospera Financial Services Inc | 5,822 | 7,754 | +1,932 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 56,406 | 58,328 | +1,922 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,630 | 21,515 | +1,885 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 9,800 | 11,600 | +1,800 | 0.01 | 0.01 | -0.00 | buy |
| Values First Advisors, Inc. | 19,692 | 21,319 | +1,627 | 0.48 | 0.47 | -0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 6,353 | 7,857 | +1,504 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 21,615 | 22,736 | +1,121 | 0.00 | 0.00 | -0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 900 | +900 | 0.00 | 0.01 | +0.01 | buy |
| STRS OHIO | 5,900 | 6,600 | +700 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 6,733 | 7,371 | +638 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,232 | 36,770 | +538 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 15,906 | 16,231 | +325 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 303 | +303 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 20 | 320 | +300 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 129,544 | 129,787 | +243 | 0.01 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 139 | +139 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 2,086 | 2,182 | +96 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 8,235 | 8,322 | +87 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,399 | 2,485 | +86 | 0.05 | 0.05 | -0.01 | buy |
| AXA S.A. | 142,209 | 142,290 | +81 | 0.02 | 0.02 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,680 | 12,733 | +53 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 392 | 431 | +39 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 89 | 124 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 25 | +20 | 0.00 | 0.00 | +0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 368 | 381 | +13 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 119 | 125 | +6 | 0.00 | 0.00 | -0.00 | buy |
| Blue Trust, Inc. | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |