| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 866,468 | 1,425,000 | +558,532 | 2.43 | 3.60 | +1.17 | buy |
| Kynam Capital Management, LP | 2,900,000 | 3,388,967 | +488,967 | 13.54 | 13.13 | -0.41 | buy |
| JENNISON ASSOCIATES LLC | 688,080 | 1,003,085 | +315,005 | 0.02 | 0.02 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,119,087 | 3,327,132 | +208,045 | 2.05 | 2.11 | +0.06 | buy |
| Bellevue Group AG | 2,796,615 | 2,971,615 | +175,000 | 1.79 | 1.79 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 299,316 | 374,910 | +75,594 | 3.52 | 3.43 | -0.10 | buy |
| Laurion Capital Management LP | 248,818 | 290,850 | +42,032 | 0.09 | 0.13 | +0.04 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 276,996 | 309,265 | +32,269 | 1.63 | 1.56 | -0.07 | buy |
| Rock Springs Capital Management LP | 1,372,185 | 1,398,994 | +26,809 | 1.46 | 1.56 | +0.10 | buy |
| Cinctive Capital Management LP | 68,481 | 91,127 | +22,646 | 0.15 | 0.18 | +0.03 | buy |
| TWINBEECH CAPITAL LP | 18,546 | 37,005 | +18,459 | 0.02 | 0.03 | +0.01 | buy |
| Polar Capital Holdings Plc | 3,059,492 | 3,076,783 | +17,291 | 0.67 | 0.67 | -0.00 | buy |
| PFM Health Sciences, LP | 35,000 | 52,120 | +17,120 | 0.07 | 0.10 | +0.03 | buy |
| NEOS Investment Management LLC | 11,910 | 28,535 | +16,625 | 0.03 | 0.04 | +0.01 | buy |
| Crestline Management, LP | 69,289 | 85,351 | +16,062 | 0.26 | 0.25 | -0.01 | buy |
| Mirador Capital Partners LP | 104,759 | 112,379 | +7,620 | 0.84 | 0.78 | -0.06 | buy |
| Atom Investors LP | 45,140 | 52,164 | +7,024 | 0.24 | 0.19 | -0.04 | buy |
| Woodline Partners LP | 751,060 | 757,771 | +6,711 | 0.29 | 0.27 | -0.02 | buy |
| Magnetar Financial LLC | 10,777 | 17,390 | +6,613 | 0.01 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 45,440 | 51,399 | +5,959 | 0.01 | 0.01 | -0.00 | buy |
| DnB Asset Management AS | 5,349 | 7,872 | +2,523 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 9,800 | 11,600 | +1,800 | 0.01 | 0.01 | +0.00 | buy |
| Values First Advisors, Inc. | 19,692 | 21,319 | +1,627 | 0.48 | 0.47 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 2,399 | 2,485 | +86 | 0.05 | 0.05 | -0.01 | buy |
| Overbrook Management Corp | 7,089 | 6,837 | -252 | 0.08 | 0.06 | -0.02 | sell |
| E Fund Management Co., Ltd. | 9,046 | 7,258 | -1,788 | 0.02 | 0.01 | -0.01 | sell |
| Fisher Asset Management, LLC | 123,836 | 120,544 | -3,292 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD ADVISERS, LLC | 212,035 | 198,429 | -13,606 | 0.36 | 0.31 | -0.05 | sell |
| Affinity Asset Advisors, LLC | 510,000 | 475,400 | -34,600 | 3.48 | 2.77 | -0.71 | sell |
| NATIXIS | 213,900 | 165,500 | -48,400 | 0.05 | 0.04 | -0.01 | sell |
| Eversept Partners, LP | 711,115 | 633,015 | -78,100 | 1.99 | 1.60 | -0.39 | sell |
| Redmile Group, LLC | 896,454 | 718,723 | -177,731 | 1.38 | 1.61 | +0.23 | sell |
| Sofinnova Investments, Inc. | 801,777 | 547,707 | -254,070 | 1.87 | 1.05 | -0.82 | sell |