| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 198,646 | 1,750,000 | +1,551,354 | 0.26 | 1.87 | +1.62 | buy |
| BAKER BROS. ADVISORS LP | 247,644 | 665,370 | +417,726 | 0.05 | 0.13 | +0.08 | buy |
| Woodline Partners LP | 1,188,429 | 1,500,455 | +312,026 | 0.14 | 0.16 | +0.02 | buy |
| Commodore Capital LP | 3,200,000 | 3,450,000 | +250,000 | 4.28 | 4.96 | +0.68 | buy |
| Bellevue Group AG | 3,071,615 | 3,307,569 | +235,954 | 1.25 | 1.48 | +0.23 | buy |
| Eversept Partners, LP | 696,499 | 838,736 | +142,237 | 1.28 | 1.57 | +0.29 | buy |
| Cinctive Capital Management LP | 43,395 | 138,040 | +94,645 | 0.06 | 0.15 | +0.09 | buy |
| PDT Partners, LLC | 20,899 | 97,822 | +76,923 | 0.03 | 0.11 | +0.09 | buy |
| TFG Asset Management GP Ltd | 261,000 | 316,150 | +55,150 | 1.08 | 1.04 | -0.04 | buy |
| ADAR1 Capital Management, LLC | 14,600 | 57,466 | +42,866 | 0.05 | 0.19 | +0.14 | buy |
| Mirador Capital Partners LP | 127,874 | 158,717 | +30,843 | 0.41 | 0.52 | +0.12 | buy |
| SummitTX Capital, L.P. | 86,070 | 96,070 | +10,000 | 0.07 | 0.08 | +0.02 | buy |
| J.Safra Asset Management Corp | 330 | 235 | -95 | 0.00 | 0.00 | -0.00 | sell |
| DnB Asset Management AS | 12,634 | 12,300 | -334 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 1,798 | 566 | -1,232 | 0.01 | 0.00 | -0.01 | sell |
| Virtus Investment Advisers, LLC | 6,208 | 4,621 | -1,587 | 0.03 | 0.03 | +0.00 | sell |
| PROFUND ADVISORS LLC | 22,645 | 15,425 | -7,220 | 0.02 | 0.01 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 205,962 | 198,441 | -7,521 | 0.78 | 0.83 | +0.05 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 32,670 | 19,146 | -13,524 | 0.09 | 0.06 | -0.03 | sell |
| TWINBEECH CAPITAL LP | 38,344 | 23,676 | -14,668 | 0.01 | 0.01 | -0.00 | sell |
| Fisher Asset Management, LLC | 871,628 | 822,208 | -49,420 | 0.01 | 0.01 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 507,829 | 419,540 | -88,289 | 2.12 | 2.00 | -0.12 | sell |
| Polar Capital Holdings Plc | 1,403,435 | 1,228,435 | -175,000 | 0.16 | 0.13 | -0.02 | sell |
| Redmile Group, LLC | 590,175 | 343,026 | -247,149 | 1.01 | 0.74 | -0.27 | sell |
| TSP Capital Management Group, LLC | 335,977 | 0 | -335,977 | 2.01 | 2.37 | +0.37 | sell |
| Kynam Capital Management, LP | 6,500,000 | 6,100,729 | -399,271 | 10.09 | 13.37 | +3.27 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,754,793 | 1,356,186 | -2,398,607 | 1.36 | 0.48 | -0.87 | sell |