| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 6,500,000 | 6,100,729 | -399,271 | 10.09 | 13.37 | +3.27 | sell |
| BlackRock, Inc. | 5,524,132 | 5,550,016 | +25,884 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,380,091 | 5,439,118 | +59,027 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,354,151 | 5,232,326 | -3,121,825 | 0.03 | 0.02 | -0.01 | sell |
| VANGUARD GROUP INC | 3,898,435 | 3,957,122 | +58,687 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,410,499 | 3,817,820 | +407,321 | 0.01 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 3,200,000 | 3,450,000 | +250,000 | 4.28 | 4.96 | +0.68 | buy |
| Bellevue Group AG | 3,071,615 | 3,307,569 | +235,954 | 1.25 | 1.48 | +0.23 | buy |
| Point72 Asset Management, L.P. | 2,621,175 | 2,801,721 | +180,546 | 0.13 | 0.13 | +0.00 | buy |
| STATE STREET CORP | 2,806,359 | 2,405,495 | -400,864 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 2,000,000 | 2,000,000 | 0 | 1.18 | 1.31 | +0.13 | hold |
| Vestal Point Capital, LP | 198,646 | 1,750,000 | +1,551,354 | 0.26 | 1.87 | +1.62 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,589,806 | 1,672,980 | +83,174 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,188,429 | 1,500,455 | +312,026 | 0.14 | 0.16 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,754,793 | 1,356,186 | -2,398,607 | 1.36 | 0.48 | -0.87 | sell |
| Pictet Asset Management Holding SA | 957,794 | 1,300,329 | +342,535 | 0.02 | 0.03 | +0.01 | buy |
| Polar Capital Holdings Plc | 1,403,435 | 1,228,435 | -175,000 | 0.16 | 0.13 | -0.02 | sell |
| Novo Holdings A/S | 1,200,000 | 1,200,000 | 0 | 1.66 | 1.72 | +0.07 | hold |
| UBS Group AG | 1,468,240 | 841,246 | -626,994 | 0.01 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 696,499 | 838,736 | +142,237 | 1.43 | 1.72 | +0.29 | buy |
| Fisher Asset Management, LLC | 871,628 | 822,208 | -49,420 | 0.01 | 0.01 | -0.00 | sell |
| Rock Springs Capital Management LP | 812,653 | 812,653 | 0 | 0.84 | 1.03 | +0.19 | hold |
| AMERICAN CENTURY COMPANIES INC | 625,321 | 779,985 | +154,664 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 696,007 | 727,504 | +31,497 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 247,644 | 665,370 | +417,726 | 0.05 | 0.13 | +0.08 | buy |
| MORGAN STANLEY | 902,882 | 661,518 | -241,364 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 406,161 | 645,657 | +239,496 | 0.01 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 0 | 600,000 | +600,000 | 0.00 | 1.63 | +1.63 | buy |
| NORTHERN TRUST CORP | 577,361 | 575,875 | -1,486 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 535,844 | 553,081 | +17,237 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 497,270 | 497,270 | 0 | 3.41 | 3.89 | +0.48 | hold |
| MILLENNIUM MANAGEMENT LLC | 399,932 | 477,227 | +77,295 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 507,829 | 419,540 | -88,289 | 2.27 | 2.23 | -0.04 | sell |
| SEGALL BRYANT & HAMILL, LLC | 0 | 387,888 | +387,888 | 0.00 | 0.11 | +0.11 | buy |
| CITADEL ADVISORS LLC | 603,401 | 378,738 | -224,663 | 0.01 | 0.01 | -0.00 | sell |
| Redmile Group, LLC | 590,175 | 343,026 | -247,149 | 1.01 | 0.74 | -0.27 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 335,000 | +335,000 | 0.00 | 0.28 | +0.28 | buy |
| TFG Asset Management GP Ltd | 261,000 | 316,150 | +55,150 | 1.52 | 1.16 | -0.36 | buy |
| BANK OF AMERICA CORP /DE/ | 244,936 | 276,184 | +31,248 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 429,126 | 265,555 | -163,571 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 116,566 | 262,725 | +146,159 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 241,354 | 233,821 | -7,533 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 131,296 | 213,846 | +82,550 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 105,140 | 211,260 | +106,120 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 201,717 | +201,717 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 205,962 | 198,441 | -7,521 | 0.78 | 0.83 | +0.05 | sell |
| Bank of New York Mellon Corp | 173,886 | 194,101 | +20,215 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 184,803 | 185,100 | +297 | 0.01 | 0.01 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 146,588 | 181,388 | +34,800 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 133,597 | 180,965 | +47,368 | 0.06 | 0.08 | +0.02 | buy |
| Mirador Capital Partners LP | 127,874 | 158,717 | +30,843 | 0.41 | 0.52 | +0.12 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 143,886 | +143,886 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 43,395 | 138,040 | +94,645 | 0.06 | 0.16 | +0.09 | buy |
| DEUTSCHE BANK AG\ | 138,289 | 128,581 | -9,708 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 78,878 | 127,878 | +49,000 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 94,785 | 124,546 | +29,761 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 118,775 | +118,775 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 115,700 | 114,100 | -1,600 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 78,210 | 112,464 | +34,254 | 0.02 | 0.03 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 93,670 | 111,399 | +17,729 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 98,266 | 106,599 | +8,333 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 106,553 | +106,553 | 0.00 | 0.80 | +0.80 | buy |
| CITIGROUP INC | 130,688 | 99,200 | -31,488 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 20,899 | 97,822 | +76,923 | 0.03 | 0.11 | +0.09 | buy |
| SummitTX Capital, L.P. | 86,070 | 96,070 | +10,000 | 0.07 | 0.09 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 34,855 | 84,726 | +49,871 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 28,656 | 80,733 | +52,077 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 73,000 | +73,000 | 0.00 | 1.22 | +1.22 | buy |
| Rafferty Asset Management, LLC | 108,338 | 71,558 | -36,780 | 0.01 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 64,141 | 71,190 | +7,049 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 65,540 | 65,540 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 52,443 | 62,886 | +10,443 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 58,398 | +58,398 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 14,600 | 57,466 | +42,866 | 0.05 | 0.19 | +0.14 | buy |
| Jefferies Financial Group Inc. | 55,000 | 57,000 | +2,000 | 0.02 | 0.02 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 56,170 | 55,508 | -662 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 0 | 50,615 | +50,615 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 21,418 | 48,415 | +26,997 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 48,099 | 48,099 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WELLS FARGO & COMPANY/MN | 33,378 | 43,276 | +9,898 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 42,287 | +42,287 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 34,221 | 41,900 | +7,679 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 40,600 | +40,600 | 0.00 | 0.00 | +0.00 | buy |
| Perbak Capital Partners LLP | 0 | 40,410 | +40,410 | 0.00 | 0.19 | +0.19 | buy |
| Sovran Advisors, LLC | 0 | 39,476 | +39,476 | 0.00 | 0.09 | +0.09 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,451 | 39,388 | -4,063 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 39,004 | 39,004 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 39,301 | 36,699 | -2,602 | 0.01 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 49,938 | 35,812 | -14,126 | 0.01 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 18,396 | 33,871 | +15,475 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 31,066 | +31,066 | 0.00 | 0.06 | +0.06 | buy |
| Creative Planning | 23,669 | 29,902 | +6,233 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 19,248 | 29,503 | +10,255 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 214,426 | 28,860 | -185,566 | 0.01 | 0.00 | -0.01 | sell |
| SIMPLEX TRADING, LLC | 2,038 | 28,271 | +26,233 | 0.00 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 27,650 | +27,650 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 24,783 | 25,995 | +1,212 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 25,642 | 25,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 25,000 | 25,000 | 0 | 0.01 | 0.01 | +0.00 | hold |