| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 8,560,476 | 9,543,671 | +983,195 | 0.05 | 0.06 | +0.01 | buy |
| BlackRock, Inc. | 5,369,885 | 7,002,530 | +1,632,645 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 5,840,567 | 5,322,908 | -517,659 | 11.76 | 10.95 | -0.81 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,086,332 | 4,685,223 | +2,598,891 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 2,804,168 | 3,900,427 | +1,096,259 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,749,048 | 3,722,888 | -26,160 | 0.01 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 1,283,979 | 2,939,151 | +1,655,172 | 0.84 | 1.61 | +0.77 | buy |
| Logos Global Management LP | 450,000 | 2,100,000 | +1,650,000 | 0.74 | 3.36 | +2.63 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,688,074 | 2,022,226 | +334,152 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 1,788,016 | 1,785,941 | -2,075 | 3.74 | 3.62 | -0.11 | sell |
| GOLDMAN SACHS GROUP INC | 988,416 | 1,615,343 | +626,927 | 0.00 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 2,696,616 | 1,350,000 | -1,346,616 | 4.95 | 2.99 | -1.96 | sell |
| Bellevue Group AG | 1,200,000 | 1,200,000 | 0 | 0.91 | 0.94 | +0.03 | hold |
| BAKER BROS. ADVISORS LP | 665,370 | 1,182,611 | +517,241 | 0.12 | 0.22 | +0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,253,532 | 1,170,787 | -82,745 | 0.03 | 0.03 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,059,534 | 1,073,985 | +14,451 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 856,310 | 1,042,395 | +186,085 | 0.01 | 0.02 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,037,000 | 1,037,000 | 0 | 0.54 | 0.52 | -0.03 | hold |
| Novo Holdings A/S | 1,200,000 | 1,025,000 | -175,000 | 3.08 | 2.21 | -0.87 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 989,442 | +989,442 | 0.00 | 0.21 | +0.21 | buy |
| Fisher Asset Management, LLC | 1,013,648 | 985,677 | -27,971 | 0.01 | 0.01 | +0.00 | sell |
| Pictet Asset Management Holding SA | 923,696 | 917,408 | -6,288 | 0.03 | 0.03 | +0.00 | sell |
| Foresite Capital Management VI LLC | 315,913 | 879,713 | +563,800 | 2.18 | 5.09 | +2.92 | buy |
| Assenagon Asset Management S.A. | 146,525 | 788,696 | +642,171 | 0.01 | 0.04 | +0.03 | buy |
| NORTHERN TRUST CORP | 577,267 | 719,647 | +142,380 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 500,127 | 700,830 | +200,703 | 0.06 | 0.08 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 500,000 | 700,000 | +200,000 | 0.93 | 1.27 | +0.34 | buy |
| Rock Springs Capital Management LP | 650,270 | 699,146 | +48,876 | 1.22 | 1.27 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 137,015 | 661,235 | +524,220 | 0.00 | 0.02 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 655,954 | +655,954 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 545,486 | 655,954 | +110,468 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 215,159 | 647,836 | +432,677 | 0.10 | 0.29 | +0.18 | buy |
| ADAR1 Capital Management, LLC | 427,816 | 619,542 | +191,726 | 0.82 | 1.08 | +0.27 | buy |
| BANK OF AMERICA CORP /DE/ | 708,647 | 607,195 | -101,452 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 142,327 | 572,538 | +430,211 | 0.02 | 0.07 | +0.05 | buy |
| Nuveen, LLC | 201,949 | 568,460 | +366,511 | 0.00 | 0.01 | +0.00 | buy |
| 5AM Venture Management, LLC | 497,270 | 497,270 | 0 | 4.38 | 6.43 | +2.05 | hold |
| FEDERATED HERMES, INC. | 0 | 492,893 | +492,893 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 296,970 | 481,997 | +185,027 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 278,888 | 481,125 | +202,237 | 0.05 | 0.08 | +0.03 | buy |
| Ikarian Capital, LLC | 461,247 | 478,500 | +17,253 | 2.09 | 2.91 | +0.82 | buy |
| BRAIDWELL LP | 1,356,082 | 436,646 | -919,436 | 1.43 | 0.60 | -0.83 | sell |
| Redmile Group, LLC | 261,508 | 433,921 | +172,413 | 0.55 | 1.08 | +0.53 | buy |
| CITIGROUP INC | 217,335 | 404,703 | +187,368 | 0.00 | 0.01 | +0.00 | buy |
| Palo Alto Investors LP | 296,408 | 399,856 | +103,448 | 1.44 | 2.06 | +0.62 | buy |
| TSP Capital Management Group, LLC | 0 | 371,127 | +371,127 | 2.90 | 3.30 | +0.40 | buy |
| PFM Health Sciences, LP | 324,957 | 342,751 | +17,794 | 1.08 | 1.11 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 352,302 | 342,328 | -9,974 | 0.24 | 0.23 | -0.01 | sell |
| SEGALL BRYANT & HAMILL, LLC | 266,670 | 336,291 | +69,621 | 0.09 | 0.15 | +0.06 | buy |
| TFG Asset Management GP Ltd | 312,316 | 290,441 | -21,875 | 1.95 | 1.76 | -0.19 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 180,048 | 287,583 | +107,535 | 4.08 | 6.76 | +2.68 | buy |
| SummitTX Capital, L.P. | 236,637 | 254,959 | +18,322 | 0.24 | 0.25 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 243,575 | 240,868 | -2,707 | 1.33 | 1.28 | -0.05 | sell |
| Bank of New York Mellon Corp | 190,399 | 224,176 | +33,777 | 0.00 | 0.00 | +0.00 | buy |
| Rosalind Advisors, Inc. | 330,000 | 200,000 | -130,000 | 4.29 | 2.80 | -1.49 | sell |
| MORGAN STANLEY | 217,549 | 196,974 | -20,575 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 70,053 | 195,788 | +125,735 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 184,524 | +184,524 | 0.00 | 0.04 | +0.04 | buy |
| Mirador Capital Partners LP | 178,053 | 181,054 | +3,001 | 0.80 | 0.83 | +0.03 | buy |
| STEMPOINT CAPITAL LP | 254,267 | 178,412 | -75,855 | 1.55 | 1.15 | -0.40 | sell |
| Corient Private Wealth LLC | 14,636 | 176,956 | +162,320 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 143,037 | 176,592 | +33,555 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 164,778 | 157,241 | -7,537 | 0.00 | 0.00 | +0.00 | sell |
| Cinctive Capital Management LP | 41,233 | 145,637 | +104,404 | 0.09 | 0.22 | +0.13 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 134,945 | 140,064 | +5,119 | 0.10 | 0.10 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 68,470 | 138,682 | +70,212 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 117,900 | 135,000 | +17,100 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 120,807 | 134,958 | +14,151 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 121,297 | +121,297 | 0.00 | 0.09 | +0.09 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 184,104 | 120,428 | -63,676 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 3,229,939 | 117,217 | -3,112,722 | 0.18 | 0.01 | -0.17 | sell |
| BNP Paribas Asset Management Holding S.A. | 122,404 | 117,045 | -5,359 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 8,820 | 116,293 | +107,473 | 0.00 | 0.04 | +0.03 | buy |
| RHUMBLINE ADVISERS | 85,983 | 104,963 | +18,980 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 131,364 | 103,695 | -27,669 | 2.61 | 2.02 | -0.59 | sell |
| Invesco Ltd. | 93,684 | 103,131 | +9,447 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 8,491 | 100,309 | +91,818 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.15 | +0.15 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 77,772 | 89,338 | +11,566 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 65,540 | 88,640 | +23,100 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 89,397 | 86,964 | -2,433 | 0.78 | 0.74 | -0.05 | sell |
| AQR CAPITAL MANAGEMENT LLC | 7,777 | 86,893 | +79,116 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 97,822 | 80,899 | -16,923 | 0.18 | 0.16 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 70,292 | 79,326 | +9,034 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 54,190 | 79,165 | +24,975 | 0.01 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 35,158 | 78,176 | +43,018 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 79,630 | 77,723 | -1,907 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 12,074 | 75,135 | +63,061 | 0.01 | 0.04 | +0.03 | buy |
| Birchview Capital, LP | 70,095 | 69,900 | -195 | 1.27 | 1.22 | -0.05 | sell |
| Quantinno Capital Management LP | 65,744 | 69,048 | +3,304 | 0.00 | 0.00 | -0.00 | buy |
| DAFNA Capital Management LLC | 68,518 | 68,518 | 0 | 0.49 | 0.49 | -0.01 | hold |
| Man Group plc | 0 | 63,504 | +63,504 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 33,098 | 59,732 | +26,634 | 0.01 | 0.02 | +0.01 | buy |
| Legal & General Group Plc | 55,080 | 59,551 | +4,471 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 65,050 | 56,157 | -8,893 | 0.01 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 55,700 | +55,700 | 0.00 | 0.07 | +0.07 | buy |
| Simplify Asset Management Inc. | 68,994 | 53,134 | -15,860 | 0.03 | 0.03 | -0.01 | sell |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.07 | +0.07 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.07 | +0.07 | buy |
| Hennion & Walsh Asset Management, Inc. | 47,525 | 47,113 | -412 | 0.05 | 0.05 | -0.00 | sell |