| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 2,600,000 | 3,200,000 | +600,000 | 13.52 | 14.64 | +1.12 | buy |
| Sofinnova Investments, Inc. | 197,758 | 424,259 | +226,501 | 0.44 | 0.81 | +0.37 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,377,740 | 1,600,000 | +222,260 | 0.79 | 0.79 | +0.00 | buy |
| Bellevue Group AG | 1,800,000 | 1,900,000 | +100,000 | 0.87 | 0.84 | -0.03 | buy |
| Rock Springs Capital Management LP | 421,615 | 500,101 | +78,486 | 0.34 | 0.37 | +0.03 | buy |
| Commodore Capital LP | 631,665 | 706,665 | +75,000 | 2.41 | 2.27 | -0.14 | buy |
| Affinity Asset Advisors, LLC | 87,031 | 150,000 | +62,969 | 1.16 | 1.35 | +0.19 | buy |
| Woodline Partners LP | 54,499 | 107,496 | +52,997 | 0.02 | 0.03 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 18,376 | 62,583 | +44,207 | 0.01 | 0.03 | +0.02 | buy |
| Crestline Management, LP | 41,727 | 63,110 | +21,383 | 0.15 | 0.21 | +0.05 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 160,000 | 180,000 | +20,000 | 1.16 | 1.19 | +0.03 | buy |
| Polar Capital Holdings Plc | 2,416,756 | 2,426,756 | +10,000 | 0.56 | 0.50 | -0.07 | buy |
| Mirador Capital Partners LP | 104,715 | 107,818 | +3,103 | 0.84 | 0.68 | -0.17 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 87,228 | 87,394 | +166 | 0.07 | 0.06 | -0.01 | buy |
| ALPS ADVISORS INC | 34,735 | 34,848 | +113 | 0.01 | 0.01 | -0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 122,343 | 122,341 | -2 | 2.81 | 2.45 | -0.36 | sell |
| Overbrook Management Corp | 7,763 | 7,644 | -119 | 0.06 | 0.05 | -0.01 | sell |
| TSP Capital Management Group, LLC | 251,895 | 251,695 | -200 | 3.08 | 2.67 | -0.41 | sell |
| VIRTUS ADVISERS, LLC | 2,892 | 2,631 | -261 | 0.06 | 0.04 | -0.01 | sell |
| E Fund Management Co., Ltd. | 11,052 | 8,465 | -2,587 | 0.03 | 0.02 | -0.01 | sell |
| Headlands Technologies LLC | 3,984 | 718 | -3,266 | 0.04 | 0.01 | -0.03 | sell |
| HighVista Strategies LLC | 24,742 | 17,482 | -7,260 | 0.38 | 0.22 | -0.16 | sell |
| PROFUND ADVISORS LLC | 37,421 | 28,039 | -9,382 | 0.07 | 0.04 | -0.03 | sell |
| Redmile Group, LLC | 1,696,004 | 1,635,938 | -60,066 | 2.21 | 2.14 | -0.07 | sell |
| Eversept Partners, LP | 785,740 | 588,143 | -197,597 | 2.82 | 1.80 | -1.02 | sell |
| Candriam S.C.A. | 550,509 | 322,509 | -228,000 | 0.13 | 0.06 | -0.07 | sell |
| JENNISON ASSOCIATES LLC | 1,329,095 | 26,890 | -1,302,205 | 0.04 | 0.00 | -0.04 | sell |