| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 0 | 1,734,522 | +1,734,522 | 0.00 | 0.04 | +0.04 | buy |
| Woodline Partners LP | 757,771 | 2,341,121 | +1,583,350 | 0.27 | 0.67 | +0.40 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 8,075,940 | 9,243,599 | +1,167,659 | 0.05 | 0.06 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 874,193 | 1,835,843 | +961,650 | 0.01 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 900,000 | +900,000 | 0.00 | 3.43 | +3.43 | buy |
| CITADEL ADVISORS LLC | 321,212 | 847,281 | +526,069 | 0.01 | 0.03 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 1,003,085 | 1,324,410 | +321,325 | 0.02 | 0.03 | +0.00 | buy |
| MORGAN STANLEY | 163,992 | 435,818 | +271,826 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 198,429 | 456,202 | +257,773 | 0.31 | 0.60 | +0.29 | buy |
| Fisher Asset Management, LLC | 120,544 | 374,352 | +253,808 | 0.00 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 1,425,000 | 1,618,937 | +193,937 | 3.60 | 3.44 | -0.16 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 179,518 | +179,518 | 0.00 | 0.32 | +0.32 | buy |
| VANGUARD GROUP INC | 3,739,039 | 3,869,782 | +130,743 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 126,963 | 243,795 | +116,832 | 0.25 | 0.43 | +0.18 | buy |
| Novo Holdings A/S | 850,000 | 963,663 | +113,663 | 1.70 | 1.63 | -0.07 | buy |
| Caption Management, LLC | 0 | 110,000 | +110,000 | 0.00 | 0.40 | +0.40 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 309,265 | 419,103 | +109,838 | 1.87 | 2.33 | +0.47 | buy |
| TWINBEECH CAPITAL LP | 37,005 | 140,502 | +103,497 | 0.03 | 0.09 | +0.06 | buy |
| Bellevue Group AG | 2,971,615 | 3,071,615 | +100,000 | 1.79 | 1.69 | -0.10 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 86,573 | +86,573 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 54,174 | 130,381 | +76,207 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 3,388,967 | 3,458,609 | +69,642 | 13.13 | 9.11 | -4.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 43,750 | 108,103 | +64,353 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 64,000 | +64,000 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 85,351 | 137,988 | +52,637 | 0.25 | 0.27 | +0.02 | buy |
| XTX Topco Ltd | 0 | 45,917 | +45,917 | 0.00 | 0.11 | +0.11 | buy |
| AXA S.A. | 142,290 | 185,334 | +43,044 | 0.02 | 0.02 | +0.00 | buy |
| Man Group plc | 0 | 35,967 | +35,967 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 7,754 | 38,486 | +30,732 | 0.01 | 0.03 | +0.02 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 25,632 | +25,632 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 25,265 | 50,730 | +25,465 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,168 | 28,181 | +21,013 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 21,000 | +21,000 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 7,857 | 25,343 | +17,486 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 545,594 | 562,720 | +17,126 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,817 | 64,576 | +16,759 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 14,819 | +14,819 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 9,044 | 20,316 | +11,272 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 5,533 | 16,114 | +10,581 | 0.01 | 0.04 | +0.03 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 9,324 | +9,324 | 0.00 | 0.07 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 530,443 | 538,856 | +8,413 | 0.00 | 0.00 | -0.00 | buy |
| Magnetar Financial LLC | 17,390 | 25,513 | +8,123 | 0.01 | 0.02 | +0.01 | buy |
| Point72 (DIFC) Ltd | 6,998 | 14,114 | +7,116 | 0.02 | 0.04 | +0.01 | buy |
| Brevan Howard Capital Management LP | 10,945 | 17,815 | +6,870 | 0.03 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,533,956 | 1,540,513 | +6,557 | 0.00 | 0.00 | -0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 0 | 6,356 | +6,356 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 96,326 | 102,595 | +6,269 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 160,596 | 166,597 | +6,001 | 0.00 | 0.00 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,327,132 | 3,332,005 | +4,873 | 2.11 | 1.95 | -0.16 | buy |
| ADAR1 Capital Management, LLC | 303 | 5,000 | +4,697 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 58,328 | 62,981 | +4,653 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 4,591 | +4,591 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 36,770 | 41,360 | +4,590 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 8,324 | 12,206 | +3,882 | 0.00 | 0.00 | +0.00 | buy |
| Mirador Capital Partners LP | 112,379 | 116,147 | +3,768 | 0.78 | 0.71 | -0.07 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,412 | 38,941 | +3,529 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 27,392 | 30,538 | +3,146 | 0.06 | 0.06 | +0.01 | buy |
| Values First Advisors, Inc. | 21,319 | 24,172 | +2,853 | 0.47 | 0.45 | -0.03 | buy |
| Handelsbanken Fonder AB | 11,200 | 13,800 | +2,600 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 7,872 | 10,169 | +2,297 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 12,733 | 14,878 | +2,145 | 0.00 | 0.00 | -0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 40,558 | 42,628 | +2,070 | 0.01 | 0.01 | -0.00 | buy |
| Swiss National Bank | 114,300 | 115,900 | +1,600 | 0.00 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 6,626 | 7,753 | +1,127 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 16,231 | 17,080 | +849 | 0.00 | 0.00 | -0.00 | buy |
| KBC Group NV | 1,586 | 2,081 | +495 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,198 | 6,544 | +346 | 0.01 | 0.01 | -0.00 | buy |
| Smartleaf Asset Management LLC | 28 | 190 | +162 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 25 | 183 | +158 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 41,133 | 41,230 | +97 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 95 | +95 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 92 | +92 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 83 | +83 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 3 | 59 | +56 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 637 | 682 | +45 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,485 | 2,529 | +44 | 0.05 | 0.04 | -0.00 | buy |
| GAMMA Investing LLC | 10 | 51 | +41 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 25 | 60 | +35 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 647 | 682 | +35 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 124 | 136 | +12 | 0.00 | 0.00 | -0.00 | buy |
| Federation des caisses Desjardins du Quebec | 1,534 | 1,544 | +10 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 125 | 133 | +8 | 0.00 | 0.00 | -0.00 | buy |
| Farther Finance Advisors, LLC | 320 | 323 | +3 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 48,099 | 48,099 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 65,540 | 65,540 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 247,644 | 247,644 | 0 | 0.12 | 0.09 | -0.03 | hold |
| Overbrook Management Corp | 6,837 | 6,837 | 0 | 0.06 | 0.05 | -0.01 | hold |
| JANUS HENDERSON GROUP PLC | 25,642 | 25,642 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ASSETMARK, INC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 14,111 | 14,111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFM Health Sciences, LP | 52,120 | 52,120 | 0 | 0.11 | 0.10 | -0.00 | hold |
| Ensign Peak Advisors, Inc | 23,428 | 23,428 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 25,000 | 25,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MetLife Investment Management, LLC | 37,332 | 37,332 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Arax Advisory Partners | 139 | 139 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 650,000 | 650,000 | 0 | 0.74 | 0.76 | +0.02 | hold |