| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 757,771 | 2,341,121 | +1,583,350 | 0.27 | 0.67 | +0.40 | buy |
| JENNISON ASSOCIATES LLC | 1,003,085 | 1,324,410 | +321,325 | 0.02 | 0.03 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 198,429 | 456,202 | +257,773 | 0.31 | 0.60 | +0.29 | buy |
| Fisher Asset Management, LLC | 120,544 | 374,352 | +253,808 | 0.00 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 1,425,000 | 1,618,937 | +193,937 | 3.60 | 3.44 | -0.16 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 126,963 | 243,795 | +116,832 | 0.25 | 0.43 | +0.18 | buy |
| Novo Holdings A/S | 850,000 | 963,663 | +113,663 | 1.70 | 1.63 | -0.07 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 309,265 | 419,103 | +109,838 | 1.56 | 2.27 | +0.71 | buy |
| TWINBEECH CAPITAL LP | 37,005 | 140,502 | +103,497 | 0.03 | 0.09 | +0.06 | buy |
| Bellevue Group AG | 2,971,615 | 3,071,615 | +100,000 | 1.79 | 1.69 | -0.10 | buy |
| Kynam Capital Management, LP | 3,388,967 | 3,458,609 | +69,642 | 13.13 | 9.11 | -4.02 | buy |
| Crestline Management, LP | 85,351 | 137,988 | +52,637 | 0.25 | 0.24 | -0.00 | buy |
| Magnetar Financial LLC | 17,390 | 25,513 | +8,123 | 0.01 | 0.02 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,327,132 | 3,332,005 | +4,873 | 2.11 | 1.95 | -0.16 | buy |
| ADAR1 Capital Management, LLC | 303 | 5,000 | +4,697 | 0.00 | 0.03 | +0.03 | buy |
| Mirador Capital Partners LP | 112,379 | 116,147 | +3,768 | 0.78 | 0.71 | -0.07 | buy |
| Values First Advisors, Inc. | 21,319 | 24,172 | +2,853 | 0.47 | 0.45 | -0.03 | buy |
| DnB Asset Management AS | 7,872 | 10,169 | +2,297 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 25 | 183 | +158 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,485 | 2,529 | +44 | 0.05 | 0.04 | -0.00 | buy |
| TSFG, LLC | 100 | 50 | -50 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 9,627 | 8,981 | -646 | 0.13 | 0.11 | -0.02 | sell |
| ALPS ADVISORS INC | 51,399 | 50,657 | -742 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 2,053 | 1,210 | -843 | 0.02 | 0.01 | -0.01 | sell |
| TSP Capital Management Group, LLC | 249,220 | 247,820 | -1,400 | 2.89 | 2.61 | -0.29 | sell |
| Polar Asset Management Partners Inc. | 11,600 | 9,700 | -1,900 | 0.01 | 0.01 | -0.00 | sell |
| NEOS Investment Management LLC | 28,535 | 26,592 | -1,943 | 0.04 | 0.03 | -0.02 | sell |
| Cinctive Capital Management LP | 91,127 | 33,797 | -57,330 | 0.16 | 0.06 | -0.10 | sell |
| Redmile Group, LLC | 718,723 | 657,175 | -61,548 | 1.61 | 1.32 | -0.29 | sell |
| Eversept Partners, LP | 633,015 | 564,902 | -68,113 | 1.60 | 1.32 | -0.29 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 374,910 | 145,000 | -229,910 | 3.43 | 1.11 | -2.31 | sell |
| Rock Springs Capital Management LP | 1,398,994 | 1,103,778 | -295,216 | 1.56 | 1.22 | -0.34 | sell |
| Affinity Asset Advisors, LLC | 475,400 | 125,000 | -350,400 | 2.03 | 0.58 | -1.45 | sell |
| Polar Capital Holdings Plc | 3,076,783 | 2,720,877 | -355,906 | 0.67 | 0.44 | -0.23 | sell |