| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 6,100,729 | 6,100,729 | 0 | 13.37 | 11.75 | -1.62 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 5,232,326 | 5,800,003 | +567,677 | 0.02 | 0.03 | +0.01 | buy |
| BlackRock, Inc. | 5,550,016 | 5,505,988 | -44,028 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 5,439,118 | 4,962,088 | -477,030 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 3,957,122 | 3,954,590 | -2,532 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 2,801,721 | 3,893,942 | +1,092,221 | 0.13 | 0.22 | +0.08 | buy |
| Bellevue Group AG | 3,307,569 | 3,557,669 | +250,100 | 1.48 | 1.91 | +0.43 | buy |
| Commodore Capital LP | 3,450,000 | 3,028,335 | -421,665 | 4.96 | 3.82 | -1.13 | sell |
| STATE STREET CORP | 2,405,495 | 2,842,134 | +436,639 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,817,820 | 2,382,518 | -1,435,302 | 0.01 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 2,000,000 | 2,000,000 | 0 | 1.31 | 1.44 | +0.14 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,356,186 | 1,859,095 | +502,909 | 0.48 | 0.79 | +0.31 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,672,980 | 1,647,136 | -25,844 | 0.00 | 0.00 | +0.00 | sell |
| Polar Capital Holdings Plc | 1,228,435 | 1,300,436 | +72,001 | 0.13 | 0.16 | +0.03 | buy |
| Pictet Asset Management Holding SA | 1,300,329 | 1,211,990 | -88,339 | 0.03 | 0.03 | +0.00 | sell |
| Vestal Point Capital, LP | 1,750,000 | 1,205,000 | -545,000 | 1.87 | 1.41 | -0.46 | sell |
| Novo Holdings A/S | 1,200,000 | 1,200,000 | 0 | 1.72 | 2.00 | +0.28 | hold |
| Eversept Partners, LP | 838,736 | 1,153,920 | +315,184 | 1.72 | 2.29 | +0.57 | buy |
| GOLDMAN SACHS GROUP INC | 727,504 | 1,029,460 | +301,956 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 477,227 | 975,195 | +497,968 | 0.01 | 0.02 | +0.01 | buy |
| Fisher Asset Management, LLC | 822,208 | 927,157 | +104,949 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 779,985 | 815,560 | +35,575 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 812,653 | 721,538 | -91,115 | 1.03 | 1.09 | +0.06 | sell |
| BAKER BROS. ADVISORS LP | 665,370 | 665,370 | 0 | 0.13 | 0.12 | -0.01 | hold |
| NORTHERN TRUST CORP | 575,875 | 595,385 | +19,510 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 591,689 | +591,689 | 0.00 | 0.45 | +0.45 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 553,081 | 553,873 | +792 | 0.00 | 0.00 | +0.00 | buy |
| SEGALL BRYANT & HAMILL, LLC | 387,888 | 528,597 | +140,709 | 0.11 | 0.18 | +0.07 | buy |
| 5AM Venture Management, LLC | 497,270 | 497,270 | 0 | 3.89 | 4.71 | +0.82 | hold |
| UBS Group AG | 841,246 | 416,447 | -424,799 | 0.00 | 0.00 | -0.00 | sell |
| TSP Capital Management Group, LLC | 0 | 375,927 | +375,927 | 2.37 | 2.60 | +0.23 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 198,441 | 348,922 | +150,481 | 0.83 | 1.31 | +0.48 | buy |
| BANK OF AMERICA CORP /DE/ | 276,184 | 338,811 | +62,627 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 343,026 | 327,008 | -16,018 | 0.74 | 0.82 | +0.08 | sell |
| CITADEL ADVISORS LLC | 378,738 | 319,332 | -59,406 | 0.01 | 0.01 | -0.00 | sell |
| MORGAN STANLEY | 661,518 | 311,919 | -349,599 | 0.00 | 0.00 | -0.00 | sell |
| TFG Asset Management GP Ltd | 316,150 | 303,600 | -12,550 | 1.16 | 1.14 | -0.02 | sell |
| Affinity Asset Advisors, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.72 | +0.72 | buy |
| D. E. Shaw & Co., Inc. | 645,657 | 257,332 | -388,325 | 0.01 | 0.01 | -0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 143,886 | 257,083 | +113,197 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 265,555 | 249,195 | -16,360 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 262,725 | 244,825 | -17,900 | 0.00 | 0.00 | +0.00 | sell |
| Corient Private Wealth LLC | 201,717 | 239,606 | +37,889 | 0.01 | 0.01 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 419,540 | 207,764 | -211,776 | 2.23 | 1.27 | -0.96 | sell |
| Bank of New York Mellon Corp | 194,101 | 205,694 | +11,593 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,500,455 | 199,291 | -1,301,164 | 0.16 | 0.02 | -0.14 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 181,388 | 194,588 | +13,200 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 233,821 | 184,775 | -49,046 | 0.00 | 0.00 | -0.00 | sell |
| Mirador Capital Partners LP | 158,717 | 165,921 | +7,204 | 0.52 | 0.61 | +0.08 | buy |
| Propel Bio Management, LLC | 0 | 155,000 | +155,000 | 0.00 | 4.01 | +4.01 | buy |
| HighVista Strategies LLC | 106,553 | 135,258 | +28,705 | 0.80 | 0.86 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 128,581 | 134,557 | +5,976 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 211,260 | 133,883 | -77,377 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 114,100 | 115,800 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 57,466 | 109,442 | +51,976 | 0.19 | 0.28 | +0.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 213,846 | 105,478 | -108,368 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 180,965 | 103,747 | -77,218 | 0.08 | 0.04 | -0.03 | sell |
| RHUMBLINE ADVISERS | 106,599 | 103,157 | -3,442 | 0.00 | 0.00 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 20,973 | 100,308 | +79,335 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 97,822 | 97,822 | 0 | 0.11 | 0.16 | +0.05 | hold |
| Rafferty Asset Management, LLC | 71,558 | 97,460 | +25,902 | 0.00 | 0.01 | +0.00 | buy |
| SummitTX Capital, L.P. | 96,070 | 96,070 | 0 | 0.09 | 0.10 | +0.02 | hold |
| TD ASSET MANAGEMENT INC | 127,878 | 92,450 | -35,428 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 124,546 | 87,074 | -37,472 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 0 | 85,000 | +85,000 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 62,886 | 78,886 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 80,733 | 73,401 | -7,332 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 71,190 | 69,579 | -1,611 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 43,276 | 67,756 | +24,480 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 65,540 | 65,540 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HRT FINANCIAL LP | 48,415 | 64,169 | +15,754 | 0.00 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 42,287 | 63,594 | +21,307 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,508 | 55,511 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 33,871 | 55,140 | +21,269 | 0.00 | 0.01 | +0.00 | buy |
| Jefferies Financial Group Inc. | 57,000 | 50,000 | -7,000 | 0.02 | 0.01 | -0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 58,398 | 48,906 | -9,492 | 0.03 | 0.03 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 48,099 | 48,099 | 0 | 0.00 | 0.00 | +0.00 | hold |
| READYSTATE ASSET MANAGEMENT LP | 335,000 | 46,520 | -288,480 | 0.28 | 0.06 | -0.22 | sell |
| ROYAL BANK OF CANADA | 50,615 | 45,401 | -5,214 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 84,726 | 44,759 | -39,967 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 39,004 | 39,004 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Hennion & Walsh Asset Management, Inc. | 21,054 | 35,783 | +14,729 | 0.02 | 0.03 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 0 | 35,531 | +35,531 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,388 | 35,413 | -3,975 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 29,902 | 33,270 | +3,368 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 36,699 | 33,098 | -3,601 | 0.01 | 0.01 | +0.00 | sell |
| ALPS ADVISORS INC | 35,812 | 31,916 | -3,896 | 0.00 | 0.00 | +0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 31,618 | +31,618 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 41,900 | 30,891 | -11,009 | 0.01 | 0.01 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 30,446 | +30,446 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 27,650 | 27,390 | -260 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 111,399 | 27,367 | -84,032 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 25,642 | 25,642 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 25,000 | 25,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DAFNA Capital Management LLC | 0 | 24,518 | +24,518 | 0.00 | 0.16 | +0.16 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,060 | 22,800 | +3,740 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 25,995 | 22,721 | -3,274 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 99,200 | 22,394 | -76,806 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,237 | 22,237 | 0 | 0.00 | 0.00 | +0.00 | hold |