| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 2,801,721 | 3,893,942 | +1,092,221 | 0.13 | 0.22 | +0.08 | buy |
| BRAIDWELL LP | 0 | 591,689 | +591,689 | 0.00 | 0.45 | +0.45 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,232,326 | 5,800,003 | +567,677 | 0.02 | 0.03 | +0.01 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,356,186 | 1,859,095 | +502,909 | 0.48 | 0.79 | +0.31 | buy |
| MILLENNIUM MANAGEMENT LLC | 477,227 | 975,195 | +497,968 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 2,405,495 | 2,842,134 | +436,639 | 0.00 | 0.00 | +0.00 | buy |
| TSP Capital Management Group, LLC | 0 | 375,927 | +375,927 | 2.37 | 2.60 | +0.23 | buy |
| Eversept Partners, LP | 838,736 | 1,153,920 | +315,184 | 1.72 | 2.29 | +0.57 | buy |
| GOLDMAN SACHS GROUP INC | 727,504 | 1,029,460 | +301,956 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 300,000 | +300,000 | 0.00 | 0.72 | +0.72 | buy |
| Bellevue Group AG | 3,307,569 | 3,557,669 | +250,100 | 1.48 | 1.91 | +0.43 | buy |
| Propel Bio Management, LLC | 0 | 155,000 | +155,000 | 0.00 | 4.01 | +4.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 198,441 | 348,922 | +150,481 | 0.83 | 1.31 | +0.48 | buy |
| SEGALL BRYANT & HAMILL, LLC | 387,888 | 528,597 | +140,709 | 0.11 | 0.18 | +0.07 | buy |
| DIMENSIONAL FUND ADVISORS LP | 143,886 | 257,083 | +113,197 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 822,208 | 927,157 | +104,949 | 0.01 | 0.01 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 85,000 | +85,000 | 0.00 | 0.04 | +0.04 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 20,973 | 100,308 | +79,335 | 0.00 | 0.01 | +0.01 | buy |
| Polar Capital Holdings Plc | 1,228,435 | 1,300,436 | +72,001 | 0.13 | 0.16 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 276,184 | 338,811 | +62,627 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 57,466 | 109,442 | +51,976 | 0.19 | 0.28 | +0.09 | buy |
| Corient Private Wealth LLC | 201,717 | 239,606 | +37,889 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 779,985 | 815,560 | +35,575 | 0.01 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 35,531 | +35,531 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 31,618 | +31,618 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 30,446 | +30,446 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 106,553 | 135,258 | +28,705 | 0.80 | 0.86 | +0.06 | buy |
| Rafferty Asset Management, LLC | 71,558 | 97,460 | +25,902 | 0.00 | 0.01 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 24,518 | +24,518 | 0.00 | 0.16 | +0.16 | buy |
| WELLS FARGO & COMPANY/MN | 43,276 | 67,756 | +24,480 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 42,287 | 63,594 | +21,307 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 33,871 | 55,140 | +21,269 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 575,875 | 595,385 | +19,510 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 19,468 | +19,468 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 18,308 | +18,308 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 62,886 | 78,886 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 48,415 | 64,169 | +15,754 | 0.00 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 21,054 | 35,783 | +14,729 | 0.02 | 0.03 | +0.02 | buy |
| Brevan Howard Capital Management LP | 0 | 14,362 | +14,362 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 181,388 | 194,588 | +13,200 | 0.00 | 0.01 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 11,632 | +11,632 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 194,101 | 205,694 | +11,593 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 9,905 | +9,905 | 0.00 | 0.00 | +0.00 | buy |
| TRANSCEND CAPITAL ADVISORS, LLC | 0 | 9,237 | +9,237 | 0.00 | 0.02 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 8,809 | +8,809 | 0.00 | 0.00 | +0.00 | buy |
| Overbrook Management Corp | 0 | 8,797 | +8,797 | 0.00 | 0.04 | +0.04 | buy |
| Argent Trust Co | 0 | 8,481 | +8,481 | 0.00 | 0.01 | +0.01 | buy |
| Mirador Capital Partners LP | 158,717 | 165,921 | +7,204 | 0.52 | 0.61 | +0.08 | buy |
| DEUTSCHE BANK AG\ | 128,581 | 134,557 | +5,976 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 15,425 | 21,305 | +5,880 | 0.01 | 0.02 | +0.01 | buy |
| Advisory Services Network, LLC | 0 | 5,390 | +5,390 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,315 | 7,362 | +5,047 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 19,060 | 22,800 | +3,740 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 29,902 | 33,270 | +3,368 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 2,900 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 15,272 | 18,143 | +2,871 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 16,495 | 19,297 | +2,802 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,768 | 4,535 | +2,767 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 2,442 | +2,442 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 114,100 | 115,800 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 1,633 | +1,633 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 1,633 | +1,633 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 1,014 | +1,014 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 4,621 | 5,592 | +971 | 0.03 | 0.04 | +0.01 | buy |
| DnB Asset Management AS | 12,300 | 13,251 | +951 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 553,081 | 553,873 | +792 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 264 | +264 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 17,419 | 17,649 | +230 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 160 | +160 | 0.00 | 0.00 | +0.00 | buy |
| Strategic Advocates LLC | 0 | 130 | +130 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 171 | 262 | +91 | 0.00 | 0.00 | +0.00 | buy |
| HALBERT HARGROVE GLOBAL ADVISORS, LLC | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 73 | +73 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 70 | 141 | +71 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 615 | 669 | +54 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 363 | 417 | +54 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 7 | 52 | +45 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 25 | 51 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Apella Capital, LLC | 17,000 | 17,024 | +24 | 0.01 | 0.01 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 181 | 191 | +10 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 407 | 415 | +8 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 5 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 5 | 10 | +5 | 0.00 | 0.00 | 0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,508 | 55,511 | +3 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 46 | 49 | +3 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 366 | 367 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,394 | 1,395 | +1 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 6,338 | 6,338 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 48,099 | 48,099 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 65,540 | 65,540 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 665,370 | 665,370 | 0 | 0.13 | 0.12 | -0.01 | hold |
| JANUS HENDERSON GROUP PLC | 25,642 | 25,642 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CIBC Private Wealth Group LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Novo Holdings A/S | 1,200,000 | 1,200,000 | 0 | 1.72 | 2.00 | +0.28 | hold |
| Handelsbanken Fonder AB | 21,600 | 21,600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KBC Group NV | 2,411 | 2,411 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DekaBank Deutsche Girozentrale | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 25,000 | 25,000 | 0 | 0.01 | 0.01 | +0.00 | hold |