| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 1,600,000 | 3,630,013 | +2,030,013 | 0.79 | 2.35 | +1.56 | buy |
| Polar Capital Holdings Plc | 2,426,756 | 3,135,871 | +709,115 | 0.50 | 0.77 | +0.27 | buy |
| Bellevue Group AG | 1,900,000 | 2,416,296 | +516,296 | 0.84 | 1.47 | +0.62 | buy |
| Rock Springs Capital Management LP | 500,101 | 969,646 | +469,545 | 0.37 | 0.95 | +0.58 | buy |
| Sofinnova Investments, Inc. | 424,259 | 844,008 | +419,749 | 0.74 | 1.87 | +1.14 | buy |
| Woodline Partners LP | 107,496 | 387,652 | +280,156 | 0.03 | 0.17 | +0.13 | buy |
| Affinity Asset Advisors, LLC | 150,000 | 400,000 | +250,000 | 1.16 | 2.90 | +1.74 | buy |
| 5AM Venture Management, LLC | 310,270 | 497,270 | +187,000 | 2.46 | 5.23 | +2.77 | buy |
| Eversept Partners, LP | 588,143 | 754,107 | +165,964 | 1.37 | 2.63 | +1.26 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 180,000 | 315,644 | +135,644 | 0.90 | 2.01 | +1.11 | buy |
| Crestline Management, LP | 63,110 | 67,243 | +4,133 | 0.20 | 0.23 | +0.02 | buy |
| ALPS ADVISORS INC | 34,848 | 37,645 | +2,797 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 20,538 | 21,812 | +1,274 | 0.00 | 0.00 | +0.00 | buy |
| Mirador Capital Partners LP | 107,818 | 107,910 | +92 | 0.68 | 0.91 | +0.23 | buy |
| VIRTUS ADVISERS, LLC | 2,631 | 2,561 | -70 | 0.04 | 0.06 | +0.02 | sell |
| TSP Capital Management Group, LLC | 251,695 | 251,495 | -200 | 2.67 | 3.46 | +0.78 | sell |
| E Fund Management Co., Ltd. | 8,465 | 7,949 | -516 | 0.02 | 0.02 | +0.00 | sell |
| Commodore Capital LP | 706,665 | 701,967 | -4,698 | 2.27 | 2.43 | +0.16 | sell |
| Candriam S.C.A. | 322,509 | 317,509 | -5,000 | 0.06 | 0.09 | +0.02 | sell |
| JENNISON ASSOCIATES LLC | 26,890 | 20,078 | -6,812 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 87,394 | 62,172 | -25,222 | 0.06 | 0.05 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 62,583 | 37,177 | -25,406 | 0.03 | 0.02 | -0.01 | sell |
| Octagon Capital Advisors LP | 759,898 | 707,526 | -52,372 | 3.68 | 4.49 | +0.81 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 122,341 | 69,400 | -52,941 | 2.26 | 1.55 | -0.71 | sell |
| Kynam Capital Management, LP | 3,200,000 | 3,005,904 | -194,096 | 14.64 | 13.49 | -1.15 | sell |
| Redmile Group, LLC | 1,635,938 | 993,803 | -642,135 | 2.14 | 1.41 | -0.73 | sell |