| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 1,600,000 | 3,630,013 | +2,030,013 | 0.79 | 2.35 | +1.56 | buy |
| Point72 Asset Management, L.P. | 1,342,400 | 2,756,122 | +1,413,722 | 0.13 | 0.33 | +0.21 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,431,833 | 6,476,561 | +1,044,728 | 0.03 | 0.05 | +0.02 | buy |
| MARSHALL WACE, LLP | 538,319 | 1,280,084 | +741,765 | 0.03 | 0.10 | +0.07 | buy |
| Polar Capital Holdings Plc | 2,426,756 | 3,135,871 | +709,115 | 0.50 | 0.77 | +0.27 | buy |
| Bellevue Group AG | 1,900,000 | 2,416,296 | +516,296 | 0.84 | 1.47 | +0.62 | buy |
| Rock Springs Capital Management LP | 500,101 | 969,646 | +469,545 | 0.37 | 0.95 | +0.58 | buy |
| VANGUARD GROUP INC | 2,618,504 | 3,046,331 | +427,827 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 424,259 | 844,008 | +419,749 | 0.81 | 1.88 | +1.06 | buy |
| Pictet Asset Management Holding SA | 1,850,970 | 2,225,448 | +374,478 | 0.06 | 0.10 | +0.03 | buy |
| Woodline Partners LP | 107,496 | 387,652 | +280,156 | 0.03 | 0.17 | +0.13 | buy |
| Affinity Asset Advisors, LLC | 150,000 | 400,000 | +250,000 | 1.35 | 3.16 | +1.81 | buy |
| BAKER BROS. ADVISORS LP | 0 | 247,644 | +247,644 | 0.00 | 0.11 | +0.11 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 247,215 | +247,215 | 0.00 | 3.02 | +3.02 | buy |
| Invesco Ltd. | 37,135 | 257,563 | +220,428 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 310,270 | 497,270 | +187,000 | 2.46 | 5.23 | +2.77 | buy |
| Eversept Partners, LP | 588,143 | 754,107 | +165,964 | 1.80 | 2.93 | +1.14 | buy |
| Laurion Capital Management LP | 0 | 138,531 | +138,531 | 0.00 | 0.20 | +0.20 | buy |
| UBS Group AG | 21,195 | 158,092 | +136,897 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 180,000 | 315,644 | +135,644 | 1.19 | 2.32 | +1.14 | buy |
| MORGAN STANLEY | 523,700 | 658,365 | +134,665 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 130,542 | +130,542 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 5,925 | 126,328 | +120,403 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,000,425 | 1,117,994 | +117,569 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 100,209 | +100,209 | 0.00 | 0.70 | +0.70 | buy |
| Ensign Peak Advisors, Inc | 92,129 | 179,611 | +87,482 | 0.01 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 2,292,851 | 2,377,326 | +84,475 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 59,414 | 128,161 | +68,747 | 0.00 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 58,800 | +58,800 | 0.00 | 0.05 | +0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 48,099 | +48,099 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 361,547 | 409,391 | +47,844 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 91,723 | 136,601 | +44,878 | 0.01 | 0.01 | +0.00 | buy |
| Atom Investors LP | 0 | 40,882 | +40,882 | 0.00 | 0.29 | +0.29 | buy |
| Qube Research & Technologies Ltd | 4,299 | 44,968 | +40,669 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 35,000 | +35,000 | 0.00 | 0.08 | +0.08 | buy |
| Trexquant Investment LP | 0 | 31,429 | +31,429 | 0.00 | 0.03 | +0.03 | buy |
| Caption Management, LLC | 13,000 | 39,700 | +26,700 | 0.05 | 0.17 | +0.13 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 26,512 | +26,512 | 0.00 | 0.09 | +0.09 | buy |
| GOLDMAN SACHS GROUP INC | 411,834 | 437,759 | +25,925 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 17,554 | +17,554 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 62,677 | 75,470 | +12,793 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 12,653 | +12,653 | 0.00 | 0.01 | +0.01 | buy |
| FIRST TRUST ADVISORS LP | 0 | 11,563 | +11,563 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 11,560 | +11,560 | 0.00 | 0.04 | +0.04 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,249 | +11,249 | 0.00 | 0.11 | +0.11 | buy |
| Legal & General Group Plc | 40,844 | 52,012 | +11,168 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 18,155 | 28,538 | +10,383 | 0.00 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 158,993 | 169,268 | +10,275 | 0.07 | 0.09 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 17,020 | 25,883 | +8,863 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 88,300 | 97,000 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 31,949 | 40,518 | +8,569 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 8,100 | +8,100 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 7,690 | +7,690 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 7,399 | +7,399 | 0.00 | 0.18 | +0.18 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 7,252 | +7,252 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 7,768 | 14,985 | +7,217 | 0.00 | 0.00 | +0.00 | buy |
| PANORAMIC INVESTMENT ADVISORS, LLC | 0 | 6,500 | +6,500 | 0.00 | 0.22 | +0.22 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 6,327 | +6,327 | 0.00 | 0.04 | +0.04 | buy |
| Walleye Trading LLC | 8,330 | 14,079 | +5,749 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,753 | 51,474 | +5,721 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 212,257 | 217,814 | +5,557 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 6,582 | 12,032 | +5,450 | 0.00 | 0.00 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 0 | 5,058 | +5,058 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 164,157 | 169,139 | +4,982 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 4,313 | +4,313 | 0.00 | 0.02 | +0.02 | buy |
| Crestline Management, LP | 63,110 | 67,243 | +4,133 | 0.21 | 0.25 | +0.04 | buy |
| GROUP ONE TRADING LLC | 17,756 | 21,536 | +3,780 | 0.02 | 0.03 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 3,400 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 34,848 | 37,645 | +2,797 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 143,463 | 145,894 | +2,431 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 20,822 | 23,205 | +2,383 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 11,436 | 13,758 | +2,322 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 1,400 | 2,700 | +1,300 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 20,538 | 21,812 | +1,274 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,873 | 3,114 | +1,241 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 25,296 | 26,258 | +962 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 119 | 599 | +480 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 160,860 | 161,051 | +191 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 113 | +113 | 0.00 | 0.00 | +0.00 | buy |
| Mirador Capital Partners LP | 107,818 | 107,910 | +92 | 0.68 | 0.91 | +0.23 | buy |
| CWM, LLC | 26 | 87 | +61 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 392 | 425 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Scarborough Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Strategic Investment Solutions, Inc. /IL | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 19 | 20 | +1 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 3,615 | 3,615 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,616 | 4,616 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Overbrook Management Corp | 7,644 | 7,644 | 0 | 0.05 | 0.06 | +0.01 | hold |
| Hartford Financial Management Inc. | 18 | 18 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 3,463,201 | 3,463,201 | 0 | 2.01 | 2.15 | +0.13 | hold |
| MetLife Investment Management, LLC | 24,073 | 24,073 | 0 | 0.01 | 0.01 | +0.00 | hold |
| First Horizon Advisors, Inc. | 333 | 333 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 22 | 22 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Close Asset Management Ltd | 133 | 133 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TSFG, LLC | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rise Advisors, LLC | 83 | 83 | 0 | 0.00 | 0.00 | +0.00 | hold |