| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 3,458,609 | 5,064,207 | +1,605,598 | 9.11 | 8.44 | -0.67 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,332,005 | 3,753,260 | +421,255 | 1.95 | 1.73 | -0.23 | buy |
| Crestline Management, LP | 137,988 | 295,354 | +157,366 | 0.24 | 0.25 | +0.00 | buy |
| Eversept Partners, LP | 564,902 | 719,836 | +154,934 | 1.32 | 1.61 | +0.30 | buy |
| Polar Asset Management Partners Inc. | 9,700 | 137,550 | +127,850 | 0.01 | 0.04 | +0.03 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 145,000 | 264,560 | +119,560 | 1.11 | 1.49 | +0.38 | buy |
| Rock Springs Capital Management LP | 1,103,778 | 1,222,182 | +118,404 | 1.22 | 1.18 | -0.04 | buy |
| Fisher Asset Management, LLC | 374,352 | 452,497 | +78,145 | 0.01 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 419,103 | 474,103 | +55,000 | 2.27 | 2.17 | -0.10 | buy |
| Cinctive Capital Management LP | 33,797 | 81,320 | +47,523 | 0.06 | 0.10 | +0.04 | buy |
| Novo Holdings A/S | 963,663 | 1,000,000 | +36,337 | 1.63 | 1.53 | -0.10 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 9,324 | 23,290 | +13,966 | 0.07 | 0.11 | +0.04 | buy |
| Values First Advisors, Inc. | 24,172 | 29,009 | +4,837 | 0.45 | 0.40 | -0.04 | buy |
| Mirador Capital Partners LP | 116,147 | 119,492 | +3,345 | 0.71 | 0.55 | -0.16 | buy |
| ALPS ADVISORS INC | 50,657 | 53,650 | +2,993 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,529 | 2,688 | +159 | 0.04 | 0.03 | -0.01 | buy |
| J.Safra Asset Management Corp | 183 | 312 | +129 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 10,169 | 10,131 | -38 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 26,592 | 20,261 | -6,331 | 0.03 | 0.01 | -0.02 | sell |
| Brevan Howard Capital Management LP | 17,815 | 11,414 | -6,401 | 0.00 | 0.00 | -0.00 | sell |
| TSP Capital Management Group, LLC | 247,820 | 223,343 | -24,477 | 2.61 | 1.92 | -0.69 | sell |
| T. Rowe Price Investment Management, Inc. | 1,734,522 | 1,697,498 | -37,024 | 0.04 | 0.03 | -0.01 | sell |
| READYSTATE ASSET MANAGEMENT LP | 179,518 | 142,038 | -37,480 | 0.32 | 0.15 | -0.17 | sell |
| Redmile Group, LLC | 657,175 | 615,775 | -41,400 | 1.32 | 1.08 | -0.23 | sell |
| TWINBEECH CAPITAL LP | 140,502 | 34,558 | -105,944 | 0.09 | 0.01 | -0.08 | sell |
| Affinity Asset Advisors, LLC | 125,000 | 9,992 | -115,008 | 0.58 | 0.03 | -0.55 | sell |
| Woodline Partners LP | 2,341,121 | 2,014,015 | -327,106 | 0.67 | 0.34 | -0.33 | sell |
| Polar Capital Holdings Plc | 2,720,877 | 1,565,831 | -1,155,046 | 0.44 | 0.22 | -0.22 | sell |