| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 5,800,003 | 8,079,608 | +2,279,605 | 0.03 | 0.04 | +0.01 | buy |
| Kynam Capital Management, LP | 6,100,729 | 5,943,180 | -157,549 | 11.75 | 10.51 | -1.24 | sell |
| BlackRock, Inc. | 5,505,988 | 5,451,815 | -54,173 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 4,962,088 | 4,907,469 | -54,619 | 0.01 | 0.01 | +0.00 | sell |
| VANGUARD GROUP INC | 3,954,590 | 4,027,407 | +72,817 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 3,557,669 | 3,617,669 | +60,000 | 1.91 | 1.86 | -0.05 | buy |
| STATE STREET CORP | 2,842,134 | 3,397,713 | +555,579 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 3,028,335 | 2,565,000 | -463,335 | 3.82 | 4.64 | +0.81 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,382,518 | 2,039,705 | -342,813 | 0.01 | 0.01 | -0.00 | sell |
| Deep Track Capital, LP | 2,000,000 | 1,900,738 | -99,262 | 1.44 | 1.18 | -0.27 | sell |
| BRAIDWELL LP | 591,689 | 1,858,109 | +1,266,420 | 0.45 | 1.61 | +1.16 | buy |
| Point72 Asset Management, L.P. | 3,893,942 | 1,758,357 | -2,135,585 | 0.22 | 0.07 | -0.14 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,859,095 | 1,642,559 | -216,536 | 0.79 | 0.70 | -0.09 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,647,136 | 1,627,529 | -19,607 | 0.00 | 0.00 | +0.00 | sell |
| Eversept Partners, LP | 1,153,920 | 1,434,725 | +280,805 | 2.29 | 2.18 | -0.10 | buy |
| MILLENNIUM MANAGEMENT LLC | 975,195 | 1,212,705 | +237,510 | 0.02 | 0.02 | +0.00 | buy |
| Novo Holdings A/S | 1,200,000 | 1,200,000 | 0 | 2.00 | 2.53 | +0.53 | hold |
| Vestal Point Capital, LP | 1,205,000 | 1,165,000 | -40,000 | 1.41 | 1.16 | -0.25 | sell |
| GOLDMAN SACHS GROUP INC | 1,029,460 | 1,068,131 | +38,671 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,300,436 | 1,008,163 | -292,273 | 0.16 | 0.13 | -0.04 | sell |
| Pictet Asset Management Holding SA | 1,211,990 | 968,616 | -243,374 | 0.03 | 0.03 | -0.00 | sell |
| Fisher Asset Management, LLC | 927,157 | 937,158 | +10,001 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 815,560 | 855,226 | +39,666 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 721,538 | 692,538 | -29,000 | 1.09 | 0.97 | -0.13 | sell |
| BAKER BROS. ADVISORS LP | 665,370 | 665,370 | 0 | 0.12 | 0.11 | -0.02 | hold |
| DIMENSIONAL FUND ADVISORS LP | 257,083 | 651,716 | +394,633 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 109,442 | 646,767 | +537,325 | 0.28 | 1.31 | +1.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 553,873 | 550,729 | -3,144 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 595,385 | 549,998 | -45,387 | 0.00 | 0.00 | -0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 528,597 | 514,531 | -14,066 | 0.18 | 0.19 | +0.01 | sell |
| Woodline Partners LP | 199,291 | 500,127 | +300,836 | 0.02 | 0.05 | +0.03 | buy |
| 5AM Venture Management, LLC | 497,270 | 497,270 | 0 | 4.71 | 4.25 | -0.47 | hold |
| BANK OF AMERICA CORP /DE/ | 338,811 | 414,888 | +76,077 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 300,000 | 350,000 | +50,000 | 0.72 | 0.68 | -0.04 | buy |
| Logos Global Management LP | 0 | 350,000 | +350,000 | 0.00 | 0.63 | +0.63 | buy |
| UBS Group AG | 416,447 | 326,462 | -89,985 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 311,919 | 285,535 | -26,384 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 327,008 | 283,308 | -43,700 | 0.82 | 0.57 | -0.26 | sell |
| TFG Asset Management GP Ltd | 303,600 | 243,800 | -59,800 | 1.14 | 1.40 | +0.26 | sell |
| BARCLAYS PLC | 244,825 | 240,594 | -4,231 | 0.00 | 0.00 | +0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 207,764 | 239,764 | +32,000 | 1.27 | 1.36 | +0.09 | buy |
| Corient Private Wealth LLC | 239,606 | 234,698 | -4,908 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 133,883 | 230,662 | +96,779 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 249,195 | 200,696 | -48,499 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 205,694 | 194,552 | -11,142 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 348,922 | 191,074 | -157,848 | 1.31 | 0.75 | -0.56 | sell |
| JPMORGAN CHASE & CO | 184,775 | 173,677 | -11,098 | 0.00 | 0.00 | +0.00 | sell |
| Mirador Capital Partners LP | 165,921 | 170,659 | +4,738 | 0.61 | 0.64 | +0.03 | buy |
| Propel Bio Management, LLC | 155,000 | 154,300 | -700 | 4.01 | 3.58 | -0.44 | sell |
| Jump Financial, LLC | 14,143 | 145,164 | +131,021 | 0.01 | 0.05 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 134,557 | 136,485 | +1,928 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 257,332 | 136,324 | -121,008 | 0.01 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 0 | 133,161 | +133,161 | 0.00 | 0.37 | +0.37 | buy |
| TWO SIGMA INVESTMENTS, LP | 73,401 | 132,533 | +59,132 | 0.00 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 669 | 123,165 | +122,496 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 194,588 | 118,488 | -76,100 | 0.01 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 118,205 | +118,205 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 115,800 | 117,900 | +2,100 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 105,478 | 117,589 | +12,111 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 97,460 | 114,230 | +16,770 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 103,747 | 98,847 | -4,900 | 0.04 | 0.04 | -0.00 | sell |
| PDT Partners, LLC | 97,822 | 97,822 | 0 | 0.16 | 0.17 | +0.01 | hold |
| WELLS FARGO & COMPANY/MN | 67,756 | 91,599 | +23,843 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 78,886 | 90,144 | +11,258 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 88,308 | +88,308 | 0.00 | 1.28 | +1.28 | buy |
| RHUMBLINE ADVISERS | 103,157 | 87,264 | -15,893 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 85,000 | 85,000 | 0 | 0.04 | 0.04 | -0.01 | hold |
| HRT FINANCIAL LP | 64,169 | 77,640 | +13,471 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 87,074 | 75,130 | -11,944 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 24,518 | 68,518 | +44,000 | 0.16 | 0.43 | +0.28 | buy |
| TD ASSET MANAGEMENT INC | 92,450 | 66,570 | -25,880 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 65,540 | 65,540 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 69,579 | 62,599 | -6,980 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,511 | 58,397 | +2,886 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 319,332 | 55,101 | -264,231 | 0.01 | 0.00 | -0.01 | sell |
| ALPS ADVISORS INC | 31,916 | 54,559 | +22,643 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 135,258 | 51,805 | -83,453 | 0.86 | 0.36 | -0.50 | sell |
| XTX Topco Ltd | 7,894 | 51,523 | +43,629 | 0.01 | 0.04 | +0.03 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 63,594 | 49,076 | -14,518 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 19,468 | 47,340 | +27,872 | 0.00 | 0.00 | -0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 35,783 | 46,965 | +11,182 | 0.03 | 0.04 | +0.01 | buy |
| SummitTX Capital, L.P. | 96,070 | 43,324 | -52,746 | 0.10 | 0.04 | -0.07 | sell |
| PROFUND ADVISORS LLC | 21,305 | 42,454 | +21,149 | 0.02 | 0.04 | +0.02 | buy |
| FIRST TRUST ADVISORS LP | 35,531 | 38,313 | +2,782 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 44,759 | 38,066 | -6,693 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,413 | 37,066 | +1,653 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 39,004 | 37,012 | -1,992 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 30,891 | 33,499 | +2,608 | 0.01 | 0.01 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 33,098 | 33,098 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 19,297 | 32,263 | +12,966 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 33,270 | 31,404 | -1,866 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 27,390 | 27,429 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 21,600 | 25,900 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 25,642 | 25,642 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 22,800 | 25,317 | +2,517 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 25,000 | 25,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Quantinno Capital Management LP | 0 | 23,586 | +23,586 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,237 | 22,237 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 20,334 | 21,856 | +1,522 | 0.00 | 0.00 | -0.00 | buy |