| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 591,689 | 1,858,109 | +1,266,420 | 0.45 | 1.61 | +1.16 | buy |
| ADAR1 Capital Management, LLC | 109,442 | 646,767 | +537,325 | 0.28 | 1.31 | +1.03 | buy |
| Eversept Partners, LP | 1,153,920 | 1,434,725 | +280,805 | 2.06 | 1.96 | -0.09 | buy |
| Bellevue Group AG | 3,557,669 | 3,617,669 | +60,000 | 1.91 | 1.86 | -0.05 | buy |
| Affinity Asset Advisors, LLC | 300,000 | 350,000 | +50,000 | 0.72 | 0.68 | -0.04 | buy |
| DAFNA Capital Management LLC | 24,518 | 68,518 | +44,000 | 0.16 | 0.43 | +0.28 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 207,764 | 239,764 | +32,000 | 1.13 | 1.26 | +0.13 | buy |
| Hennion & Walsh Asset Management, Inc. | 35,783 | 46,965 | +11,182 | 0.03 | 0.04 | +0.01 | buy |
| Mirador Capital Partners LP | 165,921 | 170,659 | +4,738 | 0.61 | 0.64 | +0.03 | buy |
| Virtus Investment Advisers, LLC | 5,592 | 9,671 | +4,079 | 0.04 | 0.07 | +0.03 | buy |
| DnB Asset Management AS | 13,251 | 16,901 | +3,650 | 0.00 | 0.00 | +0.00 | buy |
| Overbrook Management Corp | 8,797 | 11,537 | +2,740 | 0.04 | 0.05 | +0.01 | buy |
| J.Safra Asset Management Corp | 40 | 80 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 155,000 | 154,300 | -700 | 4.01 | 3.58 | -0.44 | sell |
| SEGALL BRYANT & HAMILL, LLC | 528,597 | 514,531 | -14,066 | 8.84 | 0.19 | -8.65 | sell |
| Rock Springs Capital Management LP | 721,538 | 692,538 | -29,000 | 1.09 | 0.96 | -0.13 | sell |
| Vestal Point Capital, LP | 1,205,000 | 1,165,000 | -40,000 | 1.41 | 1.16 | -0.25 | sell |
| Redmile Group, LLC | 327,008 | 283,308 | -43,700 | 0.82 | 0.57 | -0.26 | sell |
| SummitTX Capital, L.P. | 96,070 | 43,324 | -52,746 | 0.10 | 0.04 | -0.07 | sell |
| TFG Asset Management GP Ltd | 303,600 | 243,800 | -59,800 | 1.05 | 1.40 | +0.35 | sell |
| HighVista Strategies LLC | 135,258 | 51,805 | -83,453 | 0.86 | 0.36 | -0.50 | sell |
| Deep Track Capital, LP | 2,000,000 | 1,900,738 | -99,262 | 1.44 | 1.18 | -0.27 | sell |
| Kynam Capital Management, LP | 6,100,729 | 5,943,180 | -157,549 | 11.75 | 10.51 | -1.24 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 348,922 | 191,074 | -157,848 | 1.31 | 0.75 | -0.56 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,859,095 | 1,642,559 | -216,536 | 0.79 | 0.70 | -0.09 | sell |
| Polar Capital Holdings Plc | 1,300,436 | 1,008,163 | -292,273 | 0.16 | 0.13 | -0.04 | sell |
| TSP Capital Management Group, LLC | 375,927 | 0 | -375,927 | 2.60 | 2.49 | -0.11 | sell |
| Commodore Capital LP | 3,028,335 | 2,565,000 | -463,335 | 3.82 | 4.64 | +0.81 | sell |