| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 0 | 159,183 | +159,183 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 50,559 | 72,106 | +21,547 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 124,423 | 138,949 | +14,526 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 160,936 | 170,049 | +9,113 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 8,778 | +8,778 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,155,033 | 1,160,600 | +5,567 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 3,960 | +3,960 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 250,000 | 253,770 | +3,770 | 2.00 | 4.84 | +2.84 | buy |
| Eversept Partners, LP | 93,727 | 97,065 | +3,338 | 0.17 | 0.17 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,277 | 3,543 | +1,266 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 411 | +411 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,262 | 5,638 | +376 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 2,445 | 2,778 | +333 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,044 | 1,371 | +327 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 8,157 | 8,361 | +204 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 8 | 75 | +67 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 16 | +16 | 0.00 | 0.00 | 0.00 | buy |
| CWM, LLC | 585 | 587 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 604 | 604 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 3,633,743 | 3,633,743 | 0 | 1.68 | 2.40 | +0.72 | hold |
| NATIXIS | 1,726 | 1,726 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 118,899 | 118,899 | 0 | 0.80 | 1.02 | +0.22 | hold |
| MACQUARIE GROUP LTD | 3,466 | 3,466 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Opaleye Management Inc. | 250,000 | 250,000 | 0 | 1.23 | 1.31 | +0.08 | hold |
| Avior Wealth Management, LLC | 501 | 501 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CM Management, LLC | 55,000 | 55,000 | 0 | 0.82 | 1.11 | +0.29 | hold |
| Allspring Global Investments Holdings, LLC | 15 | 15 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knott David M Jr | 19,722 | 19,722 | 0 | 0.14 | 0.17 | +0.03 | hold |
| DIMENSIONAL FUND ADVISORS LP | 25,516 | 25,516 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FIRST MANHATTAN CO. LLC. | 5,000 | 5,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,560 | 19,560 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 3,634 | 3,603 | -31 | 0.00 | 0.00 | +0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 60 | 0 | -60 | 0.00 | 0.00 | -0.00 | sell |
| TLS Advisors LLC | 120,465 | 120,365 | -100 | 7.40 | 6.74 | -0.66 | sell |
| DEUTSCHE BANK AG\ | 4,808 | 4,636 | -172 | 0.00 | 0.00 | +0.00 | sell |
| Scarborough Advisors, LLC | 175 | 0 | -175 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 707 | 531 | -176 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26,600 | 26,400 | -200 | 0.01 | 0.01 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 651 | 420 | -231 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 638 | 247 | -391 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,203 | 735 | -468 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 7,945 | 7,355 | -590 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 86,968 | 86,096 | -872 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 62,589 | 60,688 | -1,901 | 0.00 | 0.00 | +0.00 | sell |
| RBF Capital, LLC | 33,005 | 30,616 | -2,389 | 0.04 | 0.04 | +0.00 | sell |
| BARCLAYS PLC | 10,088 | 5,161 | -4,927 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 4,992 | 0 | -4,992 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 26,537 | 15,210 | -11,327 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 12,274 | 0 | -12,274 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 12,296 | 0 | -12,296 | 0.00 | 0.00 | -0.00 | sell |
| Acuitas Investments, LLC | 137,132 | 123,197 | -13,935 | 1.33 | 1.49 | +0.16 | sell |
| VANGUARD GROUP INC | 421,474 | 405,533 | -15,941 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 28,301 | 0 | -28,301 | 0.00 | 0.00 | -0.00 | sell |