| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,590,303 | 2,590,303 | 0 | 2.32 | 2.59 | +0.27 | hold |
| MORGAN STANLEY | 1,714,668 | 1,702,157 | -12,511 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,161,889 | 1,302,974 | +141,085 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 611,515 | 646,914 | +35,399 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 262,933 | 640,001 | +377,068 | 0.03 | 0.08 | +0.05 | buy |
| Opaleye Management Inc. | 292,590 | 300,000 | +7,410 | 1.03 | 1.24 | +0.21 | buy |
| GW&K Investment Management, LLC | 0 | 232,141 | +232,141 | 0.00 | 0.06 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 221,566 | 229,766 | +8,200 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 204,920 | +204,920 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 174,908 | 193,148 | +18,240 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 43,335 | 133,360 | +90,025 | 0.00 | 0.00 | +0.00 | buy |
| TLS Advisors LLC | 47,923 | 114,867 | +66,944 | 4.43 | 8.55 | +4.12 | buy |
| CITADEL ADVISORS LLC | 0 | 98,638 | +98,638 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 90,403 | 93,490 | +3,087 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 68,384 | 74,984 | +6,600 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 26,047 | 72,533 | +46,486 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 115,000 | 69,500 | -45,500 | 2.42 | 1.92 | -0.50 | sell |
| PANAGORA ASSET MANAGEMENT INC | 21,229 | 58,662 | +37,433 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 112,917 | 46,814 | -66,103 | 0.77 | 0.41 | -0.37 | sell |
| CM Management, LLC | 40,000 | 40,000 | 0 | 0.90 | 1.05 | +0.15 | hold |
| RBF Capital, LLC | 30,000 | 30,000 | 0 | 0.04 | 0.05 | +0.01 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 28,894 | +28,894 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 28,495 | +28,495 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,375 | 27,151 | -2,224 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 9,715 | 26,075 | +16,360 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 16,097 | 23,998 | +7,901 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,580 | 17,580 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,593 | 17,390 | +7,797 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 14,663 | +14,663 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 14,519 | +14,519 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 12,706 | 12,706 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 11,584 | 11,705 | +121 | 0.00 | 0.00 | +0.00 | buy |
| REGIONS FINANCIAL CORP | 0 | 9,250 | +9,250 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 124 | 8,447 | +8,323 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 7,433 | +7,433 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 6,803 | +6,803 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 6,782 | +6,782 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 5,677 | 5,677 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,498 | 4,600 | +102 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,835 | 3,992 | +157 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,755 | 3,865 | -6,890 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 3,544 | 3,444 | -100 | 0.00 | 0.00 | +0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 2,856 | 2,856 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,362 | 2,362 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 2,152 | 2,193 | +41 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 14,822 | 1,965 | -12,857 | 0.00 | 0.00 | -0.00 | sell |
| State of Alaska, Department of Revenue | 1,050 | 1,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 959 | 959 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 976 | 854 | -122 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 778 | 819 | +41 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 555 | 753 | +198 | 0.00 | 0.00 | +0.00 | buy |
| Costello Asset Management, INC | 600 | 600 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 469 | 572 | +103 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 585 | 514 | -71 | 0.00 | 0.00 | +0.00 | sell |
| NATIXIS | 372 | 372 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 290 | 290 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 283 | +283 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 19,332 | 190 | -19,142 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 113 | 152 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 233 | 145 | -88 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 66 | 90 | +24 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 69 | 59 | -10 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 19 | 19 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 12 | 14 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Root Financial Partners, LLC | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 3 | 4 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 10 | 3 | -7 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MAI Capital Management | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 39,017 | 0 | -39,017 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 335 | 0 | -335 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 6,356 | 0 | -6,356 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 173 | 0 | -173 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 134 | 0 | -134 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 8,901 | 0 | -8,901 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 29,591 | 0 | -29,591 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 298 | 0 | -298 | 0.00 | 0.00 | -0.00 | sell |