| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 1,122,289 | 1,544,967 | +422,678 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 459,088 | 638,813 | +179,725 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 532,788 | 591,673 | +58,885 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 129,813 | 152,143 | +22,330 | 2.52 | 3.78 | +1.26 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 20,925 | +20,925 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 18,379 | +18,379 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 186,672 | 203,601 | +16,929 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 16,110 | +16,110 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 14,676 | +14,676 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 168,550 | 180,230 | +11,680 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 144,728 | 153,483 | +8,755 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 8,896 | 16,640 | +7,744 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 21,882 | 27,921 | +6,039 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 89,052 | 94,222 | +5,170 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 4,819 | +4,819 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 4,600 | +4,600 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,158 | 26,375 | +3,217 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 253,043 | 255,087 | +2,044 | 1.12 | 1.30 | +0.18 | buy |
| DEUTSCHE BANK AG\ | 6,433 | 8,476 | +2,043 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 11,230 | 13,249 | +2,019 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 57,913 | 59,790 | +1,877 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 14,533 | 16,308 | +1,775 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 750 | 2,273 | +1,523 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 4,371 | 5,300 | +929 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,546 | 5,387 | +841 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,897 | 4,440 | +543 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 462 | 880 | +418 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 604 | 959 | +355 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,870 | 5,140 | +270 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 852 | 976 | +124 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 120 | +120 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 79 | +79 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 58 | +58 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 59 | 94 | +35 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 3,453 | 3,479 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 87 | 102 | +15 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 8 | 19 | +11 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 582 | 582 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26,200 | 26,200 | 0 | 0.01 | 0.02 | +0.00 | hold |
| RBF Capital, LLC | 30,616 | 30,616 | 0 | 0.04 | 0.04 | -0.00 | hold |
| HighVista Strategies LLC | 114,548 | 114,548 | 0 | 0.88 | 1.06 | +0.18 | hold |
| MACQUARIE GROUP LTD | 3,466 | 3,466 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 290 | 290 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Costello Asset Management, INC | 600 | 600 | 0 | 0.00 | 0.01 | +0.00 | hold |
| TLS Advisors LLC | 119,044 | 119,044 | 0 | 5.36 | 9.36 | +4.01 | hold |
| CM Management, LLC | 64,000 | 64,000 | 0 | 1.28 | 1.47 | +0.19 | hold |
| SBI Securities Co., Ltd. | 12 | 12 | 0 | 0.00 | 0.00 | +0.00 | hold |
| True Wealth Design, LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 1,614 | 1,614 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,362 | 2,362 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 3 | 3 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 247 | 247 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GROUP ONE TRADING LLC | 900 | 900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIXIS | 1,524 | 1,462 | -62 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 14,363 | 12,706 | -1,657 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 13,700 | 11,900 | -1,800 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 5,731 | 3,713 | -2,018 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 3,984 | 0 | -3,984 | 0.00 | 0.00 | -0.00 | sell |
| Acuitas Investments, LLC | 5,674 | 0 | -5,674 | 0.10 | 0.00 | -0.10 | sell |
| ROYAL BANK OF CANADA | 5,750 | 0 | -5,750 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,088,370 | 1,079,588 | -8,782 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 9,638 | 0 | -9,638 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 10,307 | 0 | -10,307 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 11,523 | 0 | -11,523 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 14,054 | 0 | -14,054 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 45,017 | 0 | -45,017 | 0.10 | 0.00 | -0.10 | sell |
| BVF INC/IL | 2,983,026 | 2,590,303 | -392,723 | 2.42 | 2.33 | -0.09 | sell |