| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,590,303 | 7,593,303 | +5,003,000 | 2.59 | 8.25 | +5.66 | buy |
| Newtyn Management, LLC | 0 | 709,247 | +709,247 | 0.00 | 3.76 | +3.76 | buy |
| Woodline Partners LP | 640,001 | 1,114,363 | +474,362 | 0.08 | 0.15 | +0.07 | buy |
| FMR LLC | 1,302,974 | 1,605,532 | +302,558 | 0.00 | 0.00 | +0.00 | buy |
| WATER ISLAND CAPITAL LLC | 0 | 242,000 | +242,000 | 0.00 | 1.09 | +1.09 | buy |
| ALPINE ASSOCIATES MANAGEMENT INC. | 0 | 239,318 | +239,318 | 0.00 | 0.64 | +0.64 | buy |
| HSBC HOLDINGS PLC | 0 | 149,523 | +149,523 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 84,391 | +84,391 | 0.00 | 0.01 | +0.01 | buy |
| TORNO CAPITAL, LLC | 0 | 80,000 | +80,000 | 0.00 | 0.23 | +0.23 | buy |
| Verition Fund Management LLC | 0 | 70,601 | +70,601 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,390 | 83,623 | +66,233 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 646,914 | 691,971 | +45,057 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 133,360 | 177,106 | +43,746 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 300,000 | 338,374 | +38,374 | 1.24 | 1.30 | +0.06 | buy |
| XTX Topco Ltd | 0 | 35,046 | +35,046 | 0.00 | 0.02 | +0.02 | buy |
| CREDIT INDUSTRIEL ET COMMERCIAL | 0 | 34,853 | +34,853 | 0.00 | 0.16 | +0.16 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 34,621 | +34,621 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 28,078 | +28,078 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,992 | 30,018 | +26,026 | 0.00 | 0.00 | +0.00 | buy |
| SIERRA SUMMIT ADVISORS LLC | 0 | 25,740 | +25,740 | 0.00 | 0.12 | +0.12 | buy |
| CSS LLC/IL | 0 | 19,561 | +19,561 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 229,766 | 245,321 | +15,555 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 12,200 | +12,200 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 26,075 | 36,744 | +10,669 | 0.00 | 0.00 | +0.00 | buy |
| Yakira Capital Management, Inc. | 0 | 10,311 | +10,311 | 0.00 | 0.13 | +0.13 | buy |
| Kintayl Capital LP | 0 | 8,476 | +8,476 | 0.00 | 0.17 | +0.17 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 7,620 | +7,620 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 6,066 | +6,066 | 0.00 | 0.02 | +0.02 | buy |
| Nuveen, LLC | 12,706 | 18,388 | +5,682 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 5,682 | +5,682 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 5,500 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| PenderFund Capital Management Ltd. | 0 | 5,200 | +5,200 | 0.00 | 0.03 | +0.03 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 4,958 | +4,958 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 4,891 | +4,891 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 3,865 | 8,495 | +4,630 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 193,148 | 197,764 | +4,616 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 4,511 | +4,511 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 753 | 4,560 | +3,807 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 14,519 | 18,192 | +3,673 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 93,490 | 96,179 | +2,689 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,362 | 4,762 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 819 | 3,185 | +2,366 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,139 | +2,139 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,151 | 28,078 | +927 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 8,447 | 9,139 | +692 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 74,984 | 75,348 | +364 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 19 | 366 | +347 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,803 | 7,005 | +202 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 68 | +68 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 3 | 21 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 8 | +8 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 959 | 959 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RBF Capital, LLC | 30,000 | 30,000 | 0 | 0.05 | 0.05 | +0.01 | hold |
| NATIXIS | 372 | 372 | 0 | 0.00 | 0.00 | +0.00 | hold |
| REGIONS FINANCIAL CORP | 9,250 | 9,250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| State of Alaska, Department of Revenue | 1,050 | 1,050 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 5,677 | 5,677 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Larson Financial Group LLC | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 290 | 290 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Costello Asset Management, INC | 600 | 600 | 0 | 0.01 | 0.01 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GAMMA Investing LLC | 152 | 152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 2,856 | 2,856 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 67 | 67 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 854 | 854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 283 | 283 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MAI Capital Management | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 14 | 10 | -4 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 4 | 0 | -4 | 0.00 | 0.00 | -0.00 | sell |
| Root Financial Partners, LLC | 13 | 0 | -13 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 59 | 25 | -34 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 90 | 47 | -43 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 145 | 78 | -67 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 572 | 470 | -102 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 190 | 0 | -190 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 11,705 | 11,451 | -254 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,600 | 4,258 | -342 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 514 | 128 | -386 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 1,965 | 1,400 | -565 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,193 | 1,592 | -601 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 6,782 | 4,996 | -1,786 | 0.00 | 0.00 | -0.00 | sell |
| OSAIC HOLDINGS, INC. | 3,444 | 0 | -3,444 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 23,998 | 20,122 | -3,876 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,702,157 | 1,697,167 | -4,990 | 0.00 | 0.00 | +0.00 | sell |
| Caption Management, LLC | 7,433 | 0 | -7,433 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 204,920 | 196,307 | -8,613 | 0.00 | 0.01 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 14,663 | 0 | -14,663 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,580 | 0 | -17,580 | 0.01 | 0.00 | -0.01 | sell |
| Quadrature Capital Ltd | 28,495 | 0 | -28,495 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 28,894 | 0 | -28,894 | 0.00 | 0.00 | -0.00 | sell |
| CM Management, LLC | 40,000 | 0 | -40,000 | 1.05 | 0.00 | -1.05 | sell |
| HighVista Strategies LLC | 46,814 | 0 | -46,814 | 0.41 | 0.00 | -0.41 | sell |
| UBS Group AG | 72,533 | 23,843 | -48,690 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 58,662 | 0 | -58,662 | 0.01 | 0.00 | -0.01 | sell |
| Stonepine Capital Management, LLC | 69,500 | 0 | -69,500 | 1.92 | 0.00 | -1.92 | sell |
| CITADEL ADVISORS LLC | 98,638 | 28,460 | -70,178 | 0.00 | 0.00 | -0.00 | sell |
| TLS Advisors LLC | 114,867 | 42,165 | -72,702 | 8.55 | 5.27 | -3.28 | sell |
| GW&K Investment Management, LLC | 232,141 | 0 | -232,141 | 0.06 | 0.00 | -0.06 | sell |