| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| CM Management, LLC | 0 | 55,000 | +55,000 | 0.00 | 0.82 | +0.82 | buy |
| Woodline Partners LP | 0 | 50,559 | +50,559 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 12,274 | +12,274 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 1,366 | 10,088 | +8,722 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 7,945 | +7,945 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 414,633 | 421,474 | +6,841 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 4,992 | +4,992 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 4,808 | +4,808 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 156,731 | 160,936 | +4,205 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 89,950 | 93,727 | +3,777 | 0.14 | 0.17 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 2,445 | +2,445 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 122,433 | 124,423 | +1,990 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,043 | 2,277 | +1,234 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4 | 1,044 | +1,040 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 28,027 | 28,301 | +274 | 0.00 | 0.00 | +0.00 | buy |
| Scarborough Advisors, LLC | 0 | 175 | +175 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 604 | 604 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 3,633,743 | 3,633,743 | 0 | 1.38 | 1.68 | +0.30 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26,600 | 26,600 | 0 | 0.01 | 0.01 | +0.00 | hold |
| NATIXIS | 1,726 | 1,726 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 118,899 | 118,899 | 0 | 0.78 | 0.80 | +0.02 | hold |
| MACQUARIE GROUP LTD | 3,466 | 3,466 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Acuitas Investments, LLC | 137,132 | 137,132 | 0 | 1.14 | 1.33 | +0.20 | hold |
| Avior Wealth Management, LLC | 501 | 501 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 600 | 600 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 400 | 400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Knott David M Jr | 19,722 | 19,722 | 0 | 0.11 | 0.14 | +0.03 | hold |
| TD Waterhouse Canada Inc. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 707 | 707 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,560 | 19,560 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 3,649 | 3,634 | -15 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,277 | 5,262 | -15 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 647 | 585 | -62 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 62,659 | 62,589 | -70 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 711 | 638 | -73 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 782 | 651 | -131 | 0.00 | 0.00 | -0.00 | sell |
| TLS Advisors LLC | 120,665 | 120,465 | -200 | 6.88 | 7.40 | +0.52 | sell |
| RHUMBLINE ADVISERS | 8,362 | 8,157 | -205 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 87,208 | 86,968 | -240 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,613 | 1,203 | -410 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 448 | 0 | -448 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 28,113 | 26,537 | -1,576 | 0.00 | 0.00 | +0.00 | sell |
| RBF Capital, LLC | 34,787 | 33,005 | -1,782 | 0.03 | 0.04 | +0.01 | sell |
| FIRST MANHATTAN CO. LLC. | 7,500 | 5,000 | -2,500 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 28,376 | 25,516 | -2,860 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 3,915 | 0 | -3,915 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 18,205 | 12,296 | -5,909 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 18,917 | 0 | -18,917 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 274,500 | 250,000 | -24,500 | 1.26 | 1.23 | -0.03 | sell |
| FMR LLC | 1,184,044 | 1,155,033 | -29,011 | 0.00 | 0.00 | +0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 52,100 | 0 | -52,100 | 0.02 | 0.00 | -0.02 | sell |
| Stonepine Capital Management, LLC | 436,602 | 250,000 | -186,602 | 2.04 | 2.00 | -0.04 | sell |