| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 182,852 | 317,319 | +134,467 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 95,339 | 156,266 | +60,927 | 0.02 | 0.03 | +0.01 | buy |
| VANGUARD GROUP INC | 422,394 | 463,840 | +41,446 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 3,567 | 12,089 | +8,522 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 7,852 | +7,852 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 8,481 | 16,100 | +7,619 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 14,624 | 20,970 | +6,346 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 3,353 | +3,353 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 535,658 | 538,924 | +3,266 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 9,366 | 11,065 | +1,699 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 142,857 | 144,528 | +1,671 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 11,256 | 12,784 | +1,528 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 89,841 | 91,181 | +1,340 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 21,837 | 23,113 | +1,276 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,117 | 4,300 | +1,183 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 4,883 | 6,039 | +1,156 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 94,289 | 95,417 | +1,128 | 0.19 | 0.26 | +0.07 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,562 | 2,362 | +800 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,368 | 4,636 | +268 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 15 | 107 | +92 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 95 | 149 | +54 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 12 | +12 | 0.00 | 0.00 | 0.00 | buy |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 604 | 604 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 3,633,743 | 3,633,743 | 0 | 2.81 | 3.24 | +0.42 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 582 | 582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RBF Capital, LLC | 30,616 | 30,616 | 0 | 0.04 | 0.04 | +0.00 | hold |
| NATIXIS | 1,726 | 1,726 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 114,548 | 114,548 | 0 | 1.05 | 1.12 | +0.07 | hold |
| Bank of New York Mellon Corp | 57,547 | 57,547 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 3,466 | 3,466 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 4,371 | 4,371 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Opaleye Management Inc. | 250,000 | 250,000 | 0 | 1.10 | 1.15 | +0.05 | hold |
| Avior Wealth Management, LLC | 501 | 501 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 316 | 316 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Truvestments Capital LLC | 290 | 290 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OCCUDO QUANTITATIVE STRATEGIES LP | 20,925 | 20,925 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CM Management, LLC | 55,000 | 55,000 | 0 | 1.16 | 1.29 | +0.13 | hold |
| Knott David M Jr | 19,722 | 19,722 | 0 | 0.18 | 0.19 | +0.00 | hold |
| TD Waterhouse Canada Inc. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 22,414 | 22,414 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 852 | 852 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 247 | 247 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 17 | 17 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 124 | 124 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| Copley Financial Group, Inc. | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 40 | 0 | -40 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 556 | 454 | -102 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 231 | 0 | -231 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 4,293 | 3,992 | -301 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,632 | 1,109 | -523 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 182,741 | 182,190 | -551 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 617 | 25 | -592 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 7,030 | 6,342 | -688 | 0.00 | 0.00 | -0.00 | sell |
| TLS Advisors LLC | 119,744 | 119,044 | -700 | 6.70 | 7.15 | +0.45 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 26,400 | 25,500 | -900 | 0.02 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 13,505 | 11,549 | -1,956 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 13,339 | 9,484 | -3,855 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,102,401 | 1,090,048 | -12,353 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 14,441 | 0 | -14,441 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 15,293 | 0 | -15,293 | 0.00 | 0.00 | -0.00 | sell |
| Ellsworth Advisors, LLC | 19,475 | 0 | -19,475 | 0.13 | 0.00 | -0.13 | sell |
| Acuitas Investments, LLC | 88,058 | 60,704 | -27,354 | 1.04 | 1.31 | +0.27 | sell |
| Stonepine Capital Management, LLC | 195,096 | 125,700 | -69,396 | 3.26 | 2.67 | -0.60 | sell |