| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,590,303 | 2,590,303 | 0 | 4.05 | 2.32 | -1.73 | hold |
| MORGAN STANLEY | 1,646,996 | 1,714,668 | +67,672 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,074,325 | 1,161,889 | +87,564 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 668,111 | 701,657 | +33,546 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 592,902 | 611,515 | +18,613 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 255,087 | 292,590 | +37,503 | 1.39 | 1.03 | -0.36 | buy |
| Woodline Partners LP | 209,945 | 262,933 | +52,988 | 0.04 | 0.03 | -0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 211,977 | 221,566 | +9,589 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 167,035 | 174,908 | +7,873 | 0.00 | 0.00 | -0.00 | buy |
| Stonepine Capital Management, LLC | 115,459 | 115,000 | -459 | 3.62 | 2.42 | -1.20 | sell |
| HighVista Strategies LLC | 105,714 | 112,917 | +7,203 | 1.00 | 0.77 | -0.23 | buy |
| NORTHERN TRUST CORP | 95,344 | 90,403 | -4,941 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 61,351 | 68,384 | +7,033 | 0.00 | 0.00 | -0.00 | buy |
| TLS Advisors LLC | 114,867 | 47,923 | -66,944 | 11.01 | 4.43 | -6.58 | sell |
| DIMENSIONAL FUND ADVISORS LP | 29,190 | 43,335 | +14,145 | 0.00 | 0.00 | +0.00 | buy |
| CM Management, LLC | 48,000 | 40,000 | -8,000 | 1.54 | 0.90 | -0.65 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 28,900 | 39,017 | +10,117 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 30,616 | 30,000 | -616 | 0.05 | 0.04 | -0.02 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 32,616 | 29,591 | -3,025 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,375 | 29,375 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 0 | 26,047 | +26,047 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 17,094 | 21,229 | +4,135 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 14,676 | 19,332 | +4,656 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 24,980 | 17,580 | -7,400 | 0.02 | 0.01 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 8,074 | 16,097 | +8,023 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 13,224 | 14,822 | +1,598 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 12,706 | 12,706 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 13,171 | 11,584 | -1,587 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 6,477 | 10,755 | +4,278 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 9,715 | +9,715 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 9,593 | +9,593 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 8,901 | +8,901 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 6,356 | +6,356 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 5,677 | 5,677 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,312 | 4,498 | +186 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 3,796 | 3,835 | +39 | 0.00 | 0.00 | -0.00 | buy |
| OSAIC HOLDINGS, INC. | 3,554 | 3,544 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 2,856 | 2,856 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,362 | 2,362 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 3,226 | 2,152 | -1,074 | 0.00 | 0.00 | -0.00 | sell |
| State of Alaska, Department of Revenue | 0 | 1,050 | +1,050 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 976 | 976 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 959 | 959 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 778 | 778 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Costello Asset Management, INC | 600 | 600 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 583 | 585 | +2 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 316 | 555 | +239 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 408 | 469 | +61 | 0.00 | 0.00 | -0.00 | buy |
| NATIXIS | 372 | 372 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 227 | 335 | +108 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 247 | 298 | +51 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 290 | 290 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 206 | 233 | +27 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 171 | 173 | +2 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 152 | 134 | -18 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 8,476 | 124 | -8,352 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 102 | 113 | +11 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 79 | 69 | -10 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 150 | 66 | -84 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 19 | 19 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 13 | 12 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 47 | 3 | -44 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 6,932 | 0 | -6,932 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 7,581 | 0 | -7,581 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 27,363 | 0 | -27,363 | 0.00 | 0.00 | -0.00 | sell |
| Tortoise Investment Management, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 6,397 | 0 | -6,397 | 0.00 | 0.00 | -0.00 | sell |
| Wealthspire Advisors, LLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 35 | 0 | -35 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 13,571 | 0 | -13,571 | 0.00 | 0.00 | -0.00 | sell |