| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rosalind Advisors, Inc. | 2,900,389 | 3,300,389 | +400,000 | 14.13 | 15.97 | +1.84 | buy |
| BlackRock, Inc. | 193,367 | 1,717,197 | +1,523,830 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,394,028 | 1,610,735 | +216,707 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 813,106 | 812,561 | -545 | 0.21 | 0.20 | -0.00 | sell |
| CITADEL ADVISORS LLC | 125,552 | 803,208 | +677,656 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 308,269 | 703,171 | +394,902 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 750,195 | 569,526 | -180,669 | 1.26 | 0.79 | -0.47 | sell |
| MARSHALL WACE, LLP | 0 | 483,259 | +483,259 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 113,743 | 473,893 | +360,150 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 343,131 | 457,440 | +114,309 | 0.00 | 0.00 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 362,200 | 419,400 | +57,200 | 0.23 | 0.25 | +0.02 | buy |
| Invesco Ltd. | 399,389 | 346,978 | -52,411 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 100,365 | 322,390 | +222,025 | 0.42 | 1.45 | +1.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 292,130 | 319,047 | +26,917 | 0.09 | 0.10 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 282,538 | 306,300 | +23,762 | 0.05 | 0.05 | -0.00 | buy |
| NORTHERN TRUST CORP | 97,071 | 272,324 | +175,253 | 0.00 | 0.00 | +0.00 | buy |
| Palisades Investment Partners, LLC | 171,084 | 270,310 | +99,226 | 1.09 | 1.61 | +0.51 | buy |
| MILLENNIUM MANAGEMENT LLC | 422,066 | 249,755 | -172,311 | 0.01 | 0.00 | -0.00 | sell |
| Propel Bio Management, LLC | 177,600 | 226,052 | +48,452 | 2.63 | 3.73 | +1.10 | buy |
| Informed Momentum Co LLC | 208,604 | 212,964 | +4,360 | 0.46 | 0.44 | -0.02 | buy |
| JANE STREET GROUP, LLC | 96,119 | 206,783 | +110,664 | 0.00 | 0.00 | +0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 183,000 | 205,000 | +22,000 | 1.13 | 0.99 | -0.14 | buy |
| Qube Research & Technologies Ltd | 217,001 | 203,191 | -13,810 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 197,749 | +197,749 | 0.00 | 0.02 | +0.02 | buy |
| Jump Financial, LLC | 28,013 | 197,466 | +169,453 | 0.01 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 71,300 | 178,000 | +106,700 | 0.00 | 0.00 | +0.00 | buy |
| Private Wealth Advisors, LLC | 85,193 | 168,596 | +83,403 | 0.46 | 0.90 | +0.44 | buy |
| JPMORGAN CHASE & CO | 51,127 | 168,245 | +117,118 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 123,487 | 153,554 | +30,067 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 149,385 | 149,385 | 0 | 0.37 | 0.33 | -0.04 | hold |
| CIBC WORLD MARKET INC. | 177,893 | 146,610 | -31,283 | 0.01 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 152,842 | 126,500 | -26,342 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 65,022 | 119,262 | +54,240 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 118,878 | +118,878 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 117,000 | 106,629 | -10,371 | 0.07 | 0.09 | +0.02 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 191,470 | 103,026 | -88,444 | 0.51 | 0.29 | -0.22 | sell |
| Trexquant Investment LP | 0 | 102,647 | +102,647 | 0.00 | 0.02 | +0.02 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 98,359 | +98,359 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 91,611 | +91,611 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,091 | 88,858 | +75,767 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 43,555 | 88,487 | +44,932 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors Wealth Management, LLC | 70,000 | 76,000 | +6,000 | 0.16 | 0.16 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 557,400 | 74,677 | -482,723 | 0.01 | 0.00 | -0.01 | sell |
| Engineers Gate Manager LP | 20,461 | 69,022 | +48,561 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 68,661 | +68,661 | 0.00 | 0.07 | +0.07 | buy |
| Bank of New York Mellon Corp | 0 | 66,035 | +66,035 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 47,609 | 57,579 | +9,970 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 32,861 | 56,891 | +24,030 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 117,620 | 56,066 | -61,554 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 50,665 | 53,783 | +3,118 | 0.00 | 0.00 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 31,171 | 47,035 | +15,864 | 0.01 | 0.02 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 46,941 | +46,941 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 43,064 | +43,064 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 42,816 | +42,816 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 538,500 | 33,133 | -505,367 | 0.09 | 0.00 | -0.08 | sell |
| Virtu Financial LLC | 0 | 30,822 | +30,822 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 29,432 | +29,432 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 28,363 | +28,363 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 232,722 | 25,000 | -207,722 | 0.23 | 0.02 | -0.21 | sell |
| NOMURA HOLDINGS INC | 0 | 23,807 | +23,807 | 0.00 | 0.00 | +0.00 | buy |
| Hunting Hill Global Capital, LLC | 14,118 | 22,668 | +8,550 | 0.23 | 0.17 | -0.06 | buy |
| Squarepoint Ops LLC | 92,985 | 22,250 | -70,735 | 0.00 | 0.00 | -0.00 | sell |
| Aristides Capital LLC | 21,600 | 21,600 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Quadrature Capital Ltd | 0 | 20,883 | +20,883 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 19,960 | +19,960 | 0.00 | 0.00 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 19,204 | +19,204 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 0 | 18,823 | +18,823 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 18,669 | +18,669 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 21,721 | 18,558 | -3,163 | 0.01 | 0.01 | -0.00 | sell |
| WealthPlan Investment Management, LLC | 17,443 | 17,443 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Aquatic Capital Management LLC | 0 | 17,163 | +17,163 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 17,516 | 16,790 | -726 | 0.02 | 0.02 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 16,497 | +16,497 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 16,352 | +16,352 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,164 | 15,821 | +10,657 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2 | 15,525 | +15,523 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 15,078 | +15,078 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 14,476 | +14,476 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 13,600 | +13,600 | 0.00 | 0.01 | +0.01 | buy |
| Bayesian Capital Management, LP | 0 | 13,300 | +13,300 | 0.00 | 0.03 | +0.03 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 11,932 | +11,932 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 11,101 | +11,101 | 0.00 | 0.00 | +0.00 | buy |
| Riverwater Partners LLC | 11,392 | 11,017 | -375 | 0.07 | 0.07 | -0.00 | sell |
| NBC SECURITIES, INC. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Point72 Asset Management, L.P. | 6,900 | 7,360 | +460 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 7,103 | +7,103 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 3,547 | 6,505 | +2,958 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 3,356 | +3,356 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 3,075 | +3,075 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,932 | +2,932 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 2,400 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 1,893 | +1,893 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,880 | +1,880 | 0.00 | 0.00 | +0.00 | buy |
| USA FINANCIAL FORMULAS | 0 | 1,828 | +1,828 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 1 | 1,762 | +1,761 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 1,029 | +1,029 | 0.00 | 0.00 | +0.00 | buy |
| Activest Wealth Management | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Geneos Wealth Management Inc. | 923 | 923 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 800 | 800 | 0 | 0.00 | 0.00 | -0.00 | hold |