| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | 801,000 | +801,000 | 0.00 | 0.73 | +0.73 | buy |
| Vivo Capital, LLC | 997,005 | 1,708,579 | +711,574 | 0.75 | 2.30 | +1.56 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 612,235 | +612,235 | 0.00 | 0.08 | +0.08 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,415 | 418,609 | +343,194 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 178,797 | +178,797 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 172,022 | +172,022 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 155,325 | +155,325 | 0.00 | 0.42 | +0.42 | buy |
| CITADEL ADVISORS LLC | 153,961 | 289,601 | +135,640 | 0.00 | 0.00 | +0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 0 | 134,400 | +134,400 | 0.00 | 1.08 | +1.08 | buy |
| Qube Research & Technologies Ltd | 76,311 | 205,304 | +128,993 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 136,464 | 258,782 | +122,318 | 0.03 | 0.07 | +0.04 | buy |
| ADAR1 Capital Management, LLC | 31,052 | 149,385 | +118,333 | 0.05 | 0.37 | +0.32 | buy |
| VANGUARD GROUP INC | 1,110,707 | 1,224,768 | +114,061 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 205,107 | 314,675 | +109,568 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 61,533 | +61,533 | 0.00 | 0.07 | +0.07 | buy |
| GOLDMAN SACHS GROUP INC | 20,058 | 77,792 | +57,734 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 11,479 | 65,006 | +53,527 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 53,200 | +53,200 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 50,225 | +50,225 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| Kerrisdale Advisers, LLC | 17,967 | 66,645 | +48,678 | 0.06 | 0.27 | +0.22 | buy |
| OMERS ADMINISTRATION Corp | 0 | 48,000 | +48,000 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 251,895 | 288,951 | +37,056 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 63,713 | 100,356 | +36,643 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 82,010 | 117,404 | +35,394 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 99,188 | 133,651 | +34,463 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 50,875 | 79,537 | +28,662 | 0.00 | 0.00 | +0.00 | buy |
| Aristides Capital LLC | 0 | 27,000 | +27,000 | 0.00 | 0.10 | +0.10 | buy |
| Diametric Capital, LP | 67,856 | 94,737 | +26,881 | 0.30 | 0.77 | +0.47 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 89,447 | 115,183 | +25,736 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 24,816 | +24,816 | 0.00 | 0.13 | +0.13 | buy |
| GROUP ONE TRADING LLC | 0 | 23,158 | +23,158 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 0 | 20,806 | +20,806 | 0.00 | 0.00 | +0.00 | buy |
| Palisades Investment Partners, LLC | 149,656 | 169,327 | +19,671 | 0.59 | 0.86 | +0.27 | buy |
| Man Group plc | 0 | 17,852 | +17,852 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 17,000 | +17,000 | 0.00 | 0.01 | +0.01 | buy |
| Propel Bio Management, LLC | 0 | 17,000 | +17,000 | 0.00 | 0.20 | +0.20 | buy |
| Baader Bank Aktiengesellschaft | 0 | 16,978 | +16,978 | 0.00 | 0.02 | +0.02 | buy |
| Tower Research Capital LLC (TRC) | 1,165 | 14,694 | +13,529 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 12,977 | +12,977 | 0.00 | 0.00 | +0.00 | buy |
| Private Advisor Group, LLC | 0 | 12,743 | +12,743 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 39,093 | 51,697 | +12,604 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 85,457 | 96,793 | +11,336 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 10,850 | +10,850 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 10,210 | +10,210 | 0.00 | 0.00 | +0.00 | buy |
| Riverwater Partners LLC | 18,628 | 27,229 | +8,601 | 0.08 | 0.16 | +0.08 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 26,688 | 34,749 | +8,061 | 0.01 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 30,611 | 37,326 | +6,715 | 0.02 | 0.04 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 3,266 | 9,501 | +6,235 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 17,382 | 23,497 | +6,115 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 5,470 | +5,470 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 2,863 | +2,863 | 0.00 | 0.01 | +0.01 | buy |
| Point72 (DIFC) Ltd | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 25,205 | 26,603 | +1,398 | 0.00 | 0.01 | +0.00 | buy |
| Hunting Hill Global Capital, LLC | 13,222 | 14,241 | +1,019 | 0.17 | 0.08 | -0.09 | buy |
| Geneos Wealth Management Inc. | 0 | 923 | +923 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 176,500 | 176,500 | 0 | 0.04 | 0.03 | -0.01 | hold |
| SIGNATUREFD, LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rosalind Advisors, Inc. | 2,650,389 | 2,650,389 | 0 | 14.07 | 17.19 | +3.12 | hold |
| AllSquare Wealth Management LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Activest Wealth Management | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Quent Capital, LLC | 949 | 949 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WealthPlan Investment Management, LLC | 17,443 | 17,443 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Aster Capital Management (DIFC) Ltd | 13,373 | 13,373 | 0 | 0.03 | 0.06 | +0.04 | hold |
| THURSTON, SPRINGER, MILLER, HERD & TITAK, INC. | 1,008 | 1,008 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 65,022 | 65,022 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 82 | 82 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 100,370 | 100,365 | -5 | 0.28 | 0.35 | +0.06 | sell |
| Investors Research Corp | 950 | 500 | -450 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 1,600 | 0 | -1,600 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 11,318 | 9,098 | -2,220 | 0.02 | 0.03 | +0.01 | sell |
| Jump Financial, LLC | 42,200 | 34,764 | -7,436 | 0.01 | 0.01 | +0.00 | sell |
| NBC SECURITIES, INC. | 10,000 | 10 | -9,990 | 0.01 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 17,127 | 0 | -17,127 | 0.00 | 0.00 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 18,646 | 0 | -18,646 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 88,206 | 65,447 | -22,759 | 0.12 | 0.11 | -0.01 | sell |
| CIBC WORLD MARKET INC. | 200,492 | 176,343 | -24,149 | 0.00 | 0.00 | +0.00 | sell |
| Virtu Financial LLC | 32,000 | 0 | -32,000 | 0.02 | 0.00 | -0.02 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 32,232 | 0 | -32,232 | 0.05 | 0.00 | -0.05 | sell |
| CITIGROUP INC | 49,594 | 1 | -49,593 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 90,908 | 0 | -90,908 | 0.00 | 0.00 | -0.00 | sell |
| LASRY MARC | 161,827 | 34,072 | -127,755 | 2.10 | 1.82 | -0.28 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 311,800 | 138,242 | -173,558 | 0.00 | 0.00 | -0.00 | sell |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 336,722 | 0 | -336,722 | 0.53 | 0.00 | -0.53 | sell |
| AIGH Capital Management LLC | 1,782,490 | 1,385,389 | -397,101 | 7.53 | 6.28 | -1.26 | sell |