| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BNP Paribas Asset Management Holding S.A. | 0 | 4,850,000 | +4,850,000 | 0.00 | 0.01 | +0.01 | buy |
| OFI INVEST ASSET MANAGEMENT | 3,300 | 4,004,000 | +4,000,700 | 0.11 | 0.24 | +0.13 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 2,015,000 | 3,512,000 | +1,497,000 | 0.10 | 0.17 | +0.08 | buy |
| LORD, ABBETT & CO. LLC | 0 | 1,252,000 | +1,252,000 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,210,073 | 2,453,500 | +1,243,427 | 0.73 | 1.87 | +1.14 | buy |
| EcoR1 Capital, LLC | 832,907 | 1,919,835 | +1,086,928 | 2.09 | 6.31 | +4.23 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,078,346 | +1,078,346 | 0.00 | 4.91 | +4.91 | buy |
| JPMORGAN CHASE & CO | 1,302,557 | 1,828,602 | +526,045 | 0.01 | 0.02 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 470,000 | +470,000 | 0.00 | 0.11 | +0.11 | buy |
| Logos Global Management LP | 0 | 400,000 | +400,000 | 0.00 | 5.45 | +5.45 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,200 | 240,500 | +230,300 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 644,138 | 874,147 | +230,009 | 0.06 | 0.10 | +0.04 | buy |
| Sofinnova Investments, Inc. | 0 | 227,488 | +227,488 | 0.00 | 1.74 | +1.74 | buy |
| CITADEL ADVISORS LLC | 1,342,730 | 1,523,077 | +180,347 | 0.13 | 0.19 | +0.06 | buy |
| FRED ALGER MANAGEMENT, LLC | 90,335 | 257,566 | +167,231 | 0.05 | 0.17 | +0.12 | buy |
| Pictet Asset Management Holding SA | 1,091,602 | 1,258,536 | +166,934 | 0.12 | 0.18 | +0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,601 | 281,697 | +156,096 | 0.02 | 0.05 | +0.03 | buy |
| Caption Management, LLC | 300 | 150,346 | +150,046 | 0.00 | 2.14 | +2.14 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 133,092 | +133,092 | 0.00 | 0.15 | +0.15 | buy |
| NORGES BANK | 836,849 | 968,798 | +131,949 | 0.01 | 0.02 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 459,102 | 579,637 | +120,535 | 0.22 | 0.34 | +0.11 | buy |
| Man Group plc | 0 | 120,005 | +120,005 | 0.00 | 0.04 | +0.04 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 358,845 | 458,845 | +100,000 | 0.23 | 0.33 | +0.10 | buy |
| Vestal Point Capital, LP | 0 | 100,000 | +100,000 | 0.00 | 1.07 | +1.07 | buy |
| ExodusPoint Capital Management, LP | 7,507 | 105,153 | +97,646 | 0.01 | 0.17 | +0.16 | buy |
| JANE STREET GROUP, LLC | 182,632 | 278,104 | +95,472 | 0.02 | 0.05 | +0.03 | buy |
| Cutter Capital Management, LP | 0 | 94,379 | +94,379 | 0.00 | 4.71 | +4.71 | buy |
| Cinctive Capital Management LP | 0 | 78,360 | +78,360 | 0.00 | 0.52 | +0.52 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 148,426 | 225,382 | +76,956 | 0.03 | 0.04 | +0.01 | buy |
| Capital International Investors | 4,741,485 | 4,817,517 | +76,032 | 0.10 | 0.13 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 451,873 | 525,683 | +73,810 | 0.97 | 1.20 | +0.23 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 358,548 | 430,469 | +71,921 | 0.14 | 0.20 | +0.07 | buy |
| Simplify Asset Management Inc. | 23,715 | 90,523 | +66,808 | 0.35 | 1.12 | +0.77 | buy |
| GOLDMAN SACHS GROUP INC | 184,870 | 250,047 | +65,177 | 0.00 | 0.01 | +0.00 | buy |
| Casdin Capital, LLC | 1,006,500 | 1,069,000 | +62,500 | 9.57 | 10.30 | +0.73 | buy |
| ALLIANCEBERNSTEIN L.P. | 255,911 | 318,237 | +62,326 | 0.01 | 0.01 | +0.01 | buy |
| Gladstone Institutional Advisory LLC | 0 | 56,360 | +56,360 | 0.00 | 0.40 | +0.40 | buy |
| Assenagon Asset Management S.A. | 383,779 | 437,690 | +53,911 | 0.11 | 0.15 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,469,537 | 1,520,370 | +50,833 | 0.01 | 0.02 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 45,062 | 93,614 | +48,552 | 0.05 | 0.14 | +0.08 | buy |
| Mirae Asset Global Investments Co., Ltd. | 43,050 | 90,945 | +47,895 | 0.01 | 0.03 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 89,219 | 135,466 | +46,247 | 0.14 | 0.28 | +0.13 | buy |
| Aberdeen Group plc | 146,829 | 191,857 | +45,028 | 0.03 | 0.05 | +0.02 | buy |
| GTS SECURITIES LLC | 0 | 43,901 | +43,901 | 0.00 | 0.15 | +0.15 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 12,500 | 55,614 | +43,114 | 0.22 | 1.17 | +0.94 | buy |
| TWO SIGMA INVESTMENTS, LP | 302,340 | 342,682 | +40,342 | 0.07 | 0.11 | +0.04 | buy |
| Invesco Ltd. | 68,695 | 104,963 | +36,268 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 301,771 | 337,634 | +35,863 | 0.03 | 0.04 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 32,219 | 66,780 | +34,561 | 0.10 | 0.25 | +0.16 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 27,946 | 61,657 | +33,711 | 0.00 | 0.01 | +0.01 | buy |
| MACKENZIE FINANCIAL CORP | 10,209 | 36,425 | +26,216 | 0.00 | 0.01 | +0.01 | buy |
| HRT FINANCIAL LP | 7,612 | 33,738 | +26,126 | 0.01 | 0.03 | +0.02 | buy |
| BANK OF MONTREAL /CAN/ | 152,550 | 176,840 | +24,290 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 8,062 | 31,105 | +23,043 | 0.35 | 1.10 | +0.75 | buy |
| Treasurer of the State of North Carolina | 39,677 | 62,307 | +22,630 | 0.02 | 0.04 | +0.02 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 52,627 | 75,197 | +22,570 | 0.05 | 0.09 | +0.04 | buy |
| HSBC HOLDINGS PLC | 28,513 | 49,847 | +21,334 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 132,640 | 152,278 | +19,638 | 3.50 | 5.36 | +1.86 | buy |
| FRANKLIN RESOURCES INC | 214,266 | 233,289 | +19,023 | 0.01 | 0.01 | -0.00 | buy |
| Fiera Capital Corp | 348,212 | 367,039 | +18,827 | 0.10 | 0.14 | +0.04 | buy |
| First Turn Management, LLC | 203,882 | 221,748 | +17,866 | 2.82 | 4.29 | +1.47 | buy |
| Neuberger Berman Group LLC | 70,141 | 85,661 | +15,520 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 46,519 | 61,757 | +15,238 | 0.18 | 0.31 | +0.13 | buy |
| CITIGROUP INC | 65,386 | 80,251 | +14,865 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 27,208 | 41,682 | +14,474 | 0.00 | 0.01 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 14,454 | +14,454 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 237,286 | 251,521 | +14,235 | 0.35 | 0.50 | +0.15 | buy |
| Finepoint Capital LP | 145,357 | 158,457 | +13,100 | 4.85 | 5.26 | +0.41 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 576,412 | 589,439 | +13,027 | 0.01 | 0.02 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,919,742 | 1,931,547 | +11,805 | 0.12 | 0.15 | +0.03 | buy |
| PFM Health Sciences, LP | 0 | 11,291 | +11,291 | 0.00 | 0.07 | +0.07 | buy |
| HAP Trading, LLC | 0 | 11,023 | +11,023 | 0.00 | 0.44 | +0.44 | buy |
| Qube Research & Technologies Ltd | 1,219 | 11,869 | +10,650 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 498,829 | 509,205 | +10,376 | 0.13 | 0.17 | +0.04 | buy |
| Swiss National Bank | 156,283 | 166,183 | +9,900 | 0.01 | 0.02 | +0.00 | buy |
| WOLVERINE TRADING, LLC | 8,926 | 18,151 | +9,225 | 0.01 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 9,188 | +9,188 | 0.00 | 0.09 | +0.09 | buy |
| Prime Capital Investment Advisors, LLC | 3,666 | 11,979 | +8,313 | 0.01 | 0.02 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 32,365 | 40,606 | +8,241 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,824 | 18,028 | +7,204 | 0.20 | 0.30 | +0.09 | buy |
| Pearl River Capital, LLC | 0 | 7,196 | +7,196 | 0.00 | 0.15 | +0.15 | buy |
| Sigma Planning Corp | 5,213 | 12,375 | +7,162 | 0.04 | 0.05 | +0.01 | buy |
| NewEdge Advisors, LLC | 372 | 6,954 | +6,582 | 0.00 | 0.01 | +0.01 | buy |
| Evolutionary Tree Capital Management, LLC | 19,466 | 26,028 | +6,562 | 2.07 | 3.39 | +1.32 | buy |
| ADVENT CAPITAL MANAGEMENT /DE/ | 14,000 | 20,000 | +6,000 | 0.03 | 0.07 | +0.03 | buy |
| DnB Asset Management AS | 0 | 5,541 | +5,541 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 56,119 | 61,451 | +5,332 | 0.01 | 0.01 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 5,119 | +5,119 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 4,841 | +4,841 | 0.00 | 0.03 | +0.03 | buy |
| PFG Investments, LLC | 19,485 | 24,095 | +4,610 | 0.35 | 0.19 | -0.16 | buy |
| PFG Advisors | 0 | 4,568 | +4,568 | 0.00 | 0.04 | +0.04 | buy |
| Fisher Asset Management, LLC | 13,617 | 18,021 | +4,404 | 0.00 | 0.00 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 81,955 | 86,329 | +4,374 | 0.01 | 0.02 | +0.00 | buy |
| LPL Financial LLC | 28,138 | 32,366 | +4,228 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 123,250 | 127,429 | +4,179 | 0.02 | 0.03 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 3,956 | +3,956 | 0.00 | 0.01 | +0.01 | buy |
| EFG Asset Management (North America) Corp. | 25,134 | 28,824 | +3,690 | 0.46 | 0.64 | +0.18 | buy |
| Teza Capital Management LLC | 0 | 3,681 | +3,681 | 0.00 | 0.06 | +0.06 | buy |
| Squarepoint Ops LLC | 0 | 3,476 | +3,476 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 3,378 | +3,378 | 0.00 | 0.09 | +0.09 | buy |