| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 8,816,124 | 8,795,754 | -20,370 | 0.02 | 0.02 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,398,000 | 5,251,000 | -3,147,000 | 0.01 | 0.01 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 5,345,785 | 4,891,417 | -454,368 | 0.31 | 0.35 | +0.04 | sell |
| BNP Paribas Asset Management Holding S.A. | 0 | 4,850,000 | +4,850,000 | 0.00 | 0.01 | +0.01 | buy |
| Capital International Investors | 4,741,485 | 4,817,517 | +76,032 | 0.10 | 0.13 | +0.02 | buy |
| Avoro Capital Advisors LLC | 4,344,444 | 4,344,444 | 0 | 5.79 | 6.56 | +0.77 | hold |
| OFI INVEST ASSET MANAGEMENT | 3,300 | 4,004,000 | +4,000,700 | 0.11 | 0.24 | +0.13 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 2,015,000 | 3,512,000 | +1,497,000 | 0.10 | 0.17 | +0.08 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 4,127,610 | 3,245,798 | -881,812 | 0.07 | 0.07 | +0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 1,210,073 | 2,453,500 | +1,243,427 | 0.73 | 1.87 | +1.14 | buy |
| STATE STREET CORP | 2,399,078 | 2,122,491 | -276,587 | 0.01 | 0.01 | +0.00 | sell |
| Bank of New York Mellon Corp | 2,329,556 | 2,067,037 | -262,519 | 0.05 | 0.05 | +0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 1,919,742 | 1,931,547 | +11,805 | 0.12 | 0.15 | +0.03 | buy |
| EcoR1 Capital, LLC | 832,907 | 1,919,835 | +1,086,928 | 2.09 | 6.31 | +4.23 | buy |
| JPMORGAN CHASE & CO | 1,302,557 | 1,828,602 | +526,045 | 0.01 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 1,342,730 | 1,523,077 | +180,347 | 0.13 | 0.19 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,469,537 | 1,520,370 | +50,833 | 0.01 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,474,962 | 1,460,475 | -14,487 | 0.07 | 0.09 | +0.02 | sell |
| FMR LLC | 1,507,064 | 1,348,570 | -158,494 | 0.01 | 0.01 | +0.00 | sell |
| Pictet Asset Management Holding SA | 1,091,602 | 1,258,536 | +166,934 | 0.12 | 0.18 | +0.06 | buy |
| LORD, ABBETT & CO. LLC | 0 | 1,252,000 | +1,252,000 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 1,078,346 | +1,078,346 | 0.00 | 4.91 | +4.91 | buy |
| Casdin Capital, LLC | 1,006,500 | 1,069,000 | +62,500 | 9.57 | 10.30 | +0.73 | buy |
| NORGES BANK | 836,849 | 968,798 | +131,949 | 0.01 | 0.02 | +0.01 | buy |
| Bank of New York Mellon Corp | 900,000 | 900,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MORGAN STANLEY | 1,380,149 | 888,433 | -491,716 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 644,138 | 874,147 | +230,009 | 0.06 | 0.10 | +0.04 | buy |
| ORBIMED ADVISORS LLC | 697,500 | 697,500 | 0 | 1.35 | 1.66 | +0.31 | hold |
| TWO SIGMA ADVISERS, LP | 706,134 | 661,334 | -44,800 | 0.16 | 0.20 | +0.04 | sell |
| BANK OF AMERICA CORP /DE/ | 1,212,377 | 653,465 | -558,912 | 0.01 | 0.01 | -0.00 | sell |
| FEDERATED HERMES, INC. | 708,390 | 610,216 | -98,174 | 0.17 | 0.18 | +0.01 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 828,708 | 606,735 | -221,973 | 0.17 | 0.16 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 576,412 | 589,439 | +13,027 | 0.01 | 0.02 | +0.00 | buy |
| Camber Capital Management LP | 800,000 | 585,000 | -215,000 | 2.70 | 2.65 | -0.05 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 459,102 | 579,637 | +120,535 | 0.22 | 0.34 | +0.11 | buy |
| Erste Asset Management GmbH | 701,400 | 571,400 | -130,000 | 0.99 | 1.01 | +0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 451,873 | 525,683 | +73,810 | 0.97 | 1.20 | +0.23 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 498,829 | 509,205 | +10,376 | 0.13 | 0.17 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 739,736 | 504,968 | -234,768 | 0.01 | 0.01 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 470,000 | +470,000 | 0.00 | 0.11 | +0.11 | buy |
| ROYAL BANK OF CANADA | 814,029 | 460,606 | -353,423 | 0.02 | 0.01 | -0.01 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 358,845 | 458,845 | +100,000 | 0.23 | 0.33 | +0.10 | buy |
| Assenagon Asset Management S.A. | 383,779 | 437,690 | +53,911 | 0.11 | 0.15 | +0.04 | buy |
| NORTHERN TRUST CORP | 437,566 | 430,823 | -6,743 | 0.01 | 0.01 | +0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 358,548 | 430,469 | +71,921 | 0.14 | 0.20 | +0.07 | buy |
| BANK OF NOVA SCOTIA | 528,793 | 421,536 | -107,257 | 0.10 | 0.11 | +0.01 | sell |
| Logos Global Management LP | 0 | 400,000 | +400,000 | 0.00 | 5.45 | +5.45 | buy |
| Amundi | 399,367 | 398,286 | -1,081 | 0.02 | 0.02 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 562,978 | 390,278 | -172,700 | 0.08 | 0.08 | -0.00 | sell |
| BARCLAYS PLC | 442,906 | 385,480 | -57,426 | 0.02 | 0.02 | +0.00 | sell |
| Fiera Capital Corp | 348,212 | 367,039 | +18,827 | 0.10 | 0.14 | +0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 302,340 | 342,682 | +40,342 | 0.07 | 0.11 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 301,771 | 337,634 | +35,863 | 0.03 | 0.04 | +0.01 | buy |
| Rock Springs Capital Management LP | 327,600 | 327,600 | 0 | 0.78 | 1.08 | +0.30 | hold |
| ALLIANCEBERNSTEIN L.P. | 255,911 | 318,237 | +62,326 | 0.01 | 0.01 | +0.01 | buy |
| MIZUHO MARKETS AMERICAS LLC | 305,639 | 290,800 | -14,839 | 0.89 | 1.03 | +0.14 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 125,601 | 281,697 | +156,096 | 0.02 | 0.05 | +0.03 | buy |
| JANE STREET GROUP, LLC | 182,632 | 278,104 | +95,472 | 0.02 | 0.05 | +0.03 | buy |
| UBS Group AG | 276,276 | 277,190 | +914 | 0.01 | 0.01 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 273,661 | 261,288 | -12,373 | 0.04 | 0.05 | +0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 90,335 | 257,566 | +167,231 | 0.05 | 0.17 | +0.12 | buy |
| Bellevue Group AG | 237,286 | 251,521 | +14,235 | 0.35 | 0.50 | +0.15 | buy |
| GOLDMAN SACHS GROUP INC | 184,870 | 250,047 | +65,177 | 0.00 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,200 | 240,500 | +230,300 | 0.00 | 0.03 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 214,266 | 233,289 | +19,023 | 0.01 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 231,016 | 230,822 | -194 | 0.01 | 0.01 | +0.00 | sell |
| Sofinnova Investments, Inc. | 0 | 227,488 | +227,488 | 0.00 | 1.74 | +1.74 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 148,426 | 225,382 | +76,956 | 0.03 | 0.04 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 224,201 | 224,291 | +90 | 0.01 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 203,882 | 221,748 | +17,866 | 2.82 | 4.29 | +1.47 | buy |
| Palo Alto Investors LP | 200,905 | 201,265 | +360 | 1.75 | 2.94 | +1.19 | buy |
| Aberdeen Group plc | 146,829 | 191,857 | +45,028 | 0.03 | 0.05 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 194,430 | 187,238 | -7,192 | 0.04 | 0.04 | +0.01 | sell |
| BANK OF MONTREAL /CAN/ | 152,550 | 176,840 | +24,290 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 207,112 | 176,572 | -30,540 | 0.02 | 0.02 | +0.00 | sell |
| Swiss National Bank | 156,283 | 166,183 | +9,900 | 0.01 | 0.02 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 161,012 | 161,027 | +15 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,581 | 160,639 | -10,942 | 0.02 | 0.03 | +0.00 | sell |
| Finepoint Capital LP | 145,357 | 158,457 | +13,100 | 4.85 | 5.26 | +0.41 | buy |
| Ikarian Capital, LLC | 132,640 | 152,278 | +19,638 | 3.50 | 5.36 | +1.86 | buy |
| Clearbridge Investments, LLC | 151,127 | 151,216 | +89 | 0.01 | 0.02 | +0.00 | buy |
| Candriam S.C.A. | 182,445 | 151,000 | -31,445 | 0.12 | 0.13 | +0.00 | sell |
| Caption Management, LLC | 300 | 150,346 | +150,046 | 0.00 | 2.14 | +2.14 | buy |
| C WorldWide Group Holding A/S | 140,329 | 140,329 | 0 | 0.18 | 0.21 | +0.03 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 89,219 | 135,466 | +46,247 | 0.14 | 0.28 | +0.13 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 133,092 | +133,092 | 0.00 | 0.15 | +0.15 | buy |
| Russell Investments Group, Ltd. | 123,250 | 127,429 | +4,179 | 0.02 | 0.03 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 126,386 | 123,785 | -2,601 | 0.01 | 0.01 | +0.00 | sell |
| Man Group plc | 0 | 120,005 | +120,005 | 0.00 | 0.04 | +0.04 | buy |
| TOBAM | 156,046 | 119,908 | -36,138 | 1.32 | 1.39 | +0.08 | sell |
| WELLS FARGO & COMPANY/MN | 124,193 | 119,476 | -4,717 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 118,472 | 109,999 | -8,473 | 0.01 | 0.01 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 7,507 | 105,153 | +97,646 | 0.01 | 0.17 | +0.16 | buy |
| Invesco Ltd. | 68,695 | 104,963 | +36,268 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 189,356 | 103,256 | -86,100 | 3.71 | 2.55 | -1.16 | sell |
| Vestal Point Capital, LP | 0 | 100,000 | +100,000 | 0.00 | 1.07 | +1.07 | buy |
| Cutter Capital Management, LP | 0 | 94,379 | +94,379 | 0.00 | 4.71 | +4.71 | buy |
| Cubist Systematic Strategies, LLC | 45,062 | 93,614 | +48,552 | 0.05 | 0.14 | +0.08 | buy |
| Mirae Asset Global Investments Co., Ltd. | 43,050 | 90,945 | +47,895 | 0.01 | 0.03 | +0.02 | buy |
| Simplify Asset Management Inc. | 23,715 | 90,523 | +66,808 | 0.35 | 1.12 | +0.77 | buy |