| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| OFI INVEST ASSET MANAGEMENT | 3,300 | 4,004,000 | +4,000,700 | 0.11 | 0.24 | +0.13 | buy |
| EcoR1 Capital, LLC | 832,907 | 1,919,835 | +1,086,928 | 2.09 | 6.29 | +4.20 | buy |
| JANUS HENDERSON GROUP PLC | 5,345,785 | 4,891,417 | +454,368 | 0.31 | 0.35 | 0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,200 | 240,500 | +230,300 | 0.00 | 0.03 | 0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 644,138 | 874,147 | +230,009 | 0.08 | 0.12 | 0.00 | buy |
| CITADEL ADVISORS LLC | 1,342,730 | 1,523,077 | +180,347 | 0.19 | 0.28 | +0.09 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 562,978 | 390,278 | +172,700 | 0.09 | 0.09 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 90,335 | 257,566 | +167,231 | 0.05 | 0.17 | +0.12 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 459,102 | 579,637 | +120,535 | 0.22 | 0.34 | +0.11 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 358,845 | 458,845 | +100,000 | 0.08 | 0.10 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 7,507 | 105,153 | +97,646 | 0.01 | 0.17 | 0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 148,426 | 225,382 | +76,956 | 0.03 | 0.04 | 0.00 | buy |
| Capital International Investors | 4,741,485 | 4,817,517 | +76,032 | 0.10 | 0.13 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 451,873 | 525,683 | +73,810 | 0.97 | 1.19 | +0.22 | buy |
| Simplify Asset Management Inc. | 23,715 | 90,523 | +66,808 | 0.35 | 1.12 | +0.77 | buy |
| Casdin Capital, LLC | 1,006,500 | 1,069,000 | +62,500 | 9.53 | 10.29 | +0.76 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,469,537 | 1,520,370 | +50,833 | 0.02 | 0.02 | 0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 89,219 | 135,466 | +46,247 | 0.14 | 0.28 | +0.13 | buy |
| Aberdeen Group plc | 146,829 | 191,857 | +45,028 | 0.03 | 0.05 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 12,500 | 55,614 | +43,114 | 0.19 | 1.01 | +0.82 | buy |
| TWO SIGMA INVESTMENTS, LP | 302,340 | 342,682 | +40,342 | 0.08 | 0.12 | 0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 27,946 | 61,657 | +33,711 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 8,062 | 31,105 | +23,043 | 0.35 | 1.10 | +0.75 | buy |
| Treasurer of the State of North Carolina | 39,677 | 62,307 | +22,630 | 0.02 | 0.04 | 0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 52,627 | 75,197 | +22,570 | 0.05 | 0.09 | +0.04 | buy |
| Ikarian Capital, LLC | 132,640 | 152,278 | +19,638 | 3.50 | 5.36 | +1.86 | buy |
| Fiera Capital Corp | 348,212 | 367,039 | +18,827 | 0.10 | 0.14 | +0.04 | buy |
| First Turn Management, LLC | 203,882 | 221,748 | +17,866 | 2.82 | 4.29 | +1.47 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 23,108 | 6,813 | +16,295 | 0.16 | 0.06 | 0.00 | sell |
| ALGERT GLOBAL LLC | 46,519 | 61,757 | +15,238 | 0.18 | 0.31 | 0.00 | buy |
| Bellevue Group AG | 237,286 | 251,521 | +14,235 | 0.35 | 0.50 | +0.15 | buy |
| Finepoint Capital LP | 145,357 | 158,457 | +13,100 | 4.42 | 5.26 | +0.84 | buy |
| Allspring Global Investments Holdings, LLC | 273,661 | 261,288 | +12,373 | 0.04 | 0.05 | 0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 1,919,742 | 1,931,547 | +11,805 | 0.12 | 0.15 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 498,829 | 509,205 | +10,376 | 0.14 | 0.18 | 0.00 | buy |
| Swiss National Bank | 156,283 | 166,183 | +9,900 | 0.01 | 0.02 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 26,700 | 17,186 | +9,514 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 118,472 | 109,999 | +8,473 | 0.01 | 0.01 | 0.00 | sell |
| Prime Capital Investment Advisors, LLC | 3,666 | 11,979 | +8,313 | 0.01 | 0.02 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,824 | 18,028 | +7,204 | 0.20 | 0.30 | +0.09 | buy |
| Evolutionary Tree Capital Management, LLC | 19,466 | 26,028 | +6,562 | 2.07 | 3.39 | +1.32 | buy |
| ADVENT CAPITAL MANAGEMENT /DE/ | 14,000 | 20,000 | +6,000 | 0.03 | 0.07 | +0.03 | buy |
| PROFUND ADVISORS LLC | 16,277 | 11,165 | +5,112 | 0.07 | 0.06 | 0.00 | sell |
| Fisher Asset Management, LLC | 13,617 | 18,021 | +4,404 | 0.00 | 0.00 | +0.00 | buy |
| EFG Asset Management (North America) Corp. | 25,134 | 28,824 | +3,690 | 0.46 | 0.64 | +0.18 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 37,461 | 34,234 | +3,227 | 0.01 | 0.02 | 0.00 | sell |
| Brevan Howard Capital Management LP | 8,059 | 10,712 | +2,653 | 0.01 | 0.01 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 23,809 | 26,335 | +2,526 | 0.02 | 0.03 | 0.00 | buy |
| Beacon Pointe Advisors, LLC | 6,304 | 4,022 | +2,282 | 0.01 | 0.01 | 0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 6,641 | 5,052 | +1,589 | 0.06 | 0.06 | 0.00 | sell |
| Nicholas Investment Partners, LP | 3,329 | 4,514 | +1,185 | 0.04 | 0.06 | +0.02 | buy |
| CI INVESTMENTS INC. | 2,182 | 3,263 | +1,081 | 0.00 | 0.00 | 0.00 | buy |
| Fox Hill Wealth Management | 23,000 | 24,000 | +1,000 | 0.02 | 0.03 | +0.00 | buy |
| Advisors Asset Management, Inc. | 13,415 | 14,151 | +736 | 0.03 | 0.04 | 0.00 | buy |
| ProShare Advisors LLC | 5,977 | 6,578 | +601 | 0.00 | 0.00 | 0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 85,512 | 84,921 | +591 | 0.01 | 0.01 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 3,451 | 4,031 | +580 | 0.21 | 0.28 | +0.07 | buy |
| SHELL ASSET MANAGEMENT CO | 4,115 | 3,740 | +375 | 0.02 | 0.03 | 0.00 | sell |
| Palo Alto Investors LP | 200,905 | 201,265 | +360 | 1.75 | 2.94 | +1.19 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 17,376 | 17,621 | +245 | 0.01 | 0.01 | 0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 9,942 | 9,714 | +228 | 0.01 | 0.01 | 0.00 | sell |
| WCM INVESTMENT MANAGEMENT, LLC | 6,137 | 6,279 | +142 | 0.00 | 0.00 | +0.00 | buy |
| Riggs Asset Managment Co. Inc. | 100 | 225 | +125 | 0.00 | 0.01 | +0.01 | buy |
| Clearbridge Investments, LLC | 151,127 | 151,216 | +89 | 0.01 | 0.02 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 34,035 | 34,076 | +41 | 0.08 | 0.10 | +0.02 | buy |
| MONEY CONCEPTS CAPITAL CORP | 27,398 | 27,430 | +32 | 0.25 | 0.33 | +0.08 | buy |
| First Pacific Financial | 3 | 6 | +3 | 0.00 | 0.00 | +0.00 | buy |
| GUIDANCE CAPITAL, INC | 2,011 | 2,010 | -1 | 0.08 | 0.09 | +0.01 | sell |
| Rakuten Securities, Inc. | 8 | 4 | -4 | 0.00 | 0.00 | -0.00 | sell |
| JOHNSON INVESTMENT COUNSEL INC | 3,352 | 3,348 | -4 | 0.00 | 0.00 | +0.00 | sell |
| Baldwin Investment Management, LLC | 2,300 | 2,250 | -50 | 0.03 | 0.04 | +0.00 | sell |
| DMC Group, LLC | 3,793 | 3,711 | -82 | 0.35 | 0.42 | +0.07 | sell |
| Utah Retirement Systems | 15,471 | 15,371 | -100 | 0.02 | 0.02 | +0.00 | sell |
| SAPIENT CAPITAL LLC | 10,146 | 10,015 | -131 | 0.03 | 0.03 | +0.00 | sell |
| Mount Lucas Management LP | 1,972 | 1,810 | -162 | 0.07 | 0.08 | +0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 17,612 | 17,194 | -418 | 0.02 | 0.03 | +0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 1,790 | 1,350 | -440 | 0.03 | 0.02 | -0.01 | sell |
| Capula Management Ltd | 2,295 | 1,615 | -680 | 0.01 | 0.00 | -0.00 | sell |
| L & S Advisors Inc | 14,392 | 13,594 | -798 | 0.17 | 0.20 | +0.03 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 3,271 | 1,711 | -1,560 | 0.06 | 0.05 | -0.01 | sell |
| PINNACLE ASSOCIATES LTD | 91,951 | 90,318 | -1,633 | 0.15 | 0.18 | +0.04 | sell |
| E Fund Management Co., Ltd. | 5,519 | 3,485 | -2,034 | 0.03 | 0.03 | -0.01 | sell |
| ATWOOD & PALMER INC | 5,194 | 3,000 | -2,194 | 0.04 | 0.03 | -0.01 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 9,533 | 6,801 | -2,732 | 0.23 | 0.19 | -0.04 | sell |
| Diametric Capital, LP | 4,568 | 1,717 | -2,851 | 0.27 | 0.12 | -0.14 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 38,463 | 35,514 | -2,949 | 0.11 | 0.13 | +0.02 | sell |
| Bridgewater Associates, LP | 26,388 | 23,222 | -3,166 | 0.01 | 0.02 | +0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 7,156 | 3,335 | -3,821 | 0.12 | 0.07 | -0.05 | sell |
| STRS OHIO | 20,000 | 16,000 | -4,000 | 0.01 | 0.01 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 4,000 | 0 | -4,000 | 0.00 | 0.01 | +0.00 | sell |
| THORNBURG INVESTMENT MANAGEMENT INC | 40,345 | 36,271 | -4,074 | 0.06 | 0.07 | +0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 21,541 | 17,291 | -4,250 | 0.89 | 0.88 | -0.01 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 70,600 | 64,162 | -6,438 | 3.83 | 5.40 | +1.56 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,581 | 160,639 | -10,942 | 0.02 | 0.03 | +0.00 | sell |
| MIZUHO MARKETS AMERICAS LLC | 305,639 | 290,800 | -14,839 | 0.89 | 1.03 | +0.14 | sell |
| AGF MANAGEMENT LTD | 33,917 | 16,652 | -17,265 | 0.02 | 0.01 | -0.01 | sell |
| 683 Capital Management, LLC | 86,600 | 62,829 | -23,771 | 0.68 | 0.60 | -0.09 | sell |
| Rafferty Asset Management, LLC | 103,153 | 73,739 | -29,414 | 0.04 | 0.04 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 207,112 | 176,572 | -30,540 | 0.02 | 0.02 | +0.00 | sell |
| Candriam S.C.A. | 182,445 | 151,000 | -31,445 | 0.12 | 0.13 | +0.00 | sell |