| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 1,252,000 | 11,079,000 | +9,827,000 | 0.00 | 0.05 | +0.04 | buy |
| VANGUARD GROUP INC | 8,795,754 | 9,035,624 | +239,870 | 0.02 | 0.03 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 4,850,000 | 4,850,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 3,512,000 | 4,389,000 | +877,000 | 0.17 | 0.29 | +0.11 | buy |
| Capital International Investors | 4,817,517 | 4,320,827 | -496,690 | 0.13 | 0.14 | +0.01 | sell |
| STATE STREET CORP | 2,122,491 | 4,141,793 | +2,019,302 | 0.01 | 0.03 | +0.02 | buy |
| OFI INVEST ASSET MANAGEMENT | 4,004,000 | 4,000,000 | -4,000 | 0.24 | 0.13 | -0.12 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,251,000 | 3,899,000 | -1,352,000 | 0.01 | 0.01 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 4,891,417 | 3,815,368 | -1,076,049 | 0.35 | 0.32 | -0.02 | sell |
| Avoro Capital Advisors LLC | 4,344,444 | 3,000,000 | -1,344,444 | 6.56 | 6.31 | -0.25 | sell |
| MORGAN STANLEY | 888,433 | 2,623,361 | +1,734,928 | 0.01 | 0.03 | +0.02 | buy |
| TORONTO DOMINION BANK | 0 | 2,506,000 | +2,506,000 | 0.00 | 0.01 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 2,453,500 | 2,295,000 | -158,500 | 1.87 | 2.14 | +0.27 | sell |
| Bank of New York Mellon Corp | 2,067,037 | 2,130,651 | +63,614 | 0.05 | 0.06 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,245,798 | 2,061,526 | -1,184,272 | 0.07 | 0.06 | -0.02 | sell |
| T. Rowe Price Investment Management, Inc. | 1,931,547 | 1,958,635 | +27,088 | 0.15 | 0.20 | +0.04 | buy |
| FMR LLC | 1,348,570 | 1,860,545 | +511,975 | 0.01 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,828,602 | 1,843,769 | +15,167 | 0.02 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,520,370 | 1,652,048 | +131,678 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,460,475 | 1,573,577 | +113,102 | 0.09 | 0.11 | +0.02 | buy |
| EcoR1 Capital, LLC | 1,919,835 | 1,407,322 | -512,513 | 6.31 | 6.80 | +0.49 | sell |
| Casdin Capital, LLC | 1,069,000 | 1,073,500 | +4,500 | 10.30 | 12.95 | +2.65 | buy |
| Pictet Asset Management Holding SA | 1,258,536 | 957,218 | -301,318 | 0.18 | 0.17 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 1,078,346 | 947,574 | -130,772 | 4.91 | 5.73 | +0.82 | sell |
| NORGES BANK | 968,798 | 924,428 | -44,370 | 0.02 | 0.02 | +0.00 | sell |
| Bank of New York Mellon Corp | 900,000 | 900,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 278,104 | 869,129 | +591,025 | 0.05 | 0.15 | +0.10 | buy |
| CITADEL ADVISORS LLC | 1,523,077 | 775,821 | -747,256 | 0.19 | 0.12 | -0.07 | sell |
| BANK OF AMERICA CORP /DE/ | 653,465 | 721,401 | +67,936 | 0.01 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 579,637 | 690,408 | +110,771 | 0.34 | 0.45 | +0.12 | buy |
| NORTHERN TRUST CORP | 430,823 | 668,078 | +237,255 | 0.01 | 0.02 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 697,500 | 646,000 | -51,500 | 1.66 | 2.03 | +0.37 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 606,735 | 644,675 | +37,940 | 0.16 | 0.21 | +0.05 | buy |
| TWO SIGMA ADVISERS, LP | 661,334 | 606,834 | -54,500 | 0.20 | 0.21 | +0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 589,439 | 604,757 | +15,318 | 0.02 | 0.02 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 874,147 | 572,275 | -301,872 | 0.10 | 0.07 | -0.02 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 458,845 | 558,845 | +100,000 | 0.33 | 0.45 | +0.13 | buy |
| TWO SIGMA INVESTMENTS, LP | 342,682 | 541,794 | +199,112 | 0.11 | 0.20 | +0.09 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 509,205 | 532,918 | +23,713 | 0.17 | 0.22 | +0.05 | buy |
| Erste Asset Management GmbH | 571,400 | 521,400 | -50,000 | 1.01 | 1.09 | +0.08 | sell |
| FEDERATED HERMES, INC. | 610,216 | 508,329 | -101,887 | 0.18 | 0.19 | +0.01 | sell |
| ROYAL BANK OF CANADA | 460,606 | 495,540 | +34,934 | 0.01 | 0.02 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 250,047 | 439,577 | +189,530 | 0.01 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 385,480 | 400,898 | +15,418 | 0.02 | 0.03 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 470,000 | 400,000 | -70,000 | 0.11 | 0.12 | +0.00 | sell |
| Man Group plc | 120,005 | 386,424 | +266,419 | 0.04 | 0.16 | +0.12 | buy |
| Fiera Capital Corp | 367,039 | 382,645 | +15,606 | 0.14 | 0.19 | +0.05 | buy |
| Invesco Ltd. | 104,963 | 380,377 | +275,414 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 45,734 | 363,011 | +317,277 | 0.00 | 0.03 | +0.03 | buy |
| Assenagon Asset Management S.A. | 437,690 | 359,696 | -77,994 | 0.15 | 0.14 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 390,278 | 352,000 | -38,278 | 0.08 | 0.09 | +0.01 | sell |
| UBS Group AG | 277,190 | 350,764 | +73,574 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 504,968 | 340,030 | -164,938 | 0.01 | 0.01 | -0.00 | sell |
| Amundi | 398,286 | 332,956 | -65,330 | 0.02 | 0.02 | -0.00 | sell |
| Aberdeen Group plc | 191,857 | 329,845 | +137,988 | 0.05 | 0.10 | +0.05 | buy |
| MIZUHO MARKETS AMERICAS LLC | 290,800 | 326,300 | +35,500 | 1.03 | 1.42 | +0.40 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 337,634 | 322,835 | -14,799 | 0.04 | 0.05 | +0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 257,566 | 318,252 | +60,686 | 0.17 | 0.24 | +0.08 | buy |
| AMERIPRISE FINANCIAL INC | 230,822 | 308,413 | +77,591 | 0.01 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 161,027 | 301,481 | +140,454 | 0.01 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 430,469 | 288,617 | -141,852 | 0.20 | 0.17 | -0.03 | sell |
| Rock Springs Capital Management LP | 327,600 | 284,000 | -43,600 | 1.08 | 1.35 | +0.28 | sell |
| RHUMBLINE ADVISERS | 109,999 | 270,941 | +160,942 | 0.01 | 0.04 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 224,291 | 255,396 | +31,105 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF NOVA SCOTIA | 421,536 | 252,825 | -168,711 | 0.11 | 0.08 | -0.03 | sell |
| Bellevue Group AG | 251,521 | 252,321 | +800 | 0.50 | 0.65 | +0.15 | buy |
| FRANKLIN RESOURCES INC | 233,289 | 243,642 | +10,353 | 0.01 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 151,216 | 237,354 | +86,138 | 0.02 | 0.03 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 240,500 | 230,300 | -10,200 | 0.03 | 0.04 | +0.00 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 135,466 | 228,529 | +93,063 | 0.28 | 0.62 | +0.34 | buy |
| Caption Management, LLC | 150,346 | 227,000 | +76,654 | 2.14 | 3.80 | +1.66 | buy |
| Ensign Peak Advisors, Inc | 187,238 | 225,328 | +38,090 | 0.04 | 0.07 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 318,237 | 214,371 | -103,866 | 0.01 | 0.01 | -0.00 | sell |
| Ikarian Capital, LLC | 152,278 | 203,612 | +51,334 | 5.36 | 10.04 | +4.68 | buy |
| Palo Alto Investors LP | 201,265 | 201,683 | +418 | 2.94 | 3.69 | +0.75 | buy |
| Sofinnova Investments, Inc. | 227,488 | 195,852 | -31,636 | 1.74 | 1.95 | +0.21 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 281,697 | 194,794 | -86,903 | 0.05 | 0.05 | -0.00 | sell |
| First Turn Management, LLC | 221,748 | 181,669 | -40,079 | 4.29 | 4.67 | +0.37 | sell |
| BANK OF MONTREAL /CAN/ | 176,840 | 177,890 | +1,050 | 0.01 | 0.01 | +0.00 | buy |
| BLAIR WILLIAM & CO/IL | 43,170 | 174,282 | +131,112 | 0.02 | 0.08 | +0.07 | buy |
| Swiss National Bank | 166,183 | 166,083 | -100 | 0.02 | 0.02 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 176,572 | 159,082 | -17,490 | 0.02 | 0.02 | +0.00 | sell |
| NOMURA HOLDINGS INC | 0 | 158,890 | +158,890 | 0.00 | 0.16 | +0.16 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 160,639 | 158,462 | -2,177 | 0.03 | 0.03 | +0.01 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 123,785 | 151,851 | +28,066 | 0.01 | 0.02 | +0.01 | buy |
| Camber Capital Management LP | 585,000 | 150,000 | -435,000 | 2.65 | 0.91 | -1.73 | sell |
| Logos Global Management LP | 400,000 | 150,000 | -250,000 | 5.45 | 2.73 | -2.72 | sell |
| Cubist Systematic Strategies, LLC | 93,614 | 148,114 | +54,500 | 0.14 | 0.41 | +0.27 | buy |
| Rafferty Asset Management, LLC | 73,739 | 146,584 | +72,845 | 0.04 | 0.09 | +0.05 | buy |
| C WorldWide Group Holding A/S | 140,329 | 140,329 | 0 | 0.21 | 0.24 | +0.03 | hold |
| Legal & General Group Plc | 88,882 | 139,171 | +50,289 | 0.00 | 0.01 | +0.00 | buy |
| Finepoint Capital LP | 158,457 | 132,835 | -25,622 | 5.26 | 5.96 | +0.70 | sell |
| Candriam S.C.A. | 151,000 | 129,000 | -22,000 | 0.13 | 0.12 | -0.00 | sell |
| Cormorant Asset Management, LP | 0 | 125,000 | +125,000 | 0.00 | 1.15 | +1.15 | buy |
| Russell Investments Group, Ltd. | 127,429 | 121,754 | -5,675 | 0.03 | 0.03 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 86,866 | 117,840 | +30,974 | 0.01 | 0.03 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 105,153 | 117,215 | +12,062 | 0.17 | 0.20 | +0.03 | buy |
| Retirement Systems of Alabama | 0 | 116,667 | +116,667 | 0.00 | 0.07 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 119,476 | 107,570 | -11,906 | 0.00 | 0.00 | +0.00 | sell |
| Simplify Asset Management Inc. | 90,523 | 104,536 | +14,013 | 1.12 | 1.45 | +0.33 | buy |