| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 9,906,868 | 12,115,222 | +2,208,354 | 0.01 | 0.00 | -0.01 | buy |
| VANGUARD GROUP INC | 9,032,613 | 9,160,179 | +127,566 | 0.01 | 0.00 | -0.01 | buy |
| STATE STREET CORP | 4,068,472 | 4,695,027 | +626,555 | 0.01 | 0.00 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 4,406 | 4,478,638 | +4,474,232 | 0.00 | 0.08 | +0.08 | buy |
| BNP Paribas Asset Management Holding S.A. | 4,399,999 | 4,400,000 | +1 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,646,619 | 2,530,455 | -116,164 | 0.03 | 0.01 | -0.02 | sell |
| Fort Baker Capital Management LP | 0 | 2,500,000 | +2,500,000 | 0.99 | 0.32 | -0.67 | buy |
| TWO SIGMA INVESTMENTS, LP | 550,880 | 2,161,697 | +1,610,817 | 0.08 | 0.07 | -0.01 | buy |
| Exome Asset Management LLC | 0 | 2,000,000 | +2,000,000 | 0.00 | 1.19 | +1.19 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 276,334 | 1,985,734 | +1,709,400 | 0.04 | 0.07 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,820,921 | 1,875,997 | +55,076 | 0.01 | 0.00 | -0.01 | buy |
| Erste Asset Management GmbH | 1,061,065 | 1,621,415 | +560,350 | 0.81 | 0.23 | -0.57 | buy |
| Qube Research & Technologies Ltd | 31,908 | 1,598,472 | +1,566,564 | 0.00 | 0.04 | +0.03 | buy |
| MORGAN STANLEY | 1,972,122 | 1,486,926 | -485,196 | 0.01 | 0.00 | -0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 457,328 | 1,474,155 | +1,016,827 | 0.11 | 0.09 | -0.02 | buy |
| FEDERATED HERMES, INC. | 292,130 | 1,308,199 | +1,016,069 | 0.04 | 0.04 | +0.00 | buy |
| Aberdeen Group plc | 650,279 | 1,242,404 | +592,125 | 0.08 | 0.04 | -0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 34,008 | 1,233,749 | +1,199,741 | 0.00 | 0.02 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 206,945 | 1,062,205 | +855,260 | 0.01 | 0.02 | +0.00 | buy |
| Casdin Capital, LLC | 900,783 | 990,097 | +89,314 | 4.70 | 1.54 | -3.16 | buy |
| BANK OF AMERICA CORP /DE/ | 692,145 | 916,795 | +224,650 | 0.00 | 0.00 | -0.00 | buy |
| NORGES BANK | 1,192,398 | 913,407 | -278,991 | 0.01 | 0.00 | -0.01 | sell |
| Y-Intercept (Hong Kong) Ltd | 47,382 | 870,181 | +822,799 | 0.20 | 0.36 | +0.16 | buy |
| Assenagon Asset Management S.A. | 712,581 | 867,939 | +155,358 | 0.08 | 0.02 | -0.06 | buy |
| DIMENSIONAL FUND ADVISORS LP | 586,318 | 803,888 | +217,570 | 0.01 | 0.00 | -0.01 | buy |
| NORTHERN TRUST CORP | 769,817 | 759,553 | -10,264 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 155,052 | 676,277 | +521,225 | 0.02 | 0.02 | +0.00 | buy |
| 683 Capital Management, LLC | 165,000 | 675,000 | +510,000 | 1.07 | 1.17 | +0.10 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 646,291 | 673,877 | +27,586 | 0.01 | 0.00 | -0.01 | buy |
| JPMORGAN CHASE & CO | 2,244,432 | 652,199 | -1,592,233 | 0.01 | 0.00 | -0.01 | sell |
| Bank of New York Mellon Corp | 791,083 | 649,278 | -141,805 | 0.01 | 0.00 | -0.01 | sell |
| FIRST TRUST ADVISORS LP | 394,170 | 627,561 | +233,391 | 0.02 | 0.01 | -0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 624,478 | +624,478 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 244,769 | 615,441 | +370,672 | 0.07 | 0.04 | -0.03 | buy |
| Jump Financial, LLC | 5,785 | 603,269 | +597,484 | 0.01 | 0.13 | +0.13 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 200,137 | 514,745 | +314,608 | 0.16 | 0.10 | -0.07 | buy |
| UBS Group AG | 1,446,458 | 501,084 | -945,374 | 0.02 | 0.00 | -0.02 | sell |
| Opaleye Management Inc. | 0 | 500,000 | +500,000 | 0.00 | 1.73 | +1.73 | buy |
| Capital International Investors | 9,060,772 | 498,337 | -8,562,435 | 0.11 | 0.00 | -0.11 | sell |
| C WorldWide Group Holding A/S | 250,329 | 490,329 | +240,000 | 0.20 | 0.11 | -0.08 | buy |
| ING GROEP NV | 0 | 489,100 | +489,100 | 0.00 | 0.04 | +0.04 | buy |
| ROYAL BANK OF CANADA | 543,383 | 488,676 | -54,707 | 0.01 | 0.00 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 1,997,991 | 474,758 | -1,523,233 | 0.08 | 0.01 | -0.08 | sell |
| AMERIPRISE FINANCIAL INC | 336,789 | 461,000 | +124,211 | 0.01 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 169,087 | 449,087 | +280,000 | 3.52 | 2.54 | -0.97 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 444,728 | +444,728 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 12,947 | 436,225 | +423,278 | 0.01 | 0.07 | +0.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 420,300 | +420,300 | 0.00 | 0.36 | +0.36 | buy |
| BARCLAYS PLC | 445,657 | 411,523 | -34,134 | 0.01 | 0.00 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 463,342 | 396,167 | -67,175 | 0.01 | 0.00 | -0.01 | sell |
| Trexquant Investment LP | 187,984 | 387,497 | +199,513 | 0.14 | 0.07 | -0.06 | buy |
| GOLDMAN SACHS GROUP INC | 182,075 | 376,284 | +194,209 | 0.00 | 0.00 | -0.00 | buy |
| Fiera Capital Corp | 345,752 | 344,077 | -1,675 | 0.08 | 0.02 | -0.06 | sell |
| MPM BioImpact LLC | 0 | 321,696 | +321,696 | 0.00 | 0.95 | +0.95 | buy |
| CITADEL ADVISORS LLC | 235,788 | 302,156 | +66,368 | 0.01 | 0.00 | -0.01 | buy |
| Quinn Opportunity Partners LLC | 0 | 289,722 | +289,722 | 0.00 | 0.43 | +0.43 | buy |
| Jain Global LLC | 0 | 282,437 | +282,437 | 0.00 | 0.08 | +0.08 | buy |
| TWINBEECH CAPITAL LP | 264,996 | 280,096 | +15,100 | 0.31 | 0.11 | -0.20 | buy |
| WELLS FARGO & COMPANY/MN | 148,829 | 273,056 | +124,227 | 0.00 | 0.00 | -0.00 | buy |
| Hudson Bay Capital Management LP | 200,250 | 268,100 | +67,850 | 0.08 | 0.03 | -0.05 | buy |
| RHUMBLINE ADVISERS | 265,244 | 267,314 | +2,070 | 0.02 | 0.00 | -0.01 | buy |
| Deep Track Capital, LP | 899,731 | 259,800 | -639,931 | 1.86 | 0.14 | -1.72 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 244,533 | +244,533 | 0.00 | 0.02 | +0.02 | buy |
| Invesco Ltd. | 205,241 | 243,481 | +38,240 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 208,270 | 234,810 | +26,540 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 234,912 | 232,147 | -2,765 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF NOVA SCOTIA | 0 | 228,731 | +228,731 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 244,766 | 223,886 | -20,880 | 0.01 | 0.00 | -0.01 | sell |
| Aquatic Capital Management LLC | 92,316 | 215,817 | +123,501 | 0.15 | 0.07 | -0.08 | buy |
| CITIGROUP INC | 383,827 | 210,320 | -173,507 | 0.02 | 0.00 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 122,921 | 210,313 | +87,392 | 1.51 | 0.58 | -0.93 | buy |
| Amundi | 456,789 | 202,800 | -253,989 | 0.01 | 0.00 | -0.01 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 4,982 | 199,446 | +194,464 | 0.01 | 0.14 | +0.12 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,776 | 180,246 | +121,470 | 0.01 | 0.00 | -0.00 | buy |
| Pictet Asset Management Holding SA | 937,023 | 178,651 | -758,372 | 0.07 | 0.00 | -0.06 | sell |
| Nuveen, LLC | 352,740 | 174,284 | -178,456 | 0.01 | 0.00 | -0.01 | sell |
| Swiss National Bank | 166,483 | 166,483 | 0 | 0.01 | 0.00 | -0.01 | hold |
| SPHERA FUNDS MANAGEMENT LTD. | 157,931 | 159,323 | +1,392 | 2.49 | 0.71 | -1.77 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 52,914 | 153,460 | +100,546 | 0.12 | 0.08 | -0.04 | buy |
| ALGERT GLOBAL LLC | 76,669 | 149,910 | +73,241 | 0.12 | 0.05 | -0.07 | buy |
| Rafferty Asset Management, LLC | 99,105 | 149,760 | +50,655 | 0.03 | 0.01 | -0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 133,124 | 148,409 | +15,285 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 75,397 | 142,827 | +67,430 | 0.08 | 0.03 | -0.05 | buy |
| GROUP ONE TRADING LLC | 52,555 | 142,334 | +89,779 | 0.14 | 0.08 | -0.06 | buy |
| Swedbank AB | 137,400 | 137,400 | 0 | 0.01 | 0.00 | -0.01 | hold |
| DEUTSCHE BANK AG\ | 1,663,573 | 134,078 | -1,529,495 | 0.04 | 0.00 | -0.04 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 129,562 | 129,562 | 0 | 0.01 | 0.00 | -0.01 | hold |
| Squarepoint Ops LLC | 252,456 | 127,824 | -124,632 | 0.04 | 0.00 | -0.03 | sell |
| AQR CAPITAL MANAGEMENT LLC | 5,385 | 125,979 | +120,594 | 0.00 | 0.00 | +0.00 | buy |
| Retirement Systems of Alabama | 116,259 | 120,118 | +3,859 | 0.03 | 0.01 | -0.02 | buy |
| PDT Partners, LLC | 53,781 | 116,246 | +62,465 | 0.24 | 0.11 | -0.13 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 107,675 | 115,340 | +7,665 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 35,144 | 111,658 | +76,514 | 0.01 | 0.01 | -0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 74,219 | 110,464 | +36,245 | 0.01 | 0.00 | -0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 77,194 | 108,846 | +31,652 | 0.01 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 88,390 | 106,275 | +17,885 | 0.01 | 0.00 | -0.01 | buy |
| Generali Investments CEE, investicni spolecnost, a.s. | 2,000 | 105,326 | +103,326 | 0.01 | 0.15 | +0.14 | buy |
| Nebula Research & Development LLC | 0 | 98,075 | +98,075 | 0.00 | 0.14 | +0.14 | buy |
| FORA Capital, LLC | 6,042 | 93,189 | +87,147 | 0.04 | 0.18 | +0.14 | buy |