| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 11,079,000 | 10,892,000 | -187,000 | 0.05 | 0.04 | -0.01 | sell |
| VANGUARD GROUP INC | 9,035,624 | 8,967,552 | -68,072 | 0.03 | 0.02 | -0.01 | sell |
| Capital International Investors | 4,320,827 | 6,259,282 | +1,938,455 | 0.14 | 0.15 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,899,000 | 4,497,000 | +598,000 | 0.01 | 0.01 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 4,850,000 | 4,400,000 | -450,000 | 0.02 | 0.01 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 4,389,000 | 4,389,000 | 0 | 0.29 | 0.22 | -0.06 | hold |
| JANUS HENDERSON GROUP PLC | 3,815,368 | 4,358,511 | +543,143 | 0.32 | 0.28 | -0.04 | buy |
| STATE STREET CORP | 4,141,793 | 4,270,766 | +128,973 | 0.03 | 0.02 | -0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,061,526 | 2,726,613 | +665,087 | 0.06 | 0.06 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 2,295,000 | 2,580,000 | +285,000 | 2.14 | 1.77 | -0.37 | buy |
| Avoro Capital Advisors LLC | 3,000,000 | 2,555,555 | -444,445 | 6.31 | 4.65 | -1.66 | sell |
| JPMORGAN CHASE & CO | 1,843,769 | 2,198,883 | +355,114 | 0.03 | 0.02 | -0.00 | buy |
| Bank of New York Mellon Corp | 2,130,651 | 2,118,903 | -11,748 | 0.06 | 0.05 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 1,958,635 | 1,946,240 | -12,395 | 0.20 | 0.15 | -0.05 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,652,048 | 1,696,354 | +44,306 | 0.02 | 0.02 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 1,573,577 | 1,463,176 | -110,401 | 0.11 | 0.07 | -0.04 | sell |
| FMR LLC | 1,860,545 | 1,235,742 | -624,803 | 0.02 | 0.01 | -0.01 | sell |
| Casdin Capital, LLC | 1,073,500 | 1,073,500 | 0 | 12.95 | 8.94 | -4.01 | hold |
| Pictet Asset Management Holding SA | 957,218 | 1,051,011 | +93,793 | 0.17 | 0.14 | -0.03 | buy |
| NORGES BANK | 924,428 | 1,006,396 | +81,968 | 0.02 | 0.02 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 646,000 | 954,500 | +308,500 | 2.03 | 2.18 | +0.15 | buy |
| MORGAN STANLEY | 2,623,361 | 953,104 | -1,670,257 | 0.03 | 0.01 | -0.02 | sell |
| CITADEL ADVISORS LLC | 775,821 | 926,219 | +150,398 | 0.12 | 0.12 | +0.00 | buy |
| Bank of New York Mellon Corp | 900,000 | 800,000 | -100,000 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 721,401 | 783,029 | +61,628 | 0.01 | 0.01 | -0.00 | buy |
| Camber Capital Management LP | 150,000 | 775,000 | +625,000 | 0.91 | 3.76 | +2.84 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 690,408 | 753,845 | +63,437 | 0.45 | 0.36 | -0.09 | buy |
| NORTHERN TRUST CORP | 668,078 | 655,637 | -12,441 | 0.02 | 0.01 | -0.00 | sell |
| Erste Asset Management GmbH | 521,400 | 636,065 | +114,665 | 1.09 | 0.95 | -0.14 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 558,845 | 633,845 | +75,000 | 0.45 | 0.43 | -0.02 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 644,675 | 624,888 | -19,787 | 0.21 | 0.15 | -0.06 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 604,757 | 611,749 | +6,992 | 0.02 | 0.01 | -0.00 | buy |
| ROYAL BANK OF CANADA | 495,540 | 585,989 | +90,449 | 0.02 | 0.02 | -0.00 | buy |
| FEDERATED HERMES, INC. | 508,329 | 508,836 | +507 | 0.19 | 0.14 | -0.05 | buy |
| Invesco Ltd. | 380,377 | 482,161 | +101,784 | 0.01 | 0.01 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 101,916 | 464,916 | +363,000 | 0.02 | 0.06 | +0.04 | buy |
| BARCLAYS PLC | 400,898 | 459,900 | +59,002 | 0.03 | 0.03 | -0.00 | buy |
| Aberdeen Group plc | 329,845 | 431,098 | +101,253 | 0.10 | 0.10 | -0.00 | buy |
| MIZUHO MARKETS AMERICAS LLC | 326,300 | 399,065 | +72,765 | 1.42 | 1.22 | -0.20 | buy |
| BRAIDWELL LP | 81,900 | 370,400 | +288,500 | 0.41 | 1.31 | +0.91 | buy |
| UBS Group AG | 350,764 | 364,172 | +13,408 | 0.02 | 0.01 | -0.00 | buy |
| Fiera Capital Corp | 382,645 | 359,996 | -22,649 | 0.19 | 0.14 | -0.05 | sell |
| Amundi | 332,956 | 357,919 | +24,963 | 0.02 | 0.02 | -0.00 | buy |
| Assenagon Asset Management S.A. | 359,696 | 350,052 | -9,644 | 0.14 | 0.09 | -0.05 | sell |
| Bellevue Group AG | 252,321 | 344,348 | +92,027 | 0.65 | 0.70 | +0.05 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 532,918 | 324,332 | -208,586 | 0.22 | 0.10 | -0.11 | sell |
| AMERIPRISE FINANCIAL INC | 308,413 | 317,301 | +8,888 | 0.01 | 0.01 | -0.00 | buy |
| Man Group plc | 386,424 | 311,338 | -75,086 | 0.16 | 0.11 | -0.05 | sell |
| Rock Springs Capital Management LP | 284,000 | 307,500 | +23,500 | 1.35 | 1.25 | -0.10 | buy |
| GOLDMAN SACHS GROUP INC | 439,577 | 301,021 | -138,556 | 0.01 | 0.01 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 318,252 | 286,879 | -31,373 | 0.24 | 0.17 | -0.07 | sell |
| DIMENSIONAL FUND ADVISORS LP | 255,396 | 280,195 | +24,799 | 0.01 | 0.01 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 275,000 | -125,000 | 0.12 | 0.06 | -0.06 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 228,529 | 272,954 | +44,425 | 0.62 | 0.59 | -0.03 | buy |
| RHUMBLINE ADVISERS | 270,941 | 270,872 | -69 | 0.04 | 0.03 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 301,481 | 268,203 | -33,278 | 0.01 | 0.01 | -0.01 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 363,011 | 267,037 | -95,974 | 0.03 | 0.02 | -0.02 | sell |
| BANK OF NOVA SCOTIA | 252,825 | 252,768 | -57 | 0.08 | 0.06 | -0.01 | sell |
| Clearbridge Investments, LLC | 237,354 | 237,077 | -277 | 0.03 | 0.02 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 340,030 | 236,533 | -103,497 | 0.01 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 60,000 | 235,240 | +175,240 | 0.05 | 0.15 | +0.10 | buy |
| FRANKLIN RESOURCES INC | 243,642 | 235,187 | -8,455 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 352,000 | 230,478 | -121,522 | 0.09 | 0.04 | -0.05 | sell |
| Ensign Peak Advisors, Inc | 225,328 | 225,328 | 0 | 0.07 | 0.05 | -0.02 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 322,835 | 225,039 | -97,796 | 0.05 | 0.03 | -0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 214,371 | 219,010 | +4,639 | 0.01 | 0.01 | -0.00 | buy |
| Palo Alto Investors LP | 201,683 | 210,258 | +8,575 | 3.69 | 3.41 | -0.28 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 206,583 | +206,583 | 0.00 | 0.51 | +0.51 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 204,146 | +204,146 | 0.00 | 0.28 | +0.28 | buy |
| TWO SIGMA INVESTMENTS, LP | 541,794 | 202,270 | -339,524 | 0.20 | 0.06 | -0.15 | sell |
| Simplify Asset Management Inc. | 104,536 | 193,010 | +88,474 | 1.45 | 1.66 | +0.21 | buy |
| BANK OF MONTREAL /CAN/ | 177,890 | 185,592 | +7,702 | 0.01 | 0.01 | +0.00 | buy |
| Altium Capital Management LLC | 81,900 | 170,000 | +88,100 | 5.34 | 6.33 | +0.98 | buy |
| Swiss National Bank | 166,083 | 166,083 | 0 | 0.02 | 0.01 | -0.00 | hold |
| NOMURA HOLDINGS INC | 158,890 | 158,890 | 0 | 0.16 | 0.15 | -0.01 | hold |
| HSBC HOLDINGS PLC | 2,358 | 158,639 | +156,281 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 151,851 | 150,520 | -1,331 | 0.02 | 0.01 | -0.00 | sell |
| Logos Global Management LP | 150,000 | 150,000 | 0 | 2.73 | 2.10 | -0.63 | hold |
| Legal & General Group Plc | 139,171 | 142,862 | +3,691 | 0.01 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 159,082 | 142,396 | -16,686 | 0.02 | 0.02 | -0.01 | sell |
| C WorldWide Group Holding A/S | 140,329 | 140,329 | 0 | 0.24 | 0.18 | -0.06 | hold |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 21,318 | 138,118 | +116,800 | 0.16 | 0.78 | +0.62 | buy |
| Rafferty Asset Management, LLC | 146,584 | 138,042 | -8,542 | 0.09 | 0.06 | -0.03 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 158,462 | 136,362 | -22,100 | 0.03 | 0.02 | -0.01 | sell |
| Finepoint Capital LP | 132,835 | 133,535 | +700 | 5.96 | 2.03 | -3.93 | buy |
| TWO SIGMA ADVISERS, LP | 606,834 | 128,034 | -478,800 | 0.21 | 0.04 | -0.18 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 83,659 | 125,846 | +42,187 | 2.15 | 2.57 | +0.42 | buy |
| Russell Investments Group, Ltd. | 121,754 | 125,096 | +3,342 | 0.03 | 0.02 | -0.01 | buy |
| Neuberger Berman Group LLC | 88,451 | 120,706 | +32,255 | 0.01 | 0.01 | +0.00 | buy |
| Retirement Systems of Alabama | 116,667 | 115,846 | -821 | 0.07 | 0.05 | -0.02 | sell |
| Corebridge Financial, Inc. | 120,635 | 113,804 | -6,831 | 0.10 | 0.08 | -0.03 | sell |
| WELLS FARGO & COMPANY/MN | 107,570 | 111,367 | +3,797 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 194,794 | 110,175 | -84,619 | 0.05 | 0.02 | -0.03 | sell |
| Twin Tree Management, LP | 0 | 107,549 | +107,549 | 0.00 | 0.31 | +0.31 | buy |
| BRAUN STACEY ASSOCIATES INC | 98,185 | 103,012 | +4,827 | 0.60 | 0.49 | -0.11 | buy |
| J. Goldman & Co LP | 43,653 | 99,238 | +55,585 | 0.26 | 0.54 | +0.28 | buy |
| PINNACLE ASSOCIATES LTD | 50,115 | 91,951 | +41,836 | 0.12 | 0.15 | +0.03 | buy |
| PFM Health Sciences, LP | 88,216 | 88,216 | 0 | 0.76 | 0.63 | -0.13 | hold |
| 683 Capital Management, LLC | 63,500 | 87,222 | +23,722 | 1.05 | 1.11 | +0.06 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 85,860 | 84,230 | -1,630 | 0.03 | 0.02 | -0.01 | sell |