| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 12,115,222 | 13,199,845 | +1,084,623 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 9,160,179 | 10,817,446 | +1,657,267 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 4,695,027 | 5,304,907 | +609,880 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 4,400,000 | 4,400,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| STATE OF WISCONSIN INVESTMENT BOARD | 2,000,000 | 3,000,000 | +1,000,000 | 0.00 | 0.01 | +0.00 | buy |
| Erste Asset Management GmbH | 1,621,415 | 2,685,945 | +1,064,530 | 0.23 | 0.49 | +0.26 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 624,478 | 2,650,178 | +2,025,700 | 0.01 | 0.07 | +0.05 | buy |
| Fort Baker Capital Management LP | 2,500,000 | 2,500,000 | 0 | 0.32 | 0.36 | +0.04 | hold |
| TWO SIGMA INVESTMENTS, LP | 2,161,697 | 2,137,764 | -23,933 | 0.07 | 0.06 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 4,478,638 | 2,007,025 | -2,471,613 | 0.08 | 0.03 | -0.05 | sell |
| Exome Asset Management LLC | 2,000,000 | 2,000,000 | 0 | 1.19 | 1.17 | -0.03 | hold |
| UBS Group AG | 501,084 | 1,990,508 | +1,489,424 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 1,242,404 | 1,982,764 | +740,360 | 0.04 | 0.06 | +0.02 | buy |
| TWO SIGMA ADVISERS, LP | 1,985,734 | 1,958,034 | -27,700 | 0.07 | 0.08 | +0.01 | sell |
| MORGAN STANLEY | 1,486,926 | 1,948,359 | +461,433 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 627,561 | 1,939,781 | +1,312,220 | 0.01 | 0.03 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,233,749 | 1,781,348 | +547,599 | 0.02 | 0.03 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 615,441 | 1,745,051 | +1,129,610 | 0.04 | 0.11 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,875,997 | 1,721,124 | -154,873 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 125,979 | 1,405,675 | +1,279,696 | 0.00 | 0.02 | +0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 474,758 | 1,366,690 | +891,932 | 0.01 | 0.02 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,474,155 | 1,308,738 | -165,417 | 0.09 | 0.08 | -0.01 | sell |
| FEDERATED HERMES, INC. | 1,308,199 | 1,308,691 | +492 | 0.04 | 0.04 | +0.00 | buy |
| CITIGROUP INC | 210,320 | 1,018,922 | +808,602 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 180,246 | 990,866 | +810,620 | 0.00 | 0.03 | +0.02 | buy |
| 683 Capital Management, LLC | 675,000 | 990,000 | +315,000 | 1.17 | 1.73 | +0.56 | buy |
| Amundi | 202,800 | 969,826 | +767,026 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 243,481 | 832,638 | +589,157 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 832,100 | +832,100 | 0.00 | 0.48 | +0.48 | buy |
| BANK OF AMERICA CORP /DE/ | 916,795 | 803,058 | -113,737 | 0.00 | 0.00 | -0.00 | sell |
| CAPITAL FUND MANAGEMENT S.A. | 514,745 | 780,054 | +265,309 | 0.10 | 0.15 | +0.05 | buy |
| MPM BioImpact LLC | 321,696 | 700,000 | +378,304 | 0.95 | 2.21 | +1.25 | buy |
| JPMORGAN CHASE & CO | 652,199 | 669,382 | +17,183 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 803,888 | 651,598 | -152,290 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 759,553 | 638,780 | -120,773 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 673,877 | 609,151 | -64,726 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 420,300 | 600,000 | +179,700 | 0.36 | 0.45 | +0.08 | buy |
| Bank of New York Mellon Corp | 649,278 | 590,271 | -59,007 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 500,000 | 585,000 | +85,000 | 1.73 | 1.59 | -0.14 | buy |
| CITADEL ADVISORS LLC | 302,156 | 512,477 | +210,321 | 0.00 | 0.01 | +0.00 | buy |
| Voleon Capital Management LP | 10,547 | 501,142 | +490,595 | 0.01 | 0.24 | +0.23 | buy |
| SG Americas Securities, LLC | 37,593 | 499,621 | +462,028 | 0.00 | 0.04 | +0.03 | buy |
| C WorldWide Group Holding A/S | 490,329 | 490,329 | 0 | 0.11 | 0.15 | +0.03 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 223,886 | 468,067 | +244,181 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 381,172 | +381,172 | 0.00 | 0.03 | +0.03 | buy |
| Quinn Opportunity Partners LLC | 289,722 | 376,244 | +86,522 | 0.43 | 0.53 | +0.10 | buy |
| Bridgewater Associates, LP | 0 | 352,275 | +352,275 | 0.00 | 0.03 | +0.03 | buy |
| ALGERT GLOBAL LLC | 149,910 | 351,984 | +202,074 | 0.05 | 0.11 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 210,313 | 349,807 | +139,494 | 0.58 | 0.67 | +0.08 | buy |
| WELLS FARGO & COMPANY/MN | 273,056 | 328,576 | +55,520 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 91,600 | 321,729 | +230,129 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 603,269 | 301,009 | -302,260 | 0.13 | 0.09 | -0.05 | sell |
| BARCLAYS PLC | 411,523 | 299,086 | -112,437 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,062,205 | 284,210 | -777,995 | 0.02 | 0.00 | -0.01 | sell |
| Silver Point Capital L.P. | 0 | 278,278 | +278,278 | 0.00 | 0.28 | +0.28 | buy |
| Legal & General Group Plc | 234,810 | 266,562 | +31,752 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 244,533 | 262,331 | +17,798 | 0.02 | 0.02 | +0.00 | buy |
| Boxer Capital Management, LLC | 25,000 | 250,000 | +225,000 | 0.22 | 1.54 | +1.32 | buy |
| ING GROEP NV | 489,100 | 240,800 | -248,300 | 0.04 | 0.03 | -0.01 | sell |
| ROYAL BANK OF CANADA | 488,676 | 238,440 | -250,236 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 396,167 | 233,461 | -162,706 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 461,000 | 217,287 | -243,713 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 268,100 | 200,003 | -68,097 | 0.03 | 0.02 | -0.01 | sell |
| DARK FOREST CAPITAL MANAGEMENT LP | 199,446 | 199,446 | 0 | 0.14 | 0.09 | -0.04 | hold |
| Aquatic Capital Management LLC | 215,817 | 188,453 | -27,364 | 0.07 | 0.07 | -0.01 | sell |
| HRT FINANCIAL LP | 111,658 | 181,855 | +70,197 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 267,314 | 178,421 | -88,893 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 376,284 | 177,151 | -199,133 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 149,760 | 175,135 | +25,375 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 174,284 | 171,640 | -2,644 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 166,483 | 171,483 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 82,979 | 170,797 | +87,818 | 0.04 | 0.10 | +0.06 | buy |
| Russell Investments Group, Ltd. | 106,275 | 168,294 | +62,019 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 387,497 | 160,662 | -226,835 | 0.07 | 0.03 | -0.04 | sell |
| Walleye Capital LLC | 436,225 | 156,780 | -279,445 | 0.07 | 0.02 | -0.04 | sell |
| Engineers Gate Manager LP | 142,827 | 153,257 | +10,430 | 0.03 | 0.03 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 50,851 | 152,803 | +101,952 | 0.01 | 0.02 | +0.01 | buy |
| Verition Fund Management LLC | 89,888 | 148,367 | +58,479 | 0.01 | 0.02 | +0.01 | buy |
| Generali Investments CEE, investicni spolecnost, a.s. | 105,326 | 123,649 | +18,323 | 0.15 | 0.18 | +0.03 | buy |
| GROUP ONE TRADING LLC | 142,334 | 122,341 | -19,993 | 0.08 | 0.07 | -0.01 | sell |
| PDT Partners, LLC | 116,246 | 116,246 | 0 | 0.11 | 0.14 | +0.03 | hold |
| Squarepoint Ops LLC | 127,824 | 106,881 | -20,943 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 105,113 | +105,113 | 0.00 | 0.00 | +0.00 | buy |
| Union Square Park Capital Management, LLC | 0 | 105,000 | +105,000 | 0.00 | 1.39 | +1.39 | buy |
| CANADA LIFE ASSURANCE Co | 71,533 | 97,041 | +25,508 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 32,125 | 91,900 | +59,775 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 76,784 | 90,027 | +13,243 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 62,424 | 89,986 | +27,562 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 108,846 | 89,271 | -19,575 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 148,409 | 88,343 | -60,066 | 0.00 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 63,000 | 84,000 | +21,000 | 0.25 | 0.35 | +0.10 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 84,640 | 83,607 | -1,033 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 76,471 | 82,415 | +5,944 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 82,123 | 82,141 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 870,181 | 78,735 | -791,446 | 0.36 | 0.04 | -0.33 | sell |
| CWM, LLC | 1,759 | 72,705 | +70,946 | 0.00 | 0.00 | +0.00 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 69,363 | 71,851 | +2,488 | 0.00 | 0.00 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 23,140 | 70,493 | +47,353 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 68,076 | +68,076 | 0.00 | 0.00 | +0.00 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 0 | 66,000 | +66,000 | 0.00 | 0.00 | +0.00 | buy |