| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital International Investors | 1,823,688 | 4,741,485 | +2,917,797 | 0.06 | 0.10 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 810,467 | 302,340 | +508,127 | 0.29 | 0.08 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 5,782,449 | 5,345,785 | +436,664 | 0.46 | 0.31 | 0.00 | sell |
| Avoro Capital Advisors LLC | 4,025,000 | 4,344,444 | +319,444 | 7.61 | 5.79 | -1.82 | buy |
| MILLENNIUM MANAGEMENT LLC | 349,445 | 644,138 | +294,693 | 0.06 | 0.08 | 0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 220,425 | 498,829 | +278,404 | 0.08 | 0.14 | 0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 182,720 | 451,873 | +269,153 | 0.74 | 0.97 | +0.23 | buy |
| ORBIMED ADVISORS LLC | 529,200 | 697,500 | +168,300 | 1.38 | 1.35 | -0.03 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 145,724 | 10,200 | +135,524 | 0.03 | 0.00 | 0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 682,878 | 562,978 | +119,900 | 0.15 | 0.09 | -0.06 | sell |
| CITADEL ADVISORS LLC | 1,227,974 | 1,342,730 | +114,756 | 0.22 | 0.19 | -0.04 | buy |
| Palo Alto Investors LP | 94,030 | 200,905 | +106,875 | 1.08 | 1.75 | +0.67 | buy |
| Allspring Global Investments Holdings, LLC | 354,502 | 273,661 | +80,841 | 0.08 | 0.04 | 0.00 | sell |
| ExodusPoint Capital Management, LP | 87,413 | 7,507 | +79,906 | 0.14 | 0.01 | 0.00 | sell |
| 683 Capital Management, LLC | 20,000 | 86,600 | +66,600 | 0.19 | 0.68 | +0.50 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 397,456 | 459,102 | +61,646 | 0.29 | 0.22 | -0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,408,775 | 1,469,537 | +60,762 | 0.02 | 0.02 | 0.00 | buy |
| MIZUHO MARKETS AMERICAS LLC | 245,939 | 305,639 | +59,700 | 1.11 | 0.89 | -0.22 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 15,500 | 70,600 | +55,100 | 1.26 | 3.83 | +2.57 | buy |
| Candriam S.C.A. | 135,709 | 182,445 | +46,736 | 0.12 | 0.12 | +0.00 | buy |
| Hudson Bay Capital Management LP | 45,000 | 88,208 | +43,208 | 0.04 | 0.05 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 9,197 | 46,884 | +37,687 | 0.42 | 1.39 | +0.98 | buy |
| Rafferty Asset Management, LLC | 74,180 | 103,153 | +28,973 | 0.05 | 0.04 | -0.01 | buy |
| Portman Square Capital LLP | 71,527 | 97,927 | +26,400 | 1.19 | 1.64 | +0.44 | buy |
| FRED ALGER MANAGEMENT, LLC | 65,674 | 90,335 | +24,661 | 0.05 | 0.05 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,895,320 | 1,919,742 | +24,422 | 0.16 | 0.12 | -0.04 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 16,939 | 40,345 | +23,406 | 0.03 | 0.06 | +0.02 | buy |
| Treasurer of the State of North Carolina | 61,912 | 39,677 | +22,235 | 0.04 | 0.02 | 0.00 | sell |
| Erste Asset Management GmbH | 685,400 | 701,400 | +16,000 | 1.43 | 0.99 | -0.44 | buy |
| Eagle Health Investments LP | 174,212 | 189,356 | +15,144 | 4.65 | 3.71 | -0.94 | buy |
| Advisors Asset Management, Inc. | 22,704 | 13,415 | +9,289 | 0.06 | 0.03 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 2,397 | 10,824 | +8,427 | 0.08 | 0.20 | +0.12 | buy |
| TOBAM | 148,941 | 156,046 | +7,105 | 1.45 | 1.32 | -0.13 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 89,931 | 85,512 | +4,419 | 0.02 | 0.01 | -0.01 | sell |
| RHUMBLINE ADVISERS | 122,851 | 118,472 | +4,379 | 0.02 | 0.01 | 0.00 | sell |
| PROFUND ADVISORS LLC | 12,190 | 16,277 | +4,087 | 0.08 | 0.07 | 0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 18,006 | 21,541 | +3,535 | 0.43 | 0.89 | +0.47 | buy |
| ALGERT GLOBAL LLC | 43,182 | 46,519 | +3,337 | 0.25 | 0.18 | 0.00 | buy |
| Inspire Investing, LLC | 5,598 | 8,492 | +2,894 | 0.09 | 0.09 | +0.00 | buy |
| Evolutionary Tree Capital Management, LLC | 16,650 | 19,466 | +2,816 | 2.60 | 2.07 | -0.53 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 40,145 | 37,461 | +2,684 | 0.02 | 0.01 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 204,626 | 207,112 | +2,486 | 0.03 | 0.02 | -0.01 | buy |
| EFG Asset Management (North America) Corp. | 22,712 | 25,134 | +2,422 | 0.65 | 0.46 | -0.19 | buy |
| E Fund Management Co., Ltd. | 3,814 | 5,519 | +1,705 | 0.04 | 0.03 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,847 | 17,376 | +1,529 | 0.01 | 0.01 | 0.00 | buy |
| FIRST TRUST ADVISORS LP | 430,974 | 432,350 | +1,376 | 0.06 | 0.05 | 0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 5,347 | 4,115 | +1,232 | 0.03 | 0.02 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,334 | 3,451 | +1,117 | 0.17 | 0.21 | +0.04 | buy |
| GILDER GAGNON HOWE & CO LLC | 16,610 | 17,612 | +1,002 | 0.03 | 0.02 | -0.01 | buy |
| DMC Group, LLC | 3,297 | 3,793 | +496 | 0.37 | 0.35 | -0.03 | buy |
| Beacon Pointe Advisors, LLC | 6,767 | 6,304 | +463 | 0.01 | 0.01 | 0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 23,520 | 23,809 | +289 | 0.03 | 0.02 | 0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 6,815 | 6,641 | +174 | 0.08 | 0.06 | 0.00 | sell |
| GPS Wealth Strategies Group, LLC | 345 | 176 | +169 | 0.01 | 0.00 | 0.00 | sell |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 9,776 | 9,942 | +166 | 0.01 | 0.01 | 0.00 | buy |
| ProShare Advisors LLC | 6,098 | 5,977 | +121 | 0.00 | 0.00 | 0.00 | sell |
| Utah Retirement Systems | 15,371 | 15,471 | +100 | 0.03 | 0.02 | -0.01 | buy |
| L & S Advisors Inc | 14,294 | 14,392 | +98 | 0.25 | 0.17 | -0.08 | buy |
| Vanguard Capital Wealth Advisors | 2,360 | 2,450 | +90 | 0.27 | 0.19 | -0.07 | buy |
| GUIDANCE CAPITAL, INC | 1,967 | 2,011 | +44 | 0.11 | 0.08 | -0.03 | buy |
| CI INVESTMENTS INC. | 2,146 | 2,182 | +36 | 0.00 | 0.00 | 0.00 | buy |
| ARMSTRONG ADVISORY GROUP, INC | 279 | 289 | +10 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 509 | 500 | +9 | 0.01 | 0.00 | 0.00 | sell |
| WHITTIER TRUST CO | 651 | 647 | +4 | 0.00 | 0.00 | 0.00 | sell |
| Mount Lucas Management LP | 1,974 | 1,972 | -2 | 0.09 | 0.07 | -0.02 | sell |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 97 | 90 | -7 | 0.00 | 0.00 | -0.00 | sell |
| Itau Unibanco Holding S.A. | 195 | 169 | -26 | 0.00 | 0.00 | -0.00 | sell |
| NBC SECURITIES, INC. | 6,160 | 6,110 | -50 | 0.08 | 0.06 | -0.02 | sell |
| MOODY ALDRICH PARTNERS LLC | 7,227 | 7,156 | -71 | 0.17 | 0.12 | -0.04 | sell |
| VALLEY NATIONAL ADVISERS INC | 444 | 341 | -103 | 0.01 | 0.01 | -0.00 | sell |
| INCEPTIONR LLC | 3,224 | 3,061 | -163 | 0.22 | 0.21 | -0.01 | sell |
| PINNACLE ASSOCIATES LTD | 92,163 | 91,951 | -212 | 0.21 | 0.15 | -0.06 | sell |
| MONEY CONCEPTS CAPITAL CORP | 27,740 | 27,398 | -342 | 0.35 | 0.25 | -0.11 | sell |
| NORDEA INVESTMENT MANAGEMENT AB | 28,296 | 27,946 | -350 | 0.00 | 0.00 | -0.00 | sell |
| Platform Technology Partners | 3,125 | 2,137 | -988 | 0.18 | 0.11 | -0.07 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 3,244 | 1,790 | -1,454 | 0.08 | 0.03 | -0.05 | sell |
| C M BIDWELL & ASSOCIATES LTD | 1,553 | 4 | -1,549 | 0.14 | 0.00 | -0.14 | sell |
| Worth Venture Partners, LLC | 7,300 | 5,400 | -1,900 | 0.53 | 0.28 | -0.24 | sell |
| PFG Investments, LLC | 21,530 | 19,485 | -2,045 | 0.49 | 0.35 | -0.14 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 173,772 | 171,581 | -2,191 | 0.03 | 0.02 | -0.01 | sell |
| Prime Capital Investment Advisors, LLC | 7,429 | 3,666 | -3,763 | 0.02 | 0.01 | -0.01 | sell |
| Casdin Capital, LLC | 1,010,330 | 1,006,500 | -3,830 | 13.55 | 9.53 | -4.03 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 22,508 | 18,347 | -4,161 | 0.02 | 0.01 | -0.01 | sell |
| Bellevue Group AG | 241,752 | 237,286 | -4,466 | 0.47 | 0.35 | -0.12 | sell |
| ATWOOD & PALMER INC | 10,547 | 5,194 | -5,353 | 0.11 | 0.04 | -0.07 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 45,178 | 38,463 | -6,715 | 0.16 | 0.11 | -0.05 | sell |
| Sigma Planning Corp | 12,405 | 5,213 | -7,192 | 0.06 | 0.04 | -0.02 | sell |
| Fiera Capital Corp | 356,323 | 348,212 | -8,111 | 0.14 | 0.10 | -0.04 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 61,171 | 52,627 | -8,544 | 0.08 | 0.05 | -0.03 | sell |
| Capula Management Ltd | 11,627 | 2,295 | -9,332 | 0.03 | 0.01 | -0.02 | sell |
| Diametric Capital, LP | 21,657 | 4,568 | -17,089 | 1.10 | 0.27 | -0.83 | sell |
| Swiss National Bank | 174,083 | 156,283 | -17,800 | 0.02 | 0.01 | -0.01 | sell |
| Bridgewater Associates, LP | 50,464 | 26,388 | -24,076 | 0.04 | 0.01 | -0.02 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 122,643 | 89,219 | -33,424 | 0.27 | 0.14 | -0.13 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 50,000 | 12,500 | -37,500 | 1.10 | 0.19 | -0.91 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 787,956 | 739,736 | -48,220 | 0.01 | 0.01 | -0.00 | sell |
| Rock Springs Capital Management LP | 392,000 | 327,600 | -64,400 | 1.27 | 0.78 | -0.50 | sell |
| GREAT POINT PARTNERS LLC | 165,200 | 80,000 | -85,200 | 3.65 | 1.31 | -2.33 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 458,845 | 358,845 | -100,000 | 0.10 | 0.08 | -0.02 | sell |
| Nicholas Investment Partners, LP | 188,085 | 3,329 | -184,756 | 1.70 | 0.04 | -1.67 | sell |