| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEW YORK STATE COMMON RETIREMENT FUND | 3,319,000 | 8,398,000 | +5,079,000 | 0.01 | 0.01 | +0.01 | buy |
| Capital International Investors | 1,823,688 | 4,741,485 | +2,917,797 | 0.06 | 0.10 | +0.05 | buy |
| TORONTO DOMINION BANK | 1,000,000 | 2,500,000 | +1,500,000 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 832,907 | +832,907 | 0.00 | 2.09 | +2.09 | buy |
| BANK OF AMERICA CORP /DE/ | 527,846 | 1,212,377 | +684,531 | 0.01 | 0.01 | +0.01 | buy |
| BANK OF NOVA SCOTIA | 0 | 528,793 | +528,793 | 0.00 | 0.10 | +0.10 | buy |
| MORGAN STANLEY | 855,444 | 1,380,149 | +524,705 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 500,000 | +500,000 | 0.00 | 1.69 | +1.69 | buy |
| STATE STREET CORP | 1,985,576 | 2,399,078 | +413,502 | 0.01 | 0.01 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 1,071,118 | 1,474,962 | +403,844 | 0.08 | 0.07 | -0.01 | buy |
| ROYAL BANK OF CANADA | 448,795 | 814,029 | +365,234 | 0.02 | 0.02 | +0.00 | buy |
| Avoro Capital Advisors LLC | 4,025,000 | 4,344,444 | +319,444 | 7.61 | 5.79 | -1.83 | buy |
| MILLENNIUM MANAGEMENT LLC | 349,445 | 644,138 | +294,693 | 0.04 | 0.06 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 220,425 | 498,829 | +278,404 | 0.07 | 0.13 | +0.06 | buy |
| PERCEPTIVE ADVISORS LLC | 182,720 | 451,873 | +269,153 | 0.74 | 0.97 | +0.23 | buy |
| D. E. Shaw & Co., Inc. | 92,158 | 355,533 | +263,375 | 0.02 | 0.05 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 97,979 | 358,548 | +260,569 | 0.06 | 0.14 | +0.08 | buy |
| VANGUARD GROUP INC | 8,572,944 | 8,816,124 | +243,180 | 0.03 | 0.02 | -0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,909,800 | 4,127,610 | +217,810 | 0.09 | 0.07 | -0.02 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 630,961 | 828,708 | +197,747 | 0.18 | 0.17 | -0.01 | buy |
| ORBIMED ADVISORS LLC | 529,200 | 697,500 | +168,300 | 1.38 | 1.35 | -0.03 | buy |
| TWINBEECH CAPITAL LP | 0 | 154,788 | +154,788 | 0.00 | 0.24 | +0.24 | buy |
| Clearbridge Investments, LLC | 0 | 151,127 | +151,127 | 0.00 | 0.01 | +0.01 | buy |
| Aberdeen Group plc | 0 | 146,829 | +146,829 | 0.00 | 0.03 | +0.03 | buy |
| Ikarian Capital, LLC | 0 | 132,640 | +132,640 | 0.00 | 3.50 | +3.50 | buy |
| Pictet Asset Management Holding SA | 964,944 | 1,091,602 | +126,658 | 0.14 | 0.12 | -0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 30,230 | 148,426 | +118,196 | 0.01 | 0.03 | +0.02 | buy |
| CITADEL ADVISORS LLC | 1,227,974 | 1,342,730 | +114,756 | 0.16 | 0.13 | -0.03 | buy |
| Palo Alto Investors LP | 94,030 | 200,905 | +106,875 | 1.08 | 1.75 | +0.67 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 201,313 | 301,771 | +100,458 | 0.03 | 0.03 | +0.00 | buy |
| JANE STREET GROUP, LLC | 84,352 | 182,632 | +98,280 | 0.02 | 0.02 | +0.01 | buy |
| Amundi | 307,487 | 399,367 | +91,880 | 0.02 | 0.02 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 75,696 | +75,696 | 0.00 | 0.09 | +0.09 | buy |
| Trexquant Investment LP | 0 | 67,433 | +67,433 | 0.00 | 0.15 | +0.15 | buy |
| Walleye Capital LLC | 41,768 | 108,841 | +67,073 | 0.08 | 0.15 | +0.07 | buy |
| 683 Capital Management, LLC | 20,000 | 86,600 | +66,600 | 0.25 | 0.84 | +0.59 | buy |
| Jefferies Financial Group Inc. | 0 | 65,733 | +65,733 | 0.00 | 0.10 | +0.10 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 62,800 | +62,800 | 0.00 | 0.08 | +0.08 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 397,456 | 459,102 | +61,646 | 0.29 | 0.22 | -0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,408,775 | 1,469,537 | +60,762 | 0.02 | 0.01 | -0.01 | buy |
| MIZUHO MARKETS AMERICAS LLC | 245,939 | 305,639 | +59,700 | 1.11 | 0.89 | -0.22 | buy |
| Aquatic Capital Management LLC | 0 | 59,500 | +59,500 | 0.00 | 0.15 | +0.15 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 15,500 | 70,600 | +55,100 | 1.37 | 3.83 | +2.47 | buy |
| UBS Group AG | 227,871 | 276,276 | +48,405 | 0.01 | 0.01 | -0.00 | buy |
| Candriam S.C.A. | 135,709 | 182,445 | +46,736 | 0.12 | 0.12 | +0.00 | buy |
| Hudson Bay Capital Management LP | 45,000 | 88,208 | +43,208 | 0.05 | 0.07 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 9,197 | 46,884 | +37,687 | 0.42 | 1.39 | +0.98 | buy |
| PDT Partners, LLC | 0 | 35,225 | +35,225 | 0.00 | 0.38 | +0.38 | buy |
| AGF MANAGEMENT LTD | 0 | 33,917 | +33,917 | 0.00 | 0.02 | +0.02 | buy |
| Rafferty Asset Management, LLC | 74,180 | 103,153 | +28,973 | 0.05 | 0.04 | -0.01 | buy |
| DUALITY ADVISERS, LP | 0 | 28,830 | +28,830 | 0.00 | 0.29 | +0.29 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 21,990 | 49,539 | +27,549 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 27,160 | +27,160 | 0.00 | 0.07 | +0.07 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 26,700 | +26,700 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 18,419 | 45,062 | +26,643 | 0.03 | 0.05 | +0.03 | buy |
| Portman Square Capital LLP | 71,527 | 97,927 | +26,400 | 1.19 | 1.64 | +0.44 | buy |
| HSBC HOLDINGS PLC | 2,515 | 28,513 | +25,998 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 65,674 | 90,335 | +24,661 | 0.05 | 0.05 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,895,320 | 1,919,742 | +24,422 | 0.16 | 0.12 | -0.04 | buy |
| NORGES BANK | 812,965 | 836,849 | +23,884 | 0.02 | 0.01 | -0.01 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 33,892 | 57,749 | +23,857 | 0.13 | 0.19 | +0.06 | buy |
| Simplify Asset Management Inc. | 0 | 23,715 | +23,715 | 0.00 | 0.35 | +0.35 | buy |
| THORNBURG INVESTMENT MANAGEMENT INC | 16,939 | 40,345 | +23,406 | 0.03 | 0.06 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 23,108 | +23,108 | 0.00 | 0.07 | +0.07 | buy |
| LMR Partners LLP | 0 | 22,654 | +22,654 | 0.00 | 0.05 | +0.05 | buy |
| DIMENSIONAL FUND ADVISORS LP | 203,278 | 224,201 | +20,923 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 45,682 | 65,386 | +19,704 | 0.01 | 0.01 | +0.00 | buy |
| JUPITER ASSET MANAGEMENT LTD | 0 | 17,140 | +17,140 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 560,351 | 576,412 | +16,061 | 0.02 | 0.01 | -0.01 | buy |
| Erste Asset Management GmbH | 685,400 | 701,400 | +16,000 | 1.43 | 0.99 | -0.44 | buy |
| Polar Asset Management Partners Inc. | 24,300 | 40,000 | +15,700 | 0.07 | 0.10 | +0.03 | buy |
| Eagle Health Investments LP | 174,212 | 189,356 | +15,144 | 4.65 | 3.71 | -0.94 | buy |
| Jump Financial, LLC | 0 | 14,077 | +14,077 | 0.00 | 0.04 | +0.04 | buy |
| ADVENT CAPITAL MANAGEMENT /DE/ | 0 | 14,000 | +14,000 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 425,423 | 437,566 | +12,143 | 0.01 | 0.01 | -0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 120 | 11,379 | +11,259 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Trading LLC | 29,822 | 39,373 | +9,551 | 0.08 | 0.06 | -0.03 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 9,533 | +9,533 | 0.00 | 0.23 | +0.23 | buy |
| Cetera Investment Advisers | 0 | 9,401 | +9,401 | 0.00 | 0.01 | +0.01 | buy |
| Empowered Funds, LLC | 0 | 9,241 | +9,241 | 0.00 | 0.02 | +0.02 | buy |
| SIMPLEX TRADING, LLC | 23,559 | 32,219 | +8,660 | 0.10 | 0.10 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 2,397 | 10,824 | +8,427 | 0.08 | 0.20 | +0.12 | buy |
| HRT FINANCIAL LP | 0 | 7,612 | +7,612 | 0.00 | 0.01 | +0.01 | buy |
| TOBAM | 148,941 | 156,046 | +7,105 | 1.45 | 1.32 | -0.13 | buy |
| Atom Investors LP | 0 | 6,414 | +6,414 | 0.00 | 0.11 | +0.11 | buy |
| Brevan Howard Capital Management LP | 1,875 | 8,059 | +6,184 | 0.07 | 0.08 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 0 | 6,137 | +6,137 | 0.00 | 0.00 | +0.00 | buy |
| Alpha DNA Investment Management LLC | 0 | 5,832 | +5,832 | 0.00 | 0.33 | +0.33 | buy |
| AE Wealth Management LLC | 0 | 5,805 | +5,805 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 5,558 | +5,558 | 0.00 | 0.05 | +0.05 | buy |
| Mach-1 Financial Group, LLC | 0 | 5,144 | +5,144 | 0.00 | 0.19 | +0.19 | buy |
| EP Wealth Advisors, LLC | 0 | 4,796 | +4,796 | 0.00 | 0.01 | +0.01 | buy |
| NATIONAL BANK OF CANADA /FI/ | 7,493 | 11,993 | +4,500 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 4,454 | +4,454 | 0.00 | 0.04 | +0.04 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 4,403 | +4,403 | 0.00 | 0.20 | +0.20 | buy |
| Point72 Hong Kong Ltd | 0 | 4,168 | +4,168 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 49,172 | 53,320 | +4,148 | 0.00 | 0.00 | -0.00 | buy |
| HighTower Advisors, LLC | 31,949 | 36,071 | +4,122 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 12,190 | 16,277 | +4,087 | 0.08 | 0.07 | -0.01 | buy |
| Virtus Investment Advisers, LLC | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |