| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TORONTO DOMINION BANK | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.01 | +0.01 | buy |
| Capital International Investors | 6,259,282 | 8,697,137 | +2,437,855 | 0.15 | 0.20 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,497,000 | 6,123,000 | +1,626,000 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 364,172 | 1,479,998 | +1,115,826 | 0.01 | 0.04 | +0.03 | buy |
| EcoR1 Capital, LLC | 0 | 770,000 | +770,000 | 0.00 | 3.74 | +3.74 | buy |
| Sofinnova Investments, Inc. | 0 | 428,771 | +428,771 | 0.00 | 3.82 | +3.82 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 2,580,000 | 2,865,100 | +285,100 | 1.77 | 1.84 | +0.07 | buy |
| Vestal Point Capital, LP | 0 | 250,000 | +250,000 | 0.00 | 1.80 | +1.80 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 138,118 | 379,150 | +241,032 | 0.78 | 1.54 | +0.77 | buy |
| Camber Capital Management LP | 775,000 | 1,000,000 | +225,000 | 3.76 | 4.76 | +1.00 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 633,845 | 853,845 | +220,000 | 0.43 | 0.60 | +0.17 | buy |
| DEUTSCHE BANK AG\ | 1,463,176 | 1,663,349 | +200,173 | 0.07 | 0.08 | +0.00 | buy |
| Brandywine Global Investment Management, LLC | 0 | 185,976 | +185,976 | 0.00 | 0.16 | +0.16 | buy |
| GOLDMAN SACHS GROUP INC | 301,021 | 477,066 | +176,045 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 11,023,314 | 11,191,986 | +168,672 | 0.03 | 0.03 | -0.00 | buy |
| NORTHERN TRUST CORP | 655,637 | 803,511 | +147,874 | 0.01 | 0.01 | +0.00 | buy |
| Swedbank AB | 0 | 137,400 | +137,400 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 74,778 | 193,652 | +118,874 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 8,967,552 | 9,085,456 | +117,904 | 0.02 | 0.02 | -0.00 | buy |
| Amundi | 357,919 | 453,732 | +95,813 | 0.02 | 0.02 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 508 | 85,434 | +84,926 | 0.00 | 0.02 | +0.02 | buy |
| MUFG Securities EMEA plc | 0 | 79,000 | +79,000 | 0.00 | 0.18 | +0.18 | buy |
| Erste Asset Management GmbH | 636,065 | 708,248 | +72,183 | 0.95 | 0.93 | -0.02 | buy |
| New Age Alpha Advisors, LLC | 0 | 70,340 | +70,340 | 0.00 | 0.35 | +0.35 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 78,244 | 147,236 | +68,992 | 0.05 | 0.08 | +0.03 | buy |
| Capital Group Private Client Services, Inc. | 60,883 | 119,218 | +58,335 | 0.07 | 0.13 | +0.06 | buy |
| C WorldWide Group Holding A/S | 140,329 | 190,329 | +50,000 | 0.18 | 0.28 | +0.10 | buy |
| Woodline Partners LP | 0 | 46,986 | +46,986 | 0.00 | 0.04 | +0.04 | buy |
| Cutter Capital Management, LP | 83,756 | 124,256 | +40,500 | 3.09 | 6.19 | +3.10 | buy |
| MORGAN STANLEY | 953,104 | 991,655 | +38,551 | 0.01 | 0.01 | -0.00 | buy |
| Crestline Management, LP | 0 | 33,893 | +33,893 | 0.00 | 0.14 | +0.14 | buy |
| ADAR1 Capital Management, LLC | 7,100 | 40,002 | +32,902 | 0.15 | 1.00 | +0.85 | buy |
| NORGES BANK | 1,006,396 | 1,038,861 | +32,465 | 0.02 | 0.02 | -0.00 | buy |
| Proficio Capital Partners LLC | 0 | 31,492 | +31,492 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 268,203 | 299,301 | +31,098 | 0.01 | 0.01 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 280,195 | 310,810 | +30,615 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 459,900 | 490,037 | +30,137 | 0.03 | 0.03 | +0.00 | buy |
| Finepoint Capital LP | 133,535 | 161,935 | +28,400 | 2.03 | 2.27 | +0.24 | buy |
| Aberdeen Group plc | 431,098 | 457,695 | +26,597 | 0.10 | 0.10 | +0.00 | buy |
| Bank of New York Mellon Corp | 2,118,903 | 2,145,484 | +26,581 | 0.05 | 0.05 | -0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 206,583 | 230,893 | +24,310 | 0.51 | 0.49 | -0.03 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 66,279 | 88,808 | +22,529 | 0.01 | 0.01 | +0.00 | buy |
| HSBC HOLDINGS PLC | 158,639 | 180,553 | +21,914 | 0.01 | 0.01 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 21,525 | +21,525 | 0.00 | 0.11 | +0.11 | buy |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 0 | 19,000 | +19,000 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,018 | 19,100 | +18,082 | 0.01 | 0.14 | +0.13 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 17,888 | +17,888 | 0.00 | 0.08 | +0.08 | buy |
| CITIGROUP INC | 56,760 | 74,095 | +17,335 | 0.01 | 0.01 | +0.00 | buy |
| GROUP ONE TRADING LLC | 37,045 | 54,128 | +17,083 | 0.18 | 0.22 | +0.04 | buy |
| CHOREO, LLC | 17,000 | 34,000 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 0 | 16,924 | +16,924 | 0.00 | 0.08 | +0.08 | buy |
| VAN ECK ASSOCIATES CORP | 68,176 | 84,834 | +16,658 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 38,910 | 55,533 | +16,623 | 0.01 | 0.01 | +0.00 | buy |
| Capital International Sarl | 18,848 | 35,256 | +16,408 | 0.06 | 0.10 | +0.04 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 267,037 | 282,084 | +15,047 | 0.02 | 0.02 | +0.00 | buy |
| Capital International, Inc./CA/ | 7,671 | 22,493 | +14,822 | 0.01 | 0.03 | +0.02 | buy |
| 683 Capital Management, LLC | 87,222 | 102,000 | +14,778 | 1.11 | 1.22 | +0.11 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 624,888 | 639,332 | +14,444 | 0.15 | 0.15 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 10,917 | 22,977 | +12,060 | 0.00 | 0.01 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 0 | 12,055 | +12,055 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 611,749 | 623,749 | +12,000 | 0.01 | 0.01 | -0.00 | buy |
| BOKF, NA | 2 | 11,992 | +11,990 | 0.00 | 0.03 | +0.03 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 41,839 | 53,804 | +11,965 | 0.16 | 0.19 | +0.04 | buy |
| PFM Health Sciences, LP | 88,216 | 100,172 | +11,956 | 0.63 | 0.93 | +0.30 | buy |
| INCEPTIONR LLC | 0 | 10,908 | +10,908 | 0.00 | 0.30 | +0.30 | buy |
| NORDEA INVESTMENT MANAGEMENT AB | 56,731 | 67,546 | +10,815 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,946,240 | 1,956,583 | +10,343 | 0.15 | 0.15 | +0.00 | buy |
| SPX Gestao de Recursos Ltda | 0 | 10,000 | +10,000 | 0.00 | 0.18 | +0.18 | buy |
| Sivik Global Healthcare LLC | 0 | 10,000 | +10,000 | 0.00 | 0.67 | +0.67 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,696,354 | 1,706,353 | +9,999 | 0.02 | 0.02 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 954,500 | 963,400 | +8,900 | 2.18 | 2.43 | +0.25 | buy |
| Legal & General Group Plc | 142,862 | 151,356 | +8,494 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 36,352 | 44,390 | +8,038 | 0.10 | 0.12 | +0.02 | buy |
| PineBridge Investments, L.P. | 17,623 | 25,143 | +7,520 | 0.02 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 43,998 | 51,314 | +7,316 | 0.01 | 0.01 | +0.00 | buy |
| Smith Salley Wealth Management | 0 | 7,308 | +7,308 | 0.00 | 0.06 | +0.06 | buy |
| ARCADIA INVESTMENT MANAGEMENT CORP/MI | 0 | 6,935 | +6,935 | 0.00 | 0.13 | +0.13 | buy |
| MIZUHO MARKETS AMERICAS LLC | 399,065 | 405,715 | +6,650 | 1.22 | 0.95 | -0.28 | buy |
| Corient Private Wealth LLC | 0 | 6,468 | +6,468 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 47,543 | 53,438 | +5,895 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 69,206 | 74,984 | +5,778 | 0.23 | 0.21 | -0.02 | buy |
| SEI INVESTMENTS CO | 18,171 | 23,935 | +5,764 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 5,580 | +5,580 | 0.00 | 0.05 | +0.05 | buy |
| Tower Research Capital LLC (TRC) | 9,151 | 14,522 | +5,371 | 0.03 | 0.04 | +0.00 | buy |
| Bridgewater Associates, LP | 0 | 5,245 | +5,245 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 236,533 | 241,663 | +5,130 | 0.00 | 0.00 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 8,338 | 13,242 | +4,904 | 0.04 | 0.06 | +0.02 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 40,767 | 45,614 | +4,847 | 0.00 | 0.00 | +0.00 | buy |
| Yorktown Management & Research Co Inc | 0 | 4,600 | +4,600 | 0.00 | 0.54 | +0.54 | buy |
| NOMURA HOLDINGS INC | 158,890 | 163,352 | +4,462 | 0.15 | 0.10 | -0.04 | buy |
| MetLife Investment Management, LLC | 53,327 | 57,749 | +4,422 | 0.04 | 0.04 | -0.00 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 14,073 | 18,430 | +4,357 | 0.08 | 0.09 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 57,860 | 62,058 | +4,198 | 0.02 | 0.02 | +0.00 | buy |
| SYON CAPITAL LLC | 0 | 4,112 | +4,112 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 111,367 | 115,458 | +4,091 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 21,336 | 25,412 | +4,076 | 0.01 | 0.01 | -0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 3,830 | +3,830 | 0.00 | 0.04 | +0.04 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 25,681 | 29,457 | +3,776 | 0.07 | 0.08 | +0.01 | buy |
| ASSETMARK, INC | 39,025 | 42,759 | +3,734 | 0.01 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 24,391 | 27,965 | +3,574 | 0.00 | 0.00 | -0.00 | buy |