Ionis Pharmaceuticals Inc
| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 17,961,299 | 21,186,369 | +3,225,070 | 0.19 | 0.22 | +0.02 | buy |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 2,340,000 | +2,340,000 | 0.25 | 0.24 | -0.01 | buy |
| Artisan Partners Limited Partnership | 1,181,416 | 2,058,308 | +876,892 | 0.14 | 0.25 | +0.11 | buy |
| BAKER BROS. ADVISORS LP | 1,791,841 | 2,047,727 | +255,886 | 0.83 | 0.88 | +0.05 | buy |
| Deep Track Capital, LP | 1,700,000 | 1,950,000 | +250,000 | 3.07 | 3.02 | -0.05 | buy |
| J. Goldman & Co LP | 67,639 | 235,260 | +167,621 | 0.21 | 0.82 | +0.61 | buy |
| Eversept Partners, LP | 538,218 | 632,100 | +93,882 | 2.39 | 3.13 | +0.74 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 584,970 | 672,858 | +87,888 | 0.16 | 0.20 | +0.04 | buy |
| Aberdeen Group plc | 28,926 | 113,843 | +84,917 | 0.00 | 0.01 | +0.01 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 417,833 | 500,522 | +82,689 | 10.37 | 11.51 | +1.14 | buy |
| GROUPAMA ASSET MANAGMENT | 766,889 | 824,540 | +57,651 | 0.89 | 0.90 | +0.02 | buy |
| Privium Fund Management B.V. | 240,824 | 290,024 | +49,200 | 3.51 | 4.53 | +1.03 | buy |
| Lisanti Capital Growth, LLC | 32,789 | 75,699 | +42,910 | 0.61 | 1.43 | +0.82 | buy |
| China Universal Asset Management Co., Ltd. | 42,394 | 77,315 | +34,921 | 0.26 | 0.44 | +0.18 | buy |
| E Fund Management Co., Ltd. | 16,160 | 46,688 | +30,528 | 0.03 | 0.10 | +0.07 | buy |
| Voleon Capital Management LP | 4,288 | 23,047 | +18,759 | 0.01 | 0.04 | +0.03 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 203,730 | 219,220 | +15,490 | 0.24 | 0.24 | +0.01 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 122,190 | 137,190 | +15,000 | 0.14 | 0.15 | +0.01 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 25,017 | 38,988 | +13,971 | 0.29 | 4.26 | +3.97 | buy |
| Legato Capital Management LLC | 6,155 | 19,840 | +13,685 | 0.04 | 0.14 | +0.09 | buy |
| ADAR1 Capital Management, LLC | 147,130 | 160,338 | +13,208 | 0.87 | 0.72 | -0.15 | buy |
| Future Fund LLC | 45,851 | 58,732 | +12,881 | 1.15 | 1.55 | +0.40 | buy |
| One Capital Management, LLC | 46,121 | 58,939 | +12,818 | 0.11 | 0.12 | +0.01 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 17,410 | 27,924 | +10,514 | 0.01 | 0.01 | +0.00 | buy |
| BAMCO INC /NY/ | 36,000 | 45,000 | +9,000 | 0.01 | 0.01 | +0.00 | buy |
| WEST MICHIGAN ADVISORS, LLC | 38,413 | 44,614 | +6,201 | 0.70 | 0.74 | +0.04 | buy |
| Swedbank AB | 27,253 | 32,253 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Stanley-Laman Group, Ltd. | 36,512 | 39,306 | +2,794 | 0.37 | 0.36 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 109,291 | 111,830 | +2,539 | 0.18 | 0.18 | -0.01 | buy |
| Virtus Investment Advisers, LLC | 8,454 | 10,445 | +1,991 | 0.18 | 0.22 | +0.03 | buy |
| Wedmont Private Capital | 5,536 | 6,564 | +1,028 | 0.02 | 0.02 | -0.00 | buy |
| Raiffeisen Bank International AG | 35,000 | 36,000 | +1,000 | 0.04 | 0.04 | +0.00 | buy |
| ANB BANK | 3,193 | 3,769 | +576 | 0.10 | 0.11 | +0.01 | buy |
| Granite Investment Partners, LLC | 4,806 | 5,345 | +539 | 0.02 | 0.02 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 15 | 550 | +535 | 0.00 | 0.01 | +0.00 | buy |
| Dana Investment Advisors, Inc. | 18,026 | 18,487 | +461 | 0.04 | 0.04 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,183 | 3,637 | +454 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 13,875 | 14,316 | +441 | 0.02 | 0.02 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,157 | 3,502 | +345 | 0.00 | 0.00 | +0.00 | buy |
| Checchi Capital Advisers, LLC | 4,272 | 4,429 | +157 | 0.02 | 0.02 | -0.00 | buy |
| Dynasty Wealth Management, LLC | 13,990 | 14,080 | +90 | 0.01 | 0.01 | -0.00 | buy |
| Meeder Advisory Services, Inc. | 7,156 | 7,239 | +83 | 0.02 | 0.02 | -0.00 | buy |
| REGIONS FINANCIAL CORP | 6,089 | 6,122 | +33 | 0.00 | 0.00 | -0.00 | buy |
| BERKSHIRE ASSET MANAGEMENT LLC/PA | 3,630 | 3,637 | +7 | 0.01 | 0.01 | -0.00 | buy |
| Everhart Financial Group, Inc. | 3,465 | 3,470 | +5 | 0.03 | 0.02 | -0.00 | buy |
| Quaker Wealth Management, LLC | 14 | 15 | +1 | 0.00 | 0.00 | +0.00 | buy |
| CAPITAL COUNSEL LLC/NY | 49,605 | 49,580 | -25 | 0.15 | 0.16 | +0.01 | sell |
| B. Riley Wealth Advisors, Inc. | 2,975 | 2,945 | -30 | 0.01 | 0.01 | +0.00 | sell |
| Global X Japan Co., Ltd. | 171 | 128 | -43 | 0.00 | 0.00 | -0.00 | sell |
| NORDEN GROUP LLC | 2,935 | 2,889 | -46 | 0.02 | 0.02 | -0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 8,861 | 8,790 | -71 | 0.16 | 0.17 | +0.01 | sell |
| Steigerwald, Gordon & Koch Inc. | 380 | 295 | -85 | 0.00 | 0.00 | -0.00 | sell |
| Significant Wealth Partners LLC | 6,764 | 6,664 | -100 | 0.60 | 0.62 | +0.02 | sell |
| MITCHELL & PAHL PRIVATE WEALTH, LLC | 3,379 | 3,261 | -118 | 0.11 | 0.10 | -0.01 | sell |
| Orion Investment Co | 225,161 | 225,015 | -146 | 5.43 | 5.36 | -0.07 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 7,242 | 7,053 | -189 | 0.00 | 0.00 | -0.00 | sell |
| GRANDFIELD & DODD, LLC | 37,821 | 37,326 | -495 | 0.17 | 0.16 | -0.01 | sell |
| Elequin Capital, LP | 711 | 208 | -503 | 0.01 | 0.00 | -0.01 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 11,952 | 11,428 | -524 | 0.01 | 0.01 | -0.00 | sell |
| PRAXIS INVESTMENT MANAGEMENT INC | 6,770 | 6,232 | -538 | 0.03 | 0.03 | -0.00 | sell |
| MEEDER ASSET MANAGEMENT INC | 716 | 152 | -564 | 0.00 | 0.00 | -0.00 | sell |
| Bayforest Capital Ltd | 1,091 | 413 | -678 | 0.06 | 0.03 | -0.03 | sell |
| Inspire Advisors, LLC | 4,851 | 4,120 | -731 | 0.04 | 0.03 | -0.01 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 15,168 | 14,389 | -779 | 0.08 | 0.08 | -0.00 | sell |
| Cambria Investment Management, L.P. | 3,684 | 2,885 | -799 | 0.02 | 0.01 | -0.00 | sell |
| Nicollet Investment Management, Inc. | 20,523 | 19,646 | -877 | 0.51 | 0.51 | -0.01 | sell |
| Employees Retirement System of Texas | 1,354 | 378 | -976 | 0.00 | 0.00 | -0.00 | sell |
| INCEPTIONR LLC | 17,850 | 16,821 | -1,029 | 0.39 | 0.30 | -0.09 | sell |
| SECTORAL ASSET MANAGEMENT INC | 8,365 | 7,200 | -1,165 | 0.53 | 0.51 | -0.02 | sell |
| Qsemble Capital Management, LP | 27,579 | 25,758 | -1,821 | 0.18 | 0.15 | -0.03 | sell |
| TEMA ETFS LLC | 8,557 | 5,673 | -2,884 | 0.05 | 0.03 | -0.02 | sell |
| CenterBook Partners LP | 153,949 | 150,912 | -3,037 | 0.60 | 0.61 | +0.01 | sell |
| Cypress Capital, LLC | 10,000 | 6,000 | -4,000 | 0.22 | 0.13 | -0.09 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 24,155 | 20,146 | -4,009 | 0.13 | 0.10 | -0.03 | sell |
| Sicart Associates LLC | 163,557 | 159,412 | -4,145 | 3.43 | 3.07 | -0.36 | sell |
| Harvest Fund Management Co., Ltd | 4,816 | 234 | -4,582 | 0.01 | 0.00 | -0.01 | sell |
| Exome Asset Management LLC | 116,515 | 110,064 | -6,451 | 4.55 | 4.86 | +0.31 | sell |
| Blueshift Asset Management, LLC | 10,443 | 2,777 | -7,666 | 0.24 | 0.06 | -0.18 | sell |
| Lighthouse Investment Partners, LLC | 13,082 | 4,970 | -8,112 | 0.03 | 0.01 | -0.02 | sell |
| Alyeska Investment Group, L.P. | 481,711 | 473,150 | -8,561 | 0.11 | 0.10 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 38,423 | 28,452 | -9,971 | 0.01 | 0.01 | -0.00 | sell |
| J. Safra Sarasin Holding AG | 17,404 | 6,431 | -10,973 | 0.02 | 0.01 | -0.01 | sell |
| Boussard & Gavaudan Investment Management LLP | 12,750 | 1,000 | -11,750 | 1.53 | 0.14 | -1.39 | sell |
| Nikko Asset Management Americas, Inc. | 93,571 | 81,696 | -11,875 | 0.09 | 0.09 | +0.00 | sell |
| SECTOR GAMMA AS | 184,977 | 169,468 | -15,509 | 3.34 | 3.00 | -0.33 | sell |
| Zurich Insurance Group Ltd/FI | 261,820 | 239,645 | -22,175 | 0.14 | 0.14 | -0.00 | sell |
| PINNACLE ASSOCIATES LTD | 461,968 | 436,457 | -25,511 | 0.47 | 0.42 | -0.05 | sell |
| BLB&B Advisors, LLC | 61,520 | 35,170 | -26,350 | 0.20 | 0.11 | -0.09 | sell |
| GREAT LAKES ADVISORS, LLC | 149,180 | 118,926 | -30,254 | 0.10 | 0.07 | -0.02 | sell |
| Informed Momentum Co LLC | 53,914 | 20,608 | -33,306 | 0.48 | 0.18 | -0.30 | sell |
| NICOLA WEALTH MANAGEMENT LTD. | 87,000 | 52,000 | -35,000 | 0.63 | 0.47 | -0.16 | sell |
| DCF Advisers, LLC | 103,000 | 56,000 | -47,000 | 2.69 | 1.59 | -1.11 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 1,462,706 | 1,404,033 | -58,673 | 3.26 | 4.88 | +1.62 | sell |
| Atle Fund Management AB | 92,377 | 27,873 | -64,504 | 2.33 | 3.03 | +0.70 | sell |
| Rhenman & Partners Asset Management AB | 158,500 | 92,900 | -65,600 | 1.17 | 0.86 | -0.31 | sell |
| Ikarian Capital, LLC | 202,038 | 127,038 | -75,000 | 2.07 | 1.36 | -0.70 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 140,000 | 50,000 | -90,000 | 0.02 | 0.01 | -0.01 | sell |
| ARK Investment Management LLC | 422,968 | 288,716 | -134,252 | 0.22 | 0.17 | -0.05 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 812,747 | 666,116 | -146,631 | 0.02 | 0.02 | -0.00 | sell |
| Tweedy, Browne Co LLC | 2,464,930 | 2,275,625 | -189,305 | 15.74 | 13.57 | -2.17 | sell |