| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 839,463 | 2,252,089 | +1,412,626 | 0.01 | 0.02 | +0.01 | buy |
| Artisan Partners Limited Partnership | 416,729 | 1,671,036 | +1,254,307 | 0.03 | 0.12 | +0.09 | buy |
| BVF INC/IL | 2,428,613 | 3,186,376 | +757,763 | 2.89 | 4.26 | +1.36 | buy |
| Deep Track Capital, LP | 1,373,475 | 2,000,000 | +626,525 | 1.71 | 2.85 | +1.14 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,522,203 | 3,934,311 | +412,108 | 0.02 | 0.02 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,013,033 | 2,372,333 | +359,300 | 1.60 | 2.25 | +0.65 | buy |
| GROUPAMA ASSET MANAGMENT | 257,868 | 379,976 | +122,108 | 0.31 | 0.25 | -0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,364,256 | 2,484,544 | +120,288 | 0.01 | 0.01 | 0.00 | buy |
| Eversept Partners, LP | 376,438 | 456,881 | +80,443 | 1.09 | 1.49 | +0.40 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 159,380 | 225,070 | +65,690 | 0.11 | 0.18 | +0.06 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 115,658 | 56,222 | +59,436 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,083,879 | 1,028,142 | +55,737 | 0.12 | 0.12 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 898,362 | 952,762 | +54,400 | 0.04 | 0.04 | +0.01 | buy |
| ALGERT GLOBAL LLC | 30,242 | 75,350 | +45,108 | 0.05 | 0.12 | 0.00 | buy |
| Candriam S.C.A. | 911,897 | 948,266 | +36,369 | 0.25 | 0.27 | +0.02 | buy |
| Hudson Bay Capital Management LP | 335,500 | 366,000 | +30,500 | 0.08 | 0.08 | +0.00 | buy |
| NOMURA HOLDINGS INC | 470,837 | 501,188 | +30,351 | 0.17 | 0.16 | 0.00 | buy |
| Aberdeen Group plc | 219,421 | 246,917 | +27,496 | 0.02 | 0.02 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 29,844 | 52,552 | +22,708 | 0.01 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 226,993 | 247,267 | +20,274 | 2.63 | 2.85 | +0.22 | buy |
| Parkman Healthcare Partners LLC | 141,499 | 161,705 | +20,206 | 0.75 | 1.03 | +0.28 | buy |
| NICOLA WEALTH MANAGEMENT LTD. | 56,000 | 74,000 | +18,000 | 0.32 | 0.43 | +0.11 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 118,598 | 132,024 | +13,426 | 0.15 | 0.18 | +0.04 | buy |
| NEOS Investment Management LLC | 37,303 | 45,058 | +7,755 | 0.10 | 0.09 | -0.01 | buy |
| BLB&B Advisors, LLC | 146,100 | 153,750 | +7,650 | 0.36 | 0.40 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 215,893 | 209,194 | +6,699 | 0.12 | 0.11 | 0.00 | sell |
| COMMERCE BANK | 82,433 | 76,342 | +6,091 | 0.02 | 0.02 | 0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 249,527 | 254,343 | +4,816 | 0.22 | 0.26 | +0.04 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 9,826 | 5,777 | +4,049 | 0.01 | 0.00 | 0.00 | sell |
| Swiss National Bank | 254,900 | 258,000 | +3,100 | 0.01 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 28,144 | 31,155 | +3,011 | 0.00 | 0.00 | 0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 131,818 | 129,216 | +2,602 | 0.01 | 0.01 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 778,593 | 780,753 | +2,160 | 0.09 | 0.10 | +0.01 | buy |
| PROFUND ADVISORS LLC | 31,570 | 29,983 | +1,587 | 0.05 | 0.05 | 0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 571,763 | 572,870 | +1,107 | 0.11 | 0.11 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 54,493 | 55,296 | +803 | 0.01 | 0.01 | 0.00 | buy |
| Treasurer of the State of North Carolina | 63,582 | 63,113 | +469 | 0.01 | 0.01 | 0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 35,850 | 35,389 | +461 | 0.01 | 0.01 | 0.00 | sell |
| E Fund Management Co., Ltd. | 9,825 | 10,255 | +430 | 0.03 | 0.03 | +0.00 | buy |
| Midwest Professional Planners, LTD. | 9,716 | 10,140 | +424 | 0.15 | 0.16 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 7,648 | 8,009 | +361 | 0.18 | 0.19 | +0.01 | buy |
| CI INVESTMENTS INC. | 3,967 | 3,652 | +315 | 0.00 | 0.00 | 0.00 | sell |
| GRANDFIELD & DODD, LLC | 33,774 | 34,053 | +279 | 0.09 | 0.10 | +0.01 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 42,412 | 42,595 | +183 | 0.13 | 0.13 | 0.00 | buy |
| Plancorp, LLC | 11,155 | 11,286 | +131 | 0.02 | 0.02 | +0.00 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 341 | 218 | +123 | 0.00 | 0.00 | 0.00 | sell |
| Riggs Asset Managment Co. Inc. | 282 | 250 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Washington Trust Advisors, Inc. | 258 | 111 | -147 | 0.00 | 0.00 | -0.00 | sell |
| Global X Japan Co., Ltd. | 669 | 262 | -407 | 0.01 | 0.00 | -0.00 | sell |
| Westmount Partners, LLC | 13,872 | 13,462 | -410 | 0.22 | 0.21 | -0.01 | sell |
| Nicollet Investment Management, Inc. | 20,521 | 20,108 | -413 | 0.33 | 0.36 | +0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 10,100 | 9,660 | -440 | 0.17 | 0.19 | +0.01 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 13,315 | 12,805 | -510 | 0.01 | 0.01 | +0.00 | sell |
| Horizon Investments, LLC | 2,347 | 1,494 | -853 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 2,900 | 1,500 | -1,400 | 0.03 | 0.01 | -0.02 | sell |
| NATIXIS | 1,961 | 163 | -1,798 | 0.00 | 0.00 | -0.00 | sell |
| Granite Investment Partners, LLC | 116,144 | 114,090 | -2,054 | 0.19 | 0.23 | +0.03 | sell |
| Sicart Associates LLC | 193,993 | 191,523 | -2,470 | 3.08 | 3.50 | +0.42 | sell |
| CAPITAL COUNSEL LLC/NY | 39,580 | 37,080 | -2,500 | 0.08 | 0.08 | +0.00 | sell |
| Teza Capital Management LLC | 29,936 | 25,159 | -4,777 | 0.17 | 0.15 | -0.03 | sell |
| SECTOR GAMMA AS | 175,507 | 170,000 | -5,507 | 2.14 | 3.03 | +0.88 | sell |
| PINNACLE ASSOCIATES LTD | 459,758 | 453,379 | -6,379 | 0.31 | 0.34 | +0.02 | sell |
| ALTRINSIC GLOBAL ADVISORS LLC | 194,864 | 187,831 | -7,033 | 0.38 | 0.40 | +0.02 | sell |
| China Universal Asset Management Co., Ltd. | 28,027 | 17,150 | -10,877 | 0.15 | 0.12 | -0.04 | sell |
| Swedbank AB | 142,641 | 129,373 | -13,268 | 0.05 | 0.01 | -0.05 | sell |
| Lisanti Capital Growth, LLC | 27,835 | 10,845 | -16,990 | 0.29 | 0.12 | -0.17 | sell |
| Pearl River Capital, LLC | 25,959 | 6,187 | -19,772 | 0.18 | 0.05 | -0.13 | sell |
| Nikko Asset Management Americas, Inc. | 220,261 | 199,231 | -21,030 | 0.09 | 0.11 | +0.01 | sell |
| Atle Fund Management AB | 63,791 | 40,691 | -23,100 | 1.68 | 1.18 | -0.50 | sell |
| BAILLIE GIFFORD & CO | 295,683 | 260,254 | -35,429 | 0.01 | 0.01 | -0.00 | sell |
| Avidity Partners Management LP | 130,000 | 93,000 | -37,000 | 0.20 | 0.19 | -0.01 | sell |
| ARK Investment Management LLC | 1,399,852 | 1,361,025 | -38,827 | 0.42 | 0.58 | +0.16 | sell |
| Bellevue Group AG | 8,299,514 | 8,260,434 | -39,080 | 5.49 | 6.40 | +0.91 | sell |
| Rafferty Asset Management, LLC | 208,469 | 168,856 | -39,613 | 0.03 | 0.03 | -0.00 | sell |
| Zimmer Partners, LP | 270,300 | 200,000 | -70,300 | 0.25 | 0.18 | -0.07 | sell |
| Susquehanna Portfolio Strategies, LLC | 130,986 | 43,028 | -87,958 | 0.13 | 0.08 | -0.05 | sell |
| Cutter Capital Management, LP | 289,366 | 160,166 | -129,200 | 4.84 | 2.33 | -2.51 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | 800,000 | -200,000 | 0.08 | 0.07 | -0.01 | sell |
| J. Goldman & Co LP | 231,424 | 17,502 | -213,922 | 0.32 | 0.02 | -0.30 | sell |
| Liontrust Investment Partners LLP | 288,544 | 59,644 | -228,900 | 0.17 | 0.04 | -0.13 | sell |
| T. Rowe Price Investment Management, Inc. | 13,317,112 | 12,639,684 | -677,428 | 0.35 | 0.38 | +0.03 | sell |
| Clearbridge Investments, LLC | 4,466,191 | 2,160,270 | -2,305,921 | 0.15 | 0.08 | -0.07 | sell |