| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANE STREET GROUP, LLC | 0 | 21,797,000 | +21,797,000 | 0.00 | 0.03 | +0.03 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.01 | +0.01 | buy |
| Liberty Mutual Group Asset Management Inc. | 0 | 2,020,000 | +2,020,000 | 0.00 | 0.33 | +0.33 | buy |
| Capital World Investors | 839,463 | 2,252,089 | +1,412,626 | 0.01 | 0.02 | +0.01 | buy |
| Artisan Partners Limited Partnership | 416,729 | 1,671,036 | +1,254,307 | 0.03 | 0.12 | +0.09 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,077,321 | +1,077,321 | 0.00 | 0.13 | +0.13 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 5,695,699 | 6,568,808 | +873,109 | 0.04 | 0.06 | +0.01 | buy |
| BVF INC/IL | 2,428,613 | 3,186,376 | +757,763 | 2.89 | 4.26 | +1.36 | buy |
| Deep Track Capital, LP | 1,373,475 | 2,000,000 | +626,525 | 1.71 | 2.85 | +1.14 | buy |
| Schonfeld Strategic Advisors LLC | 170,860 | 723,618 | +552,758 | 0.06 | 0.27 | +0.21 | buy |
| CITADEL ADVISORS LLC | 78,030 | 627,033 | +549,003 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 442,887 | 968,917 | +526,030 | 0.00 | 0.01 | +0.01 | buy |
| TORONTO DOMINION BANK | 5,500,000 | 6,000,000 | +500,000 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 13,430,456 | 13,845,712 | +415,256 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,522,203 | 3,934,311 | +412,108 | 0.02 | 0.02 | +0.00 | buy |
| Man Group plc | 253,221 | 633,409 | +380,188 | 0.03 | 0.08 | +0.05 | buy |
| ORBIMED ADVISORS LLC | 2,013,033 | 2,372,333 | +359,300 | 1.60 | 2.25 | +0.65 | buy |
| GREAT POINT PARTNERS LLC | 0 | 330,000 | +330,000 | 0.00 | 3.01 | +3.01 | buy |
| Logos Global Management LP | 0 | 300,000 | +300,000 | 0.00 | 1.65 | +1.65 | buy |
| Bank of New York Mellon Corp | 0 | 250,000 | +250,000 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 250,000 | +250,000 | 0.00 | 1.19 | +1.19 | buy |
| TWO SIGMA ADVISERS, LP | 1,040,111 | 1,287,111 | +247,000 | 0.10 | 0.14 | +0.03 | buy |
| Caption Management, LLC | 0 | 160,000 | +160,000 | 0.00 | 0.81 | +0.81 | buy |
| MARSHALL WACE, LLP | 15,443 | 173,199 | +157,756 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 140,238 | +140,238 | 0.00 | 1.09 | +1.09 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 186,327 | 320,290 | +133,963 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 130,000 | +130,000 | 0.00 | 0.59 | +0.59 | buy |
| GOLDMAN SACHS GROUP INC | 200,380 | 328,305 | +127,925 | 0.00 | 0.00 | +0.00 | buy |
| GROUPAMA ASSET MANAGMENT | 257,868 | 379,976 | +122,108 | 0.31 | 0.25 | -0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,364,256 | 2,484,544 | +120,288 | 0.01 | 0.01 | +0.00 | buy |
| HRT FINANCIAL LP | 66,503 | 159,685 | +93,182 | 0.02 | 0.04 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 132,710 | 215,716 | +83,006 | 0.01 | 0.01 | +0.01 | buy |
| Eversept Partners, LP | 376,438 | 456,881 | +80,443 | 1.22 | 1.67 | +0.45 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 179,714 | 249,514 | +69,800 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA SECURITIES, LLC | 11,122 | 80,198 | +69,076 | 0.02 | 0.18 | +0.16 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 159,380 | 225,070 | +65,690 | 0.11 | 0.18 | +0.06 | buy |
| Artia Global Partners LP | 0 | 62,479 | +62,479 | 0.00 | 0.76 | +0.76 | buy |
| JANE STREET GROUP, LLC | 118,132 | 179,246 | +61,114 | 0.01 | 0.01 | +0.00 | buy |
| GTS SECURITIES LLC | 0 | 60,930 | +60,930 | 0.00 | 0.06 | +0.06 | buy |
| SIMPLEX TRADING, LLC | 8,530 | 63,347 | +54,817 | 0.01 | 0.10 | +0.09 | buy |
| TD ASSET MANAGEMENT INC | 898,362 | 952,762 | +54,400 | 0.04 | 0.04 | +0.01 | buy |
| SEI INVESTMENTS CO | 79,887 | 132,311 | +52,424 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF NOVA SCOTIA | 0 | 51,879 | +51,879 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 50,956 | +50,956 | 0.00 | 0.15 | +0.15 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 56,000 | 103,000 | +47,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,863 | 49,986 | +45,123 | 0.01 | 0.04 | +0.04 | buy |
| ALGERT GLOBAL LLC | 30,242 | 75,350 | +45,108 | 0.05 | 0.12 | +0.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 44,256 | +44,256 | 0.00 | 0.01 | +0.01 | buy |
| CHOREO, LLC | 0 | 42,000 | +42,000 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 54,196 | 95,119 | +40,923 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 577,387 | 615,674 | +38,287 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 911,897 | 948,266 | +36,369 | 0.25 | 0.27 | +0.02 | buy |
| STATE STREET CORP | 4,155,664 | 4,190,505 | +34,841 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 21,862,735 | 21,894,806 | +32,071 | 0.06 | 0.07 | +0.00 | buy |
| Hudson Bay Capital Management LP | 335,500 | 366,000 | +30,500 | 0.13 | 0.13 | +0.00 | buy |
| NOMURA HOLDINGS INC | 470,837 | 501,188 | +30,351 | 0.17 | 0.15 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 160,482 | 190,781 | +30,299 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 245,067 | 274,850 | +29,783 | 0.01 | 0.01 | +0.00 | buy |
| Aberdeen Group plc | 219,421 | 246,917 | +27,496 | 0.02 | 0.02 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,301,368 | 1,328,106 | +26,738 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 692,247 | 717,975 | +25,728 | 0.01 | 0.01 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 28,736 | 52,552 | +23,816 | 0.01 | 0.01 | +0.01 | buy |
| DCF Advisers, LLC | 0 | 23,000 | +23,000 | 0.00 | 0.57 | +0.57 | buy |
| Privium Fund Management B.V. | 226,993 | 247,267 | +20,274 | 2.63 | 2.85 | +0.22 | buy |
| Parkman Healthcare Partners LLC | 141,499 | 161,705 | +20,206 | 0.75 | 1.05 | +0.30 | buy |
| NICOLA WEALTH MANAGEMENT LTD. | 56,000 | 74,000 | +18,000 | 0.32 | 0.43 | +0.11 | buy |
| INCEPTIONR LLC | 0 | 17,289 | +17,289 | 0.00 | 0.23 | +0.23 | buy |
| Brevan Howard Capital Management LP | 4,924 | 21,847 | +16,923 | 0.02 | 0.07 | +0.05 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 15,717 | +15,717 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 53,320 | 68,270 | +14,950 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 583,589 | 597,479 | +13,890 | 0.00 | 0.01 | +0.00 | buy |
| PDT Partners, LLC | 0 | 13,430 | +13,430 | 0.00 | 0.06 | +0.06 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 118,598 | 132,024 | +13,426 | 0.15 | 0.18 | +0.04 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 13,098 | +13,098 | 0.00 | 0.01 | +0.01 | buy |
| Stratos Wealth Partners, LTD. | 0 | 12,791 | +12,791 | 0.00 | 0.01 | +0.01 | buy |
| Parallax Volatility Advisers, L.P. | 0 | 12,310 | +12,310 | 0.00 | 0.01 | +0.01 | buy |
| Annis Gardner Whiting Capital Advisors, LLC | 0 | 9,396 | +9,396 | 0.00 | 0.13 | +0.13 | buy |
| WOLVERINE TRADING, LLC | 12,047 | 21,328 | +9,281 | 0.01 | 0.02 | +0.01 | buy |
| Walleye Capital LLC | 89,130 | 97,871 | +8,741 | 0.04 | 0.05 | +0.01 | buy |
| Clearstead Advisors, LLC | 495 | 8,285 | +7,790 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 37,303 | 45,058 | +7,755 | 0.10 | 0.09 | -0.01 | buy |
| BLB&B Advisors, LLC | 146,100 | 153,750 | +7,650 | 0.36 | 0.40 | +0.04 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 5,600 | +5,600 | 0.00 | 0.01 | +0.01 | buy |
| Bridgefront Capital, LLC | 0 | 5,559 | +5,559 | 0.00 | 0.11 | +0.11 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 5,421 | +5,421 | 0.00 | 0.05 | +0.05 | buy |
| HSBC HOLDINGS PLC | 0 | 5,326 | +5,326 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 249,527 | 254,343 | +4,816 | 0.22 | 0.26 | +0.04 | buy |
| MITCHELL & PAHL PRIVATE WEALTH, LLC | 0 | 4,540 | +4,540 | 0.00 | 0.11 | +0.11 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 4,508 | +4,508 | 0.00 | 0.00 | +0.00 | buy |
| Checchi Capital Advisers, LLC | 0 | 4,234 | +4,234 | 0.00 | 0.02 | +0.02 | buy |
| CANADA LIFE ASSURANCE Co | 41,880 | 45,548 | +3,668 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 3,401 | +3,401 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 254,900 | 258,000 | +3,100 | 0.01 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 28,144 | 31,155 | +3,011 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 5,848 | 8,826 | +2,978 | 0.00 | 0.00 | +0.00 | buy |
| Twin Tree Management, LP | 7,563 | 10,381 | +2,818 | 0.01 | 0.01 | +0.01 | buy |
| Redwood Wealth Management Group, LLC | 0 | 2,408 | +2,408 | 0.00 | 0.09 | +0.09 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 3,842 | 6,074 | +2,232 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 778,593 | 780,753 | +2,160 | 0.09 | 0.10 | +0.01 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 7,607 | 9,707 | +2,100 | 0.03 | 0.04 | +0.01 | buy |