| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 23,613,585 | 23,642,990 | +29,405 | 0.05 | 0.05 | +0.01 | buy |
| VANGUARD GROUP INC | 16,383,934 | 16,714,846 | +330,912 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 16,175,533 | 16,048,721 | -126,812 | 0.32 | 0.40 | +0.08 | sell |
| Capital World Investors | 12,361,994 | 12,540,188 | +178,194 | 0.06 | 0.07 | +0.01 | buy |
| BlackRock, Inc. | 11,264,442 | 10,896,937 | -367,505 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,956,000 | 8,108,000 | +3,152,000 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 7,853,198 | 7,853,198 | 0 | 5.31 | 6.84 | +1.53 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 8,416,421 | 6,345,776 | -2,070,645 | 0.05 | 0.05 | -0.00 | sell |
| Sonora Investment Management Group, LLC | 5,499,000 | 5,285,000 | -214,000 | 0.42 | 0.41 | -0.01 | sell |
| Deep Track Capital, LP | 4,564,207 | 4,891,544 | +327,337 | 4.46 | 6.21 | +1.75 | buy |
| STATE STREET CORP | 4,845,133 | 4,530,398 | -314,735 | 0.01 | 0.01 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,075,600 | 3,800,000 | +2,724,400 | 0.06 | 0.25 | +0.19 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,265,034 | 3,126,073 | -138,961 | 0.01 | 0.01 | +0.00 | sell |
| Tweedy, Browne Co LLC | 2,983,518 | 2,891,948 | -91,570 | 7.98 | 10.60 | +2.62 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,842,954 | 2,891,095 | +48,141 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 2,092,011 | 2,667,611 | +575,600 | 0.14 | 0.22 | +0.07 | buy |
| MILLENNIUM MANAGEMENT LLC | 635,370 | 2,649,527 | +2,014,157 | 0.02 | 0.09 | +0.08 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,499,999 | 2,500,000 | +1 | 0.01 | 0.01 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.01 | +0.01 | buy |
| BVF INC/IL | 1,913,385 | 1,913,385 | 0 | 2.35 | 2.70 | +0.35 | hold |
| TWO SIGMA INVESTMENTS, LP | 1,685,853 | 1,788,367 | +102,514 | 0.11 | 0.13 | +0.02 | buy |
| UBS Group AG | 1,890,602 | 1,529,323 | -361,279 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 3,480,062 | 1,494,981 | -1,985,081 | 0.10 | 0.05 | -0.05 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,443,629 | 1,487,818 | +44,189 | 0.01 | 0.01 | +0.00 | buy |
| MACQUARIE GROUP LTD | 1,667,194 | 1,434,073 | -233,121 | 0.06 | 0.07 | +0.01 | sell |
| MORGAN STANLEY | 1,144,181 | 1,362,209 | +218,028 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,196,392 | 1,350,879 | +154,487 | 0.10 | 0.13 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 1,100,466 | 1,104,690 | +4,224 | 0.03 | 0.04 | +0.01 | buy |
| Polar Capital Holdings Plc | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.21 | +0.21 | buy |
| BANK OF AMERICA CORP /DE/ | 767,432 | 995,890 | +228,458 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 1,000,527 | 900,318 | -100,209 | 0.30 | 0.26 | -0.04 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 377,204 | 854,634 | +477,430 | 0.04 | 0.12 | +0.08 | buy |
| NORTHERN TRUST CORP | 834,847 | 814,250 | -20,597 | 0.00 | 0.00 | +0.00 | sell |
| ROYAL BANK OF CANADA | 616,081 | 799,912 | +183,831 | 0.00 | 0.01 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 659,435 | 791,072 | +131,637 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 652,518 | 777,940 | +125,422 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 768,648 | +768,648 | 0.00 | 0.07 | +0.07 | buy |
| Hudson Bay Capital Management LP | 1,049,900 | 750,000 | -299,900 | 0.20 | 0.19 | -0.01 | sell |
| Woodline Partners LP | 0 | 732,813 | +732,813 | 0.00 | 0.15 | +0.15 | buy |
| Candriam S.C.A. | 993,704 | 724,740 | -268,964 | 0.19 | 0.17 | -0.02 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 500,451 | 668,273 | +167,822 | 0.06 | 0.11 | +0.05 | buy |
| GROUPAMA ASSET MANAGMENT | 569,211 | 660,957 | +91,746 | 0.36 | 0.44 | +0.08 | buy |
| Pictet Asset Management Holding SA | 618,550 | 608,640 | -9,910 | 0.02 | 0.02 | +0.00 | sell |
| Eversept Partners, LP | 517,021 | 588,900 | +71,879 | 1.77 | 2.34 | +0.58 | buy |
| BARCLAYS PLC | 353,937 | 583,266 | +229,329 | 0.00 | 0.01 | +0.00 | buy |
| AXA S.A. | 566,486 | 566,883 | +397 | 0.06 | 0.06 | +0.01 | buy |
| Bank of New York Mellon Corp | 544,633 | 527,188 | -17,445 | 0.00 | 0.00 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 519,184 | +519,184 | 0.00 | 0.01 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 250,000 | 500,000 | +250,000 | 4.10 | 12.84 | +8.74 | buy |
| BNP Paribas Asset Management Holding S.A. | 499,999 | 500,000 | +1 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 0 | 500,000 | +500,000 | 0.00 | 1.04 | +1.04 | buy |
| PINNACLE ASSOCIATES LTD | 608,517 | 494,539 | -113,978 | 0.27 | 0.28 | +0.01 | sell |
| BANK OF MONTREAL /CAN/ | 782,835 | 483,289 | -299,546 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 116,768 | 472,749 | +355,981 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 858,228 | 450,254 | -407,974 | 0.00 | 0.00 | -0.00 | sell |
| C WorldWide Group Holding A/S | 400,000 | 450,000 | +50,000 | 0.15 | 0.24 | +0.09 | buy |
| Schonfeld Strategic Advisors LLC | 560,359 | 449,206 | -111,153 | 0.11 | 0.13 | +0.02 | sell |
| GW&K Investment Management, LLC | 182,309 | 448,830 | +266,521 | 0.05 | 0.16 | +0.11 | buy |
| Aberdeen Group plc | 446,197 | 406,694 | -39,503 | 0.03 | 0.03 | +0.00 | sell |
| Legal & General Group Plc | 338,462 | 404,366 | +65,904 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 399,646 | +399,646 | 0.00 | 0.13 | +0.13 | buy |
| JPMORGAN CHASE & CO | 421,511 | 394,978 | -26,533 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 360,188 | 368,119 | +7,931 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 203,178 | 354,962 | +151,784 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 426,480 | 340,977 | -85,503 | 0.01 | 0.01 | -0.00 | sell |
| Sovran Advisors, LLC | 328,904 | 321,913 | -6,991 | 1.21 | 1.39 | +0.18 | sell |
| Point72 Asset Management, L.P. | 287,204 | 292,647 | +5,443 | 0.02 | 0.03 | +0.00 | buy |
| Swiss National Bank | 275,300 | 288,600 | +13,300 | 0.01 | 0.01 | +0.00 | buy |
| SECTOR GAMMA AS | 285,842 | 285,842 | 0 | 2.76 | 3.69 | +0.93 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 153,514 | 270,714 | +117,200 | 0.01 | 0.01 | +0.01 | buy |
| Privium Fund Management B.V. | 267,594 | 267,594 | 0 | 2.10 | 2.31 | +0.20 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 129,273 | 265,793 | +136,520 | 0.02 | 0.04 | +0.02 | buy |
| SEI INVESTMENTS CO | 262,000 | 262,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Invesco Ltd. | 874,834 | 256,235 | -618,599 | 0.01 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 308,777 | 245,085 | -63,692 | 0.00 | 0.00 | -0.00 | sell |
| Corient Private Wealth LLC | 237,133 | 237,840 | +707 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 52,287 | 232,687 | +180,400 | 0.01 | 0.05 | +0.04 | buy |
| Orion Investment Co | 215,290 | 217,370 | +2,080 | 2.66 | 3.04 | +0.38 | buy |
| RAYMOND JAMES FINANCIAL INC | 148,690 | 210,592 | +61,902 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 256,233 | 209,857 | -46,376 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 191,004 | 201,993 | +10,989 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 300,000 | 200,000 | -100,000 | 0.00 | 0.00 | -0.00 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 124,200 | 197,600 | +73,400 | 0.07 | 0.12 | +0.06 | buy |
| STIFEL FINANCIAL CORP | 200,942 | 196,357 | -4,585 | 0.01 | 0.01 | +0.00 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 187,395 | 187,345 | -50 | 0.09 | 0.11 | +0.02 | sell |
| Sicart Associates LLC | 185,646 | 185,296 | -350 | 1.94 | 2.56 | +0.62 | sell |
| Rhenman & Partners Asset Management AB | 81,000 | 182,000 | +101,000 | 0.28 | 0.91 | +0.63 | buy |
| RHUMBLINE ADVISERS | 188,216 | 181,599 | -6,617 | 0.01 | 0.01 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 308,293 | 177,762 | -130,531 | 0.01 | 0.01 | -0.00 | sell |
| Sonora Investment Management Group, LLC | 154,147 | 163,172 | +9,025 | 0.37 | 0.48 | +0.11 | buy |
| Sonora Investment Management Group, LLC | 160,000 | 160,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 0 | 159,008 | +159,008 | 0.00 | 0.02 | +0.02 | buy |
| Aquatic Capital Management LLC | 156,157 | 158,086 | +1,929 | 0.12 | 0.13 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 152,315 | 153,895 | +1,580 | 0.01 | 0.01 | +0.00 | buy |
| BLB&B Advisors, LLC | 152,200 | 151,550 | -650 | 0.23 | 0.28 | +0.05 | sell |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 150,000 | 0 | 0.25 | 0.30 | +0.05 | hold |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 143,870 | 149,839 | +5,969 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 148,461 | +148,461 | 0.00 | 0.95 | +0.95 | buy |
| J. Goldman & Co LP | 307,770 | 147,682 | -160,088 | 0.33 | 0.18 | -0.15 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 132,238 | 145,104 | +12,866 | 0.00 | 0.01 | +0.00 | buy |