| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 2,846,015 | 4,004,613 | +1,158,598 | 3.25 | 4.90 | +1.64 | buy |
| Sonora Investment Management Group, LLC | 11,890,000 | 12,648,000 | +758,000 | 0.94 | 1.06 | +0.11 | buy |
| TWO SIGMA INVESTMENTS, LP | 213,372 | 476,057 | +262,685 | 0.02 | 0.06 | 0.00 | buy |
| FIRST TRUST ADVISORS LP | 1,323,032 | 1,134,979 | +188,053 | 0.06 | 0.06 | 0.00 | sell |
| TD ASSET MANAGEMENT INC | 785,208 | 898,852 | +113,644 | 0.04 | 0.05 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 370,500 | 269,800 | +100,700 | 0.02 | 0.02 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 198,508 | 129,812 | +68,696 | 0.04 | 0.03 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 13,083,727 | 13,123,055 | +39,328 | 0.37 | 0.42 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,156,868 | 2,194,731 | +37,863 | 0.01 | 0.01 | 0.00 | buy |
| Candriam S.C.A. | 524,067 | 549,067 | +25,000 | 0.16 | 0.18 | +0.02 | buy |
| NOMURA HOLDINGS INC | 435,380 | 459,311 | +23,931 | 0.18 | 0.23 | 0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 160,998 | 145,582 | +15,416 | 0.01 | 0.01 | +0.00 | sell |
| Rafferty Asset Management, LLC | 204,388 | 215,971 | +11,583 | 0.05 | 0.06 | +0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 51,926 | 40,475 | +11,451 | 0.02 | 0.02 | 0.00 | sell |
| Eversept Partners, LP | 241,572 | 252,446 | +10,874 | 1.05 | 1.27 | +0.22 | buy |
| COMMERCE BANK | 88,282 | 77,647 | +10,635 | 0.03 | 0.03 | 0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 72,059 | 62,059 | +10,000 | 0.11 | 0.07 | 0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 230,261 | 238,635 | +8,374 | 0.22 | 0.26 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 153,052 | 159,503 | +6,451 | 1.09 | 1.33 | +0.24 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 64,426 | 58,000 | +6,426 | 0.01 | 0.01 | 0.00 | sell |
| SECTOR GAMMA AS | 160,401 | 165,616 | +5,215 | 1.47 | 1.92 | +0.45 | buy |
| ALGERT GLOBAL LLC | 49,252 | 45,522 | +3,730 | 0.09 | 0.10 | 0.00 | sell |
| Swiss National Bank | 280,100 | 283,100 | +3,000 | 0.01 | 0.01 | +0.00 | buy |
| Privium Fund Management B.V. | 226,493 | 228,493 | +2,000 | 2.68 | 3.08 | +0.40 | buy |
| Corton Capital Inc. | 6,929 | 8,895 | +1,966 | 0.13 | 0.20 | +0.07 | buy |
| China Universal Asset Management Co., Ltd. | 1,875 | 3,670 | +1,795 | 0.02 | 0.05 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 34,903 | 36,578 | +1,675 | 0.01 | 0.01 | +0.00 | buy |
| Midwest Professional Planners, LTD. | 6,593 | 7,825 | +1,232 | 0.12 | 0.16 | +0.04 | buy |
| PDT Partners, LLC | 18,498 | 19,537 | +1,039 | 0.10 | 0.11 | +0.01 | buy |
| CI INVESTMENTS INC. | 2,908 | 2,524 | +384 | 0.00 | 0.00 | 0.00 | sell |
| Treasurer of the State of North Carolina | 62,222 | 62,532 | +310 | 0.01 | 0.02 | 0.00 | buy |
| Utah Retirement Systems | 7,500 | 7,700 | +200 | 0.00 | 0.00 | +0.00 | buy |
| GRANDFIELD & DODD, LLC | 32,679 | 32,862 | +183 | 0.09 | 0.11 | +0.02 | buy |
| Horizon Investments, LLC | 1,736 | 1,899 | +163 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 10,988 | 11,096 | +108 | 0.04 | 0.04 | +0.00 | buy |
| Global Trust Asset Management, LLC | 399 | 474 | +75 | 0.01 | 0.01 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 11,019 | 10,968 | +51 | 0.01 | 0.01 | 0.00 | sell |
| GPS Wealth Strategies Group, LLC | 184 | 198 | +14 | 0.00 | 0.00 | 0.00 | buy |
| Itau Unibanco Holding S.A. | 1,815 | 1,807 | -8 | 0.00 | 0.00 | +0.00 | sell |
| STEPHENS INC /AR/ | 7,506 | 7,485 | -21 | 0.01 | 0.01 | +0.00 | sell |
| Nicollet Investment Management, Inc. | 8,758 | 8,668 | -90 | 0.16 | 0.18 | +0.02 | sell |
| PERKINS CAPITAL MANAGEMENT INC | 5,650 | 5,550 | -100 | 0.20 | 0.25 | +0.05 | sell |
| NATIXIS | 695 | 441 | -254 | 0.01 | 0.00 | -0.00 | sell |
| Estate Counselors, LLC | 33,110 | 32,800 | -310 | 0.17 | 0.20 | +0.03 | sell |
| Bleakley Financial Group, LLC | 12,538 | 12,198 | -340 | 0.02 | 0.02 | +0.00 | sell |
| Castle Rock Wealth Management, LLC | 7,372 | 6,972 | -400 | 0.11 | 0.11 | +0.00 | sell |
| WRAPMANAGER INC | 7,993 | 7,527 | -466 | 0.10 | 0.11 | +0.01 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 162,480 | 161,730 | -750 | 0.12 | 0.14 | +0.02 | sell |
| PROFUND ADVISORS LLC | 36,284 | 35,470 | -814 | 0.08 | 0.09 | +0.01 | sell |
| VIRTUS ADVISERS, LLC | 8,418 | 7,457 | -961 | 0.20 | 0.21 | +0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 34,600 | 32,900 | -1,700 | 0.01 | 0.01 | +0.00 | sell |
| Sicart Associates LLC | 204,947 | 203,132 | -1,815 | 3.27 | 3.61 | +0.35 | sell |
| Boussard & Gavaudan Investment Management LLP | 7,805 | 5,305 | -2,500 | 0.71 | 0.61 | -0.09 | sell |
| BLB&B Advisors, LLC | 150,300 | 147,650 | -2,650 | 0.43 | 0.48 | +0.05 | sell |
| Nikko Asset Management Americas, Inc. | 296,132 | 292,473 | -3,659 | 0.13 | 0.16 | +0.03 | sell |
| Bard Financial Services, Inc. | 31,300 | 25,550 | -5,750 | 0.10 | 0.14 | +0.05 | sell |
| Liontrust Investment Partners LLP | 321,574 | 310,026 | -11,548 | 0.19 | 0.22 | +0.03 | sell |
| BAILLIE GIFFORD & CO | 330,346 | 316,629 | -13,717 | 0.01 | 0.01 | +0.00 | sell |
| PINNACLE ASSOCIATES LTD | 478,204 | 463,035 | -15,169 | 0.34 | 0.39 | +0.05 | sell |
| ALTRINSIC GLOBAL ADVISORS LLC | 307,990 | 292,184 | -15,806 | 0.48 | 0.51 | +0.03 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 26,529 | 5,769 | -20,760 | 0.00 | 0.00 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 149,198 | 126,393 | -22,805 | 0.17 | 0.17 | +0.00 | sell |
| Tweedy, Browne Co LLC | 3,540,858 | 3,510,173 | -30,685 | 7.63 | 8.52 | +0.89 | sell |
| ARK Investment Management LLC | 2,422,631 | 2,366,367 | -56,264 | 0.66 | 0.82 | +0.16 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,835,867 | 3,757,997 | -77,870 | 0.02 | 0.03 | +0.00 | sell |
| Hudson Bay Capital Management LP | 275,000 | 190,000 | -85,000 | 0.11 | 0.08 | -0.03 | sell |
| Bellevue Group AG | 9,380,300 | 9,233,700 | -146,600 | 5.49 | 6.75 | +1.26 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 549,558 | 373,117 | -176,441 | 0.13 | 0.10 | -0.03 | sell |
| Camber Capital Management LP | 2,500,000 | 2,250,000 | -250,000 | 3.34 | 3.66 | +0.32 | sell |
| Sonora Investment Management Group, LLC | 18,860,000 | 18,573,000 | -287,000 | 1.49 | 1.52 | +0.03 | sell |
| Clearbridge Investments, LLC | 5,187,204 | 4,840,695 | -346,509 | 0.19 | 0.21 | +0.02 | sell |
| Woodline Partners LP | 1,041,932 | 315,094 | -726,838 | 0.51 | 0.17 | -0.34 | sell |
| Swedbank AB | 936,748 | 136,939 | -799,809 | 0.07 | 0.01 | -0.06 | sell |