| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 21,894,806 | 22,479,529 | +584,723 | 0.07 | 0.05 | -0.01 | buy |
| VANGUARD GROUP INC | 13,845,712 | 15,055,758 | +1,210,046 | 0.01 | 0.01 | -0.00 | buy |
| Sonora Investment Management Group, LLC | 15,741,000 | 14,183,000 | -1,558,000 | 1.16 | 1.03 | -0.13 | sell |
| T. Rowe Price Investment Management, Inc. | 12,639,684 | 14,168,116 | +1,528,432 | 0.38 | 0.34 | -0.04 | buy |
| Sonora Investment Management Group, LLC | 12,518,000 | 12,363,000 | -155,000 | 0.97 | 0.91 | -0.06 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 6,568,808 | 8,735,787 | +2,166,979 | 0.06 | 0.06 | +0.01 | buy |
| Bellevue Group AG | 8,260,434 | 7,874,400 | -386,034 | 6.40 | 5.11 | -1.29 | sell |
| Capital World Investors | 2,252,089 | 7,828,372 | +5,576,283 | 0.02 | 0.05 | +0.03 | buy |
| STATE STREET CORP | 4,190,505 | 4,850,137 | +659,632 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,934,311 | 4,210,172 | +275,861 | 0.02 | 0.02 | -0.00 | buy |
| Tweedy, Browne Co LLC | 3,454,676 | 3,454,676 | 0 | 7.57 | 6.60 | -0.97 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 2,484,544 | 2,668,358 | +183,814 | 0.01 | 0.01 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,500,000 | 2,500,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 2,442,000 | +2,442,000 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,372,333 | 2,324,447 | -47,886 | 2.25 | 1.70 | -0.54 | sell |
| Artisan Partners Limited Partnership | 1,671,036 | 2,240,455 | +569,419 | 0.12 | 0.13 | +0.01 | buy |
| Deep Track Capital, LP | 2,000,000 | 2,200,000 | +200,000 | 2.85 | 2.81 | -0.03 | buy |
| NORGES BANK | 1,019,341 | 2,027,161 | +1,007,820 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 173,199 | 1,920,464 | +1,747,265 | 0.01 | 0.10 | +0.09 | buy |
| MACQUARIE GROUP LTD | 1,873,668 | 1,869,806 | -3,862 | 0.10 | 0.08 | -0.02 | sell |
| Clearbridge Investments, LLC | 2,160,270 | 1,702,393 | -457,877 | 0.08 | 0.05 | -0.03 | sell |
| BVF INC/IL | 3,186,376 | 1,451,879 | -1,734,497 | 4.26 | 1.70 | -2.55 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,328,106 | 1,443,020 | +114,914 | 0.01 | 0.01 | -0.00 | buy |
| ARK Investment Management LLC | 1,361,025 | 1,384,269 | +23,244 | 0.58 | 0.51 | -0.07 | buy |
| TWO SIGMA ADVISERS, LP | 1,287,111 | 1,332,411 | +45,300 | 0.14 | 0.13 | -0.01 | buy |
| MORGAN STANLEY | 1,012,805 | 1,310,451 | +297,646 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 2,409,954 | 1,303,501 | -1,106,453 | 0.13 | 0.06 | -0.07 | sell |
| TD ASSET MANAGEMENT INC | 952,762 | 1,092,990 | +140,228 | 0.04 | 0.04 | -0.00 | buy |
| Candriam S.C.A. | 948,266 | 948,266 | 0 | 0.27 | 0.22 | -0.06 | hold |
| TWO SIGMA INVESTMENTS, LP | 1,028,142 | 919,077 | -109,065 | 0.12 | 0.08 | -0.03 | sell |
| Invesco Ltd. | 968,917 | 810,301 | -158,616 | 0.01 | 0.01 | -0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 780,753 | 779,721 | -1,032 | 0.10 | 0.08 | -0.02 | sell |
| Hudson Bay Capital Management LP | 366,000 | 766,900 | +400,900 | 0.13 | 0.21 | +0.08 | buy |
| Logos Global Management LP | 300,000 | 750,000 | +450,000 | 1.65 | 3.37 | +1.72 | buy |
| NORTHERN TRUST CORP | 717,975 | 742,904 | +24,929 | 0.01 | 0.00 | -0.00 | buy |
| ROYAL BANK OF CANADA | 678,360 | 670,149 | -8,211 | 0.01 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 572,870 | 650,779 | +77,909 | 0.11 | 0.10 | -0.01 | buy |
| BARCLAYS PLC | 615,674 | 637,032 | +21,358 | 0.01 | 0.01 | -0.00 | buy |
| Bank of New York Mellon Corp | 597,479 | 610,893 | +13,414 | 0.01 | 0.00 | -0.00 | buy |
| J. Goldman & Co LP | 17,502 | 609,416 | +591,914 | 0.03 | 1.06 | +1.03 | buy |
| Man Group plc | 633,409 | 596,263 | -37,146 | 0.08 | 0.07 | -0.01 | sell |
| JPMORGAN CHASE & CO | 594,091 | 568,906 | -25,185 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 514,543 | 568,660 | +54,117 | 0.00 | 0.00 | -0.00 | buy |
| AXA S.A. | 464,963 | 561,243 | +96,280 | 0.07 | 0.07 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 800,000 | 500,000 | -300,000 | 0.07 | 0.04 | -0.04 | sell |
| BNP Paribas Asset Management Holding S.A. | 500,000 | 500,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.69 | +0.69 | buy |
| Eversept Partners, LP | 456,881 | 471,355 | +14,474 | 1.67 | 1.45 | -0.22 | buy |
| PINNACLE ASSOCIATES LTD | 453,379 | 458,979 | +5,600 | 0.34 | 0.39 | +0.06 | buy |
| NOMURA HOLDINGS INC | 501,188 | 453,069 | -48,119 | 0.15 | 0.14 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 128,215 | 430,723 | +302,508 | 0.01 | 0.01 | +0.01 | buy |
| GROUPAMA ASSET MANAGMENT | 379,976 | 416,060 | +36,084 | 0.25 | 0.35 | +0.10 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 225,070 | 406,870 | +181,800 | 0.18 | 0.26 | +0.08 | buy |
| FIRST TRUST ADVISORS LP | 16,194 | 402,300 | +386,106 | 0.00 | 0.02 | +0.01 | buy |
| CITADEL ADVISORS LLC | 627,033 | 401,151 | -225,882 | 0.03 | 0.02 | -0.01 | sell |
| Ghisallo Capital Management LLC | 0 | 400,000 | +400,000 | 0.00 | 0.79 | +0.79 | buy |
| AMERIPRISE FINANCIAL INC | 8,792 | 397,898 | +389,106 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 380,641 | +380,641 | 0.00 | 0.06 | +0.06 | buy |
| Schonfeld Strategic Advisors LLC | 723,618 | 362,888 | -360,730 | 0.27 | 0.12 | -0.15 | sell |
| WELLS FARGO & COMPANY/MN | 366,561 | 342,154 | -24,407 | 0.00 | 0.00 | -0.00 | sell |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 9,707 | 328,772 | +319,065 | 0.04 | 0.02 | -0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 274,850 | 308,947 | +34,097 | 0.01 | 0.01 | -0.00 | buy |
| Aberdeen Group plc | 246,917 | 303,274 | +56,357 | 0.02 | 0.02 | -0.00 | buy |
| Bank of New York Mellon Corp | 300,000 | 300,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| C WorldWide Group Holding A/S | 300,000 | 300,000 | 0 | 0.15 | 0.12 | -0.03 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 320,290 | 285,697 | -34,593 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 0 | 262,000 | +262,000 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 258,000 | 256,600 | -1,400 | 0.01 | 0.01 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 330,000 | 255,000 | -75,000 | 3.01 | 3.08 | +0.07 | sell |
| Privium Fund Management B.V. | 247,267 | 250,744 | +3,477 | 2.85 | 2.50 | -0.35 | buy |
| Bank of New York Mellon Corp | 250,000 | 250,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Corient Private Wealth LLC | 268,037 | 237,076 | -30,961 | 0.02 | 0.01 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 328,305 | 235,710 | -92,595 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 0 | 235,477 | +235,477 | 0.00 | 0.18 | +0.18 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 229,969 | +229,969 | 0.00 | 0.08 | +0.08 | buy |
| BAKER BROS. ADVISORS LP | 0 | 223,470 | +223,470 | 0.00 | 0.09 | +0.09 | buy |
| Orion Investment Co | 218,570 | 218,525 | -45 | 4.15 | 3.40 | -0.75 | sell |
| BANK OF MONTREAL /CAN/ | 220,518 | 213,883 | -6,635 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 196,484 | 211,756 | +15,272 | 0.01 | 0.01 | -0.00 | buy |
| SECTOR GAMMA AS | 170,000 | 210,842 | +40,842 | 3.03 | 2.56 | -0.46 | buy |
| Rafferty Asset Management, LLC | 168,856 | 198,759 | +29,903 | 0.03 | 0.03 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 215,716 | 198,759 | -16,957 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 178,089 | 196,942 | +18,853 | 0.01 | 0.01 | -0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 199,231 | 196,114 | -3,117 | 0.01 | 0.01 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 199,231 | 196,114 | -3,117 | 0.11 | 0.09 | -0.02 | sell |
| Rhenman & Partners Asset Management AB | 130,000 | 195,000 | +65,000 | 0.59 | 0.63 | +0.04 | buy |
| Sicart Associates LLC | 191,523 | 191,523 | 0 | 3.50 | 2.69 | -0.81 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 249,514 | 190,514 | -59,000 | 0.02 | 0.01 | -0.01 | sell |
| SEI INVESTMENTS CO | 132,311 | 189,837 | +57,526 | 0.01 | 0.01 | +0.00 | buy |
| ALTRINSIC GLOBAL ADVISORS LLC | 187,831 | 182,734 | -5,097 | 0.40 | 0.31 | -0.09 | sell |
| STIFEL FINANCIAL CORP | 216,140 | 182,505 | -33,635 | 0.01 | 0.01 | -0.00 | sell |
| JANE STREET GROUP, LLC | 179,246 | 176,560 | -2,686 | 0.01 | 0.01 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 185,944 | 175,328 | -10,616 | 0.01 | 0.01 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 168,951 | +168,951 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 152,672 | 167,880 | +15,208 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 254,343 | 162,076 | -92,267 | 0.26 | 0.14 | -0.12 | sell |
| Legal & General Group Plc | 147,644 | 157,287 | +9,643 | 0.00 | 0.00 | -0.00 | buy |
| Sonora Investment Management Group, LLC | 150,814 | 153,175 | +2,361 | 0.51 | 0.45 | -0.06 | buy |
| BLB&B Advisors, LLC | 153,750 | 152,250 | -1,500 | 0.40 | 0.31 | -0.09 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 151,055 | 151,055 | 0 | 0.01 | 0.01 | -0.00 | hold |