| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 2,252,089 | 7,828,372 | +5,576,283 | 0.02 | 0.05 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 12,639,684 | 14,168,116 | +1,528,432 | 0.38 | 0.34 | -0.04 | buy |
| J. Goldman & Co LP | 17,502 | 609,416 | +591,914 | 0.02 | 0.68 | +0.66 | buy |
| Artisan Partners Limited Partnership | 1,671,036 | 2,240,455 | +569,419 | 0.12 | 0.13 | +0.01 | buy |
| Logos Global Management LP | 300,000 | 750,000 | +450,000 | 1.65 | 3.37 | +1.72 | buy |
| Hudson Bay Capital Management LP | 366,000 | 766,900 | +400,900 | 0.08 | 0.12 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,934,311 | 4,210,172 | +275,861 | 0.02 | 0.02 | -0.00 | buy |
| Deep Track Capital, LP | 2,000,000 | 2,200,000 | +200,000 | 2.85 | 2.81 | -0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,484,544 | 2,668,358 | +183,814 | 0.01 | 0.01 | 0.00 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 225,070 | 406,870 | +181,800 | 0.18 | 0.26 | +0.08 | buy |
| TD ASSET MANAGEMENT INC | 952,762 | 1,092,990 | +140,228 | 0.04 | 0.04 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,028,142 | 919,077 | +109,065 | 0.12 | 0.09 | 0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 572,870 | 650,779 | +77,909 | 0.11 | 0.10 | -0.01 | buy |
| Rhenman & Partners Asset Management AB | 130,000 | 195,000 | +65,000 | 0.59 | 0.63 | +0.04 | buy |
| Aberdeen Group plc | 246,917 | 303,274 | +56,357 | 0.02 | 0.02 | -0.00 | buy |
| Atle Fund Management AB | 40,691 | 82,691 | +42,000 | 1.18 | 1.56 | +0.37 | buy |
| SECTOR GAMMA AS | 170,000 | 210,842 | +40,842 | 3.03 | 2.56 | -0.46 | buy |
| GROUPAMA ASSET MANAGMENT | 379,976 | 416,060 | +36,084 | 0.25 | 0.35 | +0.10 | buy |
| ALGERT GLOBAL LLC | 75,350 | 45,430 | +29,920 | 0.12 | 0.05 | 0.00 | sell |
| Rafferty Asset Management, LLC | 168,856 | 198,759 | +29,903 | 0.03 | 0.03 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 44,256 | 17,741 | +26,515 | 0.01 | 0.00 | -0.01 | sell |
| ARK Investment Management LLC | 1,361,025 | 1,384,269 | +23,244 | 0.58 | 0.51 | -0.07 | buy |
| DCF Advisers, LLC | 23,000 | 39,500 | +16,500 | 0.57 | 0.81 | +0.24 | buy |
| Eversept Partners, LP | 456,881 | 471,355 | +14,474 | 1.49 | 1.29 | -0.20 | buy |
| NEOS Investment Management LLC | 45,058 | 59,244 | +14,186 | 0.09 | 0.07 | -0.02 | buy |
| NICOLA WEALTH MANAGEMENT LTD. | 74,000 | 87,000 | +13,000 | 0.43 | 0.37 | -0.06 | buy |
| China Universal Asset Management Co., Ltd. | 17,150 | 28,121 | +10,971 | 0.12 | 0.12 | +0.01 | buy |
| PROFUND ADVISORS LLC | 29,983 | 37,596 | +7,613 | 0.05 | 0.06 | 0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 42,595 | 36,957 | +5,638 | 0.13 | 0.12 | 0.00 | sell |
| Bridgefront Capital, LLC | 5,559 | 11,196 | +5,637 | 0.11 | 0.17 | +0.06 | buy |
| PINNACLE ASSOCIATES LTD | 453,379 | 458,979 | +5,600 | 0.34 | 0.39 | +0.06 | buy |
| Treasurer of the State of North Carolina | 63,113 | 68,363 | +5,250 | 0.01 | 0.01 | 0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 52,552 | 56,699 | +4,147 | 0.01 | 0.01 | -0.00 | buy |
| Privium Fund Management B.V. | 247,267 | 250,744 | +3,477 | 2.85 | 2.50 | -0.35 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 129,216 | 126,180 | +3,036 | 0.01 | 0.01 | -0.00 | sell |
| E Fund Management Co., Ltd. | 10,255 | 12,752 | +2,497 | 0.03 | 0.03 | -0.00 | buy |
| Sonora Investment Management Group, LLC | 150,814 | 153,175 | +2,361 | 0.51 | 0.45 | -0.06 | buy |
| GUGGENHEIM CAPITAL LLC | 35,389 | 37,159 | +1,770 | 0.01 | 0.01 | 0.00 | buy |
| COMMERCE BANK | 76,342 | 77,553 | +1,211 | 0.02 | 0.02 | 0.00 | buy |
| Midwest Professional Planners, LTD. | 10,140 | 11,106 | +966 | 0.16 | 0.14 | -0.03 | buy |
| GRANDFIELD & DODD, LLC | 34,053 | 34,813 | +760 | 0.10 | 0.08 | -0.02 | buy |
| Annis Gardner Whiting Capital Advisors, LLC | 9,396 | 9,936 | +540 | 0.13 | 0.11 | -0.02 | buy |
| Utah Retirement Systems | 7,900 | 8,400 | +500 | 0.00 | 0.00 | -0.00 | buy |
| Itau Unibanco Holding S.A. | 767 | 1,081 | +314 | 0.00 | 0.00 | -0.00 | buy |
| Nicollet Investment Management, Inc. | 20,108 | 20,402 | +294 | 0.36 | 0.28 | -0.08 | buy |
| CI INVESTMENTS INC. | 3,652 | 3,380 | +272 | 0.00 | 0.00 | 0.00 | sell |
| Riverview Trust Co | 476 | 487 | +11 | 0.02 | 0.02 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 12,805 | 12,809 | +4 | 0.01 | 0.01 | -0.00 | buy |
| Global X Japan Co., Ltd. | 262 | 235 | -27 | 0.00 | 0.00 | -0.00 | sell |
| Washington Trust Advisors, Inc. | 111 | 83 | -28 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 13,430 | 13,400 | -30 | 0.06 | 0.05 | -0.01 | sell |
| Orion Investment Co | 218,570 | 218,525 | -45 | 4.15 | 3.40 | -0.75 | sell |
| SECTORAL ASSET MANAGEMENT INC | 9,660 | 9,440 | -220 | 0.19 | 0.22 | +0.04 | sell |
| Horizon Investments, LLC | 1,494 | 1,101 | -393 | 0.00 | 0.00 | -0.00 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 132,024 | 131,630 | -394 | 0.18 | 0.16 | -0.02 | sell |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 12,476 | 11,952 | -524 | 0.01 | 0.01 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 1,500 | 700 | -800 | 0.01 | 0.00 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 780,753 | 779,721 | -1,032 | 0.10 | 0.08 | -0.02 | sell |
| Swiss National Bank | 258,000 | 256,600 | -1,400 | 0.01 | 0.01 | -0.00 | sell |
| BLB&B Advisors, LLC | 153,750 | 152,250 | -1,500 | 0.40 | 0.31 | -0.09 | sell |
| Nikko Asset Management Americas, Inc. | 199,231 | 196,114 | -3,117 | 0.11 | 0.09 | -0.02 | sell |
| ALTRINSIC GLOBAL ADVISORS LLC | 187,831 | 182,734 | -5,097 | 0.40 | 0.31 | -0.09 | sell |
| Teza Capital Management LLC | 25,159 | 10,600 | -14,559 | 0.15 | 0.05 | -0.10 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 215,716 | 198,759 | -16,957 | 0.01 | 0.01 | -0.00 | sell |
| Granite Investment Partners, LLC | 114,090 | 85,793 | -28,297 | 0.23 | 0.15 | -0.08 | sell |
| Artia Global Partners LP | 62,479 | 30,479 | -32,000 | 0.76 | 0.35 | -0.42 | sell |
| Susquehanna Portfolio Strategies, LLC | 43,028 | 10,894 | -32,134 | 0.08 | 0.03 | -0.05 | sell |
| ORBIMED ADVISORS LLC | 2,372,333 | 2,324,447 | -47,886 | 2.25 | 1.70 | -0.54 | sell |
| Cutter Capital Management, LP | 160,166 | 97,300 | -62,866 | 2.33 | 1.15 | -1.18 | sell |
| GREAT POINT PARTNERS LLC | 330,000 | 255,000 | -75,000 | 3.01 | 3.01 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 140,238 | 63,821 | -76,417 | 0.91 | 0.41 | -0.50 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 254,343 | 162,076 | -92,267 | 0.26 | 0.14 | -0.12 | sell |
| Sonora Investment Management Group, LLC | 12,518,000 | 12,363,000 | -155,000 | 0.97 | 0.91 | -0.06 | sell |
| BAILLIE GIFFORD & CO | 260,254 | 39,581 | -220,673 | 0.01 | 0.00 | -0.01 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 800,000 | 500,000 | -300,000 | 0.07 | 0.04 | -0.04 | sell |
| GROUPAMA ASSET MANAGMENT | 379,976 | 0 | -379,976 | 0.25 | 0.01 | -0.23 | sell |
| Bellevue Group AG | 8,260,434 | 7,874,400 | -386,034 | 6.40 | 5.11 | -1.29 | sell |
| Clearbridge Investments, LLC | 2,160,270 | 1,702,393 | -457,877 | 0.08 | 0.05 | -0.03 | sell |
| BVF INC/IL | 3,186,376 | 1,451,879 | -1,734,497 | 4.26 | 1.70 | -2.55 | sell |