| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,979,669 | +1,979,669 | 0.00 | 1.98 | +1.98 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 2,000,000 | 3,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 13,100 | 958,829 | +945,729 | 0.00 | 0.07 | +0.07 | buy |
| CITADEL ADVISORS LLC | 1,494,981 | 2,402,065 | +907,084 | 0.05 | 0.13 | +0.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 472,749 | 1,372,225 | +899,476 | 0.01 | 0.05 | +0.04 | buy |
| Pictet Asset Management Holding SA | 608,640 | 1,393,124 | +784,484 | 0.02 | 0.09 | +0.06 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 750,000 | +750,000 | 0.00 | 1.60 | +1.60 | buy |
| NOMURA HOLDINGS INC | 32,161 | 733,398 | +701,237 | 0.01 | 0.22 | +0.21 | buy |
| D. E. Shaw & Co., Inc. | 0 | 630,938 | +630,938 | 0.00 | 0.03 | +0.03 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 630,136 | +630,136 | 0.00 | 0.03 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 265,793 | 878,155 | +612,362 | 0.04 | 0.18 | +0.14 | buy |
| Vestal Point Capital, LP | 500,000 | 1,075,000 | +575,000 | 1.04 | 3.19 | +2.15 | buy |
| BAKER BROS. ADVISORS LP | 0 | 566,798 | +566,798 | 0.00 | 0.27 | +0.27 | buy |
| Artisan Partners Limited Partnership | 354,962 | 890,072 | +535,110 | 0.02 | 0.08 | +0.06 | buy |
| ROYAL BANK OF CANADA | 799,912 | 1,226,624 | +426,712 | 0.01 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 420,950 | +420,950 | 0.00 | 0.04 | +0.04 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 417,833 | +417,833 | 0.00 | 8.96 | +8.96 | buy |
| Ikarian Capital, LLC | 0 | 415,163 | +415,163 | 0.00 | 5.49 | +5.49 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 550,000 | +400,000 | 0.30 | 1.39 | +1.09 | buy |
| AMERIPRISE FINANCIAL INC | 368,119 | 765,822 | +397,703 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 365,070 | +365,070 | 0.00 | 0.03 | +0.03 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 791,072 | 1,154,166 | +363,094 | 0.01 | 0.02 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 519,184 | 862,593 | +343,409 | 0.01 | 0.02 | +0.01 | buy |
| Man Group plc | 8,969 | 333,820 | +324,851 | 0.00 | 0.04 | +0.04 | buy |
| Assenagon Asset Management S.A. | 17,654 | 312,297 | +294,643 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF MONTREAL /CAN/ | 483,289 | 747,402 | +264,113 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 256,235 | 519,070 | +262,835 | 0.00 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 134,395 | 383,792 | +249,397 | 0.01 | 0.05 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 6,345,776 | 6,588,811 | +243,035 | 0.05 | 0.08 | +0.03 | buy |
| Jain Global LLC | 7,195 | 225,739 | +218,544 | 0.00 | 0.19 | +0.19 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 270,714 | 486,714 | +216,000 | 0.01 | 0.04 | +0.03 | buy |
| ALGERT GLOBAL LLC | 38,090 | 252,281 | +214,191 | 0.03 | 0.28 | +0.24 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 177,762 | 383,226 | +205,464 | 0.01 | 0.02 | +0.01 | buy |
| Capital World Investors | 12,540,188 | 12,722,728 | +182,540 | 0.07 | 0.11 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,891,095 | 3,066,289 | +175,194 | 0.01 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 173,819 | +173,819 | 0.00 | 0.57 | +0.57 | buy |
| Nuveen, LLC | 245,085 | 415,618 | +170,533 | 0.00 | 0.01 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 163,462 | +163,462 | 0.00 | 0.27 | +0.27 | buy |
| Capricorn Fund Managers Ltd | 0 | 162,800 | +162,800 | 0.00 | 3.58 | +3.58 | buy |
| Alyeska Investment Group, L.P. | 159,008 | 311,258 | +152,250 | 0.02 | 0.06 | +0.04 | buy |
| ExodusPoint Capital Management, LP | 0 | 152,125 | +152,125 | 0.00 | 0.14 | +0.14 | buy |
| JPMORGAN CHASE & CO | 394,978 | 544,468 | +149,490 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 145,286 | +145,286 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 583,266 | 714,048 | +130,782 | 0.01 | 0.02 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 182,000 | 310,000 | +128,000 | 0.91 | 2.24 | +1.34 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 110,444 | +110,444 | 0.00 | 0.01 | +0.01 | buy |
| Amundi | 0 | 101,531 | +101,531 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 200,000 | 300,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | 155,790 | +96,164 | 0.01 | 0.04 | +0.03 | buy |
| Lisanti Capital Growth, LLC | 0 | 92,124 | +92,124 | 0.00 | 1.47 | +1.47 | buy |
| Trexquant Investment LP | 128,869 | 215,121 | +86,252 | 0.06 | 0.15 | +0.09 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 86,972 | 168,222 | +81,250 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 209,857 | 285,293 | +75,436 | 0.00 | 0.00 | +0.00 | buy |
| Lombard Odier Asset Management (Europe) Ltd | 0 | 72,902 | +72,902 | 0.00 | 0.76 | +0.76 | buy |
| Hillsdale Investment Management Inc. | 0 | 70,900 | +70,900 | 0.00 | 0.14 | +0.14 | buy |
| Russell Investments Group, Ltd. | 9,265 | 77,293 | +68,028 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 39,638 | 100,206 | +60,568 | 0.04 | 0.14 | +0.10 | buy |
| Artia Global Partners LP | 0 | 60,176 | +60,176 | 0.00 | 0.69 | +0.69 | buy |
| Informed Momentum Co LLC | 0 | 54,977 | +54,977 | 0.00 | 0.41 | +0.41 | buy |
| Cubist Systematic Strategies, LLC | 0 | 48,654 | +48,654 | 0.00 | 0.04 | +0.04 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 149,839 | 197,434 | +47,595 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Hong Kong Ltd | 0 | 47,517 | +47,517 | 0.00 | 0.14 | +0.14 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 64,517 | 111,589 | +47,072 | 0.00 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 46,092 | +46,092 | 0.00 | 0.08 | +0.08 | buy |
| FMR LLC | 23,642,990 | 23,689,038 | +46,048 | 0.05 | 0.08 | +0.03 | buy |
| Bridgewater Associates, LP | 0 | 43,578 | +43,578 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 42,217 | +42,217 | 0.00 | 0.00 | +0.00 | buy |
| VAN ECK ASSOCIATES CORP | 73,617 | 111,819 | +38,202 | 0.00 | 0.01 | +0.00 | buy |
| LMR Partners LLP | 0 | 37,600 | +37,600 | 0.00 | 0.03 | +0.03 | buy |
| Stanley-Laman Group, Ltd. | 0 | 35,774 | +35,774 | 0.00 | 0.33 | +0.33 | buy |
| Polar Capital Holdings Plc | 1,000,000 | 1,033,622 | +33,622 | 0.21 | 0.33 | +0.12 | buy |
| FRED ALGER MANAGEMENT, LLC | 9,464 | 42,401 | +32,937 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,487,818 | 1,519,951 | +32,133 | 0.01 | 0.02 | +0.01 | buy |
| NORTHERN TRUST CORP | 814,250 | 844,943 | +30,693 | 0.00 | 0.01 | +0.00 | buy |
| Alpine Global Management, LLC | 25,437 | 55,900 | +30,463 | 0.23 | 0.66 | +0.44 | buy |
| RAYMOND JAMES FINANCIAL INC | 210,592 | 240,424 | +29,832 | 0.00 | 0.01 | +0.00 | buy |
| Twin Tree Management, LP | 0 | 28,575 | +28,575 | 0.00 | 0.09 | +0.09 | buy |
| WOLVERINE TRADING, LLC | 0 | 27,585 | +27,585 | 0.00 | 0.04 | +0.04 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 26,562 | +26,562 | 0.00 | 0.11 | +0.11 | buy |
| Calamos Advisors LLC | 0 | 25,863 | +25,863 | 0.00 | 0.01 | +0.01 | buy |
| BAMCO INC /NY/ | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| BlueCrest Capital Management Ltd | 0 | 23,370 | +23,370 | 0.00 | 0.09 | +0.09 | buy |
| Atika Capital Management LLC | 0 | 21,500 | +21,500 | 0.00 | 0.12 | +0.12 | buy |
| SEI INVESTMENTS CO | 98,348 | 119,028 | +20,680 | 0.00 | 0.01 | +0.00 | buy |
| Erste Asset Management GmbH | 51,300 | 71,800 | +20,500 | 0.02 | 0.04 | +0.03 | buy |
| Resolute Capital Asset Partners LLC | 0 | 20,000 | +20,000 | 0.00 | 0.68 | +0.68 | buy |
| Dana Investment Advisors, Inc. | 0 | 18,818 | +18,818 | 0.00 | 0.04 | +0.04 | buy |
| FIRST TRUST ADVISORS LP | 56,519 | 75,224 | +18,705 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 17,542 | 36,115 | +18,573 | 0.00 | 0.01 | +0.00 | buy |
| NOMURA HOLDINGS INC | 34,227 | 52,318 | +18,091 | 0.01 | 0.02 | +0.01 | buy |
| Gotham Asset Management, LLC | 14,279 | 32,152 | +17,873 | 0.00 | 0.01 | +0.01 | buy |
| Legato Capital Management LLC | 0 | 17,300 | +17,300 | 0.00 | 0.12 | +0.12 | buy |
| Traub Capital Management LLC | 0 | 17,000 | +17,000 | 0.00 | 0.02 | +0.02 | buy |
| DCF Advisers, LLC | 91,750 | 108,413 | +16,663 | 1.74 | 2.69 | +0.94 | buy |
| Diversified Trust Co | 0 | 15,633 | +15,633 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 83,386 | 98,023 | +14,637 | 0.00 | 0.01 | +0.00 | buy |
| Dynasty Wealth Management, LLC | 0 | 14,341 | +14,341 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 13,544 | 27,509 | +13,965 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 201,993 | 215,845 | +13,852 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 11,500 | +11,500 | 0.00 | 0.00 | +0.00 | buy |