| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 23,642,990 | 23,689,038 | +46,048 | 0.05 | 0.08 | +0.03 | buy |
| VANGUARD GROUP INC | 16,714,846 | 16,481,730 | -233,116 | 0.01 | 0.02 | +0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 16,048,721 | 13,156,929 | -2,891,792 | 0.40 | 0.53 | +0.13 | sell |
| Capital World Investors | 12,540,188 | 12,722,728 | +182,540 | 0.07 | 0.11 | +0.04 | buy |
| BlackRock, Inc. | 10,896,937 | 10,447,940 | -448,997 | 0.01 | 0.01 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 6,345,776 | 6,588,811 | +243,035 | 0.05 | 0.08 | +0.03 | buy |
| Bellevue Group AG | 7,853,198 | 6,244,451 | -1,608,747 | 6.84 | 8.49 | +1.65 | sell |
| Sonora Investment Management Group, LLC | 5,285,000 | 5,283,000 | -2,000 | 0.41 | 0.51 | +0.10 | sell |
| STATE STREET CORP | 4,530,398 | 4,388,651 | -141,747 | 0.01 | 0.01 | +0.00 | sell |
| Deep Track Capital, LP | 4,891,544 | 3,808,144 | -1,083,400 | 6.21 | 6.95 | +0.74 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,891,095 | 3,066,289 | +175,194 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 2,000,000 | 3,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| Tweedy, Browne Co LLC | 2,891,948 | 2,901,216 | +9,268 | 10.60 | 16.48 | +5.89 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,126,073 | 2,729,685 | -396,388 | 0.01 | 0.02 | +0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 2,500,000 | 2,500,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CITADEL ADVISORS LLC | 1,494,981 | 2,402,065 | +907,084 | 0.05 | 0.13 | +0.07 | buy |
| TWO SIGMA ADVISERS, LP | 2,667,611 | 2,073,111 | -594,500 | 0.22 | 0.27 | +0.06 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,979,669 | +1,979,669 | 0.00 | 1.98 | +1.98 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,788,367 | 1,575,943 | -212,424 | 0.13 | 0.16 | +0.03 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,487,818 | 1,519,951 | +32,133 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 608,640 | 1,393,124 | +784,484 | 0.02 | 0.09 | +0.06 | buy |
| AMERICAN CENTURY COMPANIES INC | 472,749 | 1,372,225 | +899,476 | 0.01 | 0.05 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,800,000 | 1,315,000 | -2,485,000 | 0.25 | 0.14 | -0.12 | sell |
| ROYAL BANK OF CANADA | 799,912 | 1,226,624 | +426,712 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 1,362,209 | 1,180,316 | -181,893 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 791,072 | 1,154,166 | +363,094 | 0.01 | 0.02 | +0.01 | buy |
| MACQUARIE GROUP LTD | 1,434,073 | 1,131,936 | -302,137 | 0.07 | 0.09 | +0.02 | sell |
| Vestal Point Capital, LP | 500,000 | 1,075,000 | +575,000 | 1.04 | 3.19 | +2.15 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,350,879 | 1,059,721 | -291,158 | 0.13 | 0.18 | +0.05 | sell |
| UBS Group AG | 1,529,323 | 1,046,990 | -482,333 | 0.01 | 0.01 | +0.00 | sell |
| Polar Capital Holdings Plc | 1,000,000 | 1,033,622 | +33,622 | 0.21 | 0.33 | +0.12 | buy |
| TD ASSET MANAGEMENT INC | 1,104,690 | 960,272 | -144,418 | 0.04 | 0.05 | +0.01 | sell |
| MARSHALL WACE, LLP | 13,100 | 958,829 | +945,729 | 0.00 | 0.07 | +0.07 | buy |
| Artisan Partners Limited Partnership | 354,962 | 890,072 | +535,110 | 0.02 | 0.08 | +0.06 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 265,793 | 878,155 | +612,362 | 0.04 | 0.18 | +0.14 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 519,184 | 862,593 | +343,409 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 995,890 | 855,295 | -140,595 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 814,250 | 844,943 | +30,693 | 0.00 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 854,634 | 803,047 | -51,587 | 0.12 | 0.18 | +0.05 | sell |
| MILLENNIUM MANAGEMENT LLC | 2,649,527 | 779,570 | -1,869,957 | 0.09 | 0.04 | -0.05 | sell |
| GOLDMAN SACHS GROUP INC | 777,940 | 777,570 | -370 | 0.00 | 0.01 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 368,119 | 765,822 | +397,703 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 768,648 | 760,111 | -8,537 | 0.07 | 0.10 | +0.03 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 750,000 | +750,000 | 0.00 | 1.60 | +1.60 | buy |
| BANK OF MONTREAL /CAN/ | 483,289 | 747,402 | +264,113 | 0.01 | 0.02 | +0.01 | buy |
| NOMURA HOLDINGS INC | 32,161 | 733,398 | +701,237 | 0.01 | 0.22 | +0.21 | buy |
| BARCLAYS PLC | 583,266 | 714,048 | +130,782 | 0.01 | 0.02 | +0.01 | buy |
| ARK Investment Management LLC | 900,318 | 631,215 | -269,103 | 0.26 | 0.25 | -0.02 | sell |
| D. E. Shaw & Co., Inc. | 0 | 630,938 | +630,938 | 0.00 | 0.03 | +0.03 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 630,136 | +630,136 | 0.00 | 0.03 | +0.03 | buy |
| Candriam S.C.A. | 724,740 | 611,237 | -113,503 | 0.17 | 0.21 | +0.04 | sell |
| BAKER BROS. ADVISORS LP | 0 | 566,798 | +566,798 | 0.00 | 0.27 | +0.27 | buy |
| GROUPAMA ASSET MANAGMENT | 660,957 | 561,777 | -99,180 | 0.44 | 0.55 | +0.10 | sell |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 550,000 | +400,000 | 0.30 | 1.39 | +1.09 | buy |
| JPMORGAN CHASE & CO | 394,978 | 544,468 | +149,490 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 588,900 | 538,661 | -50,239 | 2.34 | 2.70 | +0.35 | sell |
| Bank of New York Mellon Corp | 527,188 | 532,114 | +4,926 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 256,235 | 519,070 | +262,835 | 0.00 | 0.01 | +0.00 | buy |
| Hudson Bay Capital Management LP | 750,000 | 515,000 | -235,000 | 0.19 | 0.20 | +0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 500,000 | 500,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 270,714 | 486,714 | +216,000 | 0.01 | 0.04 | +0.03 | buy |
| PINNACLE ASSOCIATES LTD | 494,539 | 481,751 | -12,788 | 0.28 | 0.42 | +0.14 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 668,273 | 473,945 | -194,328 | 0.11 | 0.12 | +0.01 | sell |
| C WorldWide Group Holding A/S | 450,000 | 426,000 | -24,000 | 0.24 | 0.43 | +0.19 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 420,950 | +420,950 | 0.00 | 0.04 | +0.04 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 417,833 | +417,833 | 0.00 | 8.96 | +8.96 | buy |
| Nuveen, LLC | 245,085 | 415,618 | +170,533 | 0.00 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 415,163 | +415,163 | 0.00 | 5.49 | +5.49 | buy |
| Squarepoint Ops LLC | 134,395 | 383,792 | +249,397 | 0.01 | 0.05 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 177,762 | 383,226 | +205,464 | 0.01 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 365,070 | +365,070 | 0.00 | 0.03 | +0.03 | buy |
| Man Group plc | 8,969 | 333,820 | +324,851 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 404,366 | 319,565 | -84,801 | 0.00 | 0.00 | +0.00 | sell |
| Assenagon Asset Management S.A. | 17,654 | 312,297 | +294,643 | 0.00 | 0.03 | +0.03 | buy |
| Alyeska Investment Group, L.P. | 159,008 | 311,258 | +152,250 | 0.02 | 0.06 | +0.04 | buy |
| Rhenman & Partners Asset Management AB | 182,000 | 310,000 | +128,000 | 0.91 | 2.24 | +1.34 | buy |
| Bank of New York Mellon Corp | 200,000 | 300,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 288,600 | 293,100 | +4,500 | 0.01 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 209,857 | 285,293 | +75,436 | 0.00 | 0.00 | +0.00 | buy |
| SECTOR GAMMA AS | 285,842 | 270,963 | -14,879 | 3.69 | 4.40 | +0.70 | sell |
| GW&K Investment Management, LLC | 448,830 | 264,007 | -184,823 | 0.16 | 0.15 | -0.01 | sell |
| SEI INVESTMENTS CO | 262,000 | 262,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALGERT GLOBAL LLC | 38,090 | 252,281 | +214,191 | 0.03 | 0.28 | +0.24 | buy |
| Privium Fund Management B.V. | 267,594 | 248,894 | -18,700 | 2.31 | 2.93 | +0.62 | sell |
| RAYMOND JAMES FINANCIAL INC | 210,592 | 240,424 | +29,832 | 0.00 | 0.01 | +0.00 | buy |
| Jain Global LLC | 7,195 | 225,739 | +218,544 | 0.00 | 0.19 | +0.19 | buy |
| Orion Investment Co | 217,370 | 224,705 | +7,335 | 3.04 | 4.67 | +1.63 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 201,993 | 215,845 | +13,852 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 128,869 | 215,121 | +86,252 | 0.06 | 0.15 | +0.09 | buy |
| STIFEL FINANCIAL CORP | 196,357 | 202,628 | +6,271 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 449,206 | 200,839 | -248,367 | 0.13 | 0.09 | -0.04 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 149,839 | 197,434 | +47,595 | 0.01 | 0.02 | +0.01 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 187,345 | 193,045 | +5,700 | 0.11 | 0.18 | +0.07 | buy |
| GREAT LAKES ADVISORS, LLC | 399,646 | 186,950 | -212,696 | 0.13 | 0.10 | -0.03 | sell |
| RHUMBLINE ADVISERS | 181,599 | 182,061 | +462 | 0.01 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 173,819 | +173,819 | 0.00 | 0.57 | +0.57 | buy |
| Sonora Investment Management Group, LLC | 163,172 | 169,808 | +6,636 | 0.48 | 0.79 | +0.31 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 86,972 | 168,222 | +81,250 | 0.00 | 0.01 | +0.01 | buy |
| Sicart Associates LLC | 185,296 | 164,318 | -20,978 | 2.56 | 2.91 | +0.35 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 163,462 | +163,462 | 0.00 | 0.27 | +0.27 | buy |