Ionis Pharmaceuticals Inc
| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 2,649,527 | 779,570 | +1,869,957 | 0.12 | 0.05 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 265,793 | 878,155 | +612,362 | 0.04 | 0.18 | +0.15 | buy |
| Vestal Point Capital, LP | 500,000 | 1,075,000 | +575,000 | 1.04 | 3.19 | +2.15 | buy |
| Artisan Partners Limited Partnership | 354,962 | 890,072 | +535,110 | 0.02 | 0.08 | +0.06 | buy |
| TANG CAPITAL MANAGEMENT LLC | 150,000 | 550,000 | +400,000 | 0.30 | 1.39 | +1.09 | buy |
| NOMURA HOLDINGS INC | 370,332 | 733,398 | +363,066 | 0.06 | 0.22 | 0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 519,184 | 862,593 | +343,409 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 16,714,846 | 16,481,730 | +233,116 | 0.01 | 0.02 | 0.00 | sell |
| Jain Global LLC | 7,195 | 225,739 | +218,544 | 0.00 | 0.19 | +0.19 | buy |
| ALGERT GLOBAL LLC | 38,090 | 252,281 | +214,191 | 0.03 | 0.28 | 0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,788,367 | 1,575,943 | +212,424 | 0.14 | 0.17 | 0.00 | sell |
| GW&K Investment Management, LLC | 448,830 | 264,007 | +184,823 | 0.16 | 0.15 | -0.01 | sell |
| Capital World Investors | 12,540,188 | 12,722,728 | +182,540 | 0.07 | 0.11 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,891,095 | 3,066,289 | +175,194 | 0.01 | 0.01 | 0.00 | buy |
| Alyeska Investment Group, L.P. | 159,008 | 311,258 | +152,250 | 0.02 | 0.06 | +0.04 | buy |
| Rhenman & Partners Asset Management AB | 182,000 | 310,000 | +128,000 | 0.91 | 2.24 | +1.34 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 59,626 | 155,790 | +96,164 | 0.01 | 0.04 | +0.03 | buy |
| Polar Capital Holdings Plc | 1,000,000 | 1,033,622 | +33,622 | 0.21 | 0.33 | +0.12 | buy |
| FRED ALGER MANAGEMENT, LLC | 9,464 | 42,401 | +32,937 | 0.00 | 0.01 | +0.01 | buy |
| Alpine Global Management, LLC | 25,437 | 55,900 | +30,463 | 0.23 | 0.75 | +0.53 | buy |
| Erste Asset Management GmbH | 51,300 | 71,800 | +20,500 | 0.02 | 0.04 | +0.03 | buy |
| DCF Advisers, LLC | 91,750 | 108,413 | +16,663 | 1.74 | 2.69 | +0.94 | buy |
| Exome Asset Management LLC | 121,116 | 131,016 | +9,900 | 3.95 | 5.66 | +1.71 | buy |
| Tweedy, Browne Co LLC | 2,891,948 | 2,901,216 | +9,268 | 10.60 | 16.48 | +5.89 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 768,648 | 760,111 | +8,537 | 0.07 | 0.11 | 0.00 | sell |
| Bayesian Capital Management, LP | 16,600 | 24,715 | +8,115 | 0.10 | 0.33 | +0.23 | buy |
| Orion Investment Co | 217,370 | 224,705 | +7,335 | 3.04 | 4.67 | +1.63 | buy |
| Sonora Investment Management Group, LLC | 163,172 | 169,808 | +6,636 | 0.48 | 0.79 | +0.31 | buy |
| One Capital Management, LLC | 29,865 | 36,426 | +6,561 | 0.04 | 0.08 | +0.04 | buy |
| Future Fund LLC | 29,595 | 36,156 | +6,561 | 0.52 | 0.83 | +0.31 | buy |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 187,345 | 193,045 | +5,700 | 0.11 | 0.18 | +0.07 | buy |
| GUGGENHEIM CAPITAL LLC | 40,857 | 35,357 | +5,500 | 0.01 | 0.02 | 0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 8,298 | 13,578 | +5,280 | 0.04 | 0.14 | +0.09 | buy |
| Swiss National Bank | 288,600 | 293,100 | +4,500 | 0.01 | 0.01 | +0.00 | buy |
| Entropy Technologies, LP | 29,452 | 32,925 | +3,473 | 0.09 | 0.16 | +0.07 | buy |
| LAZARD ASSET MANAGEMENT LLC | 60,749 | 63,791 | +3,042 | 0.00 | 0.01 | 0.00 | buy |
| PROFUND ADVISORS LLC | 28,859 | 25,932 | +2,927 | 0.04 | 0.06 | 0.00 | sell |
| Treasurer of the State of North Carolina | 72,587 | 69,862 | +2,725 | 0.01 | 0.01 | 0.00 | sell |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 13,263 | 15,284 | +2,021 | 0.05 | 0.07 | +0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,615 | 45,220 | +1,605 | 0.00 | 0.01 | 0.00 | buy |
| CI INVESTMENTS INC. | 2,416 | 1,453 | +963 | 0.00 | 0.00 | 0.00 | sell |
| MEEDER ASSET MANAGEMENT INC | 99 | 713 | +614 | 0.00 | 0.00 | +0.00 | buy |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 11,952 | 12,476 | +524 | 0.01 | 0.01 | +0.00 | buy |
| GRANDFIELD & DODD, LLC | 37,230 | 37,675 | +445 | 0.09 | 0.14 | +0.05 | buy |
| Meeder Advisory Services, Inc. | 6,644 | 6,770 | +126 | 0.01 | 0.02 | +0.01 | buy |
| Wedmont Private Capital | 5,282 | 5,363 | +81 | 0.01 | 0.01 | +0.00 | buy |
| Global X Japan Co., Ltd. | 259 | 321 | +62 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 7,068 | 7,118 | +50 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 145,104 | 145,112 | +8 | 0.01 | 0.01 | +0.00 | buy |
| Frank, Rimerman Advisors LLC | 5,763 | 5,765 | +2 | 0.02 | 0.02 | +0.01 | buy |
| Principia Wealth Advisory, LLC | 25 | 26 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Itau Unibanco Holding S.A. | 1,124 | 1,121 | -3 | 0.00 | 0.00 | +0.00 | sell |
| Harvest Fund Management Co., Ltd | 1,829 | 1,746 | -83 | 0.00 | 0.00 | +0.00 | sell |
| Utah Retirement Systems | 8,400 | 8,300 | -100 | 0.00 | 0.01 | +0.00 | sell |
| Pinnacle Wealth Planning Services, Inc. | 5,284 | 5,113 | -171 | 0.03 | 0.04 | +0.01 | sell |
| Nicollet Investment Management, Inc. | 20,747 | 20,408 | -339 | 0.27 | 0.44 | +0.16 | sell |
| Significant Wealth Partners LLC | 15,504 | 14,967 | -537 | 0.30 | 0.48 | +0.18 | sell |
| CAPITAL COUNSEL LLC/NY | 50,205 | 49,605 | -600 | 0.08 | 0.12 | +0.04 | sell |
| GF FUND MANAGEMENT CO. LTD. | 4,042 | 3,429 | -613 | 0.00 | 0.00 | +0.00 | sell |
| Sonora Investment Management Group, LLC | 5,285,000 | 5,283,000 | -2,000 | 0.41 | 0.51 | +0.10 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 39,423 | 37,293 | -2,130 | 0.15 | 0.19 | +0.04 | sell |
| FIDUCIARY TRUST CO | 8,551 | 6,377 | -2,174 | 0.00 | 0.00 | +0.00 | sell |
| DnB Asset Management AS | 12,271 | 9,308 | -2,963 | 0.00 | 0.00 | +0.00 | sell |
| WEXFORD CAPITAL LP | 4,749 | 1,192 | -3,557 | 0.05 | 0.02 | -0.03 | sell |
| Fieldview Capital Management, LLC | 17,306 | 13,523 | -3,783 | 0.10 | 0.14 | +0.04 | sell |
| China Universal Asset Management Co., Ltd. | 31,966 | 27,939 | -4,027 | 0.12 | 0.15 | +0.03 | sell |
| Bleakley Financial Group, LLC | 18,129 | 13,878 | -4,251 | 0.02 | 0.02 | +0.00 | sell |
| Perbak Capital Partners LLP | 9,538 | 4,426 | -5,112 | 0.09 | 0.05 | -0.03 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 9,561 | 3,093 | -6,468 | 0.00 | 0.00 | -0.00 | sell |
| Raiffeisen Bank International AG | 56,754 | 50,000 | -6,754 | 0.03 | 0.04 | +0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 132,045 | 122,766 | -9,279 | 0.12 | 0.18 | +0.05 | sell |
| PINNACLE ASSOCIATES LTD | 494,539 | 481,751 | -12,788 | 0.28 | 0.42 | +0.14 | sell |
| ADAR1 Capital Management, LLC | 148,461 | 133,818 | -14,643 | 0.95 | 0.87 | -0.09 | sell |
| SECTOR GAMMA AS | 285,842 | 270,963 | -14,879 | 3.69 | 4.40 | +0.70 | sell |
| Granite Investment Partners, LLC | 43,181 | 28,033 | -15,148 | 0.08 | 0.10 | +0.02 | sell |
| NEOS Investment Management LLC | 28,161 | 12,306 | -15,855 | 0.01 | 0.01 | -0.01 | sell |
| TEMA ETFS LLC | 28,161 | 12,306 | -15,855 | 0.30 | 0.07 | -0.23 | sell |
| Privium Fund Management B.V. | 267,594 | 248,894 | -18,700 | 2.31 | 2.93 | +0.62 | sell |
| Rafferty Asset Management, LLC | 144,770 | 125,773 | -18,997 | 0.02 | 0.03 | +0.01 | sell |
| Sicart Associates LLC | 185,296 | 164,318 | -20,978 | 2.56 | 2.91 | +0.35 | sell |
| C WorldWide Group Holding A/S | 450,000 | 426,000 | -24,000 | 0.24 | 0.43 | +0.19 | sell |
| Nikko Asset Management Americas, Inc. | 139,739 | 114,592 | -25,147 | 0.06 | 0.07 | +0.02 | sell |
| BLB&B Advisors, LLC | 151,550 | 118,600 | -32,950 | 0.28 | 0.33 | +0.06 | sell |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 197,600 | 156,690 | -40,910 | 0.12 | 0.16 | +0.03 | sell |
| Eversept Partners, LP | 588,900 | 538,661 | -50,239 | 2.34 | 2.70 | +0.35 | sell |
| J. Goldman & Co LP | 147,682 | 96,198 | -51,484 | 0.18 | 0.24 | +0.05 | sell |
| Marex Group plc | 83,361 | 6,722 | -76,639 | 0.06 | 0.01 | -0.06 | sell |
| Legal & General Group Plc | 404,366 | 319,565 | -84,801 | 0.00 | 0.00 | +0.00 | sell |
| GROUPAMA ASSET MANAGMENT | 660,957 | 561,777 | -99,180 | 0.44 | 0.55 | +0.10 | sell |
| Candriam S.C.A. | 724,740 | 611,237 | -113,503 | 0.17 | 0.21 | +0.04 | sell |
| TD ASSET MANAGEMENT INC | 1,104,690 | 960,272 | -144,418 | 0.04 | 0.05 | +0.01 | sell |
| Sovran Advisors, LLC | 321,913 | 150,856 | -171,057 | 1.39 | 0.99 | -0.41 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 668,273 | 473,945 | -194,328 | 0.11 | 0.13 | +0.01 | sell |
| GREAT LAKES ADVISORS, LLC | 399,646 | 186,950 | -212,696 | 0.13 | 0.10 | -0.03 | sell |
| ARK Investment Management LLC | 900,318 | 631,215 | -269,103 | 0.26 | 0.25 | -0.02 | sell |
| Aberdeen Group plc | 406,694 | 87,924 | -318,770 | 0.03 | 0.01 | -0.02 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,126,073 | 2,729,685 | -396,388 | 0.01 | 0.02 | +0.01 | sell |
| GREAT POINT PARTNERS LLC | 500,000 | 80,000 | -420,000 | 12.84 | 2.19 | -10.66 | sell |
| Deep Track Capital, LP | 4,891,544 | 3,808,144 | -1,083,400 | 6.21 | 6.95 | +0.74 | sell |
| Bellevue Group AG | 7,853,198 | 6,244,451 | -1,608,747 | 6.84 | 8.49 | +1.65 | sell |