| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 7,828,372 | 11,465,413 | +3,637,041 | 0.05 | 0.06 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 2,324,447 | 2,817,347 | +492,900 | 1.70 | 2.05 | +0.34 | buy |
| BNP Paribas Asset Management Holding S.A. | 779,721 | 1,080,341 | +300,620 | 0.08 | 0.09 | +0.02 | buy |
| GREAT POINT PARTNERS LLC | 255,000 | 505,007 | +250,007 | 3.01 | 8.32 | +5.31 | buy |
| NOMURA HOLDINGS INC | 501,188 | 357,255 | +143,933 | 0.16 | 0.07 | 0.00 | sell |
| BAKER BROS. ADVISORS LP | 223,470 | 357,915 | +134,445 | 0.09 | 0.13 | +0.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 17,741 | 125,389 | +107,648 | 0.00 | 0.02 | +0.02 | buy |
| GROUPAMA ASSET MANAGMENT | 416,060 | 517,191 | +101,131 | 0.35 | 0.38 | +0.03 | buy |
| C WorldWide Group Holding A/S | 300,000 | 400,000 | +100,000 | 0.12 | 0.17 | +0.05 | buy |
| Aberdeen Group plc | 303,274 | 401,501 | +98,227 | 0.02 | 0.03 | +0.00 | buy |
| PINNACLE ASSOCIATES LTD | 458,979 | 547,642 | +88,663 | 0.39 | 0.26 | -0.14 | buy |
| COMMERCE BANK | 77,553 | 13,584 | +63,969 | 0.02 | 0.00 | 0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 162,076 | 223,278 | +61,202 | 0.14 | 0.17 | +0.03 | buy |
| Hudson Bay Capital Management LP | 766,900 | 821,200 | +54,300 | 0.12 | 0.10 | -0.02 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 56,222 | 100,659 | +44,437 | 0.00 | 0.00 | +0.00 | buy |
| DCF Advisers, LLC | 39,500 | 82,882 | +43,382 | 0.81 | 1.46 | +0.65 | buy |
| Rafferty Asset Management, LLC | 198,759 | 237,337 | +38,578 | 0.03 | 0.03 | +0.00 | buy |
| SECTOR GAMMA AS | 210,842 | 235,842 | +25,000 | 2.56 | 2.83 | +0.27 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 36,957 | 60,580 | +23,623 | 0.12 | 0.17 | 0.00 | buy |
| Swiss National Bank | 256,600 | 279,200 | +22,600 | 0.01 | 0.01 | -0.00 | buy |
| Rhenman & Partners Asset Management AB | 195,000 | 212,500 | +17,500 | 0.63 | 0.76 | +0.13 | buy |
| Privium Fund Management B.V. | 250,744 | 266,794 | +16,050 | 2.50 | 2.11 | -0.39 | buy |
| PDT Partners, LLC | 13,400 | 28,994 | +15,594 | 0.05 | 0.09 | +0.04 | buy |
| Y-Intercept (Hong Kong) Ltd | 20,141 | 9,407 | +10,734 | 0.05 | 0.02 | 0.00 | sell |
| Bridgefront Capital, LLC | 11,196 | 21,802 | +10,606 | 0.17 | 0.26 | +0.08 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 56,699 | 65,792 | +9,093 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 126,180 | 133,902 | +7,722 | 0.01 | 0.01 | -0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 11,612 | 17,723 | +6,111 | 0.09 | 0.11 | +0.02 | buy |
| PROFUND ADVISORS LLC | 37,596 | 43,559 | +5,963 | 0.06 | 0.06 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 28,121 | 33,480 | +5,359 | 0.12 | 0.11 | -0.01 | buy |
| Harbor Advisors LLC | 5,500 | 10,500 | +5,000 | 0.04 | 0.06 | +0.02 | buy |
| TORNO CAPITAL, LLC | 5,000 | 9,500 | +4,500 | 0.26 | 0.07 | -0.19 | buy |
| E Fund Management Co., Ltd. | 12,752 | 16,868 | +4,116 | 0.03 | 0.03 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 919,077 | 921,439 | +2,362 | 0.09 | 0.08 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 37,159 | 35,373 | +1,786 | 0.01 | 0.01 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 8,009 | 9,448 | +1,439 | 0.15 | 0.13 | -0.02 | buy |
| T. Rowe Price Investment Management, Inc. | 14,168,116 | 14,169,199 | +1,083 | 0.34 | 0.31 | -0.04 | buy |
| GRANDFIELD & DODD, LLC | 34,813 | 35,887 | +1,074 | 0.08 | 0.08 | -0.01 | buy |
| Annis Gardner Whiting Capital Advisors, LLC | 9,936 | 10,736 | +800 | 0.11 | 0.11 | -0.01 | buy |
| CI INVESTMENTS INC. | 3,380 | 4,090 | +710 | 0.00 | 0.00 | 0.00 | buy |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 11,952 | 12,476 | +524 | 0.01 | 0.01 | -0.00 | buy |
| Treasurer of the State of North Carolina | 68,363 | 68,803 | +440 | 0.01 | 0.01 | 0.00 | buy |
| Horizon Investments, LLC | 1,101 | 1,174 | +73 | 0.00 | 0.00 | +0.00 | buy |
| Itau Unibanco Holding S.A. | 1,081 | 1,151 | +70 | 0.00 | 0.00 | -0.00 | buy |
| Global X Japan Co., Ltd. | 235 | 297 | +62 | 0.00 | 0.00 | +0.00 | buy |
| Riverview Trust Co | 487 | 476 | -11 | 0.02 | 0.02 | -0.00 | sell |
| WOLFF WIESE MAGANA LLC | 110 | 41 | -69 | 0.00 | 0.00 | -0.00 | sell |
| Global Trust Asset Management, LLC | 474 | 399 | -75 | 0.01 | 0.01 | -0.00 | sell |
| Washington Trust Advisors, Inc. | 83 | 0 | -83 | 0.00 | 0.00 | -0.00 | sell |
| Boussard & Gavaudan Investment Management LLP | 55,000 | 54,910 | -90 | 5.00 | 4.45 | -0.54 | sell |
| Elequin Capital, LP | 437 | 325 | -112 | 0.00 | 0.00 | -0.00 | sell |
| Plancorp, LLC | 11,286 | 11,128 | -158 | 0.02 | 0.02 | -0.00 | sell |
| BLB&B Advisors, LLC | 152,250 | 152,050 | -200 | 0.31 | 0.27 | -0.04 | sell |
| Nicollet Investment Management, Inc. | 20,402 | 19,786 | -616 | 0.28 | 0.24 | -0.04 | sell |
| J. Goldman & Co LP | 609,416 | 607,499 | -1,917 | 0.68 | 0.55 | -0.13 | sell |
| Teza Capital Management LLC | 10,600 | 8,525 | -2,075 | 0.05 | 0.05 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 9,440 | 7,200 | -2,240 | 0.22 | 0.17 | -0.06 | sell |
| NEOS Investment Management LLC | 59,244 | 56,844 | -2,400 | 0.07 | 0.05 | -0.02 | sell |
| Orion Investment Co | 218,525 | 216,000 | -2,525 | 3.40 | 3.01 | -0.39 | sell |
| Bellevue Group AG | 7,874,400 | 7,868,700 | -5,700 | 5.11 | 5.30 | +0.18 | sell |
| Sicart Associates LLC | 191,523 | 185,821 | -5,702 | 2.69 | 2.32 | -0.37 | sell |
| Brevan Howard Capital Management LP | 28,479 | 21,366 | -7,113 | 0.01 | 0.00 | -0.00 | sell |
| Granite Investment Partners, LLC | 85,793 | 73,866 | -11,927 | 0.15 | 0.11 | -0.04 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 25,435 | 10,270 | -15,165 | 0.10 | 0.04 | -0.07 | sell |
| Liontrust Investment Partners LLP | 59,644 | 41,621 | -18,023 | 0.04 | 0.02 | -0.02 | sell |
| Alyeska Investment Group, L.P. | 168,951 | 150,000 | -18,951 | 0.03 | 0.02 | -0.01 | sell |
| Nikko Asset Management Americas, Inc. | 196,114 | 156,657 | -39,457 | 0.09 | 0.06 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 1,092,990 | 1,049,990 | -43,000 | 0.04 | 0.03 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 229,969 | 180,002 | -49,967 | 0.08 | 0.05 | -0.03 | sell |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 406,870 | 352,140 | -54,730 | 0.26 | 0.19 | -0.06 | sell |
| Clearbridge Investments, LLC | 1,702,393 | 1,618,220 | -84,173 | 0.05 | 0.05 | -0.01 | sell |
| Candriam S.C.A. | 948,266 | 849,824 | -98,442 | 0.27 | 0.17 | -0.10 | sell |
| Tweedy, Browne Co LLC | 3,454,676 | 3,248,863 | -205,813 | 6.60 | 7.66 | +1.06 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 275,000 | -225,000 | 0.04 | 0.02 | -0.02 | sell |
| Eversept Partners, LP | 471,355 | 214,952 | -256,403 | 1.29 | 0.67 | -0.63 | sell |
| Deep Track Capital, LP | 2,200,000 | 1,933,928 | -266,072 | 2.81 | 2.53 | -0.28 | sell |
| Ghisallo Capital Management LLC | 400,000 | 100,000 | -300,000 | 0.79 | 0.20 | -0.59 | sell |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 328,772 | 8,207 | -320,565 | 0.02 | 0.02 | +0.00 | sell |
| ARK Investment Management LLC | 1,384,269 | 1,025,260 | -359,009 | 0.51 | 0.30 | -0.21 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 650,779 | 281,813 | -368,966 | 0.10 | 0.03 | -0.07 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,210,172 | 3,826,939 | -383,233 | 0.02 | 0.02 | -0.00 | sell |
| Artisan Partners Limited Partnership | 2,240,455 | 252,635 | -1,987,820 | 0.13 | 0.01 | -0.12 | sell |
| Sonora Investment Management Group, LLC | 12,363,000 | 160,000 | -12,203,000 | 0.91 | 0.01 | -0.90 | sell |