VERTEX PHARMACEUTICALS INC
| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| Capital Research Global Investors | 17,316,344 | 21,125,964 | +3,809,620 | 1.45 | 1.46 | +0.01 | buy |
| Capital International Investors | 4,733,596 | 5,126,077 | +392,481 | 0.34 | 0.54 | +0.20 | buy |
| AGF MANAGEMENT LTD | 568 | 201,403 | +200,835 | 0.00 | 0.40 | +0.40 | buy |
| AMF Tjanstepension AB | 145,949 | 312,917 | +166,968 | 0.41 | 0.93 | +0.52 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 211,934 | 327,498 | +115,564 | 0.03 | 0.05 | +0.02 | buy |
| Holocene Advisors, LP | 1,478 | 67,618 | +66,140 | 0.00 | 0.07 | +0.07 | buy |
| FJARDE AP-FONDEN /FOURTH SWEDISH NATIONAL PENSION FUND | 89,062 | 149,962 | +60,900 | 0.34 | 0.37 | +0.03 | buy |
| ABN AMRO INVESTMENT SOLUTIONS | 19,070 | 68,216 | +49,146 | 0.13 | 0.40 | +0.27 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 10,526 | 49,531 | +39,005 | 0.04 | 0.23 | +0.19 | buy |
| TRILLIUM ASSET MANAGEMENT, LLC | 62,693 | 99,762 | +37,069 | 0.87 | 0.93 | +0.06 | buy |
| LBP AM SA | 67,197 | 98,975 | +31,778 | 0.35 | 0.60 | +0.25 | buy |
| NEOS Investment Management LLC | 146,198 | 174,087 | +27,889 | 0.38 | 0.39 | +0.01 | buy |
| Erste Asset Management GmbH | 67,363 | 91,958 | +24,595 | 0.26 | 0.38 | +0.12 | buy |
| OSSIAM | 17,594 | 39,357 | +21,763 | 0.16 | 0.31 | +0.15 | buy |
| Capital International Sarl | 193,438 | 208,882 | +15,444 | 1.41 | 1.53 | +0.12 | buy |
| Madison Asset Management, LLC | 16,435 | 27,387 | +10,952 | 0.09 | 0.15 | +0.07 | buy |
| Swedbank AB | 260,743 | 271,553 | +10,810 | 0.11 | 0.13 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 34,255 | 43,485 | +9,230 | 1.45 | 2.40 | +0.94 | buy |
| Korea Investment CORP | 193,435 | 201,168 | +7,733 | 0.17 | 0.19 | +0.01 | buy |
| Robeco Institutional Asset Management B.V. | 394,200 | 401,644 | +7,444 | 0.25 | 0.26 | +0.00 | buy |
| Gulf International Bank (UK) Ltd | 12,916 | 19,636 | +6,720 | 0.19 | 0.20 | +0.01 | buy |
| CITIZENS FINANCIAL GROUP INC/RI | 43,403 | 49,824 | +6,421 | 0.26 | 0.31 | +0.05 | buy |
| AVIVA PLC | 216,211 | 222,452 | +6,241 | 0.17 | 0.17 | +0.00 | buy |
| Delaney Dennis R | 6,969 | 11,649 | +4,680 | 1.59 | 1.84 | +0.25 | buy |
| Machina Capital S.A.S. | 5,064 | 9,654 | +4,590 | 0.44 | 0.85 | +0.41 | buy |
| COUNTRY TRUST BANK | 100,593 | 105,075 | +4,482 | 0.83 | 0.89 | +0.07 | buy |
| Gibbs Wealth Management | 1,235 | 5,647 | +4,412 | 0.14 | 0.33 | +0.19 | buy |
| Virtus Investment Advisers, LLC | 1,511 | 5,869 | +4,358 | 0.19 | 0.72 | +0.54 | buy |
| BANQUE PICTET & CIE SA | 24,328 | 28,550 | +4,222 | 0.11 | 0.15 | +0.04 | buy |
| Financiere des Professionnels - Fonds d,investissement inc. | 625 | 4,685 | +4,060 | 0.02 | 0.12 | +0.11 | buy |
| MRP Capital Investments, LLC | 4 | 3,925 | +3,921 | 0.00 | 1.53 | +1.53 | buy |
| BAILARD, INC. | 33,975 | 37,862 | +3,887 | 0.34 | 0.39 | +0.05 | buy |
| Smith Group Asset Management, LLC | 52,051 | 55,746 | +3,695 | 1.25 | 1.27 | +0.02 | buy |
| Candriam S.C.A. | 225,292 | 228,915 | +3,623 | 0.51 | 0.53 | +0.02 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 894 | 4,238 | +3,344 | 0.09 | 0.49 | +0.39 | buy |
| Heirloom Wealth Management | 20,199 | 23,458 | +3,259 | 2.12 | 1.89 | -0.23 | buy |
| Kentucky Retirement Systems | 16,147 | 19,299 | +3,152 | 0.20 | 0.11 | -0.09 | buy |
| Patriot Financial Group Insurance Agency, LLC | 3,034 | 6,124 | +3,090 | 0.16 | 0.15 | -0.01 | buy |
| APG Asset Management N.V. | 188,385 | 191,385 | +3,000 | 0.21 | 0.24 | +0.03 | buy |
| Varma Mutual Pension Insurance Co | 40,626 | 43,626 | +3,000 | 0.11 | 0.11 | +0.00 | buy |
| Hedeker Wealth, LLC | 4,665 | 7,626 | +2,961 | 0.44 | 0.72 | +0.27 | buy |
| MEEDER ASSET MANAGEMENT INC | 625 | 3,424 | +2,799 | 0.02 | 0.09 | +0.07 | buy |
| GROUPAMA ASSET MANAGMENT | 163,144 | 165,897 | +2,753 | 1.08 | 1.08 | -0.00 | buy |
| MASTERINVEST Kapitalanlage GmbH | 5,544 | 8,293 | +2,749 | 0.24 | 0.38 | +0.15 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 36,791 | 39,498 | +2,707 | 0.24 | 0.26 | +0.02 | buy |
| MOODY LYNN & LIEBERSON, LLC | 54,992 | 57,640 | +2,648 | 1.32 | 1.44 | +0.12 | buy |
| Americana Partners, LLC | 27,133 | 29,773 | +2,640 | 0.34 | 0.35 | +0.01 | buy |
| Lighthouse Financial LLC | 3,730 | 6,277 | +2,547 | 1.11 | 1.69 | +0.59 | buy |
| BAMCO INC /NY/ | 5,200 | 7,500 | +2,300 | 0.01 | 0.01 | +0.00 | buy |
| Czech National Bank | 66,902 | 69,176 | +2,274 | 0.20 | 0.20 | +0.01 | buy |
| Aureus Asset Management, LLC | 6,142 | 8,395 | +2,253 | 0.18 | 0.25 | +0.07 | buy |
| Capital International, Inc./CA/ | 159,660 | 161,723 | +2,063 | 0.57 | 0.56 | -0.01 | buy |
| Privium Fund Management B.V. | 9,355 | 11,355 | +2,000 | 0.78 | 1.06 | +0.27 | buy |
| BOWEN HANES & CO INC | 133,504 | 135,399 | +1,895 | 1.52 | 1.47 | -0.05 | buy |
| NISSAY ASSET MANAGEMENT CORP /JAPAN | 69,627 | 71,463 | +1,836 | 0.16 | 0.17 | +0.00 | buy |
| GW HENSSLER & ASSOCIATES LTD | 18,834 | 20,640 | +1,806 | 0.41 | 0.43 | +0.02 | buy |
| PRUDENTIAL PLC | 15,771 | 17,526 | +1,755 | 0.06 | 0.05 | -0.01 | buy |
| USS Investment Management Ltd | 45,393 | 47,128 | +1,735 | 0.10 | 0.08 | -0.01 | buy |
| Bleakley Financial Group, LLC | 15,594 | 17,226 | +1,632 | 0.12 | 0.12 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 43,221 | 44,750 | +1,529 | 0.50 | 0.50 | +0.00 | buy |
| WELCH & FORBES LLC | 218,198 | 219,669 | +1,471 | 1.20 | 1.27 | +0.07 | buy |
| Broderick Brian C | 17,202 | 18,656 | +1,454 | 1.47 | 1.54 | +0.06 | buy |
| KAYNE ANDERSON RUDNICK INVESTMENT MANAGEMENT LLC | 11,645 | 13,085 | +1,440 | 0.01 | 0.02 | +0.00 | buy |
| Banco Santander, S.A. | 98,027 | 99,388 | +1,361 | 0.33 | 0.36 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 13,716 | 15,075 | +1,359 | 0.47 | 0.40 | -0.06 | buy |
| RMR Wealth Builders | 5,789 | 7,110 | +1,321 | 0.21 | 0.25 | +0.04 | buy |
| Phoenix Financial Ltd. | 3,533 | 4,833 | +1,300 | 0.02 | 0.02 | +0.00 | buy |
| Prudent Man Advisors, LLC | 2,129 | 3,427 | +1,298 | 0.35 | 0.46 | +0.11 | buy |
| NWAM LLC | 5,038 | 6,332 | +1,294 | 0.13 | 0.16 | +0.03 | buy |
| IFM Investors Pty Ltd | 49,780 | 51,070 | +1,290 | 0.19 | 0.19 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 36,818 | 38,069 | +1,251 | 0.14 | 0.14 | -0.00 | buy |
| Tweedy, Browne Co LLC | 39,148 | 40,387 | +1,239 | 1.43 | 1.43 | -0.00 | buy |
| National Pension Service | 530,841 | 532,069 | +1,228 | 0.18 | 0.18 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 3,000 | 4,195 | +1,195 | 0.02 | 0.03 | +0.01 | buy |
| Sand Hill Global Advisors, LLC | 5,176 | 6,369 | +1,193 | 0.08 | 0.10 | +0.01 | buy |
| E Fund Management Co., Ltd. | 9,628 | 10,816 | +1,188 | 0.20 | 0.14 | -0.06 | buy |
| Calamos Wealth Management LLC | 648 | 1,834 | +1,186 | 0.01 | 0.03 | +0.02 | buy |
| Elefante Mark B | 7,015 | 8,141 | +1,126 | 1.95 | 2.00 | +0.05 | buy |
| Boston Common Asset Management, LLC | 16,081 | 17,205 | +1,124 | 0.44 | 0.49 | +0.06 | buy |
| Sumitomo Mitsui DS Asset Management Company, Ltd | 62,761 | 63,822 | +1,061 | 0.22 | 0.23 | +0.01 | buy |
| Generali Investments, Management Co LLC | 2,347 | 3,366 | +1,019 | 0.21 | 0.35 | +0.14 | buy |
| GATEWAY INVESTMENT ADVISERS LLC | 66,108 | 67,121 | +1,013 | 0.28 | 0.33 | +0.06 | buy |
| DCF Advisers, LLC | 6,000 | 7,000 | +1,000 | 0.90 | 1.18 | +0.28 | buy |
| First National Bank of Mount Dora, Trust Investment Services | 6,212 | 7,211 | +999 | 0.62 | 0.70 | +0.08 | buy |
| UNIVEST FINANCIAL Corp | 6,097 | 7,063 | +966 | 0.15 | 0.18 | +0.03 | buy |
| Slow Capital, Inc. | 11,344 | 12,307 | +963 | 0.61 | 0.71 | +0.10 | buy |
| MWA Asset Management | 3,216 | 4,143 | +927 | 0.81 | 1.01 | +0.20 | buy |
| Galvin, Gaustad & Stein, LLC | 34,309 | 35,233 | +924 | 1.21 | 1.26 | +0.05 | buy |
| Resona Asset Management Co.,Ltd. | 89,399 | 90,312 | +913 | 0.20 | 0.20 | +0.01 | buy |
| Telos Capital Management, Inc. | 22,376 | 23,234 | +858 | 0.95 | 0.99 | +0.05 | buy |
| 111 Capital | 2,892 | 3,740 | +848 | 0.29 | 0.41 | +0.13 | buy |
| Norinchukin Bank, The | 24,203 | 25,049 | +846 | 0.13 | 0.13 | +0.00 | buy |
| Northwest & Ethical Investments L.P. | 11,104 | 11,942 | +838 | 0.11 | 0.12 | +0.01 | buy |
| ASHFORD CAPITAL MANAGEMENT INC | 8,245 | 9,078 | +833 | 0.42 | 0.50 | +0.08 | buy |
| NICOLET BANKSHARES INC | 617 | 1,417 | +800 | 0.04 | 0.02 | -0.02 | buy |
| Bellevue Group AG | 681,120 | 681,908 | +788 | 5.85 | 7.25 | +1.39 | buy |
| Reynders McVeigh Capital Management, LLC | 53,905 | 54,664 | +759 | 1.15 | 1.23 | +0.08 | buy |
| Fiduciary Alliance LLC | 4,828 | 5,583 | +755 | 0.14 | 0.15 | +0.01 | buy |
| Dempze Nancy E | 7,058 | 7,810 | +752 | 1.67 | 1.92 | +0.25 | buy |
| JOURNEY STRATEGIC WEALTH LLC | 1,441 | 2,143 | +702 | 0.02 | 0.02 | +0.01 | buy |